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Revealing effect of Al content on oxidation of novel Co-Cr-Nb-W carbide-strengthened superalloy

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Rare Metals 2024年第9期43卷 4521-4534页

作者： Chen Ling Shang-ping Li Jie Hou he-Li Luo Central Iron&Steel Research Institute Beijing 100081China Beijing GAONA Materials&Technology Co. Ltd.Beijing 100081China

The high-temperature oxidation behavior of novel Co-Cr-Nb-W carbide-strengthened wear-resistance alloys with different Al contents(1wt%,2wt%and 3wt%)at 950,1000 and 1050℃was thoroughly investigated by scanning electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy and field emission electron probe *** porous property of NbC in-situ oxidation products(Nb_(2)O_(5),Co Nb_(2)O_(6)and Co_(4)Nb_(2)O_(9))induces a multi-layered oxide scale with micropores and ***-Cr-Nb-W alloy with 1 wt%Al undergoes catastrophic oxidation and spalling above 1000℃.The outward transportation of Cr and Co is effectively restrained by a continuous Al_(2)O_(3)scale formed around NbC in-situ oxidation region when Al content reaches 3 wt%.The β-Co Al in Co-Cr-Nb-W alloy with 3 wt%Al has an oxidation priority over eutectic carbides and the alloy matrix which are both enriched with Cr,thereby preventing the formation of Cr-depletion area and improving the self-healing ability of the oxide film.A slight change in Al content has a remarkable influence on the cooperative effect of Al and Cr and multiplies the antioxidant capacity of Co-Cr-Nb-W alloy above 1000℃.

关键词： High-temperature oxidation behavior Oxidation kinetics Superalloy Wear-resistant alloy Microstructure

Ca_(2)MnO_(4)-layered perovskite modified by NaNO_(3)for chemical-looping oxidative dehydrogenation of ethane to ethylene

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Chinese Journal of Chemical Engineering 2024年第4期68卷 53-64页

作者： Weixiao Ding Kun Zhao Shican Jiang Zhen Huang fang he College of Chemistry and Bioengineering Guilin University of TechnologyGuilin 541006China Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640China School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China

Chemical-looping oxidative dehydrogenation(CL-ODH)is a process designed for the conversion of alkanes into olefins through cyclic redox reactions,eliminating the need for gaseous O_(2).In this work,we investigated the use of Ca_(2)MnO_(4)-layered perovskites modified with NaNO_(3) dopants,serving as redox catalysts(also known as oxygen carriers),for the CL-ODH of ethane within a temperature range of 700-780℃.Our findings revealed that the incorporation of NaNO_(3) as a modifier significantly-nhanced the selectivity for-thylene generation from Ca_(2)MnO_(4).At 750℃and a gas hourly space velocity of 1300 h^(-1),we achieved an-thane conversion up to 68.17%,accompanied by a corresponding-thylene yield of 57.39%.X-ray photoelectron spectroscopy analysis unveiled that the doping NaNO_(3) onto Ca_(2)MnO_(4) not only played a role in reducing the oxidation state of Mn ions but also increased the lattice oxygen content of the redox ***,formation of NaNO_(3) shell on the surface of Ca_(2)MnO_(4) led to a reduction in the concentration of manganese sites and modulated the oxygen-releasing behavior in a step-wise *** modulation contributed significantly to the enhanced selectivity for ethylene of the NaNO_(3)-doped Ca_(2)MnO_(4) *** findings provide compelling evidence for the potential of Ca_(2)MnO_(4)-layered perovskites as promising redox catalysts in the context of CL-ODH reactions.

关键词： Chemical-looping oxidative dehydrogenation Ethane Ethylene NaNO_(3)-doped Ca_(2)MnO_(4)redox catalyst Layered perovskites

The pathologic relevance of metabolic criteria in patients with biopsy-proven nonalcoholic fatty liver disease and metabolic dysfunction associated fatty liver disease:A multicenter cross-sectional study in China

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hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 426-432页

