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Pre-transjugular-intrahepatic-portosystemic-shunt measurement of hepatic venous pressure gradient and its clinical application: A comparison study

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World Journal of Gastroenterology 2023年第22期29卷 3519-3533页

作者： Xi-Xuan wang Xiao-Chun Yin Li-Hong Gu Hui-wen Guo yang Cheng yan Liu Jiang-Qiang Xiao Yi wang Wei Zhang Xiao-Ping Zou Lei wang Ming Zhang yu-Zheng Zhu-Ge feng Zhang Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Medical School Southeast UniversityNanjing 210000Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND It is controversial whether transjugular intrahepatic portosystemic shunt(TIPS)placement can improve long-term *** To assess whether TIPS placement improves survival in patients with hepaticvenous-pressure-gradient(HVPG)≥16 mmHg,based on HVPG-related risk *** Consecutive variceal bleeding patients treated with endoscopic therapy+nonselectiveβ-blockers(NSBBs)or covered TIPS placement were retrospectively enrolled between January 2013 and December *** measurements were performed before *** primary outcome was transplant-free survival;secondary endpoints were rebleeding and overt hepatic ence-phalopathy(OHE).RESULTS A total of 184 patients were analyzed(mean age,55.27 years±13.86,107 males;102 in the EVL+NSBB group,82 in the covered TIPS group).Based on the HVPG guided risk stratification,70 patients had HVPG<16 mmHg,and 114 patients had HVPG≥16 *** median follow-up time of the cohort was 49.5 *** was no significant difference in transplant-free survival between the two treatment groups overall(hazard ratio[HR],0.61;95%confidence interval[CI]:0.35-1.05;P=0.07).In the high-HVPG tier,transplant-free survival was higher in the TIPS group(HR,0.44;95%CI:0.23-0.85;P=0.004).In the low-HVPG tier,transplantfree survival after the two treatments was similar(HR,0.86;95%CI:0.33-0.23;P=0.74).Covered TIPS placement decreased the rate of rebleeding independent of the HVPG tier(P<0.001).The difference in OHE between the two groups was not statistically significant(P=0.09;P=0.48).CONCLUSION TIPS placement can effectively improve transplant-free survival when the HVPG is greater than 16 mmHg.

关键词： Hepatic venous pressure gradient Transjugular intrahepatic portosystemic shunts Cirrhosis Variceal rebleeding Survival

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Nearby M subdwarfs from LAMOST data release 2

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Research in Astronomy and Astrophysics 2016年第7期16卷 55-68页

作者： yu Bai A-Li Luo Georges Comte Jing-kun Zhao Hai-feng yang yan-Xin Guo You-Fen wang Yin-Bi Li Bing Du wen Hou Xiao Kong Zhen-Ping Yi Yi-Han Song Zhong-Rui Bai Jian-Nan Zhang Meng-Xin wang Jian-Jun Chen Xiao-yan Chen Ke-Fei Wu Fang Zuo yue Wu Zi-Huang Cao Yong-Hui Hou yue-Fei wang Yong Zhang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing100012 China University of Chinese Academy of Sciences Beijing 100049 China Aix-Marseille University CNRS Institut Pytheas L.A.M. UMR 7326 13388 Marseille Cedex France School of Computer Science and Technology Taiyuan University of Science and Technology Taiyuan 030024 China School of Mechanical Electrical & Information Engineering Shandong University at Weihai Weihai 264209 China Nanjing Institute of Astronomical Optics & Technology National Astronomical Observatories Chinese Academy of Sciences Nanjing 210042 China

