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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 433-435页

作者： Paula Jiménez-Fonseca Patricia Morales del Burgo felipe alvarez-mancenido Department of Medical Oncology Hospital Universitario Central de AsturiasOviedoSpain Department of Pathology Hospital Universitario Central de AsturiasOviedoSpain Department of Pharmacology Hospital Universitario Central de AsturiasOviedoSpain

The incidence of neuroendocrine neoplasms (NEN) has grown by a factor of 6.4 between 1973 and 2012 (1). According to the United States Surveillance, Epidemiology, and End Results (SEER), some 50% of all NEN, 3.56×10^5, are gastroenteropancreatic (GEP) in origin, including 1.05, 10.4, 0.48×10^5 of the small intestine, rectum, and pancreas, respectively. Like the Spanish group, others have reported a higher incidence of pancreatic NEN (P-NEN) (2). Given its typically indolent course, GEP-NENs are the second most prevalent tumors of the digestive system, surpassed only by colorectal cancer, underscoring the importance of understanding them, their diagnosis, and efficient treatment strategies.

关键词： neoplasms intestine diagnosis

Prognostic impact of inflammatory and nutritional biomarkers in pancreatic cancer

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World Journal of Clinical Oncology 2025年第1期16卷 5-9页

作者： Macarena Teja María I Garrido Abrahams Ocanto felipe Counago Department of Radiation Oncology GenesisCare-San Francisco de Asís University HospitalMadrid 28002Spain Department of Radiation Oncology GenesisCare-Vithas La Milagrosa University HospitalMadrid 28010Spain National Director GenesisCare SpainMadrid 28043Spain Department of Medicine School of MedicineHealth and SportEuropean University of MadridMadrid 28670Spain

Pancreatic cancer is usually associated with a poor *** is the main curative treatment but pancreatic operations are aggressive and new tools that help clinicians to predict surgical and prognostic outcomes are *** et al recently published a retrospective,single centre cohort study evaluating the impact of seven nutritional and inflammatory markers in pancreatic cancer surgical patients:The albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),nutritional risk index,and the geriatric nutritional risk index.A significant correlation was found between the PNI,SII,NLR,and PLR and a hospital discharge of less than 15 *** a univariable analysis,PNI,SII,NLR and PLR were significantly related to recurrence-free survival and,in a multivariable analysis PNI was associated with overall *** meta-analyses corroborate the results in terms of prognosis but individual studies are discordant on their ***,the cut-off values for these markers vary significantly between studies and there are no clinical trials comparing them to identify the most relevant *** are limitations when implementing nutritional and inflammatory biomarkers into clinical practice and further studies are needed in order to answer these questions.

关键词： Inflammatory biomarkers Nutritional biomarkers Pancreatic cancer Prognosis Surgical complications

Grid Methods in Computational Real Algebraic (and Semialgebraic) Geometry

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Chinese Annals of Mathematics,Series B 2018年第2期39卷 373-396页

作者： felipe cucker A Philippe pour des annees d＇amiti

In recent years, a family of numerical algorithms to solve problems in real algebraic and semialgebraic geometry has been slowly growing. Unlike their counterparts in symbolic computation they are numerically stable. But their complexity analysis, based on the condition of the data, is radically different from the usual complexity analysis in symbolic computation as these numerical algorithms may run forever on a thin set of ill-posed inputs.

关键词： Numerical algorithms Complexity Condition Semialgebraic geometry

Current status and potential of morphometric sperm analysis

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Asian Journal of Andrology 2016年第6期18卷 863-870页

作者： Alejandro Maroto-Morales Olga Garcia-alvarez Manuel Ramon felipe Martinez-Pastor M Rocio Fernandez-Santos A Josefa Soler Jose Julian Garde SaBio IREC (CSIC - UCLM -JCCM) Albacete Spain Biomedical Center Medical Faculty in Pilsen Charles University in Prague Pilsen Czech Republic Regional Center of Animal Selection and Reproduction (CERSYRA) JCCM Valdepenas Spain 4Institute for Animal Health and Cattle Development University of Leon LeOn Spain Department of Molecular Biology University of Leon Leon Spain Faculty of Pharmacy (UCLM) Albacete Spain

The spermatozoon is the most diverse cell type known and this diversity is considered to reflect differences in sperm function. How the diversity in sperm morphology arose during speciation and what role the different specializations play in sperm function, however, remain incompletely characterized. This work reviews the hypotheses proposed to explain sperm morphological evolution, with a focus on some aspects of sperm morphometric evaluation; the ability of morphometrics to predict sperm cryoresistance and male fertility is also discussed. For this, the evaluation of patterns of change of sperm head morphometry throughout a process, instead of the study of the morphometric characteristics of the sperm head at different stages, allows a better identification of the males with different sperm cryoconservation ability. These new approaches, together with more studies employing a greater number of individuals, are needed to obtain novel results concerning the role of sperm morphometry on sperm function. Future studies should aim at understanding the causes of sperm design diversity and the mechanisms that generate them, giving increased attention to other sperm structures besides the sperm head. The implementation of scientific and technological advances could benefit the simultaneous examination of sperm phenotype and sperm function, demonstrating that sperm morphometry could be a useful tool for sperm assessment.

