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欧式电葫芦用超高破断拉力钢丝绳研制

金属制品 2024年第4期50卷 1-5页

作者：牛飞王紫鹏夏承堂刘星宇高明济宁长龙钢丝绳有限公司山东济宁272000

研制一种欧式电葫芦用超高破断拉力钢丝绳,产品标准参考DIN EN 12385-4:2008 2 160 MPa B级,直径为6.20~6.40 mm,捻距倍数6~8,最小破断拉力46.0 kN。通过结构和性能分析,确定钢丝绳采用K8×K19S-PWRC(K)结构,再根据股绳结构特点精确计... 详细信息

研制一种欧式电葫芦用超高破断拉力钢丝绳,产品标准参考DIN EN 12385-4:2008 2 160 MPa B级,直径为6.20~6.40 mm,捻距倍数6~8,最小破断拉力46.0 kN。通过结构和性能分析,确定钢丝绳采用K8×K19S-PWRC(K)结构,再根据股绳结构特点精确计算出股径和配丝,并匹配合理的拉丝工艺。钢丝绳采用18/500筐篮式合绳机捻制,股的张力控制采用FMS张力在线检测和调整系统,生产中采用轧制和锻打双压实工艺。钢丝绳性能检测结果显示:实测直径6.36~6.38 mm,实测捻距39.3 mm,实测破断拉力达到48.8 kN,实测锌层面质量大于30.0 g/m2,满足了欧式电葫芦设备的技术要求。

关键词：欧式电葫芦钢丝绳超高破断拉力捻距张力控制双压实

Is adjuvant chemotherapy necessary for patients with microinvasive breast cancer after surgery？

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Cancer Biology & Medicine 2016年第1期13卷 142-149页

作者： Hai-fei niu Li-Juan Wei Jin-Pu Yu Zhen Lian Jing Zhao Zi-Zheng Wu Jun-Tian Liu The Second of Department of Breast Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Breast Cancer Prevention and TherapyTianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Breast Cancer Prevention and TherapyTianjin 300060China

Objective: Survival and treatment of patients with microinvasive breast cancer(MIBC) remain controversial. In this paper, we evaluated whether adjuvant chemotherapy is necessary for patients with MIBC to identify risk factors influencing its prognosis and decide the indication for adjuvant ***: In this retrospective study, 108 patients with MIBC were recruited according to seventh edition of the staging manual of the American Joint Committee on Cancer(AJCC). The subjects were divided into chemotherapy and non-chemotherapy *** compared the 5-year disease-free survival(DFS) and overall survival(OS) rates between groups. Furthermore, we analyzed the factors related to prognosis for patients with MIBC using univariate and multivariate analyses. We also evaluated the impact of adjuvant chemotherapy on the prognostic factors by subgroup analysis after median follow-up time of 33 months(13-104months).Results: The 5-year DFS and OS rates for the chemotherapy group were 93.7% and 97.5%, whereas those for the nonchemotherapy group were 89.7% and 100%. Results indicate that 5-year DFS was superior, but OS was inferior, in the former group compared with the latter group. However, no statistical significance was observed in the 5-year DFS(P=0.223) or OS(P=0.530) rate of the two groups. Most relevant poor-prognostic factors were Ki-67 overexpression and negative hormonal receptors. Cumulative survival was 98.2% vs. 86.5% between low Ki-67(≤20%) and high Ki-67(>20%). The hazard ratio of patients with high Ki-67 was 16.585 [95% confidence interval(CI), 1.969-139.724; P=0.010]. Meanwhile, ER(-)/PR(-) patients with MIBC had cumulative survival of 79.3% compared with 97.5% for ER(+) or PR(+) patients with MIBC. The hazard ratio for ER(-)/PR(-) patients with MIBC was 19.149(95% CI, 3.702-99.057; P<0.001). Subgroup analysis showed that chemotherapy could improve the outcomes of ER(-)/PR(-) patients(P=0.014), but not those who overexpress Ki-67(P=0.105).Conclusions

关键词： Microinvasive breast cancer adjuvant chemotherapy survival

Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

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Neural Regeneration Research 2022年第2期17卷 386-394页

作者： Xiao-Jian Xu Meng-Shi Yang Bin Zhang Qian-Qian Ge fei niu Jin-Qian Dong Yuan Zhuang Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether ts RNAs are involved in traumatic brain injury-induced secondary injury remains poorly understood. In this study, a mouse controlled cortical impact model of traumatic brain injury was established, and integrated ts RNA and messenger RNA(m RNA) transcriptome sequencing were used. The results revealed that 103 ts RNAs were differentially expressed in the mouse model of traumatic brain injury at 72 hours, of which 56 ts RNAs were upregulated and 47 ts RNAs were downregulated. Based on micro RNA-like seed matching and Pearson correlation analysis, 57 differentially expressed ts RNA-m RNA interaction pairs were identified, including 29 ts RNAs and 26 m RNAs. Moreover, Gene Ontology annotation of target genes revealed that the significantly enriched terms were primarily associated with inflammation and synaptic function. Collectively, our findings suggest that ts RNAs may be associated with traumatic brain injury-induced secondary brain injury, and are thus a potential therapeutic target for traumatic brain injury. The study was approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No. 20190411) on April 11, 2019.

