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World Journal of Clinical Cases 2023年第4期11卷 866-873页

作者： Qing-Wei Cheng Hong-Li Shen Zhi-Hui Dong Qian-Qian Zhang Ya-fen wang Jin Yan Yu-Sheng wang Ning-Gang Zhang Department of Oncology The Sixth Division HospitalXinjiang Production and Construction CorpsWujiaqu 831300Xinjiang Uygur Autonomous RegionsChina Department of Gastrointestinal Oncology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina

BACKGROUND The advent of molecular targeted agents and immune checkpoint inhibitors has greatly improved the treatment of advanced renal cell carcinoma(RCC), thus significantly improving patient survival. The incidence of rare drug-related adverse events has gained increased *** SUMMARY We report a patient with advanced RCC treated with multiple lines of molecular targeted agents and immune checkpoint inhibitors, who developed a pulmonary infection after treatment with everolimus in combination with lenvatinib. Determining the pathogenic organism was difficult, but it was eventually identified as Pneumocystis jirovecii by next-generation sequencing(NGS) of bronchoscopic alveolar lavage fluid(BALF) and successfully treated with *** Rare pulmonary infections caused by molecular targeted agents are not uncommon in clinical practice, but their diagnosis is difficult. Evaluating BALF with NGS is a good method for rapid diagnosis of such infections.

关键词： Renal cell carcinoma Everolimus Pneumocystis jirovecii pneumonia Next-generation sequencing Bronchoscopic alveolar lavage fluid Case report

Rhodium(Ⅲ)-catalyzed selective access to isoindolinones via formal [4+1] annulation of arylamides and propargyl alcohols

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Chinese Journal of Catalysis 2017年第8期38卷 1390-1398页

作者： Youwei Xu fen wang Songjie Yu Xingwei Li Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 Liaoning China University of Chinese Academy of Sciences Beijing 100049 China

A mild and efficient oxidative synthesis of isoindolinones has been realized by Rh(III)‐catalyzed C?H activation of benzamides and[4+1]coupling with propargyl *** coupling system proceeds with broad substrate scope and mild conditions and provides a new approach to access the useful skeleton ofγ‐lactams with a stereogenic center.

关键词： Rhodium C-H activation [4+1] annulation Propargyl alcohol Isoindolinones

Principal Chemical Properties of Artificial Soil Composed of Fly Ash and Furfural Residue

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Pedosphere 2006年第5期16卷 668-672页

作者： fenG Yong-Jun LI fen wang Xiao-Ling LIU Xi-Min ZHANG Lei-Na College of Resources and Environment Shandong Agricultural University Tai＇an 271018 （China） Institute of Geographical Sciences and Nature Resources Research Beijing 100101 （China）

To solve soil shortage in reclaiming subsided land of coal mines, the principal chemical properties of artificial soil formed by mixing organic furfural residue and inorganic fly ash were examined. The results indicated that the artificial soil was suitable for agriculture use after irrigation and desalination, the available nutrients in the artificial soil could satisfy the growth demand of plants, and the pH tended to the neutrality.

关键词： artificial soil chemical properties fly ash furfural residue

The transcription factor CsS40 negatively regulates TCS1 expression and caffeine biosynthesis in connection to leaf senescence in Camellia sinensis

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Horticulture Research 2023年第9期10卷 194-206页

作者： Xinzhuan Yao Hufang Chen Antao Ai fen wang Shanshan Lian Hu Tang Yihe Jiang Yujie Jiao Yumei He Tong Li Litang Lu College of Tea Sciences Institute of Plant Health&MedicineThe Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education)Guizhou UniversityGuiyang 550025China School of Biological Science and Agriculture Qiannan Normal University for NationalitiesDuyun 558000China

Caffeine is considered as one of the most important bioactive components in the popular plant beverages tea,cacao,and coffee,but as a wide-spread plant secondary metabolite its biosynthetic regulation at transcription level remains largely ***,we report a novel transcription factor Camellia sinensis Senescnece 40(CsS40)as a caffeine biosynthesis regulator,which was discovered during screening a yeast expression library constructed from tea leaf cDNAs for activation of tea caffeine synthase(TCS1)*** multiple hits of the non-self-activation CsS40 clones that bound to and activated TCS1 promoter in yeast-one-hybrid assays,a split-luciferase complementation assay demonstrated that CsS40 acts as a transcription factor to activate the CsTCS1 gene and EMSA assay also demonstrated that CsS40 bound to the TCS1 gene ***,immunofluorescence data indicated that CsS40-GFP fusion was localized in the nuclei of tobacco epidermal *** expression pattern of CsS40 in‘Fuding Dabai’developing leaves was opposite to that of TCS1;and knockdown and overexpression of CsS40 in tea leaf calli significantly increased and decreased TCS1 expression levels,*** expression levels of CsS40 were also negatively correlated to caffeine accumulation in developing leaves and transgenic calli of‘Fuding Dabai’.Furthermore,overexpression of CsS40 reduced the accumulation of xanthine and hypoxanthine in tobacco plants,meanwhile,increased their susceptibility to ***40 expression in tea leaves was also induced by senescence-promoting hormones and environmental *** together,we showed that a novel senescence-related factor CsS40 negatively regulates TCS1 and represses caffeine accumulation in tea cultivar‘Fuding Dabai’.The study provides new insights into caffeine biosynthesis regulation by a plant-specific senescence regulator in tea plants in connection to leaf senescence and hormone signaling.

