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BNIP3 mediated mitophagy attenuates intermittent hypoxia-induced human renal tubular epithelial cells injury

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BNIP3 mediated mitophagy attenuates intermittent hypoxia-ind...

基于计算机屏幕显示和栅格数据的电子地图集的设计与实现——以《上海城市自然地理图集》为例

中国睡眠研究会第十四届全国学术年会

作者： Xiaobin zhang Gong-Ping Chen Mao-Hong Huang Xiang-Xing Chen feng-fu zhan Xiu-Zhen He Ling Cai Hui-Qing Zeng Department of Respiratory Medicine Second Affiliated Hospital of Fujian Medical University 福建医科大学附属第一医院

Background:As one novel pathophysiological characteristic of obstructive sleep apnea, intermittent hypoxia(IH) contributed to human renal tubular epithelial cells impairment. The underlying pathological mechanisms remain unrevealed. The present study aimed to evaluate the influence of Bcl-2 19-kDa interacting protein 3(BNIP3) mediated mitophagy on IH-induced renal tubular epithelial cell *** and methods:Human kidney proximal tubular(HK-2) cells were exposed to IH condition. IH cycles were as follows: 21% oxygen for 25 min, 21% descended to 1% for 35 min, 1% oxygen sustaining for 35 min, 1% ascended to 21% for 25 min. The IH exposure lasted 24 h with 12 cycles of hypoxia and re-oxygenation. Both the siBNIP3 and BNIP3 vector were transfected to cells. Cell viability and apoptosis, mitochondrial morphology and function, mitophagy were detected by cell counting kit-8, flow cytometry and TUNEL staining, transmission electron microscope, western blotting, and immunofluorescence, ***:In the IH-induced HK-2 cells, inhibition of BNIP3 further aggravated mitochondrial structure damage, decreased mitophagy level, leading to increased cell apoptosis and decreased cell viability. While overexpression of BNIP3 enhanced mitophagy, which protected mitochondrial structure, can decrease cell death in HK-2 cells exposed to ***:The present study showed that BNIP3-mediated mitophagy plays a protective role against IH-induced renal tubular epithelial cells impairment.

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测绘与空间地理信息 2006年第6期29卷 71-76页

作者：占丰福黄余明华东师范大学地理信息科学教育部重点实验室上海200062

探讨了电子地图集的制作现状与发展趋势,并对基于屏幕显示的电子地图集制作方法进行研究。以《上海城市自然地理图集》为例,阐述了在DeskTop Author 4环境下进行以栅格图像数据为主要对象,设计实现集图像、声音、文字并茂,既易于检索和... 详细信息

探讨了电子地图集的制作现状与发展趋势,并对基于屏幕显示的电子地图集制作方法进行研究。以《上海城市自然地理图集》为例,阐述了在DeskTop Author 4环境下进行以栅格图像数据为主要对象,设计实现集图像、声音、文字并茂,既易于检索和利用,又有互动功能的电子地图集。

关键词：电子地图集电子图书栅格数据矢量数据

Hysteresis model of magnetostrictive actuators and its numerical realization

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1059-1064页

作者： TANG Zhi-feng LV fu-zai XIANG zhan-qin Modern Manufacture Engineering Institute Zhejiang University Hangzhou 310027 China

This paper presents two numerical realization of Preisach model by Density function Method (DFM) and F function Method (FFM) for a giant magnetostrictive actuator (GMA). Experiment and simulation showed that FFM is better than DFM for predicting precision of hysteresis loops. Lagrange bilinear interpolation algorithm is used in Preisach numerical realization to enhance prediction performance. A set of hysteresis loops and higher order reversal curves are predicted and experimentally verified. The good agreement between the measured and predicted curves shows that the classical Preisach model is effective for modelling the quasi-static hysteresis of the GMA.

关键词： Magnetostrictive Actuator Hysteresis Density function Method (DFM) F function Method (FFM)

Optimizing battery deployment: Aging trajectory prediction enabling homogenous performance grouping

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Journal of Energy Chemistry 2025年第1期 565-577页

作者： Shuquan Wang feng Gao zhan Ma Hao Tian Yusen zhang School of Control Science and Engineering Shandong University Key Lab of Power System Intelligent Dispatch and Control of Ministry of Education Shandong University

As battery deployments in electric vehicles and energy storage systems grow, ensuring homogeneous performance across units is crucial. We propose a multi-derivative imaging fusion(MDIF) model, employing advanced imaging and machine learning to predict battery aging trajectories from minimal initial data, thus facilitating effective performance grouping before deployment. Utilizing a derivative strategy and Gramian Angular Difference Field for dimensional enhancement, the MDIF model uncovers subtle predictive features from discharge curve data after only ten cycles. The architecture includes a parallel convolutional neural network with lateral connections to enhance feature integration and *** on a self-developed dataset, the model achieves an average root-mean-square error of 0.047 Ah and an average mean absolute percentage error of 1.60%, demonstrating high precision and *** robustness is further validated through transfer learning on two publicly available datasets, adapting with minimal retraining. This approach significantly reduces the testing cycles required, lowering both time and costs associated with battery testing. By enabling precise battery behavior predictions with limited data, the MDIF model optimizes battery utilization and deployment strategies, enhancing system efficiency and sustainability.