关键词： gene set enrichment analysis inflammation integrated analysis neurodegenerative disease next-generation sequencing secondary injury synaptic function transfer RNA-derived small RNAs transfer RNAs traumatic brain injury

Kinetic Characteristic of Photooxidation of Cypermethrin by Organic Peroxy Radical

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Wuhan University Journal of Natural Sciences 2001年第3期6卷 725-728页

作者： Bi Gang Chen Chang-yang niu fei Gu Ying-hong Tian Shi-zhong Cheng Jie-ke Inspection Center of HEEI Quarantine Bureau Wuhan 430022 China

The kinetic characteristic of photolysis of cypermethrin (CPM) sensitized by acetophenone (AP) and the effect of probe substance 2,6-Di-tert-butyl-4-methylphenol and tetralin is studied in this report. It showed that the photolysis rate of CPM increases slightly with the increase of AP concentration; photolysis rate of CPM has no relationship with [CPM] itself; The more dipolar moment the solvent has, the more the interaction between radical and solvent has, and the slower the photolysis of CPM is. The addition of radical probe substance confirms that ROO·is more than RO·. The steady-state concentration of ROO·is about 10?8 mol·L?1.

关键词： photooxidation cypermethrin organic peroxy sensitization

Effects of iron-containing phases on transformation of sulfur-bearing ions in sodium aluminate solution

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Transactions of Nonferrous Metals Society of China 2017年第4期27卷 908-916页

作者： Xiao-bin LI fei niu Gui-hua LIU Tian-gui QI Qiu-sheng ZHOU Zhi-hong PENG School of Metallurgy and Environment Central South University Changsha 410083 China

Sulfides in the high-sulfur bauxite lead to serious steel equipment corrosion and alumina product degradation via theBayer process,owing to the reactions of sulfur and iron-containing phases in the sodium aluminate *** effects ofiron-containing phases on the transformation of sulfur-bearing ions(S2?,223S O?,23SO?and24SO?)in sodium aluminate solutionwere ***,Fe2O3and Fe3O4barely react with23SO?and24SO?,but all of them,particularly Fe,can promote theconversion of223S O?to23SO?and S2?in sodium aluminate *** can convert to3Fe(OH)?in solution at elevatedtemperatures,and further react with S2?to form FeS2,but Fe2O3and Fe3O4have little influence on the reaction behavior of S2?insodium aluminate *** temperature,duration,dosage of Fe,mole ratio of Na2Ok to Al2O3and caustic sodaconcentration are beneficial to the transformation of223S O?to23SO?and S2?.The results may contribute to the development oftechnologies for alleviating the equipment corrosion and reducing caustic consumption during the high-sulfur bauxite treatment bythe Bayer process.

关键词： high-sulfur bauxite sodium aluminate solution sulfur-bearing ion iron-containing phase transformation

Restoration of pseudo-spin symmetry in N = 32 and N = 34 isotones described by relativistic Hartree-Fock theory

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Chinese Physics C 2019年第7期43卷 79-85页

作者： Zheng-Zheng Li Shi-Yao Chang Qiang Zhao Wen-Hui Long Yi-fei niu School of Nuclear Science and Technology Lanzhou University

The restoration of pseudo-spin symmetry（PSS） along the N = 32 and N = 34 isotonic chains and the physics behind are studied by applying the relativistic Hartree-Fock theory with the effective Lagrangian PKA1. Taking the proton pseudo-spin partners(π2s1/2, π1d3/2) as candidates, the systematic restoration of PSS along both isotonic chains is found from sulphur（S） to nickel（Ni）, while an obvious PSS violation from silicon（Si） to sulphur is discovered near the drip lines. The effects of the tensor force components are investigated, introduced naturally by the Fock terms, which can only partially interpret the systematics from calcium to nickel, whereas they fail for the overall trends. Further analysis following the Schr?dinger-like equation of the lower component of Dirac spinor shows that contributions from the Hartree terms dominate the overall systematics of the PSS restoration. Such effects can be self-consistently interpreted by the evolution of the proton central density profiles along both isotonic chains. In particular, the PSS violation is found to tightly relate to the dramatic changes from the bubble-like density profiles in silicon to the central-bumped ones in sulphur.

