Histologic and molecular features of small well-differentiated pancreatic neuroendocrine tumors associated with the development of liver metastases

作     者：Paula Jiménez-Fonseca Patricia Morales del Burgo Felipe Alvarez-Mancenido 

作者机构：Department of Medical OncologyHospital Universitario Central de AsturiasOviedoSpain Department of PathologyHospital Universitario Central de AsturiasOviedoSpain Department of PharmacologyHospital Universitario Central de AsturiasOviedoSpain 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2019年第8卷第4期

页      面：433-435页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：neoplasms intestine diagnosis 

摘      要：The incidence of neuroendocrine neoplasms (NEN) has grown by a factor of 6.4 between 1973 and 2012 (1). According to the United States Surveillance, Epidemiology, and End Results (SEER), some 50% of all NEN, 3.56×10^5, are gastroenteropancreatic (GEP) in origin, including 1.05, 10.4, 0.48×10^5 of the small intestine, rectum, and pancreas, respectively. Like the Spanish group, others have reported a higher incidence of pancreatic NEN (P-NEN) (2). Given its typically indolent course, GEP-NENs are the second most prevalent tumors of the digestive system, surpassed only by colorectal cancer, underscoring the importance of understanding them, their diagnosis, and efficient treatment strategies.