检索结果-南通市图书馆

Self-supported hard carbon anode from fungus-treated basswood towards sodium-ion batteries

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第3期16卷 3832-3838页

作者： Ping Wang Yu-Jie Guo Wan-Ping Chen Hui Duan Huan Ye Hu-Rong Yao Ya-Xia Yin fei-fei cao Institute of Advanced Materials Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationCollege of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China College of Science Huazhong Agricultural UniversityWuhan 430070China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China Fujian Provincial Engineering Technology Research Center of Solar Energy Conversion and Energy Storage Fuzhou 350117China

Hard carbon derived from biomass is regarded as a promising anode material for sodium-ion batteries(SIBs)because of its low operating potential,high capacity,resource availability,and low ***,scientific and technological challenges still exist to prepare hard carbon with a high initial Coulombic efficiency(ICE),an excellent rate capability,and good cycling *** this work,we report a self-supported hard carbon electrode from fungus-pretreated basswood with an improved graphitization degree and a low *** with the hard carbon derived from basswood,the hard carbon electrode from fungus-pretreated basswood has an improved rate capability of 242.3 mAh·g^(−1)at 200 mA·g^(−1)and cycling stability with 93.9%of its capacity retention after 200 cycles at 40 mA·g^(−1),as well as the increased ICE from 84.3%to 88.2%.Additionally,ex-situ X-ray diffraction indicates that Na+adsorption caused the sloping capacity,whereas Na+intercalation between interlayer spacing corresponded to the low potential plateau *** work provides a new perspective for the preparation of high-performance hard carbon and gains the in-depth understanding of Na storage mechanism.

关键词： sodium-ion battery anode hard carbon fungus-pretreated basswood

Inhibitory Effect of Progesterone on Inflammatory Factors After Experimental Traumatic Brain Injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2007年第5期20卷 432-438页

作者： DE-SHENG PAN WEI-GUO LIU XIAO-FENG YANG AND fei cao Department of Neurosurgery The First Affiliated Hospital Medical College of Zhejiang University Hangzhou 310003 Zhejiang China Department of Neurosurgery The Second Affiliated Hospital Medical College of Zhejiang University Hangzhou 310009 Zhejiang China

Objective Traumatic brain injury （TBI） is one of the leading causes of morbidity and mortality in young people. Inflammatory cytokines play an important part in the pathophysiology of TBI. Recent studies demonstrate that progesterone significantly reduces cerebral edema and enhances functional recovery from TBI and stroke in several animal models. This study was designed to investigate the inhibitory effect of progesterone on inflammatory response after traumatic brain injury. Methods Progesterone was injected intraperitoneally using rats as a model of traumatic brain injury, and Western blot technique was applied to detect the expression of three inflammation-related factors： nuclear factor kappa B p65 （NFκB p65）, glial fibrillary acidic protein （GFAP）, and tumor necrosis factor-α （TNF-α）. The water content of injured brain was also examined. A neurological severity score was recorded to evaluate the effect of progesterone on neurodeficit recovery. Results NFκB p65, GFAP, and TNF-α were increased in all injured animals. In rats treated with progesterone, the expression level of NFκB p65 and TNF-α were reduced significantly in comparison with vehicle-treated rats. However, progesterone did not alter the expression of GFAP in the injured rats. Progesterone also reduced the water content of injured brain and the lesion volume. In addition, progesterone-treated injured rats showed significant improvements in the Neurological Severity Score test, compared with vehicle-treated ones. Conclusions Progesterone inhibits the inflammatory response after experimental traumatic brain injury and mitigates the severity of brain damage.

