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Study on the mechanism of SND in the treatment of anxiety disorders based on network pharmacology, molecular docking and experiment validation

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Pharmacology Discovery 2024年第2期4卷 10-23页

作者： fei-yan wang Ping Yuan Mei-Ling Zheng Xiao-Di Guo Long Li Jin wang Shan Miao Ya-Jun Shi Shan-Bo Ma Xiao-Peng Shi College of pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Department of Pharmacy Xijing HospitalAir Force Medical UniversityXi’an 710032China Outpatient Department of University Hospital Northwestern Polytechnical University HospitalXi’an 710072China The College of Life Sciences Northwest UniversityXi’an 710127China

Background:Sini decoction(SND)is a classic traditional Chinese medicine(TCM)formulation that can be used to treat anxiety-related disorders,but the active substance and underlying molecular mechanism of its anxiolytic effects are *** this study,network pharmacology,molecular docking research and experimental verification methods were used to preliminarily explore the bioactive compounds and potential target mechanisms of SND ***:The active components and corresponding targets of SND were collected by ***,OMIM,PharmGkb,TTD and Drugbank were used to search for the targets of anxiety *** core target of SND in the treatment of anxiety was screened by PPI.R language was used to analyze the intersection targets of SND in the treatment of anxiety disorders by GO and KEGG enrichment *** Vina was used for molecular docking,and Discovery Studio was used for visual conformation analysis after *** anti-anxiety effect and molecular mechanism of SND were studied by in vivo ***:Based on network pharmacological analysis,we obtained 112 active ingredients and 350 effective targets related to anxiety from *** PPI analysis,26 targets such as STAT3,MAPK3,MAPK1,MAPK14,SRC,HSP90AA1,TP53 and PIK3CA were identified as core *** and KEGG analysis showed that the anxiolytic mechanism of SND may be related to the neuroactive ligand-receptor interaction pathway and inflammatory *** docking showed that quercetin,naringenin,licochalcone A had high affinity with JAK2,MAPK14 and *** experiments have shown that SND reverses the upregulation of GluN2B(NMDAR)and GluA1(AMPAR)proteins,and SND improves anxiety disorders by regulating glutamate transmitter levels,which may be related to neuroactive ligand-receptor interaction pathways,particularly glutamate ***:This study shows that SND can improve FS-induced behavioral changes in mice and can modulate hippocampal synapse-asso

关键词： SND anxiety disorders network pharmacology molecular docking pharmacological mechanisms

Quantitative evaluation of gas hydrate reservoir by AVO attributes analysis based on the Brekhovskikh equation

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Petroleum Science 2023年第4期20卷 2045-2059页

作者： Yao wang yan-fei wang Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China University of Chinese Academy of Sciences Beijing100049China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing100029China

AVO (Amplitude variation with offset) technology is widely used in gas hydrate research. BSR (Bottom simulating reflector), caused by the huge difference in wave impedance between the hydrate reservoir and the underlying free gas reservoir, is the bottom boundary mark of the hydrate reservoir. Analyzing the AVO attributes of BSR can evaluate hydrate reservoirs. However, the Zoeppritz equation which is the theoretical basis of conventional AVO technology has inherent problems: the Zoeppritz equation does not consider the influence of thin layer thickness on reflection coefficients;the approximation of the Zoeppritz equation assumes that the difference of wave impedance between the two sides of the interface is small. These assumptions are not consistent with the occurrence characteristics of natural gas hydrate. The Brekhovskikh equation, which is more suitable for thin-layer reflection coefficient calculation, is used as the theoretical basis for AVO analysis. The reflection coefficients calculated by the Brekhovskikh equation are complex numbers with phase angles. Therefore, attributes of the reflection coefficient and its phase angle changing with offset are used to analyze the hydrate reservoir's porosity, saturation, and thickness. Finally, the random forest algorithm is used to predict the reservoir porosity, hydrate saturation, and thickness of the hydrate reservoir. In the synthetic data, the inversion results based on the four attributes of the Brekhovskikh equation are better than the conventional inversion results based on the two attributes of Zoeppritz, and the thickness can be accurately predicted. The proposed method also achieves good results in the application of Blake Ridge data. According to the method proposed in this paper, the hydrate reservoir in the area has a high porosity (more than 50%), and a medium saturation (between 10% and 20%). The thickness is mainly between 200m and 300m. It is consistent with the previous results obtained by veloci

关键词： Natural gas hydrate Brekhovskikh equation AVO attributes Random forest

RESEARCH ON IMPROVED CUT-OFF NEGATIVE PRESSURE METHOD FOR UNSTEADY SEEPAGE FLOW WITH FREE SURFACE

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Journal of Hydrodynamics 2005年第5期17卷 521-531页