作者： Rui-Xu Yang Zheng-Sheng Zou Bi-Hui Zhong Hong Deng fang-ping he Jun-ping Shi Cai-Yan Zhao Yu-Qiang Mi Yong-Jian Zhou Fu-Sheng Di Rui-Dan Zheng Qin Du Jia Shang Branko Popovic Jin Jun Chen Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Liver Disease Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Gastroenterology the First Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510080China Department of Infectious Diseases the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Gastroenterology II the First Affiliated Hospital of Xinjiang Medical UniversityXinjiang Uygur Autonomous RegionsUrumqi 830011China The Affiliated Hospital of Hangzhou Normal University Hangzhou 310015China Department of Infectious Disease the Third Hospital of Hebei Medical UniversityShijiazhuang 050051China Department of Infectious Diseases Tianjin Second People's HospitalTianjin 300192China Department of Gastroenterology and hepatology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Department of Endocrinology and Metabolism The Third Central Hospital of TianjinTianjin 300170China Diagnosis and Treatment Center for Liver Diseases Zhengxing HospitalZhangzhou 363000China Department of Gastroenterology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 450003China Sanofi-Aventis Deutschland GmbH Frankfurt 65929Germany hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515China

Background:This study aimed to assess the association between metabolic syndrome(Met S)and severity of nonalcoholic fatty liver disease(NAFLD),and to discuss the pathological relevance of the diagnostic criteria in metabolic(dysfunction)associated fatty liver disease(MAFLD).Methods:This was a multicenter,cross-sectional *** with NAFLD confirmed by liver biopsy were enrolled between July 2016 and December 2018 from 14 centers across the mainland of *** and metabolic parameters were collected to assess the pathological ***:Of 246 enrolled patients with NAFLD,150(61.0%)had the comorbidity of Met *** the increase of metabolic components,the proportions of nonalcoholic steatohepatitis(NASH)and significant fibrosis were notably *** comorbid three metabolic components significantly increased the proportion of NASH,and further increase of metabolic components did not increase the proportion of ***,the increase of metabolic components was parallel to the increase of the proportion of liver *** the 246 patients,239(97.2%)met the diagnostic criteria of *** non-MAFLD patients had less NASH,they present with similar proportion of significant fibrosis and *** the diagnostic criteria of MAFLD,BMI≥23 kg/m2 was related to NASH(Mantel-Haenszel Common Estimate OR:2.975;95%CI:1.037–8.538;P=0.043),and T2 DM was related to significant fibrosis(Mantel-Haenszel Common Estimate OR:2.531;95%CI:1.388–4.613;P=0.002).The homeostasis model assessment of insulin resistance(HOMA-IR)≥2.5 was the most significant factor for NASH(OR:4.100;95%CI:1.772–9.487;P=0.001)and significant factor for liver fibrosis(OR:2.947;95%CI:1.398–6.210;P=0.004)after the adjustments of the BMI and ***:Metabolic dysregulations are important risk factors in NAFLD *** insulin resistance status may play a predominant role in the progression in MAFLD patients.

关键词： Nonalcoholic fatty liver disease Metabolic syndrome Insulin resistance

Improving Federated Learning through Abnormal Client Detection and Incentive

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 383-403页

作者： Hongle Guo Yingchi Mao Xiaoming he Benteng Zhang Tianfu Pang ping ping College of Computer and Information Hohai UniversityNanjing211100China Key Laboratory ofWater Big Data Technology of Ministry ofWater Resources Hohai UniversityNanjing211100China

Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central *** reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their *** central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective *** reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize *** this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated *** build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection *** them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational ***,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively *** training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in *** to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.

关键词： Federated learning abnormal clients incentive credit score abnormal score detection

Adrenocorticotropic hormone combined with magnesium sulfate therapy for infantile epileptic spasms syndrome:a real-world study

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World Journal of Pediatrics 2024年第8期20卷 834-847页

作者： Wen he Qiu-Hong Wang Jiu-Wei Li Yang-Yang Wang Xiao-Mei Luo Lin Wan Jing Wang Xiu-Yu Shi Wei-Hua Zhang fang fang Li-ping Zou Senior Department of Pediatrics the Seventh Medical Center of Chinese PLA General HospitalDepartment of Pediatricsthe First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Infantile epileptic spasms syndrome(IESS)is a serious disease in infants,and it usually evolves to other epilepsy types or syndromes,especially refractory or super-refractory focal *** adrenocorticotropic hormone(ACTH)is one of the first-line and effective treatment plans for IESS,it has serious side effects and is not sufficiently *** A retrospective study of the clinical outcomes of ACTH combined with magnesium sulfate(MgSO4)therapy for IESS in two hospital centers was *** major outcome of the single and combined treatment was evaluated by changes in seizure frequency and improvements in hypsarrhythmia electroencephalography(EEG).To reduce the confounding bias between the two groups,we used SPSS for the propensity score matching(PSM)*** We initially recruited 1205 IESS patients from two Chinese hospitals and treated them with ACTH combined with MgSO4 and ACTH *** 1005 patients were enrolled in the treatment(ACTH combined with MgSO4:744,ACTH:261),and both treatment plans had a more than 55%response ***,compared to patients treated with ACTH alone,those patients treated with ACTH combined with MgSO4 had better performance in terms of the seizure frequency and hypsarrhythmia *** PSM,the two groups also showed significant differences in responder rate[70.8%(95%confidence interval,CI)=66.7%–74.8%)vs.53.8%(95%CI=47.4%–60.2%),Phe lead time to treatment and the number of antiseizure medications taken before treatment were two factors that may affect the clinical *** with less than 3 months of lead time responded to the treatment much better than those with>3 months(Phe overall incidence of adverse reactions in the ACTH combined with MgSO4 group was much lower than that in the ACTH group(31.4%vs.63.1%,Phe treatment,only