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Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin Tang Jun zhan Yiyuan Xue feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Theory and experiment of observer based magnetostrictive self-sensing actuator

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 99-103页

作者： Zhi-feng TANG fu-zai LV zhan-qin XIANG Modern Manufacture Engineering Institute Zhejiang University Hangzhou 310027 China

Giant magnetostrictive actuators (GMAs) often work in a close-loop feedback system. This system needs independent sensors which may be difficult to be fixed, besides, excessive sensors may cause more unpredicted problems in a large system. This paper aims to develop a self-sensing GMA. An observer based on piezomagnetic equations is constructed to estimate the stress and strain of the magnetostrictive material. The observer based self-sensing approach depends on the facts that the magnetic field is controllable and that the magnetic induction is measurable. Aiming at the nonlinear hysteresis in magnetization, a hys- teresis compensation observer based on Preisach model is developed. Experiment verified the availability of the observer approach, and the hysteresis compensation observer has higher tracking precision than linear observer for dynamic force sensing.

关键词： Magnetostrictive Self-sensing actuator Hysteresis Giant magnetostrictive actuators (GMAs)

氢化物-原子荧光光谱法测定富硒酵母中有机硒和无机硒

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饲料工业 2017年第10期38卷 51-53页

作者：占峰付志欢林羽周萌吴国杰舒绪刚周新华邱桂雄仲恺农业工程学院化学化工学院广东广州510225 广州天科生物科技有限公司广东广州510627

采用氢化物-原子荧光光谱法与盐酸相结合测定硒酵母中有机硒和无机硒的含量,并对试验条件作了优化。在优化条件下,硒的检出限为0.020 1μg/l,线性范围为0~40μg/l,通过加标回收试验,无机硒回收率为83.4%~89.7%,该方法操作简单,精密度高... 详细信息

采用氢化物-原子荧光光谱法与盐酸相结合测定硒酵母中有机硒和无机硒的含量,并对试验条件作了优化。在优化条件下,硒的检出限为0.020 1μg/l,线性范围为0~40μg/l,通过加标回收试验,无机硒回收率为83.4%~89.7%,该方法操作简单,精密度高,回收率好,适合于硒酵母中有机硒和无机硒的测定。

关键词：无机硒有机硒酵母氢化物-原子荧光光谱法

WAEAS:An Optimization Scheme of EAS Scheduler for Wearable Applications

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Tsinghua Science and Technology 2021年第1期26卷 72-84页

作者： zhan zhang Xiang Cong Wei feng Haipeng zhang Guodong fu Jianyun Chen the School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150001China Beijing Information Technology Institute Beijing 100192China

The rapid development of wearable computing technologies has led to an increased involvement of wearable devices in the daily lives of *** main power sources of wearable devices are batteries;so,researchers must ensure high performance while reducing power consumption and improving the battery life of wearable *** purpose of this study is to analyze the new features of an Energy-Aware Scheduler(EAS)in the Android 7.1.2 operating system and the scarcity of EAS schedulers in wearable application ***,the paper proposed an optimization scheme of EAS scheduler for wearable applications(Wearable-Application-optimized Energy-Aware Scheduler(WAEAS)).This scheme improves the accuracy of task workload prediction,the energy efficiency of central processing unit core selection,and the load *** experimental results presented in this paper have verified the effectiveness of a WAEAS scheduler.

关键词： wearable devices heterogeneous multicore system big.LITTLE architecture task scheduling

中国城市化进程与人群呼吸系统常见疾病病死率的相关性分析

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中华肺部疾病杂志（电子版） 2013年第2期6卷 7-10页

作者：占丰富万春申永春贾留群胡倩婧文富强厦门大学附属中山医院呼吸内科福建厦门361004 四川大学华西医院呼吸内科生物治疗国家重点实验室呼吸病学研究室四川成都610041

目的探讨中国城市化进程与人群呼吸系统常见疾病病死率的相关性。方法从国家统计数据库检索2003-2009年中国具有代表性的城市化经济指标,筛选出最可能对呼吸系统疾病产生影响的10项指标(工业总产值,能源消费总量,民用汽车总量,铁路营业... 详细信息

目的探讨中国城市化进程与人群呼吸系统常见疾病病死率的相关性。方法从国家统计数据库检索2003-2009年中国具有代表性的城市化经济指标,筛选出最可能对呼吸系统疾病产生影响的10项指标(工业总产值,能源消费总量,民用汽车总量,铁路营业及民航航线里程,卷烟、纸板、水泥和塑料总产量,商品房销售面积)。从《中国卫生统计年鉴》筛选2003-2009年呼吸系统常见疾病的病死率。采用Spearman秩相关分析,计算出该10项指标与呼吸系统常见疾病病死率的相关系数。结果该10项指标水平、城市居民肺炎、尘肺病死率都随时间增长而增加,慢性下呼吸道疾病及呼吸系统的其它疾病病死率随时间增长而下降。该10项指标与城市肺炎、尘肺呈正相关(rs>0,P0.05)。按城市级别分层,10项指标仅与大城市肺炎、尘肺显著相关(rs>0,P0.05)。结论城市化进程可能是中国城市居民肺炎、尘肺病死率增加的原因之一。

关键词：城市化进程呼吸系统疾病病死率相关性分析