作者： ZHANG Qian-fei wang yan-ming Shanghai Municipal Engineering Design Institute Shanghai 200092 China

The cut-off negative pressure method is one of effective approaches to solve the seepage flow with free surface. According to the characteristics of this method, however, it has been found out that the deficiency of the algorithms is to easily cause inaccurate simulation in the vicinity of free surface owing to the penalty function with only one controlling penalty parameter. Therefore, an improved cut-off pressure method was presented by constructing penalty function with two controlling penalty parameters. The improved algorithms were illustrated to be able to improve the simulation accuracy and raise the convergence speed through considering the effects of the partially saturated or unsaturated elements more reasonably and calculating the nodal external forces more accurately. Finally, the improved cut-off negative pressure method was applied to the simulation of unsteady seepage flow with free surface, and the corresponding program codes were developed with validation of some cases.

关键词： free surface unsteady seepage flow finite element method improved cut-off negative pressure method

DUAL RECIPROCITY HYBRID BOUNDARY NODE METHOD FOR THREE-DIMENSIONAL ELASTICITY WITH BODY FORCE

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Acta Mechanica Solida Sinica 2008年第3期21卷 267-277页

作者： fei yan Yuanhan wang Yu Miao fei Tan School of Civil Engineering and Mechanics Huazhong University of Science and Technology Wuhan 430074 China

Combining Dual Reciprocity Method （DRM） with Hybrid Boundary Node Method （HBNM）, the Dual Reciprocity Hybrid Boundary Node Method （DRHBNM） is developed for three-dimensional linear elasticity problems with body force. This method can be used to solve the elasticity problems with body force without domain integral, which is inevitable by HBNM. To demonstrate the versatility and the fast convergence of this method, some numerical examples of 3-D elasticity problems with body forces are examined. The computational results show that the present method is effective and can be widely applied in solving practical engineering problems.

关键词： hybrid boundary node method dual reciprocity method body force radial basis function

Micro-macro fracture mechanism of heterogeneous granite in percussive drilling

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Petroleum Science 2023年第5期20卷 3131-3142页

作者： Wei-Ji Liu yan-fei wang Zhao-wang Dan Xiao-Hua Zhu School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500SichuanChina Geothermal Energy Research Center Southwest Petroleum UniversityChengdu610500SichuanChina Powerchina Sinohydro Bureau 7 Co. LTDChengdu610500SichuanChina

The conventional rotary rock breaking method faces a technical bottleneck in improving the rate of penetration(ROP)in deep hard *** drilling is the most potential approach to increase rock-breaking efficiency and ***,the rock-breaking mechanism of percussive drilling is still unclear enough,especially the micro-fracture mechanism of rock under confining pressure(under lateral pressure and hydraulic pressure).In this paper,the impact rock breaking experiments by four kinds of Polycrystalline Diamond Compact(PDC)cutters are carried out using a drop-weight impact testing machine and an acoustic emission(AE)recording system,the influence of parameters such as cutter shape,rake angle,and impact energy on rock-breaking are systematically *** study includes a numerical simulation to examine the process of crack initiation,propagation,and cuttings formation during the impact process with the consideration of confining *** results show the conicalshaped cutter is the most aggressive with high breaking *** penetration depth of the cutter is mainly influenced by the impact energy and cutter shape than the rake angle of the *** exists critical impact energy makes the rock breaking efficiency the *** critical impact energy is about 40 J when using the conical-shaped cutter with a rake angle of 15°.The rock mainly failed in tensile mode,and the inter-grain crack is the main *** pressure can inhibit the formation of horizontal cracks,while lateral pressure can inhibit the formation of vertical cracks and reduce the proportion of tensile *** research results can provide some reference and basis for improving the rock-breaking efficiency in deep hard formations.

关键词： Percussive drilling PFC Rock fragmentation characteristics Rock breaking efficiency

Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis

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World Journal of Gastroenterology 2023年第48期29卷 6222-6234页

