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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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心肌梗塞:予后指标

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心肺血管病杂志 1985年第2期 6-6页

作者： alvarez G Duenas A. 张筑明哈瓦那心脏病和心血管外科研究所

本文运用多元分析法对73年5月至74年4月由重症冠心病监护室和缺血性心脏病病房出院的224例患者的资料（此资料被搜集于专门医疗表格中）进行了三年随访和分析。有关变量以数学方式表示:a1x1-a2x2……amxm通过判别式函数获得的此数代表x... 详细信息

本文运用多元分析法对73年5月至74年4月由重症冠心病监护室和缺血性心脏病病房出院的224例患者的资料（此资料被搜集于专门医疗表格中）进行了三年随访和分析。有关变量以数学方式表示:a1x1-a2x2……amxm通过判别式函数获得的此数代表x值。通过分析,作者对住院期间和其后三年随访期作出予后指标。住院期的予后指标为:年

关键词：予后

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雷帕霉素治疗蓝色橡皮庖样痣综合征的疗效

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中国口腔颌面外科杂志 2017年第1期15卷 35-35页

作者： Salloum R Fox CE alvarez-Allende CR

蓝色橡皮庖样痣综合征（BRBNS）是一种罕见的多灶型静脉畸形综合征,主要累及皮肤和消化道。传统的治疗方法包括激素治疗、α干扰素治疗、硬化治疗和手术治疗。雷帕霉素治疗之前有少量个案报道。该文作者对4例接受雷帕霉素治疗的BRBNS患... 详细信息

蓝色橡皮庖样痣综合征（BRBNS）是一种罕见的多灶型静脉畸形综合征,主要累及皮肤和消化道。传统的治疗方法包括激素治疗、α干扰素治疗、硬化治疗和手术治疗。雷帕霉素治疗之前有少量个案报道。该文作者对4例接受雷帕霉素治疗的BRBNS患儿进行单中心回顾性研究。

关键词： α干扰素静脉畸形病理学检测单中心口腔黏膜炎放射学检查生活质量中性粒细胞

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Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma:the PLANET study

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National Science Review 2022年第3期9卷 96-109页

作者： Weiwei Zhai Hannah Lai Neslihan Arife Kaya Jianbin Chen Hechuan Yang Bingxin Lu Jia Qi Lim Siming Ma Sin Chi Chew Khi Pin Chua Jacob Josiah Santiago alvarez Pauline Jieqi Chen Mei Mei Chang Lingyan Wu Brian K.P.Goh Alexander Yaw-Fui Chung Chung Yip Chan Peng Chung Cheow Ser Yee Lee Juinn Huar Kam Alfred Wei-Chieh Kow Iyer Shridhar Ganpathi Rawisak Chanwat Jidapa Thammasiri Boon Koon Yoong Diana Bee-Lan Ong Vanessa H.de Villa Rouchelle D.Dela Cruz Tracy Jiezhen Loh Wei Keat Wan Zeng Zeng Anders Jacobsen Skanderup Yin Huei Pang Krishnakumar Madhavan Tony Kiat-Hon Lim Glenn Bonney Wei Qiang Leow Valerie Chew Yock Young Dan Wai Leong Tam Han Chong Toh Roger Sik-Yin Foo Pierce Kah-Hoe Chow Genome Institute of Singapore Agency for Science Technology and Research Key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences School of Biological Sciences Nanyang Technological University Division of Biosciences Faculty of Life Sciences Division of Surgery and Surgical Oncology National Cancer Centre Department of Hepato-Pancreato-Biliary and Transplant Surgery Singapore General Hospital Division of Hepatobiliary and Pancreatic Surgery Department of Surgery University Surgical Cluster National University Health System Hepato-Pancreato-Biliary Surgery Unit Department of Surgery National Cancer Institute Division of Pathology National Cancer Institute Department of Surgery Faculty of Medicine University of Malaya Department of Surgery and Center for Liver Disease Management and Transplantation The Medical City 13. Department of Laboratories The Medical City Department of Pathology Singapore General Hospital Institute for Infocomm Research ASTAR Department of Pathology National University Health System Translational Immunology Institute (TII) Sing Health Duke-NUS Academic Medical Centre Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Cancer Science Institute of Singapore National University of Singapore Division of Medical Oncology National Cancer Center Singapore Cardiovascular Research Institute National University of Singapore National University Healthcare System Singhealth-Duke-NUS Academic Surgery Program Duke-NUS Graduate Medical School Institute of Molecular and Cell Biology Agency for Science Technology and Research