We identify 108 M subdwarfs（sd Ms） out of more than two hundred thousand M type spectra from the second data release（DR2） of the LAMOST regular survey. This sample, among which 58 members are identified for the first time, includes 33 extreme subdwarfs（esd Ms） and 11 ultra subdwarfs（usd Ms）.The selection is based on the usual ratio of absorption depth of Ca H2, Ca H3 and TiO 5 band *** also emphasize the use of the Ca H1 band. We provide estimates of spectral subtype（SPT）, L′epine metallicity index ζ, effective temperature and [Fe/H]. Both ζ–[Fe/H] and SPT–Teff figures show reasonable consistency; compared to PHOENIX model spectra, average rounded values of [Fe/H] for sd Ms, esd Ms and usd Ms are respectively –0.5, –1 and –1.5. The photometric distances are estimated, indicating that most sources are located within 500 pc of the Sun and 350 pc of the Galactic disk. Velocities and 3D Galactic motions are also briefly discussed. Among the 108 subdwarfs, seven stars appear to be active with a significant Hα emission line. The source LAMOST J104521.52＋482823.3 is a white dwarf- M subdwarf binary, while LAMOST J123045.52＋410943.8, also active, exhibits carbon features in red.

关键词： stars late-type stars statistics subdwarfs

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Interface-Induced High-Temperature Superconductivity in Single Unit-Cell FeSe Films on SrTiO_(3)

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Chinese Physics Letters 2012年第3期29卷 204-207页

作者： wang Qing-yan LI Zhi ZHANG wen-Hao ZHANG Zuo-Cheng ZHANG Jin-Song LI Wei DING Hao OU yun-Bo DENG Peng CHANG Kai wen Jing SONG Can-Li HE Ke JIA Jin-feng JI Shuai-Hua wang Ya-yu wang Li-Li CHEN Xi MA Xu-Cun XUE Qi-kun State Key Lab of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084 Institute of Physics Chinese Academy of SciencesBeijing 100190

We report high transition temperature superconductivity in one unit-cell(UC)thick FeSe films grown on a Seetched SrTiO_(3)(001)substrate by molecular beam epitaxy(MBE).A superconducting gap as large as 20 meV and the magnetic field induced vortex state revealed by in situ scanning tunneling microscopy(STM)suggest that the superconductivity of the 1 UC FeSe films could occur around *** control transport measurement shows that the onset superconductivity temperature is well above *** work not only demonstrates a powerful way for finding new superconductors and for raising Tc,but also provides a well-defined platform for systematic studies of the mechanism of unconventional superconductivity by using different superconducting materials and substrates.

关键词： superconductivity SrTiO_(3) vortex

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Optimization,validation and application of an assay for the activity of HMG-CoA reductase in vitro by LC–MS/MS

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Journal of Pharmaceutical Analysis 2015年第6期5卷 383-388页

作者： Jing wang Ji-Ye Sun Chun-Jie Sha yu-feng Shao yan-Hong Liu You-Xin Li Zhen-wen Duan Wan-Hui Liu School of Pharmacy Yantai University State Key Laboratory of Long-acting and Targeting Drug Delivery System Shandong Luye Pharmaceutical Co. Ltd. Peking University WBL Biotech Co. Ltd.

A stable HMG-CoA reductase （HMGR） reaction in vitro was developed by a sensitive, selective and precise liquid chromatography-tandem mass spectrometry （LC-MS/MS） method. The optimized enzyme reaction condition contained 1.5 lag of HMGR, 20 nM of NADPH with 50 rain of reaction time. The method was validated by several intraand inter-day assays. The production transitions of m/z 147.0/59.1 and m/z 154.0/59.1 were used to detect and quantify mevalonolactone （MVAL） and MVAL-DT, respectively. The accuracy and precision of the method were evaluated over the concentration range of 0.005- 1.000 lag/mL for MVAL and 0.010-0.500 lag/mL for lovastatin acid in three validation batch runs. The lower limit of quantitation was found to be 0.005 lag/mL for MVAL and 0.010 lag/mL for lovastatin acid. Intra-day and inter-day precision ranged from 0.95% to 2.39% and 2.26% to 3.38% for MVAL, 1.46% to 3.89% and 0.57% to 5.10% for lovastatin acid, respectively. The results showed that the active ingredients in Xuezhikang capsules were 12.2 and 14.5 mg/g, respectively. This assay method could be successfully anDlied to the oualitv control study of Xuezhikanu caosule for the first time.

