检索结果-南通市图书馆

Adsorption,in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides

引用

Food Science and Human Wellness 2024年第3期13卷 1685-1697页

作者： fangming zhang Hui Zheng Tao Zheng Pan Xu Yao Xu Yuxin Cao Fan Jia Yiqiong Zeng Yubing Fan Kai He Xinwen Dai Fengfei Hou Yong Yang College of Pharmacy Hunan University of Chinese MedicineChangsha 410208China School of Pharmaceutical Science Hunan University of MedicineHuaihua 418000China Hunan Fuling Engineering Technology Research Center Huaihua 418100China

Poria cocos(PC)is a famous traditional Chinese medicine(TCM)and a widely used healthcare ingredient,which has antiobesity,enhancing immunity and improving sleep ***,only water-soluble poria polysaccharide(WSP)is extracted and applied for clinical application,while insoluble polysaccharide(alkali-soluble poria polysaccharide,ASP)is discarded as herb ***,the whole PC has also been historically utilized as functional herbal *** the beneficial role of dietary fiber and the traditional use of PC,ASP may also contribute substantially to the therapy function of *** to WSP,little attention has been paid to ASP and ASP modified product carboxymethyl poria polysaccharide(CMP)which has been used as an antitumor adjuvant *** this study,the oil,cholesterol,metal ions and polyphenols adsorption ability,in vitro simulated digestive and the gut microbiota fermentation characteristics of WSP,ASP and CMP were studied to evaluate the functional values of three *** polysaccharides(PCPs).The results showed that all three PCPs had good adsorption capacity on cholesterol,polyphenols and metal ions(Cd^(2+)/Zn^(2+)/Mg^(2+)),among which ASP showed the highest capacity than WSP and *** adsorption capacity of all three PCPs on heavy metal ions(Cd^(2+)/Zn^(2+))was stronger than that of non-heavy metal ions(Mg^(2+));The in vitro digestibility of all three PCPs was very low,but WSP was slightly higher than ASP and CMP;Moreover,the indigestible residue of all three PCPs could improve the richness and diversity of gut microbiota,among which ASP had the greatest *** general,ASP and CMP could significantly promote the proliferation of some probiotics and inhibit the growth of some harmful *** gut microbiota diversity of CMP was reduced,but the richness of probiotics,especially Parabacteroides distasonis was significantly enhanced compared with the ASP group,and the growth of harmful bacteria Klebsiella pneumoniae was inh

关键词： Poria cocos polysaccharides Alkali-soluble poria polysaccharide Carboxymethyl poria polysaccharide Adsorption characteristics In vitro simulated digestion In vitro simulated gut microbiota fermentation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中职语文文言文教学与传统文化结合的研究

引用

成才之路 2024年第6期 81-84页

作者：张芳明湖南省资兴市职业技术学校湖南资兴423400

传统文化是中华民族的瑰宝,蕴含着无穷的智慧及价值。中职教育应将文言文教学作为传承和弘扬传统文化的载体,让学生在文言文学习中深入了解和体会传统文化,增强文化自信、民族自信。在文言文教学中,教师要创设良好的教学环境,创新教学... 详细信息

传统文化是中华民族的瑰宝,蕴含着无穷的智慧及价值。中职教育应将文言文教学作为传承和弘扬传统文化的载体,让学生在文言文学习中深入了解和体会传统文化,增强文化自信、民族自信。在文言文教学中,教师要创设良好的教学环境,创新教学方法、策略及形式,建立科学的评价标准,培养学生的人文素养和语言运用能力,让学生更好地传承和弘扬传统文化。

关键词：中职语文文言文教学传统文化结合教学环境教学方法

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

羧甲基茯苓多糖的生物活性与食品应用

引用

食品与机械 2024年第6期40卷 213-220页

作者：徐攀张芳铭郑慧戴鑫汶杨勇湖南中医药大学药学院湖南长沙410208 湖南省茯苓工程技术研究中心湖南怀化418100

羧甲基茯苓多糖(CMP)是茯苓水不溶性多糖的羧甲基化修饰产物,具有调节免疫、抑菌抗炎、抗肿瘤、抗氧化、肝损伤保护和调节肠道菌群等多种生物活性,在功能性食品、活性分子载体、药物等领域有着广泛的应用前景。文章聚焦近年来国内外对CM... 详细信息