Intra-tumor heterogeneity(ITH) is a key challenge in cancer treatment, but previous studies have focused mainly on the genomic alterations without exploring phenotypic(transcriptomic and immune)heterogeneity. Using one of the largest prospective surgical cohorts for hepatocellular carcinoma(HCC)with multi-region sampling, we sequenced whole genomes and paired transcriptomes from 67 HCC patients(331 samples). We found that while genomic ITH was rather constant across stages, phenotypic ITH had a very different trajectory and quickly diversified in stage Ⅱ patients. Most strikingly, 30% of patients were found to contain more than one transcriptomic subtype within a single tumor. Such phenotypic ITH was found to be much more informative in predicting patient survival than genomic ITH and explains the poor efficacy of single-target systemic therapies in HCC. Taken together, we not only revealed an unprecedentedly dynamic landscape of phenotypic heterogeneity in HCC, but also highlighted the importance of studying phenotypic evolution across cancer types.

关键词： hepatocellular carcinoma intra-tumor heterogeneity phenotypic evolution tumor evolution

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TNFα和IL-6体外对颗粒物的反应：随颗粒物大小、季节、多环芳烃和土壤含量的变化

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环境与职业医学 2016年第12期33卷 1202-1208页

作者： Natalia Manzano-León Jesús Serrano-Lomelin Brisa N.Sánchez Raúl Quintana-Belmares Elizabeth Vega Inés Vázquez-López Leonora Rojas-Bracho Maria Tania López-Villegas felipe Vadillo-Ortega Andrea De Vizcaya-Ruiz Irma Rosas Perez Marie S.O’Neill Alvaro R.Osornio-Vargas 季麟(翻译) 金泰廙(审校) Departamento de Investigacion Basica Instituto Nacional de CancerologiaMexicoDFMexico School of Public Health University of AlbertaEdmontonAlbertaCanada Department of Environmental Health Sciences Department of Epidemiology School of Public HealthUniversity of MichiganAnn ArborMichiganUSA Direccion de Investigacion y Posgrado Instituto Mexicano del PetroleoMexicoDFMexico Gerencia de Ciencias Ambientales Instituto Nacional de Investigaciones NuclearesLa MarquesaOcoyoacacEstado de MexieoMexico Instituto Nacional de Ecologta y Cambio Climatico MexicoDFMexico National Autonomous University of Mexico(UNAM)at the National Institute of Genomic Medicine MexicoDFMexico Departamento de Toxicologla CinvestavMexicoDFMexico Centro de Ciencias de la Atmosfera UNAMMexicoDFMexico Department of Paediatrics University of AlbertaEdmontonAlbertaCanada 不详

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地... 详细信息

[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地区为采集地点,每周采集样本,在多雨温暖季节和干燥寒冷季节累积采集90份PM_(10)和PM_(2.5)样本。对其中检测到的元素、多环芳烃(PAHs)和内毒素进行主成分分析(PCA)。在人单核细胞(THP-1)中检测PM诱导肿瘤坏死因子α(TNFα)和白介素6(IL-6)分泌的可能性,并用组分评分建立促炎症反应的模型。[结果]PM的成分随其大小和季节而变化。PCA确定了PM中两种随季节变化的主要组分。燃烧相关的成分(如钒、苯并(a)芘、苯并(a)蒽)组成组分1(C_1),土壤相关的成分(如内毒素、硅、铝)组成组分2(C_2)。多雨温暖季节采集的PM中C_2含量较高,而干燥寒冷季节采集的PM(尤其是PM_(2.5))中C_1含量较高。细胞因子生成水平与PM_(10)和C_2(多雨温暖季节)正相关,但与PM_(2.5)和C_1(干燥寒冷季节)负相关。C_2含量较高的PM暴露水平越高,TNFα分泌越多;样本含有≥0.1%的C_1相关PAHs时,无论样本中C_2含量高低,暴露于该样本后TNFα对PM的反应性分泌都会降低。IL-6检测结果提示PM成分和颗粒大小之间存在复杂的交互作用。[结论]TNFα分泌具有季节性并与PM大小相关,PM中的土壤含量及PAH含量的变化是其根本原因。这些结果提示,流行病学研究中一些健康结局与PM之间关联的季节性差异能用PM组分的混合物来解释。

