检索结果-南通市图书馆

Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： Yao Rong Ming-Zheng Tang Song-Hua Liu Xiao-feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient and selective removal of Pb(Ⅱ) from landfill leachate using L-serine-modified polyethylene/polypropylene nonwoven fabric synthesized via radiation grafting technique

引用

Nuclear Science and Techniques 2024年第4期35卷 144-155页

作者： Xin-Xin feng Cheng Li Xuan-Zhi Mao Wan-ning Ren Yang Gao Yu-Long He Zhe Xing Rong Li Guo-Zhong Wu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

In this study,to efficiently remove Pb(Ⅱ) from aqueous environments,a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent(NWF-serine)was fabricated through the radiation grafting of glycidyl methacrylate and subsequent L-serine *** effect of the absorbed dose was investigated in the range of 5–50 ***-serine was characterized by Fourier transform infrared spectroscopy,thermogravimetric analysis,and scanning electron *** adsorption tests were conducted to investigate the influences of pH,adsorption time,temperature,initial concentration,and sorbent dosage on the Pb(Ⅱ) adsorption performance of *** results indicated that Pb(Ⅱ) adsorption onto NWF-serine was an endothermic process,following the pseudo-second-order kinetic model and Langmuir isotherm *** saturated adsorption capacity was 198.1 mg/***-serine exhibited Pb(Ⅱ) removal rates of 99.8% for aqueous solutions with initial concentrations of 100 mg/L and 82.1% for landfill leachate containing competitive metal ions such as Cd,Cu,Ni,Mn,and ***,NWF-serine maintained 86% of its Pb(Ⅱ) uptake after five use *** coordination of the carboxyl and amino groups with Pb(Ⅱ) was confirmed using X-ray photoelectron spectroscopy and extended X-ray absorption fine structure analysis.

关键词： Landfill leachate Radiation grafting Polyethylene/polypropylene nonwoven fabric Pb(Ⅱ)removal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental Study on Ammonia Co-Firing with Coal for Carbon Reduction in the Boiler of a 300-MW Coal-Fired Power Station

引用

Engineering 2024年第9期40卷 247-259页

作者： Qifu Lin Wangping Sun Haiyan Li Yangjiong Liu Yuwei Chen Chengzhou Liu Yiman Jiang Yu Cheng ning Ma Huaqing Ya Longwei Chen Shidong Fang Hansheng feng Guang-Nan Luo Jiangang Li Kaixin Xiang Jie Cong Cheng Cheng Institute of Energy Hefei Comprehensive National Science Center(Anhui Energy Laboratory)Hefei 230088China Anbang Technology Co.Ltd Tongling 244000China Institute of Plasma Physics Hefei Institute of Matter ScienceChinese Academy of SciencesHefei 230031China

To reduce CO_(2) emissions from coal-fired power plants,the development of low-carbon or carbon-free fuel combustion technologies has become *** a new zero-carbon fuel,ammonia(NH_(3))can be used to address the storage and transportation issues of hydrogen *** it is not feasible to completely replace coal with ammonia in the short term,the development of ammonia-coal co-combustion technology at the current stage is a fast and feasible approach to reduce CO_(2) emissions from coal-fired power *** study focuses on modifying the boiler and installing two layers of eight pure-ammonia burners in a 300-MW coal-fired power plant to achieve ammonia-coal co-combustion at proportions ranging from 20%to 10%(by heat ratio)at loads of 180-to 300-MW,*** results show that,during ammonia-coal co-combustion in a 300-MW coal-fired power plant,there was a more significant change in NO_(x) emissions at the furnace outlet compared with that under pure-coal combustion as the boiler oxygen levels ***,ammonia burners located in the middle part of the main combustion zone exhibited a better high-temperature reduction performance than those located in the upper part of the main combustion *** all ammonia co-combustion conditions,the NH_(3) concentration at the furnace outlet remained below 1 parts per million(ppm).Compared with that under pure-coal conditions,the thermal efficiency of the boiler slightly decreased(by 0.12%-0.38%)under different loads when ammonia co-combustion reached 15 t·h^(-1).Ammonia co-combustion in coal-fired power plants is a potentially feasible technology route for carbon reduction.