关键词： Adrenocorticotropic hormone Clinical trial Infantile epileptic spasms syndrome Magnesium sulfate Real-world study

Implication of community-level ecophysiological parameterization to modelling ecosystem productivity:a case study across nine contrasting forest sites in eastern China

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Journal of Forestry Research 2024年第1期35卷 1-11页

作者： Minzhe fang Changjin Cheng Nianpeng he Guoxin Si Osbert Jianxin Sun School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China Research Institute of Energy Saving Environmental ProtectionOccupational Safety and HealthChina Academy of Railway Sciences Corporation LimitedBeijing 100081China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Parameterization is a critical step in modelling ecosystem ***,assigning parameter values can be a technical challenge for structurally complex natural plant communities;uncertainties in model simulations often arise from inappropriate model *** we compared five methods for defining community-level specific leaf area(SLA)and leaf C:N across nine contrasting forest sites along the North-South Transect of Eastern China,including biomass-weighted average for the entire plant community(AP_BW)and four simplified selective sampling(biomass-weighted average over five dominant tree species[5DT_BW],basal area weighted average over five dominant tree species[5DT_AW],biomass-weighted average over all tree species[AT_BW]and basal area weighted average over all tree species[AT_AW]).We found that the default values for SLA and leaf C:N embedded in the Biome-BGC v4.2 were higher than the five computational methods produced across the nine sites,with deviations ranging from 28.0 to 73.3%.In addition,there were only slight deviations(he whole plant community sampling(AP_BW)predicted NPP and the four simplified selective sampling methods,and no significant difference between the predictions of AT_BW and AP_BW except the Shennongjia *** findings in this study highlights the critical importance of computational strategies for community-level parameterization in ecosystem process modelling,and will support the choice of parameterization methods.

关键词： Biome-BGC Community traits Forest Ecosystems Model parameterization

heat distribution model under hydrogen-rich low-carbon conditions in blast furnace

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Journal of Iron and Steel Research International 2024年第3期31卷 584-594页

作者： Gang Wang Jun Xu Kun he Zhong-ping Zou Hao Bai School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China CISDI Low-Carbon Blast Furnace Research Office MCC Low-Carbon Technology Research InstituteChongqing 401122China

Low carbon development of blast furnaces is one of the key technological directions in the current development of *** to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of ***,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical *** model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production ***,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were *** indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace ***,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature *** combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions.

关键词： heat distribution Blast furnace Low-carbon condition Hydrogen enrichment Calculation model

Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies

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Cancer Biology & Medicine 2024年第1期21卷 45-64页

作者： Jiawen Zhang Sihui Yu Qiao Peng ping Wang Lan fang Tongji University Cancer Center Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200072China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Obstetrics and Gynecology Zhongshan HospitalFudan UniversityShanghai 200032China

The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer *** this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key *** cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor ***,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer *** strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint *** approaches have shown promise in preclinical and clinical settings,by enhancing patient survival *** review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and ***,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy *** challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.

关键词： cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy

Nondegenerate Soliton Solutions of(2+1)-Dimensional Multi-Component Maccari System

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Chinese Physics Letters 2024年第6期41卷 11-17页

作者：孟勇方乒乒林机 Department of Physics Zhejiang Normal UniversityJinhua 321004China

For a multi-component Maccari system with two spatial dimensions,nondegenerate one-soliton and two-soliton solutions are obtained with the bilinear *** can be seen by drawing the spatial graphs of nondegenerate solitons that the real component of the system shows a cross-shaped structure,while the two solitons of the complex component show a multi-solitoff *** the same time,the asymptotic analysis of the interaction behavior of the two solitons is conducted,and it is found that under partially nondegenerate conditions,the real and complex components of the system experience elastic collision and inelastic collision,respectively.

关键词： structure. degenerate soliton