关键词： Traumatic brain injury Progesterone Inflammation

Self-doped n-type small molecular electron transport materials for high-performance organic solar cells

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2017年第8期60卷 1136-1144页

作者： jinju liu nannan zheng zhicheng hu zhenfeng wang xiye yang fei huang yong cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 China

Two naphthalene diimide （NDI） and perylene diimide （PDI） based n-type water/alcohol soluble small molecules （NFN and PFP） are designed and utilized as electron transport layers （ETLs） for organic solar cells （OSCs）. NFN and PFP are synthesized by using Sonogashira coupling from alkynyl modified fluorene with mono-bromo substituted NDI and PDI. Density functional theory study results of NFN and PFP show that they possess excellent planarity due to the employment of triple bonds as connection units. Moreover, it was shown by electron paramagnetic resonance study that both NFN and PFP possess obvious self-doping behaviors, which may effectively enhance their charge transporting capability as ETLs in OSCs. Power conversion efficiencies of 8.59% and 9.80% can be achieved for OSCs with NFN and PFP as ETLs, respectively. The higher power conversion efficiency （PCE） of PFP based photovoltaic device is originated from the stronger doping property and higher mobility of PFR

关键词： self-doped n-type small molecules organic solar cells electron transport layers

胰腺癌免疫基因组学分型、特征及其临床意义研究

在线全文

学校读者我要写书评

暂无评论

吉林医药学院学报 2024年第3期45卷 194-199页

作者：曹非张国耀史磊马天江张磊漯河市中心医院肿瘤科河南漯河462005

目的通过基因组学建立胰腺癌免疫分型,并进一步探讨其免疫特征和临床意义。方法癌症基因组图谱数据库下载178例胰腺癌患者的基因表达谱及临床特征数据,通过单样本基因集富集分析(ssGSEA)评分对患者进行分组;采用ESTIMATE及CIBERSORT... 详细信息

目的通过基因组学建立胰腺癌免疫分型,并进一步探讨其免疫特征和临床意义。方法癌症基因组图谱数据库下载178例胰腺癌患者的基因表达谱及临床特征数据,通过单样本基因集富集分析(ssGSEA)评分对患者进行分组;采用ESTIMATE及CIBERSORT分别评估各胰腺癌免疫分型样本中免疫微环境及免疫细胞的组成;采用Kaplan-Meier绘制生存曲线并对组间差异进行log-rank检验;GSEA鉴定不同免疫分型GO富集通路。结果根据基质评分、免疫评分和肿瘤纯度将患者分为高、中、低免疫组,三组间预后具有统计学差异。高免疫组所包含的免疫细胞和基质细胞数量最多,肿瘤纯度最低;HLA、PD-L1(CD274)和CTLA4表达明显增高;浆细胞、活化的CD4^(+)记忆性T细胞、CD8^(+)T细胞以及γδT细胞含量最高,而M0巨噬细胞和M2巨噬细胞最少;总生存率明显低于低免疫组患者;抗免疫活性明显升高。结论胰腺癌免疫分型有助于判断患者的预后,高免疫组患者具有较高的抗免疫活性和较低的生存率。

关键词：胰腺癌基因组学免疫分型免疫活性生存率

两株黑曲霉生长代谢能力与浸出富钾页岩效果的比较分析

在线全文

学校读者我要写书评

暂无评论

土壤通报 2024年第4期55卷 1022-1030页

作者：包麒钰刘鹏付奇伟于志楠陈浩曹飞孙德四江西省生态化工工程技术研究中心江西九江332005 九江学院图书馆江西九江332005 矿物加工科学与技术国家重点实验室北京100070

【目的】研究两株不同来源Aspergillus niger菌种(MQ013、MQ039)对富钾页岩中K、Fe、Si、Al等主要元素的溶出动力学差异,并结合菌种的生长代谢特性,探明菌种选择性浸出矿物中主要元素的可能生物化学机制。【方法】通过在Czapek’s培养... 详细信息

