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Paleogene integrative stratigraphy and timescale of China

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Science China Earth Sciences 2019年第1期62卷 287-309页

作者： Yuanqing WANG Qian LI Bin BAI Xun JIN fangyuan mao Jin MENG Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences CAS Center for Excellence in Life and Paleoenvironment College of Earth Sciences University of Chinese Academy of Sciences American Museum of Natural History

The Paleogene is the first period after the Mesozoic Mass Extinction. Mammals become the dominant group in the terrestrial ecosystem with a rapid radiation, and Asia has been considered to be the origin place of several mammalian *** Paleogene System consists mostly of terrestrial deposits in Asia, especially in East Asia. A well-established regional chronostratigraphic framework is the foundation for understanding both the Paleogene geologic history and evolutionary history of Asia and their relationships. The Paleogene is subdivided into the Paleocene, Eocene and Oligocene in the International Chronostratigraphic Chart. Based on the land mammal ages, the Chinese terrestrial Paleogene can be subdivided into 11 stages:the Shanghuan, Nongshanian and Bayanulanian stages of the Paleocene, the Lingchan, Arshantan, Irdinmanhan, Sharamurunian,Ulangochuian and Baiyinian stages of the Eocene, and the Ulantatalian and Tabenbulukian stages of the Oligocene. These stages have distinctive paleontological characters, with special significance of fossil mammals, which provide a reliable practical *** bases of the Shanghuan, Lingchan, and Ulantatalian stages are coincident respectively with those of the Paleocene, Eocene and Oligocene. The ages for their bases are determined as 66.0, 56.0 and 33.9 Ma, respectively, following that for the corresponding series in the International Chronostratigraphic Chart. For other stages, estimated ages are provided based on available paleomagnetic results.

关键词： Paleogene Correlation Biostratigraphy Magnetostratigraphy Chronostratigraphy

Exploring ancestral phenotypes and evolutionary development of the mammalian middle ear based on Early Cretaceous Jehol mammals

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National Science Review 2021年第5期8卷 57-66页

作者： fangyuan mao Cunyu Liu Morgan Hill Chase Andrew K.Smith Jin Meng Key Laboratory of Evolutionary Systematics of Vertebrates Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of Sciences CAS Center for Excellence in Life and Paleoenvironment Division of Paleontology American Museum of Natural History Beipiao Pterosaur Museum of China 5. Microscopy and Imaging Facility American Museum of Natural History Earth and Environmental Sciences Graduate CenterCity University of New York

We report a new Cretaceous multituberculate mammal with 3 D auditory bones preserved. Along with other fossil and extant mammals, the unequivocal auditory bones display features potentially representing ancestral phenotypes of the mammalian middle ear. These phenotypes show that the ectotympanic and the malleus-incus complex changed notably during their retreating from the dentary at various evolutionary stages and suggest convergent evolution of some features to extant mammals. In contrast, the incudomalleolar joint was conservative in having a braced hinge configuration, which narrows the morphological gap between the quadroarticular jaw joint of non-mammalian cynodonts and the incudomalleolar articulations of extant mammals. The saddle-shaped and abutting malleus-incus complexes in therians and monotremes, respectively, could have evolved from the braced hinge joint *** evolutionary changes recorded in the Mesozoic mammals are largely consistent with the middle ear morphogenesis during the ontogeny of extant mammals, supporting the relation between evolution and development.

关键词： Cretaceous Jehol Biota malleus-incus ectotympanic mammal evolution

Ten-Minute Synthesis of a New Redox-Active Aqueous Binder for Flame-Retardant Li-S Batteries

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Energy & Environmental Materials 2024年第2期7卷 48-57页

作者： Tianpeng Zhang Borui Li Zihui Song Wanyuan Jiang Siyang Liu Runyue mao Xigao Jian fangyuan Hu School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsFrontiers Science Center for Smart Materials Oriented Chemical Engineering Technology Innovation Center of High Performance Resin Materials(Liaoning Province)Key Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of Chemical Engineering Technology Innovation Center of High Performance Resin Materials(Liaoning Province)Key Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024China