关键词： Coal-fired boiler Coal mixing with ammonia Ammonia-coal co-firing Nitrogen oxide(NO_(x)) CO_(2)reduction Boiler thermal efficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Catalytic Asymmetric Diastereodivergent Synthesis of 2-Alkenylindoles Bearing both Axial and Central Chirality

引用

Precision Chemistry 2024年第5期2卷 208-220页

作者： Shuang Yang Jia-Bo Huang Da-Hua Wang ning-Yi Wang Yu-Yu Chen Xin-Yan Ke Hao Chen Shao-Fei Ni Yu-Chen Zhang feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhou 221116China Department of Chemistry Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Department of Otolaryngology Xuzhou First People’s HospitalAffiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221002China School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China

The catalytic asymmetric diastereodivergent synthesis of axially chiral 2-alkenylindoles was established via chiral phosphoric acid-catalyzed addition reactions of C3-unsubstituted 2-alkenylindoles with o-hydroxybenzyl alcohols under different reaction *** this strategy,two series of 2-alkenylindoles bearing both axial and central chirality were synthesized in a diastereodivergent fashion with moderate to high yields and good stereoselectivities(up to 99%yield,95:5 er,>95:5 dr).Moreover,theoretical calculations were performed on the key transition states leading to different stereoisomers,which provided an in-depth understanding of the origin of the observed stereoselectivity and diastereodivergence of the products under different reaction *** importantly,these 2-alkenylindoles were utilized in asymmetric catalysis as chiral organocatalysts and in medicinal chemistry for evaluation of their cytotoxicity,which demonstrated their potential *** study has not only established the catalytic atroposelective synthesis of axially chiral 2-alkenylindoles,but also provided an efficient strategy for catalytic asymmetric diastereodivergent construction of indole-based scaffolds bearing both axial and central chirality.

关键词： 2-Alkenylindole Axial chirality Central chirality Diastereodivergent synthesis Chiral phosphoric acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机器学习算法在不同形态浙贝母与湖北贝母的干法REIMS指纹图谱鉴别分析中的应用研究

引用

药物分析杂志 2024年第1期44卷 134-143页

作者：石岩李宁魏锋中国食品药品检定研究院北京102629 北京市药品检验研究院北京102206

目的:使用快速蒸发离子化质谱(REIMS)指纹图谱与机器学习相关技术对不同形态的浙贝母和湖北贝母进行预测和判别。方法:通过干法灼烧使样品组分形成气溶胶,引入REIMS中,质谱扫描范围m/z 50~1 200,扫描模式为灵敏模式,扫描时间为0.2 s。... 详细信息

目的:使用快速蒸发离子化质谱(REIMS)指纹图谱与机器学习相关技术对不同形态的浙贝母和湖北贝母进行预测和判别。方法:通过干法灼烧使样品组分形成气溶胶,引入REIMS中,质谱扫描范围m/z 50~1 200,扫描模式为灵敏模式,扫描时间为0.2 s。正离子模式采集,数据记录为continuum模式,测得样品的REIMS指纹图谱数据。通过对数据进行聚类分析、相关性分析、相似度分析、主成分分析,得到数据分布的基本情况,最后建立逻辑回归模型,模型惩罚项参数选择岭回归(l2),优化算法选择拟牛顿法(lbfgs)。结果:测得样品的REIMS指纹图谱具有品种差异的特征性,逻辑回归模型交叉验证和测试集验证准确率均达到1.0,可以准确预测和判别样品的品种。结论:REIMS技术结合机器学习在中药领域的潜在应用前景十分广阔。

关键词：浙贝母湖北贝母快速蒸发离子化质谱机器学习人工智能逻辑回归中药分析真伪鉴别

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

引用

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： Huang Chen Rui-Ying Jiang Zhan Hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian feng Jie Luo Wu ning Yan-Fen Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

大模型时代的青年发展

引用

中国青年社会科学 2024年第4期43卷 37-48页

作者：肖峰来宁上海大学马克思主义学院上海200444

大模型发展深刻变革着人类社会,尤其对青年的发展产生了多重影响,包括造就学习型青年、催生创业型青年、锻造抗风险型青年等,同时也可能会给青年发展带来无节制生成内容的误导、过度的大模型依赖、未来“双重”失业压力更为突出、潜在... 详细信息