【目的】研究两株不同来源Aspergillus niger菌种(MQ013、MQ039)对富钾页岩中K、Fe、Si、Al等主要元素的溶出动力学差异,并结合菌种的生长代谢特性,探明菌种选择性浸出矿物中主要元素的可能生物化学机制。【方法】通过在Czapek’s培养基中摇瓶培养考察菌株生长代谢特性与浸矿实验效果;培养液中的有机酸、蛋白质与多糖分别采用HPLC、苯酚-硫酸法与考马斯亮蓝G-250试剂盒进行测定;采用ICP-AES方法测定浸矿上清液中的K、Fe、Si、Al等金属离子的含量;矿物表面形貌特征及矿物组成分别采用SEM-EDS与XRD进行分析确定。【结果】MQ013具有较强代谢产苹果酸、酒石酸和琥珀酸的能力,而产胞外多糖和蛋白质能力弱于MQ039,其培养液中以上各代谢产物最大值分别为118.25、78.88、60.12、5920、5.29 mg L−1;MQ039不产酒石酸与琥珀酸,但代谢产柠檬酸、草酸、胞外多糖与蛋白质的能力较MQ013强,培养液中以上各代谢产物最大值分别可达91.20、85.21、9100、6.44 mg L−1;MQ013对富钾页岩中Si的浸出选择性要明显好于MQ039,其浸出液中SiO2的含量是MQ039的1.60倍,而MQ039对Al、K、Fe的浸出选择性要明显强于MQ013,其浸出液中Al2O3、K2O和Fe2O3的浓度分别是MQ013的1.82、1.17和1.22倍。【结论】同种菌株由于生长环境不同会导致其存在一定的生长代谢特性差异。两株黑曲霉MQ013与MQ039之间代谢产物的组分与分泌量差异是影响其选择性浸出富钾页岩中K、Fe、Al、Si等元素效率的关键因素,其中蛋白质与多糖对黑曲霉选择性浸出K和Fe有利,而苹果酸与柠檬酸可分别促进黑曲霉优先释放Si与Al。

关键词：富钾页岩曲霉真菌活性钾选择性浸出生物化学机制

Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第48期29卷 6222-6234页

作者： Yan-fei Wang Ruo-Yu He Chan Xu Xiao-Ling Li Yan-fei cao Department of Gastroenterology The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Clinical laboratory The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina Elder Medicine Department The Third Affiliated Hospital of Zhejiang Chinese Medical UniversityNo.219 Moganshan RoadXihu DistrictHangzhou 310005Zhejiang ProvinceChina

BACKGROUND Ulcerative colitis(UC)is a chronic gastrointestinal disorder characterized by inflammation and ulceration,representing a significant predisposition to colorectal *** advances in single-cell RNA sequencing(scRNA-seq)technology offer a promising avenue for dissecting the complex cellular interactions and molecular signatures driving UC *** To utilize scRNA-seq technology to dissect the complex cellular interactions and molecular signatures that underlie UC *** In this research,we integrated and analyzed the scRNA-seq data from UC ***,we conducted mRNA and protein level assays as well as pathology-related staining tests on clinical patient *** In this study,we identified the sustained upregulation of inflammatory response pathways during UC progression,characterized the features of damaged endothelial cells in ***,we uncovered the downregulation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase(LHPP)has a negative correlation with signal transducer and activator of transcription *** downregulation of LHPP in UC patient tissues and plasma suggests that LHPP may serve as a potential therapeutic target for *** paper highlights the importance of LHPP as a potential key target in UC and unveils its potential role in inflammation *** The findings suggest that LHPP may serve as a potential therapeutic target for UC,emphasizing its importance as a potential key target in UC and unveiling its role in inflammation regulation.

关键词： Ulcerative colitis Single-cell RNA sequencing Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

超声诊断仪无图像故障的快速诊断及应急维修方法

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国医疗设备 2024年第9期39卷 175-180页

作者：上官林峰陈晓飞陶亚飞曹飞联勤保障部队第九八〇医院采购管理办公室河北石家庄050082 联勤保障部队第九八〇医院医学工程科河北石家庄050082 联勤保障部队第九八〇医院放射诊断科河北石家庄050082

目的由于超声诊断仪故障类型复杂多变,因其实时性使得获取准确故障数据困难较大,且仅通过人工诊断具有主观性,导致诊断效率不高。为了提高对超声诊断仪故障诊断的精准性,设计超声诊断仪无图像故障的快速诊断及应急维修方法。方法利用... 详细信息