As a critical role in battery systems,polymer binders have been shown to efficiently suppress the lithium polysulfide shuttling and accommodate volume changes in recent ***,preparation processes and safety,as the key criterions for Li-S batteries'practical applications,still attract less ***,an aqueous multifunction binder(named PEI-TIC)is prepared via an easy and fast epoxy-amine ring-opening reaction(10 min),which can not only give the sulfur cathode a stable mechanical property,a strong chemical adsorption and catalytic conversion ability,but also a fire safety *** Li-S batteries based on the PEI-TIC binder display a high discharge capacity(1297.8 mAh g^(-1)),superior rate performance(823.0 mAh g^(-1)at 2 C),and an ultralow capacity decay rate of 0.035%over more than 800 *** under 7.1 mg cm^(-2)S-loaded,the PEI-TIC electrode can also achieve a high areal capacity of 7.2 mA h g^(-1)and excellent cycling stability,confirming its application ***,it is also noted that TG-FTIR test is performed for the first time to explore the flame-retardant mechanism of polymer *** work provides an economically and environmentally friendly binder for the practical application and inspires the exploration of the flame-retardant mechanism of all electrode components.

关键词： 3D cross-linked network environmentally friendly flame retardant Li-S batteries multifunction binder

Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection

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Cellular & Molecular Immunology 2023年第8期20卷 924-940页

作者： Yongsheng Teng Rui Xie Jingyu Xu Pan Wang Wanyan Chen Zhiguo Shan Zongbao Yan fangyuan mao Ping Cheng Liusheng Peng Jinyu Zhang Wenqing Tian Shiming Yang Yongliang Zhao Weisan Chen Quanming Zou Yuan Zhuang Department of Microbiology and Biochemical Pharmacy College of Pharmacy and Laboratory MedicineThird Military Medical UniversityChongqingChina The 940th Hospital of Joint Logistics Support Force of PLA LanzhouChina The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University ZunyiGuizhouChina Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery Southwest HospitalThird Military Medical UniversityChongqingChina Department of Gastroenterology Chongqing University Cancer HospitalChongqingChina Department of Gastroenterology XinQiao HospitalThird Military Medical UniversityChongqingChina La Trobe Institute of Molecular Science La Trobe UniversityBundooraVICAustralia Department of Gastroenterology Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanChina National Engineering Research Center of Immunological Products Third Military Medical UniversityChongqingChina

The interaction between the gastric epithelium and immune cells plays key roles in H. pylori-associated pathology. Here, we demonstrate a procolonization and proinflammatory role of tubulointerstitial nephritis antigen-like 1 (TINAGL1), a newly discovered matricellular protein, in H. pylori infection. Increased TINAGL1 production by gastric epithelial cells (GECs) in the infected gastric mucosa was synergistically induced by H. pylori and IL-1β via the ERK-SP1 pathway in a cagA-dependent manner. Elevated human gastric TINAGL1 correlated with H. pylori colonization and the severity of gastritis, and mouse TINAGL1 derived from non-bone marrow-derived cells promoted bacterial colonization and inflammation. Importantly, H. pylori colonization and inflammation were attenuated in Tinagl1−/− and Tinagl1ΔGEC mice and were increased in mice injected with mouse TINAGL1. Mechanistically, TINAGL1 suppressed CCL21 expression and promoted CCL2 production in GECs by directly binding to integrin α5β1 to inhibit ERK and activate the NF-κB pathway, respectively, which not only led to decreased gastric influx of moDCs via CCL21-CCR7-dependent migration and, as a direct consequence, reduced the bacterial clearance capacity of the H. pylori-specific Th1 response, thereby promoting H. pylori colonization, but also resulted in increased gastric influx of Ly6Chigh monocytes via CCL2-CCR2-dependent migration. In turn, TINAGL1 induced the production of the proinflammatory protein S100A11 by Ly6Chigh monocytes, promoting H. pylori-associated gastritis. In summary, we identified a model in which TINAGL1 collectively ensures H. pylori persistence and promotes gastritis.