关键词： S40 caffeine TCS

Application of tensor CSAMT with high-power orthogonal signal sources in Jiama porphyry copper deposit,South Tibet

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China Geology 2023年第1期6卷 37-49页

作者： Peng-liang Yu Ting Qu Ri-zheng He Jian-li Liu Su-fen wang Xiao-long Chen Shaanxi Geology and Mining Geophysical and Geoehemical Prospecting Team Co. Ltd.Xi’an 710043China Chinese Academy of Geological Sciences Beijing 100037China

The Jiama porphyry copper deposit in Tibet is one of the proven supergiant copper deposits in the Qinghai-Tibet Plateau at present,with the reserves of geological resources equivalent to nearly 20×10^(6) ***,it features wavy and steep terrain,leading to extremely difficult field operation and heavy *** study attempts to determine the effects of the tensor controlled-source audiomagnetotellurics(CSAMT)with high-power orthogonal signal sources(also referred to as the high-power tensor CSAMT)when it is applied to the deep geophysical exploration in plateaus with complex terrain and mining areas with strong *** test results show that the high current provided by the highpower tensor CSAMT not only greatly improved the signal-to-noise ratio but also guaranteed that effective signals were received in the case of a long transmitter-receiver ***,the tensor data better described the anisotropy of deep geologic *** addition,the tests also show that when the transmitting current reaches 60 A,it is still guaranteed that strong enough signals can be received in the case of the transmitter-receiver distance of about 25 km,sounding curves show no near field effect,and effective exploration depth can reach 3 *** 2D inversion results are roughly consistent with drilling results,indicating that the high-power tensor CSAMT can be used to achieve nearly actual characteristics of underground electrical ***,this method has great potential for application in deep geophysical exploration in plateaus and mining areas with complex terrain and strong interference,*** study not only serves as important guidance on the prospecting in the Qinghai-Tibet Plateau but also can be used as positive references for deep mineral exploration in other areas.

关键词： Jiama porphyry copper deposit Supergiant copper polymetallic deposit Tensor CSAMT of 150 kw High power 2D inversion Deep prospecting Mineral exploration engineering Xizang(Tibet)

Coke-resistant Au–Ni/MgAl2O4 catalyst for direct methanation of syngas

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Journal of Energy Chemistry 2019年第12期28卷 198-207页

作者： fen wang Jing-Cai Zhang Wei-Zhen Li Bing-Hui Chen National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters Department of Chemical and Biochemical EngineeringCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005Fujian.China Dalian Institute of Chemical Physics.Chinese Academy of Sciences Dalian 116023LiaoningChina Dalian National Laboratory for Clean Energy Dalian 116023LiaoningChina

Carbon deposition is one of the major issues for catalytic methanation,especially when using high CO content syngas(such as H2/CO=1)due to the inevitable Boudouard *** we report the significant enhancement on the coke-resistance of Ni/MgAl2 O4 catalyst during methanation by modifying with *** coke-resistant property was increased with Au addition while the catalytic activity decreased with excess *** and stable syngas conversions can be obtained over Au-Ni/MgAl2O4 catalyst at 450-500℃.With comprehensive characterizations by using BET,H2 chemisorption,H2-TPR,XPS,XRD,STEM,EDS,TEM,TG/DTA,Raman and TPH,we found that Au and Ni formed bimetallic nanoparticles of^10 nm with electron donation from Ni to *** deposited carbon on the spent Au-Ni/MgAl2O4 is very similar to that on the spent Ni/MgAl2O4 in the nature and in the gasification behaviour but is significantly *** results suggest that the enhanced coke-resistance of Au-Ni/MgAl2 O4 is presumably due to the suppression on CO disproportionation by modifying Ni with Au.