羧甲基茯苓多糖(CMP)是茯苓水不溶性多糖的羧甲基化修饰产物,具有调节免疫、抑菌抗炎、抗肿瘤、抗氧化、肝损伤保护和调节肠道菌群等多种生物活性,在功能性食品、活性分子载体、药物等领域有着广泛的应用前景。文章聚焦近年来国内外对CMP的研究,综述了CMP的生物活性、制备鉴定和应用开发,并对CMP的未来发展方向进行了展望。

关键词：羧甲基茯苓多糖(CMP) 生物活性制备方法健康应用

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

农光互补电站的生态产品价值核算——以正泰江山200 MW农光互补电站为例

引用

农业资源与环境学报 2024年第1期41卷 197-211页

作者：魏宇帆金建峰丁倩周金莺张芳明杨武浙江大学环境与资源学院杭州310058 国网浙江省电力有限公司湖州供电公司浙江安吉313000 浙江九亩智慧农业科技有限公司杭州310000

为定量评估农光互补电站的生态效益,本研究基于生态产品价值核算的功能价值法,以华东地区最大的农光互补电站——正泰江山200 MW农光互补电站作为案例区开展了农光互补电站生态产品价值的核算。研究基于农光互补电站的特点对生态产品指... 详细信息

为定量评估农光互补电站的生态效益,本研究基于生态产品价值核算的功能价值法,以华东地区最大的农光互补电站——正泰江山200 MW农光互补电站作为案例区开展了农光互补电站生态产品价值的核算。研究基于农光互补电站的特点对生态产品指标进行了筛选,选取了农业产品、水源涵养、土壤保持、固碳、释氧和空气净化6个核算指标,同时结合遥感和地理信息数据、实地采样数据以及农业种植数据,量化了农光互补电站的生态效益。根据光伏板下种植类型的差异,将案例区划分为山茶区、蔬菜区、中药区、养殖区和猕猴桃区5个区域。核算结果表明:2021年该电站的生态产品价值量为1605.64万元,其中,供给产品为169.37万元,占10.55%,调节服务为1436.27万元,占89.45%;从不同分区来看,山茶区的生态产品价值最高,其次是猕猴桃区、蔬菜区和养殖区,中药区最低;从单位面积生态产品价值来看,2021年案例区的单位面积生态产品价值为3.79元·m^(-2)。农光互补电站的生态产品价值核算定量地展示了农光互补模式良好的生态效益,填补了定量评估农光互补电站生态效益的研究空白,对进一步提升农光互补电站的综合效益提供了技术支撑,同时为光伏资源和生态产品价值协同实现提供了新思路。

关键词：生态产品价值实现生态系统服务农业光伏可再生能源碳达峰碳中和

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

客车电控空气悬架系统侧跪控制策略研究

引用

青岛大学学报(工程技术版) 2024年第2期39卷 68-73页

作者：张方明孙京哲魏文智谢琪琦严天一电子科技大学机械与电气工程学院浙江科力车辆控制系统有限公司青岛大学机电工程学院

为实现两桥客车电控空气悬架系统侧跪控制，采用汽车动力学仿真软件TruckSim和逻辑控制软件Simulink&Stateflow开发客车侧跪控制策略。通过TruckSim搭建客车整车车体模型，Simulink构建的电控空气悬架模型，包括空气弹簧模型、储气罐模... 详细信息

为实现两桥客车电控空气悬架系统侧跪控制，采用汽车动力学仿真软件TruckSim和逻辑控制软件Simulink&Stateflow开发客车侧跪控制策略。通过TruckSim搭建客车整车车体模型，Simulink构建的电控空气悬架模型，包括空气弹簧模型、储气罐模型、管路模型、电磁阀模型等，借助Simulink&Stateflow建立侧跪控制策略仿真模型，仿真实验结果表明，侧跪前后客车车身高度和气囊压力发生明显变化，车身侧倾角从0°增加至2°,乘客上下车更便利。

关键词：客车电控空气悬架系统侧跪控制策略 Simulink&Stateflow

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于遗传算法整定参数的火力发电用电机伺服控制分析

引用

中国工程机械学报 2024年第1期22卷 27-31页

作者：金宏伟方匡坤张方明银奇英浙江浙能台州第二发电有限责任公司浙江三门317109 浙江省能源集团有限公司浙江杭州310007 浙江浙能电力工程技术有限公司浙江宁波315000 杭州培慕科技有限公司浙江杭州310000