关键词： Helicobacter pylori TINAGL1 Colonization Gastritis

An all-biomaterials-based aqueous binder based on adsorption redox-mediated synergism for advanced lithium–sulfur batteries

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eScience 2024年第3期4卷 116-126页

作者： Wanyuan Jiang Tianpeng Zhang Runyue mao Zihui Song Siyang Liu Ce Song Xigao Jian fangyuan Hu State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of Chemical EngineeringTechnology Innovation Center of High Performance Resin Materials(Liaoning Province)Key Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024China School of Materials Science and Engineering State Key Laboratory of Fine ChemicalsFrontiers Science Center for Smart Materials Oriented Chemical EngineeringTechnology Innovation Center of High Performance Resin Materials(Liaoning Province)Key Laboratory of Energy Materials and Devices(Liaoning Province)Dalian University of TechnologyDalian 116024China

The complex multistep electrochemical reactions of lithium polysulfides and the solid–liquid–solid phase transformation involved in the S8 to Li2S reactions lead to slow redox kinetics in lithium–sulfur batteries(Li–S batteries).However,some targeted researches have proposed strategies requiring the introduction of significant additional inactive components,which can seriously affect the energy *** polymer binders,proven to be effective in suppressing shuttle effects and constraining electrode volume expansion,also have promising potential in enhancing Li–S batteries redox ***,a novel aqueous polymer binder is prepared by convenient amidation reaction of fully biomaterials,utilizing its inherent rich amide groups for chemisorption and redox mediating ability of thiol groups to achieve adsorption redox-mediated synergism for efficient conversion of ***–S batteries based on N-Acetyl-L-Cysteine-Chitosan(NACCTS)binder exhibit high initial discharge specific capacity(1260.1mAhg−1 at 0.2C)and excellent cycling performance over 400 cycles(capacity decay rate of 0.018%per cycle).In addition,the batteries exhibit great areal capacity and stable capacity retention of 83.6%over 80 cycles even under high sulfur loading of 8.4mgcm−*** work offers a novel perspective on the redox-mediated functional design and provides an environmentally friendly biomaterials-based aqueous binder for practical Li–S battery.

关键词： Li–S batteries Aqueous binder Biomaterials Adsorption redox-mediated synergism Hydrogen bonding

幽门螺杆菌感染对胃黏膜上皮细胞REDD1表达的影响及调控机制

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陆军军医大学学报 2022年第5期44卷 413-420页

作者：闫宗宝毛方圆单治国赵永亮庄园陆军军医大学(第三军医大学)第一附属医院普通外科重庆2400038 陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室重庆400038

目的探讨DNA损伤应答蛋白1(regulated in development and DNA damage responses-1,REDD1)在幽门螺杆菌(Helicobacter pylori,***)感染中的表达及调控机制。方法建立***感染C57小鼠及胃上皮细胞模型,运用实时荧光定量PCR、免疫组织化学染色和Western blot检测REDD1 mRNA和蛋白的表达;并在细胞模型中采用信号通路抑制剂的方法探讨***感染诱导REDD1上调的机制。结果相对于未感染组,***感染小鼠胃黏膜中的REDD1水平显著增高;而相对于野生型(Wild Type,WT)全毒株,敲除cagA基因后,***感染诱导REDD1上调的能力则显著下降(P<0.05);***感染可诱导胃上皮细胞AGS REDD1表达上调,并具有时间、感染菌量以及cagA依赖性(P<0.05);P38/MAPK信号通路阻断可显著抑制***感染诱导的REDD1上调表达(P<0.05)。结论***依赖磷酸化的cagA蛋白激活MAPKp38通路诱导REDD1表达增高。

关键词：幽门螺杆菌 DNA损伤应答蛋白1 MAPK P38

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西安美术学院王卫民师生作品选刊

书画世界 2021年第12期238卷 63-67页

作者：毛方远张壮壮宋燕董磊张鑫西安美术学院

肾上腺髓质素在幽门螺杆菌感染中的表达调控及其功能的初步研究

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第三军医大学学报 2018年第3期40卷 183-189页