目的由于超声诊断仪故障类型复杂多变,因其实时性使得获取准确故障数据困难较大,且仅通过人工诊断具有主观性,导致诊断效率不高。为了提高对超声诊断仪故障诊断的精准性,设计超声诊断仪无图像故障的快速诊断及应急维修方法。方法利用实时监测环境监测超声诊断仪应用状态,计算超声诊断仪故障出现的时刻,获取故障数据,并对其进行初次特征提取;通过计算故障特征的权重值,进行二次特征提取,构建故障矩阵;利用故障诊断函数,诊断超声诊断仪故障;根据诊断结果,提出应急维修方案,完成超声诊断仪无图像故障的快速诊断及应急维修方法的设计。结果在实验测试中,超声诊断仪无图像故障的快速诊断及应急维修方法诊断时间仅为0.89 ms,诊断效率更高。结论通过设计快速诊断及应急维修方法,可以提高超声诊断仪的响应速度和诊断准确性,从而优化医疗服务质量,更好地为患者提供可靠的诊断结果。

关键词：超声诊断仪无图像故障故障矩阵快速诊断应急维修

Capping CsPbBr3 with ZnO to improve performance and stability of perovskite memristors

在线全文

学校读者我要写书评

暂无评论

Nano Research 2017年第5期10卷 1584-1594页

作者： Ye Wu Yi Wei Yong Huang fei cao Dejian Yu Xiaoming Li Haibo Zeng Institute ofOptoelectronics & Nanomaterials Herbert Gleiter Institute ofNanoscience Jiangsu Key Laboratory of Advanced Micro & Nano Materials and Technology College of Material Science and Engineering Nanjing University of Science and Technology Nanjing 210094 China State Key Laboratory of Mechanics and Control of Mechanical Structures College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

The rapid development of information technology has led to an urgent need for devices with fast information storage and processing, a high density, and low energy consumption. Memristors are considered to be next-generation memory devices with all of the aforementioned advantages. Recently, organometallic halide perovskites were reported to be promising active materials for memristors, although they have poor stability and mediocre performance. Herein, we report for the first time the fabrication of stable and high-performance memristors based on inorganic halide perovskite （CsPbBr3, CPB）. The devices have electric field-induced bipolar resistive switching （ReS） and memory behaviors with a large on/off ratio （〉105）, low working voltage （〈1 V） and energy consumption, long data retention （〉104 s）, and high environmental stability, which are achieved via ZnO capping within the devices. Such a design can be adapted to various devices. Additionally, the heterojunction between the CPB and ZnO endows the devices with a light-induced ReS effect of more than 103 with a rapid response speed （〈1 ms）, which enables us to tune the resistance state by changing the light and electric field simultaneously. Such multifunctional devices achieved by the combination of information storage and processing abilities have potential applications for future computing that transcends traditional architectures.

关键词： inorganic perovskite bipolar resistive switching nonvolatile ZnO capping low power consumption

LINC01410促进食管鳞状细胞癌细胞增殖和迁移的作用及其机制研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国癌症杂志 2024年第8期34卷 753-762页

作者：曹飞俞文豪唐晓男马子冬常廷民龚亚斌廖明娟康小红河南省平顶山市第一人民医院科教科河南平顶山467000 新乡医学院第一附属医院肿瘤科河南新乡453100 新乡医学院第一附属医院消化科河南新乡453100 上海中医药大学附属岳阳中西医结合医院肿瘤科上海200437 上海交通大学医学院附属第九人民医院中医科上海200125