关键词：多环芳烃主成分分析内毒素检测采集样流行病学研究细胞因子城市地区肿瘤坏死因子α 变异系数苯并

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改善焦炭质量的可能性和局限性

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燃料与化工 1998年第5期29卷 256-263页

作者： T.Vander B.vdVelden R.alvarez M.Ferraro J.Fohl K.Hofherr J.M.Huart E.Mattila R.ProPson R.Willmers 陈世读

0 前言控制焦炭质量、开发和试验与其性能相关的焦炭质量指数是高炉工作者的任务。提供焦炭强度和耐磨性测量的试验大都基于焦炭经受已知能量的作用后确定其粒度降低的程度,然后以不同的指数形式来表示这些试验的结果。对给予焦炭机械... 详细信息

0 前言控制焦炭质量、开发和试验与其性能相关的焦炭质量指数是高炉工作者的任务。提供焦炭强度和耐磨性测量的试验大都基于焦炭经受已知能量的作用后确定其粒度降低的程度,然后以不同的指数形式来表示这些试验的结果。对给予焦炭机械处理下的条件要考虑与焦炭在使用中所经受破裂情况相近似。当焦炭自晾焦台到高炉内运行的过程中,焦炭即有落下,滚动又有滑动。

关键词：焦炭质量控制可能性局限性

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黑种人和白种人健康眼之间视功能和视神经结构的差别

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美国医学会眼科杂志（中文版） 2006年第3期18卷 162-168,187页

作者： Lyne Racette Catherine Boden Shannon L. Kleinhandler Christopher A. Girkin Jeffrey M. Liebmann Linda M. Zangwill felipe A. Medeiros Christopher Bowd Robert N. Weinreb M. Roy Wilson Pamela A. Sample 韩静（译）惠延年（校） Hamilton Glaucoma Center and Visual Function Laboratory . Department of Ophthalmology University of Callfomia at San Diego La Jolla Departments of Ophthalmology University ofAlabama at Birmingham New York Eye and Ear Infirmary New York Texas Tech University Lubbock 不详

目的：观察黑种人和白种人健康眼之间视功能、视盘地形和视网膜神经纤维层（RNFL）厚度的差别。方法：采用标准自动视野计检查、短波长自动视野计检查及倍频技术视野计检查评价50位黑种人和50位白种人健康眼视功能。采用Heidelberg视网... 详细信息

目的：观察黑种人和白种人健康眼之间视功能、视盘地形和视网膜神经纤维层（RNFL）厚度的差别。方法：采用标准自动视野计检查、短波长自动视野计检查及倍频技术视野计检查评价50位黑种人和50位白种人健康眼视功能。采用Heidelberg视网膜地形图和光学相干断层扫描仪测量视盘形态和RNFL厚度。结果：两组平均标准自动视野检查平均偏差均在正常范围内。黑种人倍频技术视野检查的平均偏差比白种人较差（均数±标准差，-1．8±3．2dB对-0．1±2．4dB）。采用Heidelberg视网膜地形图测得黑种人视盘面积较白种人大（均数±标准差。2．1±0．4mm^2对1．7±0.4mm^2）。光学相干断层扫描仪测得的黑种人RNFL较白种人更厚。其中上方厚16．91pm。下方厚10．10μm。而且黑种人的眼内压较白种人略高（均数±标准差,16．5±2．5mmHg对15．2±3．2mmHg），中央角膜较薄（均数±标准差，540．5±43．2μm对560．9±35．5μm）。在平均RNFL厚度、所有测试的模式标准偏差或短波长自动视野检查的变量中均未见人种差别。结论：在视功能方面发现有微小的人种差别。但在健康眼。人种显著影响视盘形态及上方和下方RNFL的厚度测量。所观察到的眼内压具有人种差别，在校正中央角膜厚度之后。理论上也是升高的。需要前瞻性研究来进一步观察这些结果。