关键词： Syngas Methanation Methane Coke resistance Ni catalyst Gold

Endoscopic ultrasound-guided intraportal injection of autologous bone marrow in patients with decompensated liver cirrhosis:A case series

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World Journal of Gastrointestinal Surgery 2023年第4期15卷 655-663页

作者： Shao-Peng Zheng Ao-Jian Deng Jing-Jing Zhou Ling-Zhi Yuan Xiao Shi fen wang Department of Gastroenterology Third Xiangya Hospital of Central South UniversityChangsha 410013Hunan ProvinceChina Hunan Key Laboratory of Nonresolving Inflammation and Cancer Central South UniversityChangsha 410000Hunan ProvinceChina

BACKGROUND Recently,stem cell therapy has been extensively studied as a promising treatment for decompensated liver cirrhosis(DLC).Technological advances in endoscopic ultrasonography(EUS)have facilitated EUS-guided portal vein(PV)access,through which stem cells can be precisely *** To investigate the feasibility and safety of fresh autologous bone marrow injection into the PV under EUS guidance in patients with *** Five patients with DLC were enrolled in this study after they provided written informed ***-guided intraportal bone marrow injection with a 22G FNA needle was performed using a transgastric,transhepatic *** parameters were assessed before and after the procedure for a follow-up period of 12 *** Four males and one female with a mean age of 51 years old participated in this *** patients had hepatitis B virus-related ***-guided intraportal bone marrow injection was performed in all patients successfully without any complications such as *** clinical outcomes of the patients revealed improvements in clinical symptoms,serum albumin,ascites,and Child-Pugh scores throughout the 12-mo *** The use of EUS-guided fine needle injection for intraportal delivery of bone marrow was feasible and safe and appeared effective in patients with *** treatment may thus be a safe,effective,non-radioactive,and minimally invasive treatment for DLC.

关键词： Endoscopic ultrasonography Fine needle injection Portal vein Decompensated liver cirrhosis Bone marrow

Novel liver-specific nitric oxide(NO) releasing drugs with bile acid as both NO carrier and targeting ligand

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Chinese Chemical Letters 2014年第5期25卷 787-790页

作者： Xue-Yuan Jin Shi-Yong Fan Hong-Wu Li Wei-Guo Shi Wei Chen Hui-fen wang Bo-Hua Zhong Chinese PLA General Hospital & Chinese PLA Medical School Beijing Institute of Pharmacology and Toxicology

Novel liver-specific nitric oxide（NO） releasing drugs with bile acid as both the NO carrier and targeting ligand were designed and synthesized by direct nitration of the hydroxyl group in bile acids or the 3-Ohydroxyl alkyl derivatives,with the intact 24-COOH being preserved for hepatocyte specific *** biological evaluation revealed that oral administrated targeted conjugates could protect mice against acute liver damage induced by acetaminophen or carbon *** nitrate level in the liver significantly increased after oral administration of 1e while nitrate level in the blood did not significantly ***-administration of ursodeoxycholic acid（UDCA） significantly antagonized the increase of nitrate in the liver resulted by administration of 1e.

关键词： Liver-specific Nitric oxide releasing drugs Hepatoprotective activity Bile acid

TEACHING INTENSIVE READING WITHIN THE FRAMEWORK OF MODERN PSYCHOLINGUISTICS

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Chinese Journal of Applied Linguistics 2001年第3期24卷 55-59页

作者： wang fen Guizhou University

Many students have difficulties in obtaining the globalmeanings of *** paper proposes some suggestions on howto help students reach a deeper understanding of texts in intensivereading classrooms within the framework of *** mainly discusses the important effect ofprior knowledge on further understanding and provides threemethods to help solve this problem:make good use of pre-reading activities;enrich the students’background information;and analyze the structure of texts.

关键词： TEACHING INTENSIVE READING WITHIN THE FRAMEWORK OF MODERN PSYCHOLINGUISTICS oral

Correlation of restenosis after rabbit carotid endarterectomy and inflammatory cytokines

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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 231-236页

作者： Jun-Jun Liang Wei Xue Li-Zhi Lou Cheng Liu Zhao-fen wang Qing-Guo Li Shao-Hua Huang Department of Cardiovascular Thoracic Surgery.Anqiu People's Hospital Department of Medical Service Anqiu People's Hospital Tianjin Cerebral Hospital Department of Neurosurgery.Anqiu People's Hospital

Objective:To establish rabbit model of restenosis after carotid endartereclomy surgery,and to study tissue inflammatory cytokines(TNF-α,IL-61 involved in ***:A total of 32 rabbits were randomly divided into two groups:model group and control *** right common carotid artery in rabbits was damaged by carotid endar terectomy in model *** tissues were harvested at different time points respectively,the pathological changes of the vascular wall after operation were observed at different time *** changes of expression of tissue vascular wall inflammatory cytokines(TNF-α.IL-6)at different lime points after the surgery was observed by RT-PCR,and the changes of serum inflammatory cytokines(TNT-α,IL-6)were detected by ***:The new intima appeared after 7 days of the injury and reached the peak on 28 d which is uneven and significantly thicker than the control group(P<0.01).The tissue inflammatory cytokines(TNF-α,IL-6)were significantlv increased after the rabbit common carotid artery injury,which was significant difference compared with normal control group(P<0.05).Conclusions:The tissue inflammatory factors significantly increase after the rabbit carotid artery injury,which suggests the mutual concurrent effects of inflammatory cytokines can result in the proliferation of vascular restenosis.

关键词： Inflammatory factors Carotid endarterectomy Restenosis after angioplasty