关键词： computer-assisted sperm morphometric analysis mammals sperm function sperm morphometry

On the Tractability of Shortest Path Problems in Weighted Edge-Coloured Graphs

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Journal of Systems Science & Complexity 2018年第2期31卷 527-538页

作者： ENSOR Andrew LILLO felipe School of Computing and Mathematical Sciences Auckland University of Technology 2 - 14 Wakefield St Auckland 1142 New Zealand Department of Economics and Management Universidad Catolica del Maule PO Box 617 Avenida San Miguel 3605 Talca Chile

A weighted edge-coloured graph is a graph for which each edge is assigned both a positive weight and a discrete colour, and can be used to model transportation and computer networks in which there are multiple transportation modes. In such a graph paths are compared by their total weight in each colour, resulting in a Pareto set of minimal paths from one vertex to another. This paper will give a tight upper bound on the cardinality of a minimal set of paths for any weighted edge-coloured graph. Additionally, a bound is presented on the expected number of minimal paths in weighted edge-bicoloured graphs. These bounds indicate that despite weighted edge-coloured graphs are theoretically intractable, amenability to computation is typically found in practice.

关键词： Edge-coloured chain graph minimal paths multimodal networks Pareto set cardinality upper bounds.

LEFT-RIGHT BROWDER LINEAR RELATIONS AND RIESZ PERTURBATIONS

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Acta Mathematica Scientia 2017年第5期37卷 1437-1452页

作者： Teresa alvarez Department of Mathematics University of Oviedo33007OviedoAsturiasSpain

A closed linear relation T in a Banach space X is called left(resp. right) Fredholm if it is upper(resp. lower) semi Fredholm and its range(resp. null space) is topologically complemented in X. We say that T is left(resp. right) Browder if it is left(resp. right)Fredholm and has a finite ascent(resp. descent). In this paper, we analyze the stability of the left(resp. right) Fredholm and the left(resp. right) Browder linear relations under commuting Riesz operator perturbations. Recent results of Zivkovic et al. to the case of bounded operators are covered.

关键词： left and right Fredholm linear relations left and right Browder linear relations Riesz perturbations

Automation in detection of recirculation in a booster fan ventilation network

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International Journal of Mining Science and Technology 2018年第3期28卷 513-517页

作者： Mahesh Shriwas felipe Calizaya Department of Mining Engineering University of Utah

Recirculation is prohibited in many coal mining countries because of the fear that the re-use of return air would allow the build-up of air contaminants at the workings. The incorrect design and location of a booster fan in any ventilation network can create unsafe condition due to recirculation. The current approach to investigating recirculation using simulation software requires manual effort which becomes tedious in a complex and a large network. An algorithm-based C++ program was designed to detect the recirculation in a booster fan ventilation networks. This program needed an input file prepared from output file generated by any ventilation simulator. This program created an output file for recirculation. This program demonstrated the strong capability to detect the recirculation in a sample network and a coal mine ventilation network. The outcomes of this program were documented in this paper.

关键词： Recirculation Ventilation Booster fan

On Rigid 2-Step Nilpotent Lie Algebras

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Algebra Colloquium 2018年第2期25卷 349-360页

作者： Maria Alejandra alvarez Departamento de Matematicas Facultad de Ciencias Basicas Universidad de Antofagasta Casilla 170 Antofagasta Chile

In this note we consider 2-step nilpotent Lie algebras and give a criterion for the rigidity of this class in the variety N2n of 2-step nilpotent Lie algebras of dimension n. We apply this criterion to prove that ever... 详细信息

关键词： nilpotent Lie algebras variety of Lie algebras deformations cohomology,nilradicals

New insights on the molecular mechanisms of collateral sprouting after peripheral nerve injury

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Neural Regeneration Research 2021年第9期16卷 1760-1761页

作者： Dominique Lemaitre felipe A.Court Universidad del Desarrollo Facultad de MedicinaCentro de Fisiología Celular e IntegrativaSantiagoChile Center for Integrative Biology Faculty of SciencesUniversidad MayorSantiagoChile Geroscience Center for Brain Health and Metabolism(GERO) SantiagoChile The Buck Institute for Research on Aging NovatoCAUSA

Axonal regeneration after injuries to the nervous system has been extensively studied due to its implication in motor and sensory functional recovery. Distinct types of regeneration has been identified, such as canonical axonal regeneration, defined as the growth of axons from the transected axonal stump to reinnervate the original target, or regenerative sprouting, in which the growth occurs from a region of the damaged axon either close or far from the injury site(Tuszynski and Steward, 2012).

关键词： injuries injury collateral

Preventing brain aging by the artificial enforcement of the unfolded protein response:future directions

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Neural Regeneration Research 2024年第2期19卷 393-394页

作者： felipe Cabral-Miranda Claudio Hetz Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Center for Geroscience Brain Health and MetabolismSantiagoChile、Biomedical Neuroscience InstituteFaculty of MedicineUniversity of ChileSantiagoChile、Program of Cellular and Molecular BiologyInstitute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile、Buck Institute for Research on AgingNovatoCAUSA

As the life expectancy of the world’s population increases,age-related diseases are emerging as one of the greatest problems facing modern *** onset of dementia and neurodegenerative diseases is strictly dependent on aging as a major risk factor and has a profound impact on various aspects of the lives of individuals and their families.

关键词： diseases aging directions