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临床儿科杂志 2016年第11期34卷 866-870页

作者：夏源园龚方戚浙江大学医学院附属儿童医院浙江杭州310000

暴发性心肌炎是一种以急性血流动力学障碍为主要表现的心肌炎,临床表现多样且病死率极高。暴发性心肌炎早期诊断需依靠血清学指标、心电图、超声心动图等进行综合分析,心脏磁共振成像检查在心肌炎诊断中也具有很好的应用价值。传统的暴... 详细信息

暴发性心肌炎是一种以急性血流动力学障碍为主要表现的心肌炎,临床表现多样且病死率极高。暴发性心肌炎早期诊断需依靠血清学指标、心电图、超声心动图等进行综合分析,心脏磁共振成像检查在心肌炎诊断中也具有很好的应用价值。传统的暴发性心肌炎治疗,包括对症支持、抗病毒及免疫疗法等,但对危重患儿往往难以奏效。体外膜肺氧合技术(ECMO)的开展,大大提高了儿童暴发性心肌炎的抢救成功率,成为救治儿童暴发性心肌炎的可靠手段。文章综述目前儿童暴发性心肌炎的诊断及最新治疗进展。

关键词：暴发性心肌炎诊断治疗儿童

The elevated serum levels of Calcineurin and NFAT1 in children with Kawasaki disease

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The elevated serum levels of Calcineurin and NFAT1 in childr...

马蹄肺合并Holt-Oram综合征一例(英文)

2018年浙江省医学会儿科学分会学术年会

作者： Yameng Sun Yanqi Qi Ying Wang Songling Fu Wei Wang Chunhong Xie Yiying Zhang fangqi gong Children’s Hospital of Zhejiang University School of Medicine

Background:To evaluate serum calcineurin (CaN) and nuclear factor of activated T-cells 1 (NFAT1) levels in patients with Kawasaki disease (KD).Methods:Serum levels of CaN and NFAT1 were measured by enzyme-linked immunosorbent assay method in66 healthy children and 74 KD patients at acute,afebrile and subacute ***:The serum levels of CaN and NFAT1 increased significantly in the acute stage,and decreased progressively in the afebrile and subacute stage,along with the reduction of C-reactive protein,white blood cells *** in the acute stage,

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马蹄肺合并Holt-Oram综合征一例(英文)

Sparse Reconstructive Evidential Clustering for Multi-View Data

2014年浙江省医学会儿科学分会学术年会暨儿内科疾病诊治新进展国家级继续教育学习班

作者：徐琴 Wei Wang fangqi gong Children’s Hospital Zhejiang University School of Medicine

Horseshoe lung,a rare congenital disease,is mostly reported with right lung hypoplasia and associated with the scimitar *** presented a case of horseshoe lung with left lung hypoplasia and associated with Holt-Oram **... 详细信息

关键词： Horseshoe lung lung hypoplasia Holt-Oram syndrome

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 459-473页

作者： Chaoyu gong Yang You School of Computing National University of SingaporeSingapore

Although many multi-view clustering(MVC) algorithms with acceptable performances have been presented, to the best of our knowledge, nearly all of them need to be fed with the correct number of clusters. In addition, these existing algorithms create only the hard and fuzzy partitions for multi-view objects,which are often located in highly-overlapping areas of multi-view feature space. The adoption of hard and fuzzy partition ignores the ambiguity and uncertainty in the assignment of objects, likely leading to performance degradation. To address these issues, we propose a novel sparse reconstructive multi-view evidential clustering algorithm(SRMVEC). Based on a sparse reconstructive procedure, SRMVEC learns a shared affinity matrix across views, and maps multi-view objects to a 2-dimensional humanreadable chart by calculating 2 newly defined mathematical metrics for each object. From this chart, users can detect the number of clusters and select several objects existing in the dataset as cluster centers. Then, SRMVEC derives a credal partition under the framework of evidence theory, improving the fault tolerance of clustering. Ablation studies show the benefits of adopting the sparse reconstructive procedure and evidence theory. Besides,SRMVEC delivers effectiveness on benchmark datasets by outperforming some state-of-the-art methods.