背景与目的:LINC01410是长度为647 bp的长链非编码RNA(long non-coding RNA,lncRNA),其异常表达参与多种肿瘤的发生、发展,但其对食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的影响研究较少。本研究旨在探讨LINC01410促进ESCC细胞增殖和迁移的作用机制,以期为防治ESCC提供生物标志物及潜在治疗靶点。方法:应用基因表达谱交互分析2(Gene Expression Profiling Interactive Analysis 2,GEPIA2)在线分析LINC01410在肿瘤与癌症基因组图谱(The Cancer Genome Atlas,TCGA)ESCC数据中的表达水平及与患者预后总生存期的关系;采用基因探针富集分析(Gene Set Enrichment Analysis,GSEA)LINC01410可能调控的信号转导通路。收集2020年1月—2021年12月在新乡医学院第一附属医院、平顶山市第一人民医院胸外科行根治性手术的ESCC患者新鲜肿瘤组织标本62例,并选取癌旁组织作为对照。本项目经医院伦理委员会批准(新乡医学院第一附属医院,编号:2018036;平顶山市第一人民医院,编号:2019-018)。本研究采用实时荧光定量聚合酶链反应(real-time fluorescence quantitative polymerase chain reaction,RTFQ-PCR)检测LINC01410的表达水平并分析其与临床病理学参数的关系。应用LV-NC、LV-over/LINC01410转染EC109细胞并建立稳定过表达细胞株EC109/NC、EC109/OE,采用shRNA-NC、shRNA-LINC01410转染EC9706细胞并建立稳定敲降细胞株EC9706/NC、EC9706/KD;应用RTFQ-PCR检测LINC01410的相对表达量;采用噻唑蓝比色法[3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide,MTT]实验和克隆形成实验检测细胞增殖;采用transwell实验检测细胞迁移能力;采用双荧光素酶报告基因实验检测LINC01410对T细胞因子/淋巴增强因子1(T cell factor/lymphoid enhancer factor 1,TCF/LEF1)启动子活性的影响;采用蛋白质印迹法(Western blot)检测Wnt/β-连环蛋白(β-catenin)信号转导通路、上皮-间质转化(epithelial-mesenchymal transition,EMT)信号转导通路相关蛋白表达水平。结果:GEPIA2分析显示,在ESCC组织中LINC01410表达水平显著高于食管正常组织,两组相比差异有统计学意义(P<0.05)。生存分析显示,高表达LINC01410的ESCC患者生存率显著低于低表达LINC01410的患者(P=0.042)。RTFQ-PCR检测结果显示,在ESCC组织中LINC01410表达水平显著高于配对癌旁组织;LINC01410高表达与肿瘤浸润程度、淋巴结转移及TNM分期显著相关(P<0.01);与食管正常上皮细胞HEEC相比,LINC01410在EC109、EC9706细胞中显著高表达(P<0.05);LINC01410在EC109/OE细胞中显著高表达(P<0.01),而在EC9706/KD细胞中显著下调(P<0.01)。MTT结果显示,EC109/OE细胞48 h时细胞活性显著高于EC109/NC细胞(P<0.01);EC9706/KD细胞48 h时细胞活性显著低于EC9706/NC(P<0.01)。细胞克隆形成实验结果显示,与EC109/NC细胞相比,EC109/OE细胞克隆数显著增多;与EC9706/NC细胞相比,EC9706/KD细胞克隆数明显减少(P<0.01)。Transwell迁移实验结果显示,EC109/OE细胞株迁移的细胞数显著多于EC109/NC细胞(P<0.01),而EC9706/KD细胞迁移的细胞数显著少于EC9706/NC细胞(P<0.01)。GSEA分析显示,Wnt/β-catenin、EMT等信号转导通路显著富集在高表达LINC01410的ESCC组织中。双荧光素酶报告基因实验结果示,EC109/OE细胞中TCF/LEF1启动子活性显著高于EC109/NC细胞,EC9706/KD细胞中TCF/LEF1启动子活性显著低于EC9706/NC细胞(P<0.01)。Western blot检测结果显示,与EC109/NC细胞相比,EC109/OE细胞中E-cadherin蛋白表达下调,而N-ca

关键词：食管鳞癌长链非编码RNA-LINC01410 增殖迁移 Wnt/β-catenin信号转导通路