作者：孔辉庄园毛方圆彭六生滕永生刘毓刚吕一品郭刚陆军军医大学(第三军医大学)药学与检验医学系微生物与生化药学教研室重庆400038

目的探讨肾上腺髓质素(adrenomedullin,ADM)在幽门螺杆菌感染中的表达调控及其对CD3+T细胞增殖的影响。方法建立幽门螺杆菌(Helicobacter pylori,***)感染C57小鼠及胃上皮细胞模型,运用定量PCR、免疫组织化学染色和Western blot检测ADM... 详细信息

目的探讨肾上腺髓质素(adrenomedullin,ADM)在幽门螺杆菌感染中的表达调控及其对CD3+T细胞增殖的影响。方法建立幽门螺杆菌(Helicobacter pylori,***)感染C57小鼠及胃上皮细胞模型,运用定量PCR、免疫组织化学染色和Western blot检测ADM的表达;并在细胞模型中探讨***感染诱导ADM上调的机制;利用ADM刺激CD3+T细胞,检测其对T细胞增殖的影响。结果 ***感染可诱导胃上皮细胞AGS和HGC-27上调ADM的表达,并具有时间和感染菌量依赖性(P<0.05);PI3K/AKT信号通路阻断可显著抑制***感染诱导的ADM上调表达(P<0.05);相对于未感染组,***感染小鼠胃组织中的ADM水平也显著增高;而相对于野生型全毒株,敲除cag A基因后,***感染诱导ADM上调的能力则显著下降(P<0.05);ADM能够以剂量依赖的方式诱导CD3+T细胞的增殖并促进IFN-γ的表达(P<0.05)。结论幽门螺杆菌感染可经PI3K/AKT信号诱导肾上腺髓质素的表达上调,后者则可能通过影响CD3+T细胞的增殖和分化而发挥免疫调节作用。

关键词：幽门螺杆菌肾上腺髓质素 PI3K/AKT信号通路 CD3+T细胞

沉积黄铁矿微量元素和硫同位素组成对黄金洞金矿床的成因约束

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矿床地质 2024年第4期43卷 935-950页

作者：孟亚群李伟毛景文吴圣刚陈孝刚阴芳圆中国地质大学(北京)地球科学与资源学院北京100083 自然资源部成矿作用与资源评价重点实验室中国地质科学院矿产资源研究所北京100037 湖南黄金洞矿业有限责任公司湖南岳阳410400

黄金洞大型金矿床位于江南造山带湘东北矿集区,矿体主要赋存于沉积黄铁矿发育的新元古代冷家溪群板岩中,含金石英脉为主要的矿化类型。为进一步约束成矿系统中金和硫的来源,揭示赋矿围岩对成矿贡献,深化矿床成因认识,文章以赋矿围岩冷... 详细信息

黄金洞大型金矿床位于江南造山带湘东北矿集区,矿体主要赋存于沉积黄铁矿发育的新元古代冷家溪群板岩中,含金石英脉为主要的矿化类型。为进一步约束成矿系统中金和硫的来源,揭示赋矿围岩对成矿贡献,深化矿床成因认识,文章以赋矿围岩冷家溪群板岩为研究对象,对其沉积黄铁矿进行了系统的岩相学、电子探针显微结构、激光剥蚀等离子质谱(LA-ICP-MS)原位微量元素和硫同位素分析。研究结果显示,冷家溪群板岩中的沉积黄铁矿主要呈团块状集合体,单个颗粒多为几百~几千微米。微量元素分析结果表明,沉积黄铁矿w(As)变化范围介于796×10^(-6)~10667×10^(-6),不可见w(Au)多低于1.0×10^(-6)。沉积黄铁矿的原位δ^(34)S值主要介于-10.7‰~-4.7‰,与矿石中的热液黄铁矿(δ^(34)S=-14.2‰~-0.5‰)具有一定相似性。以上分析结果暗示,沉积黄铁矿提供成矿系统中的金的可能性不大,推测黄金洞金矿床Au主要来自深部过程。成矿流体在与围岩相互作用过程中,沉积成因硫加入成矿系统,为解释热液成因黄铁矿硫同位素组成特征提供关键证据。

关键词：沉积黄铁矿原位和微量元素S同位素黄金洞湘东北矿集区江南造山带