关键词： Evidence theory multi-view clustering(MVC) optimization sparse reconstruction

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阿那白滞素在川崎病中的应用

中华儿科杂志 2021年第11期59卷 997-1000页

作者：童彤王毓佳龚方戚浙江大学医学院附属儿童医院心血管内科国家儿童健康与疾病临床医学研究中心杭州310052

川崎病是一种急性、自限性发热性疾病,病因不明,在急性发热期主要影响中型动脉、多个脏器和组织。最新研究发现白细胞介素(IL)-1信号通路是川崎病的致病关键环节之一。IL-1受体拮抗剂(IL-1Ra)阿那白滞素通过阻断IL-1信号通路,对于川崎... 详细信息

川崎病是一种急性、自限性发热性疾病,病因不明,在急性发热期主要影响中型动脉、多个脏器和组织。最新研究发现白细胞介素(IL)-1信号通路是川崎病的致病关键环节之一。IL-1受体拮抗剂(IL-1Ra)阿那白滞素通过阻断IL-1信号通路,对于川崎病的治疗有一定的作用,但其应用的临床证据较少,本文就阿那白滞素治疗川崎病的作用机制、疗效及安全性进行综述,旨在为该药治疗川崎病提供依据。

关键词：川崎病临床证据疗效及安全性发热性疾病自限性病因不明阿那白滞素

血管平滑肌细胞表型转化在儿童心血管疾病中的作用

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临床儿科杂志 2023年第5期41卷 394-400页

作者：许枭赵琳(综述) 龚方戚(审校) 浙江大学医学院附属儿童医院心血管内科、国家儿童健康与疾病医学研究中心浙江杭州310052

血管平滑肌细胞(VSMCs)是血管壁重要的细胞组分,对于维持血管正常生理功能发挥重要作用。VSMCs具有高度的可塑性,异常的VSMCs表型转化促进多种心血管疾病的发生发展。近年来儿童心血管健康问题日益突出,给社会经济发展带来了沉重的负担... 详细信息

血管平滑肌细胞(VSMCs)是血管壁重要的细胞组分,对于维持血管正常生理功能发挥重要作用。VSMCs具有高度的可塑性,异常的VSMCs表型转化促进多种心血管疾病的发生发展。近年来儿童心血管健康问题日益突出,给社会经济发展带来了沉重的负担。文章对VSMCs表型转化在川崎病、动脉瘤、原发性高血压、肺动脉高压、主动脉缩窄和多发性大动脉炎等儿童心血管疾病中的研究进行总结,为儿童心血管疾病的防治提供潜在靶点。

关键词：血管平滑肌细胞表型转化心血管疾病儿童

Tropical cyclone genesis over the western north Pacific in La Ni?a decay summers: Comparison between 2018 and 2021

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Science China Earth Sciences 2024年第10期67卷 3098-3109页

作者： Yunyun LIU Zhensong gong China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China

As the primary interannual signal of variability in the tropical ocean-atmosphere interaction, the El Ni?o-Southern Oscillation has a considerable impact on tropical cyclone(TC) activity over the western North Pacific(WNP). Both 2018 and2021 were La Ni?a decay years, but TC activity over the WNP during the two summers(June–August) showed notable differences. In 2018, summer TC activity was unusually high with a total of 18 TCs, and the region of TC genesis was mainly in the central and eastern WNP. In contrast, only 9 TCs were generated in summer 2021, and the region of TC genesis was primarily in the western WNP. By comparing the characteristics of the large-scale environmental conditions over the regions of TC genesis, the thermal factors of the tropical oceans, and the activity of the Madden-Julian Oscillation(MJO), this study revealed the possible causes for the marked differences in TC genesis over the WNP during the two summers, which both had a similar background of La Ni?a decay. The Indian Ocean Basin Mode(IOBM) transitioned of a cold anomaly in the winter of 2017/2018and persisted until summer 2018. At the same time, the Pacific Meridional Mode(PMM) maintained a positive phase, leading to eastward and northward displacement of the Western Pacific Subtropical High in summer, and eastward extension of the tropical monsoon trough, which presented conditions conducive to TC genesis over the Northwest Pacific. Moreover, the days when the MJO stagnated in phases 5 and 6 in the summer of 2018 increased by approximately 150% relative to climatological state,providing dynamic conditions favorable for TC formation. In 2021, the IOBM quickly turned to a warm anomaly in March and persisted until summer, whereas the PMM became a negative phase in January and remained so until summer. At the same time,the MJO stagnated in phases 2 and 3 for up to 47 days, with the center of convection located over the western Maritime Continent, producing conditions unconducive to TC ge