同步发电机的控制精度对提高火力发电效率的影响较大,为进一步提高火力发电用电机伺服控制控制精度,选用遗传算法整定驱动轴参数。从正弦信号和直线信号两个方面开展进给测试,促进跟随性能的显著提升。研究结果表明:遗传算法优化可知,... 详细信息

同步发电机的控制精度对提高火力发电效率的影响较大,为进一步提高火力发电用电机伺服控制控制精度,选用遗传算法整定驱动轴参数。从正弦信号和直线信号两个方面开展进给测试,促进跟随性能的显著提升。研究结果表明:遗传算法优化可知,在当前人工经验条件进行整定得到的系统带宽接近64 Hz,响应性能较为理想。正弦信号下,采用遗传算法进行参数整定时,跟随误差更低,表现出更优的跟随性能。绝对误差极值降低27.3%,绝对误差积分降低42.4%。直线进给状态下,跟随误差更低,表现出更优的跟随性能。绝对误差极值降低28.6%,绝对误差积分降低39.1%。相对于人工经验整定方式,达到更优的误差波动控制状态,实现了较优的伺服稳定性。

关键词：伺服电机比例积分微分(PID)参数整定遗传算法并联发电机

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The enhanced genomic 6mA metabolism contributes to the proliferation and migration of TSCC cells

引用

International Journal of Oral Science 2022年第1期14卷 100-112页

作者： Lei Xi Ying Yang Ying Xu fangming zhang Jinghui Li Xiyang Liu Zhenxi zhang Quan Du State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Department of Stomatology Beijing Friendship HospitalCapital Medical UniversityBeijingChina

In contrast to the well-established genomic 5-methylcytosine(5mC),the existence of N^(6)-methyladenine(6 mA)in eukaryotic genomes was discovered only *** studies found that it was actively regulated in cancer cells,suggesting its involvement in the process of ***,the contribution of 6 mA in tongue squamous cell carcinoma(TSCC)still remains *** this study,a pan-cancer type analysis was first performed,which revealed enhanced 6mA metabolism in diverse cancer *** study was then focused on the regulation of 6 mA metabolism,as well as its effects on TSCC *** these aspects,genome 6mA level was found greatly increased in TSCC tissues and cultured *** knocking down 6mA methylases N6AMT1 and METTL4,the level of genomic 6mA was decreased in TSCC *** led to suppressed colony formation and cell *** contrast,knockdown of 6mA demethylase ALKBH1 resulted in an increased 6 mA level,enhanced colony formation,and cell *** study suggested that regulation of the NF-κB pathway might contribute to the enhanced migration of TSCC ***,in the case of TSCC,we have shown that genomic 6mA modification is involved in the proliferation and migration of cancer cells.

关键词： metabolism involvement cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

商用车电控空气悬架提升桥牵引辅助策略研究

引用

青岛大学学报（工程技术版） 2024年第1期39卷 73-80页

作者：张方明孙京哲魏文智严天一电子科技大学机械与电气工程学院四川成都611731 浙江科力车辆控制系统有限公司浙江江山3241001 青岛大学机电工程学院山东青岛266071

为验证商用车的牵引辅助功能通过比例控制策略的原理及实现方式,本文以三桥商用车电控空气悬架系统为主要研究对象,利用拉格朗日方程建立整车行驶动力学的理论模型,此基础上搭建Simulink仿真模型,提出面向基于比例控制的提升桥控制策略... 详细信息

为验证商用车的牵引辅助功能通过比例控制策略的原理及实现方式,本文以三桥商用车电控空气悬架系统为主要研究对象,利用拉格朗日方程建立整车行驶动力学的理论模型,此基础上搭建Simulink仿真模型,提出面向基于比例控制的提升桥控制策略。为分析实车应用可行性,分别在坡道工况和水平冰雪路面工况下,验证了该控制策略的牵引辅助效果,通过控制提升桥举升,有效转移驱动轴和提升桥载荷比,使车辆在符合承载要求前提下提高车辆驱动力,通过实验仿真验证该控制策略的有效性。