关键词： XuezhikangLC-MS/MSHMG-CoA reductaseMevalonolactoneQuality control

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Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen wang Fan-lian Zeng Ya-wen Hu Xiao-yan wang Fu-lei Zhao Pei Zhou Jing Hu yuan-yuan Xiao Zhong-lan Hu Ming-feng Guo Xiao-qiong Wei Xiao Liu Nong-yu Huang Jun Zhang Shu-wen Chen Juan Cheng Hua-ping Zheng Hong Zhou Qi-xiang Zhao Chen Zhang yan Hao Song Zou Yi-yue Gui Jia-dong yu Lin-na Gu Cheng-cheng yue Hao-zhou Zhang wen-ling Wu Yi-fan Zhou Xi-kun Zhou Guo-bo Shen Xiu Teng Jiong Li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

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Establishing a rabbit model of perianal fistulizing Crohn's disease

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World Journal of Gastroenterology 2022年第15期28卷 1536-1547页

作者： Shuang-Shuang Lu wen-Jia Liu Qiu-Ya Niu Chun-yan Huo yu-Qing Cheng En-Jing wang Rong-Nan Li Fang-Fang feng Yi-Ming Cheng Rong Liu Jin Huang Gastroenterology Center The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Medical Statistics Center Changzhou UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Crohn’s disease(CD)is a chronic nonspecific intestinal inflammatory *** aetiology and pathogenesis of CD are still *** fistula is the main complication of CD and is a difficult problem to solve at *** main limitation of developing new therapies is bound up with the short of preclinical security and effectiveness ***,an ideal animal model is needed to establish persistent anal fistula and an inflamed rectal *** To improve the induction method of colitis and establish a reliable and reproducible perianal fistulizing Crohn’s disease animal model to evaluate new treatment *** Twenty male New Zealand rabbits underwent rectal enema with different doses of 2,4,6-trinitrobenzene sulfonic acid to induce *** A was treated with an improved equal interval small dose increasing *** dosage of group B was *** days later,the rabbits underwent surgical creation of a transsphincteric ***,three rabbits were randomly selected from each group every 7 d to remove the seton from the *** rabbits were examined by endoscopy every 7 days,and biopsy forceps were used to obtain tissue samples from the obvious colon lesions for histological *** disease activity index(DAI),colonoscopy and histological scores were *** endoscopic ultrasonography(EUS)was used to evaluate the healing of *** Except for the DAI score,the colonoscopy and histological scores in group A were significantly higher than those in group B(P<0.05).In the ideal model rabbit group,on the 7 th day after the removal of the seton,all animals had persistent lumens on EUS imaging,showing continuous fullthickness high *** inspection of the fistula showed acute and chronic inflammation,fibrosis,epithelialization and peripheral proctitis of the adjoining *** The improved method of CD colitis induction successfully established a rabbit perianal fistula CD pre

关键词： Crohn’s disease Perianal fistula Model Endoscopy Histology

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Clinical Analysis of 13 Cases with Burkitt Lymphoma or Burkittlike Lymphoma

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Clinical oncology and cancer researeh 2010年第2期7卷 110-115页

作者： Ning-jing LIN wen ZHENG yun-tao ZHANG Xiao-pei wang yu-qin SONG yan XIE Mei-feng TU Ling-yan PING Jun ZHU Department of Lymphoma Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University School of Oncology Beijing Cancer Hospital and Institute Beijing 100142 China.