大模型发展深刻变革着人类社会,尤其对青年的发展产生了多重影响,包括造就学习型青年、催生创业型青年、锻造抗风险型青年等,同时也可能会给青年发展带来无节制生成内容的误导、过度的大模型依赖、未来“双重”失业压力更为突出、潜在的自我怀疑等负面影响。面对大模型时代所引发的根本性变革,需要充分利用大模型时代对青年发展的正向塑造作用,尽可能减少其负面影响,要更加注重培养青年的批判性思考的能力,提高青年的大模型素养,促进青年在大模型时代更好地发展自己。

关键词：大模型青年发展人工智能青年就业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

同质区共享端元变异性的高光谱混合像元分解

引用

光学精密工程 2024年第4期32卷 578-594页

作者：王宁保文星屈克文冯伟北方民族大学计算机科学与工程学院宁夏银川750021 西安电子科技大学电子工程学院陕西西安710071

由于不同的照明条件、复杂的大气环境等因素,相同端元的光谱特征在图像的不同位置呈现出可见的差异,这种现象被称为端元的光谱变异性。在相当大的场景中,端元的变异性可能很大,但在适度的局部同质区内,变异性往往很小。扰动线性混合模型... 详细信息

由于不同的照明条件、复杂的大气环境等因素,相同端元的光谱特征在图像的不同位置呈现出可见的差异,这种现象被称为端元的光谱变异性。在相当大的场景中,端元的变异性可能很大,但在适度的局部同质区内,变异性往往很小。扰动线性混合模型(Perturbed Linear Mixing Model,PLMM)在解混的过程中可以减轻端元变异性造成的不利影响,但是对缩放效应造成的变异性的处理能力较弱。为此,本文改进了扰动线性混合模型,引入了尺度因子以处理缩放效应造成的变异性,并结合超像素分割算法划分局部同质区,然后设计出基于局部同质区共享端元变异性的解混算法(Shared Endmember Variability in Unmixing,SEVU)。与扰动线性混合模型,扩展线性混合模型(Extended Linear Mixing Model,ELMM)等算法相比,所提SEVU算法在合成数据集上平均端元光谱角距离(mean Spectral Angle Distance,mSAD)和丰度均方根误差(abundance Root Mean Square Error,aRMSE)最优,分别为0.0855和0.0562;在Jasper Ridge和Cuprite真实数据集上mSAD是最优的,分别为0.0603和0.1003。在合成数据集和两个实测数据集上的实验结果验证了SEVU算法的有效性。

关键词：高光谱图像混合像元分解光谱变异性扰动线性混合模型局部同质区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

引用

Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

习近平文化思想的时代担当、理论创新和实践要求

引用

南昌大学学报（人文社会科学版） 2024年第4期55卷 12-20页

作者：康凤云刘宁江西师范大学马克思主义学院江西南昌330022 华中师范大学政治与国际关系学院湖北武汉430079 井冈山大学马克思主义学院江西吉安343009

习近平文化思想立足新时代中国共产党治国理政的文化诉求和新的文化使命,传承和赓续中华民族生生不息的历史文脉,对内提升先进文化的凝聚力、感召力,对外增强中华文明的传播力、影响力,推动世界文明交流互鉴,展现出强烈的时代担当。习... 详细信息

习近平文化思想立足新时代中国共产党治国理政的文化诉求和新的文化使命,传承和赓续中华民族生生不息的历史文脉,对内提升先进文化的凝聚力、感召力,对外增强中华文明的传播力、影响力,推动世界文明交流互鉴,展现出强烈的时代担当。习近平文化思想以“第二个结合”为鲜明标志实现又一次思想解放,以“七个着力”为战略部署推进文化强国建设,以不断巩固中华文明的文化主体性为发展要旨,胸怀为创造人类文明新形态贡献中国智慧的博大胸襟,取得了重大的理论创新和突破。新时代践行习近平文化思想要坚持党的领导,巩固党的文化领导权;要坚定文化自信,坚持走自己的路;要秉持开放包容,推进中华文明与世界文明交往交流交融;要坚持守正创新,铸就中华文化新辉煌。

关键词：习近平文化思想中华民族现代文明 “两个结合” 文化自信

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：