关键词：眼视功能白种人黑种人健康眼视神经结构短波长自动视野检查视网膜地形图视网膜神经纤维层

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Early Hepatic Encephalopathy after a Transjugular Intrahepatic Portosystemic Shunt Procedure: Case Report

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Open Journal of Gastroenterology 2021年第6期11卷 81-88页

作者： Miriam Viviane Baron Gabriela Di Lorenzo Garcia Scherer Michele Paula dos Santos Andres felipe Mantilla Santamaria Cristine Brandenburg Isabel Cristina Reinheimer Marcus Vinicius de Mello Pinto Aline Ronis Sampaio Alexandre Gomes Sancho Alexandre Gomes Sancho Esteban Fortuny Pacheco Felice Picariello Danielle de Mello Florentino Joice Nedel Ott Carolina Gonçalves Pinheiro Nathália Ken Pereira Iketani Sonia Carvalho Patrícia Froes Meyer Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Rio Grande do Sul Brazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul (PUC/RS) Porto Alegre Rio Grande do Sul Brazil Industrial University of Santander (UIS) Bucaramanga Colombia University of Vale do Acaraú (IDJ/UVA) Ceará Brazil Celulare Institute Rio de Janeiro Brazil Unigranrio Rio de Janeiro Brazil Universidad Finis Terrae Santiago Chile Università degli Studi di Napoli Federico II Napoli Italy Uniredentor University Rio de Janeiro Brazil Postgraduate Program in Health Sciences of the Faculty of Medicine of ABC (FABC) S&#227o Paulo Brazil Hospital Beneficiente Portuguesa of Belém Pará Brazil Rigshospital Copenhagen East K&#248benhavn Denmark Centro Universitário do Rio Grande do Norte Natal Brazil

Patients with decompensated hepatic cirrhosis may present systemic alterations and dysfunction of multiple organs. Ascites, portal hypertension, esophageal varices, and hepatic encephalopathy are common complications arising from cirrhosis. The aim of this paper is to report a case of a patient with liver cirrhosis and the complications of a transjugular intrahepatic portosystemic shunt. Male, elderly, and ex-alcoholic, diagnosed with liver cirrhosis, ascites, and esophageal varices. He underwent transjugular intrahepatic portosystemic shunt due to portal hypertension and returned to the hospital after 24 hours with agitation and mental confusion. He had a bowel movement stop, neurological worsening, loss of renal function, hepatic hydrothorax, hepatic encephalopathy, hypernatremia, hypocalcemia, and hypophosphatemia. He underwent a new procedure to occlude the transjugular intrahepatic portosystemic shunt, showing improvement of the mental status and ascites. However, continued with decompensation and hydro-electrolytic disorders. He evolved with worsening of the ventilatory pattern, and neurological and renal function, with a fatal outcome. Esophageal varices due to portal hypertension can be corrected with the transjugular intrahepatic portosystemic shunt. However, complications such as hypernatremia, hepatic hydrothorax, and hepatic encephalopathy may occur. Therefore, there is a need for reintervention to shunt or reduce its caliber. Thus, for patients with advanced age and decompensated cirrhosis, the potential risks and benefits of this procedure should be carefully evaluated due to the risk of complications and death.