关键词： Tropical cyclone La Nina events Indian Ocean Basin Mode Pacific Meridional Mode Madden-Julian Oscillation Western Pacific Subtropical High Monsoon trough

Exploring a Promising Region and Enhancing Decision Space Diversity for Multimodal Multi-Objective Optimization

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Tsinghua Science and Technology 2024年第2期29卷 325-342页

作者： Fei Ming Wenyin gong School of Computer Science China University of GeosciencesWuhan 430074China

During the past decade,research efforts have been gradually directed to the widely existing yet less noticed multimodal multi-objective optimization problems(MMOPs)in the multi-objective optimization ***,researchers have begun to investigate enhancing the decision space diversity and preserving valuable dominated solutions to overcome the shortage caused by a preference for objective space ***,many existing methods still have limitations,such as giving unduly high priorities to convergence and insufficient ability to enhance decision space *** overcome these shortcomings,this article aims to explore a promising region(PR)and enhance the decision space diversity for handling *** traditional methods,we propose the use of non-dominated solutions to determine a limited region in the PR in the decision space,where the Pareto sets(PSs)are included,and explore this region to assist in solving ***,we develop a novel neighbor distance measure that is more suitable for the complex geometry of PSs in the decision space than the crowding *** on the above methods,we propose a novel dual-population-based coevolutionary *** studies on three benchmark test suites demonstrates that our proposed methods can achieve promising performance and versatility on different *** effectiveness of the proposed neighbor distance has also been justified through comparisons with crowding distance methods.

关键词： multimodal multi-objective optimization evolutionary algorithms promising region neighbor distance decision space coevolution

Follow-up of coronary artery lesions caused by Kawasaki disease and the value of coronary angiography

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Chinese Medical Journal 2002年第5期115卷 681-684,148页

作者：龚方戚白石裕比湖桃井真里子浙江大学医学院附属儿童医院浙江310003 Department of Pediatrics Jichi Medical schoolMinamikawachi

OBJECTIVE: To investigate the course of coronary artery lesions caused by Kawasaki disease, and the value of coronary angiography (CAG) and two-dimensional echocardiography (2-D Echo) in the evaluation and follow-up of coronary artery lesions. METHODS: Eighty seven patients with coronary artery lesions caused by Kawasaki disease from 1979 to 1997 were retrospectively analyzed. One hundred and sixty-seven CAGs were performed in 87 patients during follow-up. CAG was repeated every 1-3 years in each patient until complete regression was confirmed. 2-D Echo was performed before CAG each time. The longest period of follow-up was 16 years and 6 months. Patients were treated with aspirin or aspirin and warfarin. RESULTS: During follow-up, the coronary artery lesions regressed in 48/87 (55%) patients, however, they developed into severe coronary artery lesions in 6/87 (7%) patients in whom coronary artery bypass surgery was performed. The coronary artery aneurysm regressed in some patients, while stenotic lesions remained or developed. The ratio of coronary artery stenotic lesions to aneurysms increased progressively. This study showed that Echo diagnosis of coronary artery lesions has 'false positives' and 'false negatives'. Only 76% of coronary aneurysms and 18% of stenotic lesions could be found by 2-D Echo. No stenotic lesion could be found in distal segments of the coronary artery. CONCLUSIONS: Long term follow up revealed spontaneous regression occurred in 55% of patients and development into severe coronary artery stenosis in 7%. It is necessary to perform long-term follow-up in patients with coronary artery lesions caused by Kawasaki disease. 2-D Echo can not completely replace CAG during follow-up of coronary artery lesions caused by Kawasaki disease.

关键词： Adolescent Child Child, Preschool Coronary Aneurysm Coronary Angiography Coronary Vessels Disease Progression Female Follow-Up Studies Humans Infant Male Mucocutaneous Lymph Node Syndrome Retrospective Studies Time Factors