作者： yan-fei wang Ruo-Yu He Chan Xu Xiao-Ling Li yan-fei Cao Department of Gastroenterology The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Clinical laboratory The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Elder Medicine Department The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Ulcerative colitis(UC)is a chronic gastrointestinal disorder characterized by inflammation and ulceration,representing a significant predisposition to colorectal *** advances in single-cell RNA sequencing(scRNA-seq)technology offer a promising avenue for dissecting the complex cellular interactions and molecular signatures driving UC *** To utilize scRNA-seq technology to dissect the complex cellular interactions and molecular signatures that underlie UC *** In this research,we integrated and analyzed the scRNA-seq data from UC ***,we conducted mRNA and protein level assays as well as pathology-related staining tests on clinical patient *** In this study,we identified the sustained upregulation of inflammatory response pathways during UC progression,characterized the features of damaged endothelial cells in ***,we uncovered the downregulation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)has a negative correlation with signal transducer and activator of transcription *** downregulation of LHPP in UC patient tissues and plasma suggests that LHPP may serve as a potential therapeutic target for *** paper highlights the importance of LHPP as a potential key target in UC and unveils its potential role in inflammation *** The findings suggest that LHPP may serve as a potential therapeutic target for UC,emphasizing its importance as a potential key target in UC and unveiling its role in inflammation regulation.

关键词： Ulcerative colitis Single-cell RNA sequencing Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Convergence and Optimality of Adaptive Regularization for Ill-posed Deconvolution Problems in Infinite Spaces

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Acta Mathematicae Applicatae Sinica 2006年第3期22卷 429-436页

作者： yan-fei wang Qing-hua Ma State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University P.O.Box 9718 Beijing 100101 China Department of Information Sciences College of Arts and Science of Beijing Union University Beijing 100038China

The adaptive regularization method is first proposed by Ryzhikov et al. in [6] for the deconvolution in elimination of multiples which appear frequently in geoscience and remote sensing. They have done experiments to show that this method is very effective. This method is better than the Tikhonov regularization in the sense that it is adaptive, i.e., it automatically eliminates the small eigenvalues of the operator when the operator is near singular. In this paper, we give theoretical analysis about the adaptive regularization. We introduce an a priori strategy and an a posteriori strategy for choosing the regularization parameter, and prove regularities of the adaptive regularization for both strategies. For the former, we show that the order of the convergence rate can approach O（｜｜n｜｜^4v/4v＋1） for some 0 〈 v 〈 1, while for the latter, the order of the convergence rate can be at most O（｜｜n｜｜^2v/2v＋1） for some 0 〈 v 〈 1.

关键词： Ill-posed problems adaptive regularization convergence regularity

CFD-DEM study of impacts of the porous distributor medium on fluidization characteristics of a 2D-fluidized bed

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Particuology 2024年第4期87卷 54-73页

作者： fei wang Yishan Zeng Hao yan School of Mechanical Engineering Hefei University of TechnologyHefei230009China

Gas-solid bubbling fluidized beds are widely used in chemical,energy,construction,and other industrial fields due to their excellent fluidization performance.2D-fluidized beds with planar rectangular columns of finite thickness are widely used in fluidized bed studies,and it is essential for understanding the hydrodynamics of gas-particle ***,the distributor(porous medium)at the bottom of the bed has a crucial influence on the fluidization performance of the 2D-fluidized *** this work,the fluidization mechanism and gas-solid dynamic characteristics of the fluidized bed under three porous media are studied by CFD-DEM coupled with the porous medium model,and the accuracy of numerical simulation is verified by a high-speed photography *** show that with the increase in the flow resistance of the porous medium,the average and standard deviation of the bubble diameter decrease,and the time and position of particles in the dead zone to participate in the core-annular flow *** a low fluidization velocity,the dead zone in the bed can be considerably reduced by increasing the flow resistance.

关键词： Fluidized bed CFD-DEM Porous medium Bubble dynamics Solid mixing

Ultrafine-Grained Microstructure and Improved Mechanical Behaviors of Friction Stir Welded Cu and Cu–30Zn Joints

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 878-886页

作者： yan-fei wang Jian An Kun Yin Ming-Sai wang Yu-Sheng Li Chong-Xiang Huang School of Aeronautics and Astronautics Sichuan University Nano Structural Materials Center School of Materials Science and Engineering Nanjing University of Science and Technology

Ultra-strong joints of pure Cu and Cu–30Zn alloy were obtained by friction stir welding under flowing water. The effects of heat inputting condition and material characteristics on the morphologies, microstructures and mechanical properties of welding joints were studied. Defect-free stirring zones of pure Cu and Cu–30Zn were characterized by onion-ringed structure and plastic flowing bands, respectively. Both low stacking fault energy and fast cooling condition contributed to the formation of small recrystallized grains less than 1 μm in stirring zones. The welding joints in both materials exhibited enhanced mechanical performances due to ultrafine-grained microstructure in stirring zones and disappearance of soft heataffected-zone. The technique of digital image correlation was used to study the tensile deformation behaviors of welding joints and verify the improved tensile properties.

关键词： Friction stir welding Ultrafine grain Mechanical properties Stacking fault energy Digital image correlation(DIC)