关键词： Ascites Hypernatremia Portasystemic Shunt Transjugular Intrahepatic Hepatic Encephalopathy

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Meta流行病学研究：指南中专家意见的意义

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英国医学杂志中文版 2018年第5期21卷 275-279页

作者：杨楠周奇张静怡(译) 陈耀龙杨克虎(校) 兰州大学循证医学中心

指南常会使用术语“专家意见（Expert Opinion，EO）”来支撑推荐意见，本研究旨在探究EO型推荐意见的来源和证据类型。我们检索了不同数据库和网站近10年发表的含有EO型推荐意见的指南。共命中1106篇文献，纳入69篇指南（含2390条推荐... 详细信息

指南常会使用术语“专家意见（Expert Opinion，EO）”来支撑推荐意见，本研究旨在探究EO型推荐意见的来源和证据类型。我们检索了不同数据库和网站近10年发表的含有EO型推荐意见的指南。共命中1106篇文献，纳入69篇指南（含2390条推荐意见，其中907条为EO型推荐意见），大多数EO型推荐意见（91％）未说明采用EO的理由，EO型推荐意见最常引用的证据大都是不足以回答指南问题的研究（40％为随机对照试验，38％为观察性研究，2％为病例报告或病例系列）。

关键词： Meta流行病学专家意见

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The Global Soil Mycobiome consortium dataset for boosting fungal diversity research

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Fungal Diversity 2021年第6期111卷 573-588页

作者： Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad Bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken Bobby P.Sulistyo Boris Tamgnoue Brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai Daniyal Gohar Dipon Sharmah Elisabeth Machteld Biersma Erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.Barrio Jaan Pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta alvarez-Manjarrez Jutamart Monkai Kadri Põldmaa Kadri Runnel Kalev Adamson Kari A.Bråthen Karin Pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel Panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn Bauters Miklós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.Mortimer Peter Meidl RHenrik Nilsson Rasmus Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou Sergei Põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike Piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov Mycology and Microbiology Center University of TartuTartuEstonia Institute of Ecology and Earth Sciences TartuEstonia Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden Department of Botany University of the PunjabQuaid-e-Azam CampusLahorePakistan Centro de Investigaciones en Microbiología y Biotecnología-UR(CIMBIUR) Facultad de Ciencias NaturalesUniversidad del RosarioBogotáColombia Grupo de Microbiología Ambiental y BioMicro Escuela de MicrobiologíaUniversidad de Antioquia UdeAMedellínColombia Department of Agricultural Food and Forest SciencesUniversity of PalermoPalermoItaly Royal Botanic Gardens SurreyUK Department of Biomedical Sciences University of CagliariCagliariItaly Research Group Mycology Department of BiologyGhent UniversityGhentBelgium Department of Biomedicine Indonesia International Institute for Life SciencesJakartaIndonesia Plant Pathology and Agricultural Zoology Research Unit Department of Plant ProtectionFaculty of Agronomy and Agricultural SciencesUniversity of DschangDschangCameroon Department of Ecology and Genetics Uppsala UniversityUppsalaSweden Eukaryotic Microbiology University of Duisburg-EssenEssenGermany Department of Biological Sciences and Biotechnology Botswana International University of Science and TechnologyPalapyeBotswana Natural History Museum of Zimbabwe BulawayoZimbabwe Institute of Botany Czech Academy of SciencesPrůhoniceCzech Republic Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingPeople’s Republic of China Department of Botany Jawaharlal Nehru Rajkeeya MahavidyalayaPondicherry UniversityPort BlairIndia British Antarctic Survey NERCCambridgeUK Natural History Museum of Denmark University of CopenhagenCopenhagenDenmark Department of Environmental Science Saint Mary’s UniversityHalifaxNSCanada Altai State University BarnaulRussia CSIRO Land and Water WembleyWAAustralia Department of N

Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and *** data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and *** dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from PacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all *** plots are supplied with geographical and edaphic *** OTUs are taxonomically and functionally assigned to guilds and other functional *** entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential *** dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published *** GSMc dataset is available over the PlutoF repository.

关键词： Soil fungi Global dataset PacBio sequencing Fungal richness

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