OBJECTIVE To summarize the clinical characteristics and treatment effects of Burkitt lymphoma （BL） and Burkitt-like lymphoma （BLL）, and to explore the best possible optimal regimens and the treatment-related *** Clinical data of 13 BL and BLL patients, who were pathologically diagnosed and treated in the Beijing Cancer Hospital from August 1996 to October 2008, were retrospectively analyzed, All patients received the therapeutic regimen with chemotherapy as the first-line treatment. The treatment effect and adverse reactions were *** Of the 13 patients, 12 were men and 1 was woman, with a median age of 15 years （range, 11-62）. Three of the patients were in stage Ⅰ, 2 in stage Ⅱ, 2 in stage Ⅲ, and 6 in stage Ⅳ. Advanced cases were 8 （stage Ⅲ and Ⅳ）, accounting for 61.5% of the patients. Bone marrow involvement was found in 2 cases （15.4%） and central nervous system invasion in 4 （30.8%） at the beginning of the treatment. The common involved sites included the superficial lymph nodes （61.5%）, abdominal organs （53.8%）, and abdominal and retro-peritoneal lymph nodes （38.5%）. B symptoms were observed in 7 patients （53.8%）. Serum lactate dehydrogenase （LDH） level was increased in 8 of the 10 patients who underwent the serum LDH determination, while serum uric acid level was increased in 1 of the 10. Pathological diagnosis showed that 11 of the cases were BL and 2 BLL. Of the 13 patients, 11 （84.6%） achieved a complete remission （CR） or CR/unconfirmed （CRu）, and 1 （7.7%） a partial remission （PR）, with a total responsive rate of 92.3%. At a median follow-up of 8 months （range 5-35）, 6 patients were found dead at the end of the follow-up. One of the 13 patients was lost to the follow-up. The 1-year overall survival, progression-free survival and disease-free survival rates were 56.98%, 32.31% and 39.77%, respectively. The grade-Ⅲ or Ⅳ myelosuppression was found in 9 patients during the chemotherapy （69.2%）, and tumor lysis syndrome and grade-

关键词： Burkitt lymphoma invasion biomedicalresearch drug therapy combination.

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基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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非透析慢性肾脏病3~5期患者血管钙化发生及影响因素分析

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中华肾脏病杂志 2024年第6期40卷 431-441页

作者：薛妙容朱文娇赖志满冯少珍王燕李剑波余健文夏茜文琼王欣阳晓毛海萍陈雄辉李志坚黄锋先陈崴李树荣郭群英中山大学附属第一医院肾内科国家卫生健康委员会肾脏病临床研究重点实验室(中山大学)广州510080 中国国家卫生健康委员会临床肾病学重点实验室(中山大学)和广东省肾病重点实验室广州510080 中山大学附属第一医院影像科广州510080 中山大学附属第一医院超声科广州510080

目的分析非透析慢性肾脏病(choronic kidney disease,CKD)3~5期患者血管钙化患病率及其独立相关因素。方法该研究为单中心横断面观察性研究,纳入2022年5月1日至2022年12月31日在中山大学附属第一医院肾内科住院并接受血管钙化情况评估... 详细信息