关键词： pseudo-spin symmetry relativistic Hartree-Fock theory tensor force bubble-like structure

Glucose metabolism:A link between traumatic brain injury and Alzheimer’s disease

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Chinese Journal of Traumatology 2021年第1期24卷 5-10页

作者： Xiao-Jian Xu Meng-Shi Yang Bin Zhang fei niu Jin-Qian Dong Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijing100070China Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China Nerve Injury and Repair Center of Beijing Institute for Brain Disorders Beijing100070China China National Clinical Research Center for Neurological Diseases Beijing100070China

Traumatic brain injury(TBI),a growing public health problem,is a leading cause of death and disability worldwide,although its prevention measures and clinical cares are substantially *** evidence shows that TBI may increase the risk of mood disorders and neurodegenerative diseases,including Alzheimer’s disease(AD).However,the complex relationship between TBI and AD remains *** dysfunction has been the common pathology in both TBI and *** the one hand,TBI perturbs the glucose metabolism of the brain,and causes energy crisis and subsequent *** the other hand,glucose deprivation promotes amyloidogenesis viaβ-site APP cleaving enzyme-1 dependent mechanism,and triggers tau pathology and synaptic *** findings suggest that TBI might facilitate Alzheimer’s pathogenesis by altering metabolism,which provides clues to metabolic link between TBI and *** this review,we will explore how TBI-induced metabolic changes contribute to the development of AD.

关键词： Alzheimer’s disease Traumatic brain injury Glucose metabolism Neurological disorder

吡仑帕奈单药和添加治疗局灶性癫痫患儿的疗效及安全性研究

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实用药物与临床 2024年第8期27卷 593-598页

作者：李晓媛杜丽君闫婷牛菲王文徽贾利芳山西医科大学儿科医学系山西太原030001 山西省儿童医院神经内科山西太原030000

目的探讨吡仑帕奈(PER)单药和添加治疗4~12岁局灶性癫痫患儿的有效性、安全性及影响疗效的因素。方法选取2021年9月至2023年1月山西省儿童医院符合入组标准的局灶性癫痫(局灶性发作伴或不伴继发全面性发作)患儿,根据其治疗方式的不同分... 详细信息

目的探讨吡仑帕奈(PER)单药和添加治疗4~12岁局灶性癫痫患儿的有效性、安全性及影响疗效的因素。方法选取2021年9月至2023年1月山西省儿童医院符合入组标准的局灶性癫痫(局灶性发作伴或不伴继发全面性发作)患儿,根据其治疗方式的不同分为单药组和添加组,添加组又根据添加数量不同分为合并1种、2种、3种及以上抗癫痫发作药物(ASMs)治疗组,评估各组别治疗3、6、12个月时的疗效、安全性及保留率,并分析末次随访时影响患儿疗效的因素。结果共纳入研究对象107例,单药治疗56例,添加治疗51例。单药组及添加组12个月有效率分别为81.8%、60.5%,无发作率分别为75.6%、28.9%,两组之间有效率差异无统计学意义(P>0.05)。107例患儿治疗12个月时总保留率76.6%。添加组中,合并1种ASMs治疗组有效率高于其他合并用药组(P0.05)。PER单药组与添加组不良反应发生率分别为23.3%、26.7%,差异无统计学意义(P>0.05)。结论PER对儿童局灶性癫痫单药和添加治疗疗效均较好,总体安全,不良反应少,保留率高。PER影响局灶性癫痫患儿疗效的因素可能与癫痫发作类型、病因及合并药物数量有关。

关键词：吡仑帕奈局灶性癫痫疗效安全性

Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury

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Neural Regeneration Research 2023年第5期18卷 1046-1051页

作者： Xiao-Jian Xu Qian-Qian Ge Meng-Shi Yang Yuan Zhuang Bin Zhang Jin-Qian Dong fei niu Hao Li Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

After brain injury, infiltration and abnormal activation of neutrophils damages brain tissue and worsens inflammation, but the mediators that connect activated neutrophils with neuroinflammation have not yet been fully clarified. To identify regulators of neutrophil-mediated neuroinflammation after traumatic brain injury, a mouse model of traumatic brain injury was established by controlled cortical impact. At 7 days post-injury(sub-acute phase), genome-wide transcriptomic data showed that interleukin 17 A-associated signaling pathways were markedly upregulated, suggesting that interleukin 17 A may be involved in neuroinflammation. Double immunofluorescence staining showed that interleukin 17 A was largely secreted by neutrophils rather than by glial cells and neurons. Furthermore, nuclear factor-kappaB and Stat3, both of which are important effectors in interleukin 17 A-mediated proinflammatory responses, were significantly activated. Collectively, our findings suggest that neutrophil-derived interleukin 17 A participates in neutrophil-mediated neuroinflammation during the subacute phase of traumatic brain injury. Therefore, interleukin 17 A may be a promising therapeutic target for traumatic brain injury.

关键词： immune infiltration innate immunity interleukin-17A neurodegenerative disease neuroinflammation neutrophils secondary brain injury transcription factor transcriptome traumatic brain injury