关键词：电控空气悬架系统牵引辅助控制策略提升桥控制策略坡道工况

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

引用

Chinese Medical Journal 2024年第2期137卷 181-189页

作者： fangming Liu Yuting Wu Baohui zhang Shuhui Yang Kezhuo Shang Jie Li Pengju zhang Weiwei Deng Linlin Chen Liang Zheng Xiaochen Gai Hongbing zhang Department of Physiology State Key Laboratory of Common Mechanism Research for Major DiseasesHaihe Laboratory of Cell EcosystemInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Physiology Institute of Basic Medical Sciences and School of Basic MedicineGraduate School of Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing100005China Department of Physiology School of Life ScienceChina Medical UniversityShenyangLiaoning 110122China School of Life Sciences Westlake UniversityHangzhouZhejiang 310024China Key Laboratory of Pediatric Hematology and Oncology Ministry of HealthInstitute of Pediatric Translational MedicineShanghai Children’s Medical CenterShanghai Jiao Tong School of MedicineShanghai 200127China

Background:Liver cancer is largely resistant to *** study aimed to identify the effective chemotherapeutics forβ-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1(CTNNB1),the most frequently altered proto-oncogene in hepatic ***:Constitutiveβ-catenin-activated mouse embryonic fibroblasts(MEFs)were established by deleting exon 3(β-catenin^(Δ(ex3)/+)),the most common mutation site in CTNNB1 gene.A screening of 12 widely used chemotherapy drugs was conducted for the ones that selectively inhibitedβ-catenin^(Δ(ex3)/+)but not for wild-type *** metabolomics was carried out to examine the alterations of metabolites in nucleotide *** efficacy and selectivity of methotrexate(MTX)onβ-catenin-activated human liver cancer cells were determined in ***-deficient nude mice subcutaneously inoculated withβ-catenin wild-type or mutant liver cancer cells and hepatitis B virus(HBV);β-catenin^(lox(ex3)/+)mice were used,respectively,to evaluate the efficacy of MTX in the treatment ofβ-catenin mutant liver ***:MTX was identified and validated as a preferential agent against the proliferation and tumor formation ofβ-catenin-activated *** nucleotide synthesis was the major metabolic aberration inβ-catenin-active cells,and this alteration was also the target of ***,MTX abrogated hepatocarcinogenesis of HBV;β-catenin^(lox(ex3)/+)mice,which stimulated concurrent Ctnnb1-activated mutation and HBV infection in liver ***:MTX is a promising chemotherapeutic agent forβ-catenin hyperactive liver *** repurposing MTX has the advantages of lower risk,shorter timelines,and less investment in drug discovery and development,a clinical trial is warranted to test its efficacy in the treatment ofβ-catenin mutant liver cancer.

关键词： Liver cancer β-catenin Methotrexate Nucleotide synthesis Chemotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plasma proteome profiling reveals biomarkers of chemotherapy resistance in patients with advanced colorectal cancer

引用

Quantitative Biology 2024年第2期12卷 215-224页

作者： Jingxin Yang Jin Chen Luobin zhang fangming Zhou Xiaozhen Cui Ruijun Tian Ruilian Xu Medical Genetic Center Affiliated Shenzhen Maternity and Child Healthcare HospitalSouthern Medical UniversityShenzhenChina Clinical Center for Molecular Diagnosis and Therapy The Second Affiliated Hospital of Fujian Medical UniversityQuanzhouChina Department of Chemistry and Research Center for Chemical Biology and Omics Analysis School of ScienceSouthern University of Science and TechnologyShenzhenChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenChina

Colorectal cancer(CRC)is one of the most common *** with advanced CRC can only rely on chemotherapy to improve ***,primary drug resistance frequently occurs and is difficult to *** in plasma protein composition have shown potential in clinical ***,it is urgent to identify potential protein biomarkers for primary resistance to chemotherapy for patients with *** sample preparation and high-throughput analysis were used to explore potential plasma protein *** susceptibility testing of circulating tumor cells(CTCs)has been investigated,and the relationship between their values and protein expressions has been *** addition,the differential proteins in different chemotherapy outcomes have been ***,the potential biomarkers have been detected via enzyme-linked immunosorbent assay(ELISA).Plasma proteome of 60 CRC patients were *** correlation between plasma protein levels and the results of drug susceptibility testing of CTCs was performed,and 85 proteins showed a significant positive or negative correlation with chemotherapy ***-four CRC patients were then divided into three groups according to their chemotherapy outcomes(objective response,stable disease,and progressive disease),and 37 differential proteins were found to be related to chemotherapy *** overlapping proteins were further investigated in an additional group of 79 patients using *** levels of F5 and PROZ significantly increased in the progressive disease group compared to other outcome *** study indicated that F5 and PROZ proteins could represent potential biomarkers of resistance to chemotherapy in advanced CRC patients.

关键词： biomarker chemotherapy resistance colorectal cancer plasma proteome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：