目的分析非透析慢性肾脏病(choronic kidney disease,CKD)3~5期患者血管钙化患病率及其独立相关因素。方法该研究为单中心横断面观察性研究,纳入2022年5月1日至2022年12月31日在中山大学附属第一医院肾内科住院并接受血管钙化情况评估的年龄≥18岁非透析CKD 3~5期患者。收集患者的一般资料、实验室检查资料及影像学资料,通过心电门控胸部CT(Agatston评分)、侧位腹部X线平片(Kauppila评分)、颈部大血管彩超、超声心动图分别评估患者冠状动脉、胸主动脉、腹主动脉、颈动脉和心脏瓣膜的钙化情况。比较不同CKD分期患者临床资料及各部位血管钙化情况的差异,并比较不同年龄组[青年组(18~44岁)、中年组(45~64岁)和老年组(≥65岁)]患者以及是否合并糖尿病患者各部位血管钙化情况的差异,采用Logistic回归分析法分析患者不同部分动脉钙化及总体心血管钙化的独立相关因素。结果共纳入206例患者,年龄为(51±14)岁,其中男性129例(62.6%);CKD 3期44例(21.4%),CKD 4期51例(24.8%),CKD 5期111例(53.9%)。CKD病因为慢性肾小球肾炎[104例(50.5%)]、糖尿病肾损害[35例(17.0%)]、高血压肾损害[29例(14.1%)]以及其他[38例(18.4%)]。206例患者中,131例(63.6%)患者存在心血管钙化,其中78例(37.9%)存在冠状动脉钙化,90例(43.7%)存在胸主动脉钙化,78例(37.9%)存在腹主动脉钙化,74例(35.9%)存在颈动脉钙化,20例(9.7%)存在心脏瓣膜钙化。青年、中年、老年患者总体心血管钙化患病率分别为24.6%、73.6%和97.4%,随年龄增长,各部位血管钙化患病率逐渐升高,且增高趋势均有统计学意义(均P<0.001)。CKD合并糖尿病患者总体心血管钙化患病率达92.5%(62/67),且合并糖尿病组各部位血管钙化患病率均显著高于未合并糖尿病组(均P<0.001)。多因素Logistic回归分析结果显示,年龄增长(每增加10岁,OR=2.51,95%CI 1.77~3.56,P<0.001)、高血压病史(OR=5.88,95%CI 1.57~22.10,P=0.009)和糖尿病病史(OR=4.66,95%CI 2.10~10.35,P<0.001)是患者冠状动脉钙化的独立相关因素;年龄增长(每增加10岁,OR=6.43,95%CI 3.64~11.36,P<0.001)和高血压病史(OR=6.09,95%CI 1.33~27.84,P=0.020)是患者胸主动脉钙化的独立相关因素;女性(OR=0.23,95%CI 0.07~0.72,P=0.011)、年龄增长(每增加10岁,OR=3.90,95%CI 2.42~6.29,P<0.001)、糖尿病病史(OR=5.37,95%CI 2.19~13.19,P<0.001)和血镁(OR=0.01,95%CI 0~0.35,P=0.014)是患者腹主动脉钙化的独立相关因素;同时,年龄增长和糖尿病病史还是颈动脉钙化、心脏瓣膜钙化及总体心血管钙化的独立相关因素。结论非透析CKD 3~5期患者的血管钙化患病率较高,可达63.6%,其中37.9%的患者存在冠状动脉钙化,43.7%的患者存在胸主动脉钙化,而只有9.7%的患者存在心脏瓣膜钙化。除了胸主动脉钙化以外,年龄和糖尿病是各个部位发生血管钙化的独立相关因素,而高血压是冠状动脉钙化及胸主动脉钙化的独立相关因素。

关键词：肾功能不全,慢性血管钙化冠状血管主动脉,胸主动脉,腹颈动脉心脏瓣膜危险因素

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Production of Light Nuclei from ^(36)Ar and ^(40)Ar Fragmentation at About 60 MeV/Nucleon

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Chinese Physics Letters 2001年第6期18卷 753-755页

作者： FANG De-Qing SHEN wen-Qing feng Jun CAI Xiang-Zhou MA yu-Gang ZHANG Hu-Yong HU Peng-yun ZHAN wen-Long GUO Zhong-yan XIAO Guo-Qing LI Jia-Xing wang Meng wang Jian-feng NING Zhen-Jiang wang Jin-Chuan wang Jian-Song wang Quan-Jin CHEN Zhi-Qiang Shanghai Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000 College of Science Ningbo UniversityNingbo 315211

Fragments produced in the reactions of 69 MeV/nucleon ^(36)Ar and ^(55)MeV/nucleon ^(40)Ar on a Be target have been measured *** isotopic distributions from fragmentation reaction for both projectiles are reproduced by using a modified statistical abrasion-ablation *** isospin effect exhibits in the isotopic distributions produced in ^(36)Ar and ^(40)Ar *** evidence is seen for the disappearance of the isospin effect in fragmentation reaction.

关键词： reaction. fragmentation effect

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