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Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules

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Chinese Chemical Letters 2006年第3期17卷 383-386页

作者： juan fang WU Ling Xin CHEN Guo An LUO Yong Suo LIU Yi Ming WANG Zhi Hong JIANG Department of Chemistry Tsinghua University Beijing 100084 School of Chinese Medicine Hong Kong Baptist University Kowloon Tong Hong Kong

Two 17-mer dsDNA with different sequence characteristics were designed to investigate the binding characteristics of berberine, an anticancer drug with uncertain binding mode, and Hoechst 33258, a model DNA minor groove binder, with dsDNA, respectively by the capillary zone electrophoresis （CZE）. Kenndler model analysis revealed that Hoechst 33258 exhibited intermediate affinity with dsDNA, while there was only low affinity and some weak binding preference for AATT-containing to GGCC-containing dsDNA for berberine.

关键词： Capillary zone electrophoresis interaction berberine Hoechst 33258 DNA.

基于社会支持系统护理对类风湿性关节炎生活质量、自我护理能力的影响

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吉林医学 2024年第10期45卷 2532-2536页

作者：蔡锐美方晓娟林艺婉张秋婷林晓遹厦门医学院附属第二医院血液风湿免疫科福建厦门361000

目的:分析基于社会支持系统护理对类风湿性关节炎患者生活质量及自我护理能力的影响。方法:选取厦门医学院附属第二医院于2022年3月~2023年2月收治的类风湿性关节炎患者108例为研究对象,将患者随机分为两组,分为对照组和研究组,每组各5... 详细信息

目的:分析基于社会支持系统护理对类风湿性关节炎患者生活质量及自我护理能力的影响。方法:选取厦门医学院附属第二医院于2022年3月~2023年2月收治的类风湿性关节炎患者108例为研究对象,将患者随机分为两组,分为对照组和研究组,每组各54例。其中,对照组行常规护理,研究组在此基础上加用基于社会支持系统护理。比较两组患者护理前后生活质量及自我护理能力。结果:护理前,两组得分差异无统计学意义(P>0.05);基于社会支持系统护理后,代表生活质量和自我护理能力的SF-36量表和自我护理能力测定表(ESCA),两组评分均高于护理前,其中研究组在SF-36量表中八个维度得分均高于对照组,差异有统计学意义(P<0.05),且ESCA四个维度得分及总分也均高于对照组,差异有统计学意义(P<0.05)。结论:在常规护理基础上实施基于社会支持系统护理,可改善患者生活质量,并且提高患者自我护理能力。

关键词：社会支持系统护理类风湿性关节炎生活质量自我护理能力

物联网工程专业核心课程的专创融合探究——以RFID技术课程为例

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软件导刊 2024年第8期23卷 8-12页

作者：张文博蒋竹君包振山方娟赵艳陈慧杰北京工业大学信息学部北京工业大学创新创业学院北京100124

中共二十大报告给高校教育工作者提出了新的历史使命,如何为国家培养高水平创新型人才是当前摆在高校教育工作者面前的重点研究课题。以北京工业大学新工科特色专业物联网工程的核心课程RFID技术专创融合项目建设为依托,树立起“激发创... 详细信息

中共二十大报告给高校教育工作者提出了新的历史使命,如何为国家培养高水平创新型人才是当前摆在高校教育工作者面前的重点研究课题。以北京工业大学新工科特色专业物联网工程的核心课程RFID技术专创融合项目建设为依托,树立起“激发创新热情、培养创新能力、加强创新实践”的专创融合教学改革目标,并由此分层次贯彻“以工程实践为牵引的学习能力锻炼”的教学指导思想。通过近两年团队在教学模式、教学方法、评价方式的实践探索,有效激发了学生参与各类创新活动的兴趣,借助专业技能培养增强了其投身创新创业的能力,借助各类高水平竞赛和创业项目进一步提升了该课程创新实践水平。

关键词：新工科建设专创融合 RFID技术教学改革创新思维培养

A perceptual and predictive batch-processing memory scheduling strategy for a CPU-GPU heterogeneous system

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Frontiers of Information Technology & Electronic Engineering 2023年第7期24卷 994-1006页

作者： juan fang Sheng LIN Huijing YANG Yixiang XU Xing SU SU Faculty of Information Technology Beijing University of TechnologyBeijing 100124China

When multiple central processing unit(CPU)cores and integrated graphics processing units(GPUs)share off-chip main memory,CPU and GPU applications compete for the critical memory *** causes serious resource competition and has a negative impact on the overall performance of the *** describe the competition for shared-memory resources in a CPU-GPU heterogeneous multi-core architecture,and a sharedmemory request scheduling strategy based on perceptual and predictive batch-processing is *** sensing the CPU and GPU memory request conditions in the request buffer,the proposed scheduling strategy estimates the GPU latency tolerance and reduces mutual interference between CPU and GPU by processing CPU or GPU memory requests in *** to the simulation results,the scheduling strategy improves CPU performance by8.53%and reduces mutual interference by 10.38%with low hardware complexity.

关键词： CPU-GPU heterogeneous Multi-core Unified memory Access scheduling

Progress in Research on the Role of Angiomotins in Cancer

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Wuhan University Journal of Natural Sciences 2020年第5期25卷 377-386页

作者： XU Fei LI Wenhui CHEN Linjun fang Wenjuan Department of Microbiology and Immunology Shanghai University of Medicine&Health SciencesShanghai 201318China Collaborative Irmovation Center Shanghai University of Medicine&Health SciencesShanghai 201318China

Cancer is a major public health problem worldwide and its overall morbidity and mortality have been increasing every *** growth,invasion and metastasis of cancer are vital traits of malignancy causing extreme difficulties in therapeutic *** behavioral characteristics of cancer are closely related to tumor *** argument was put forward that tumorigenesis depended on the formation of new blood vessels,which gained insight into a promising treatment strategy for cancer based on the inhibition of tumor *** date,many new therapeutic strategies targeting tumor vessels are universally accepted and become a hotspot in oncology ***(Amot),encoded by Amot gene,is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the *** the formation of new blood vessels,Amot may play an inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth *** this review,we summarized the structure and function of Amot,and its mechanism and research progress in cancer.

关键词： Angiomotin Angiomotin-like 1 Angiomotin-like 2 Hippo cancer

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江浙地区中华绒螯蟹氨基酸图谱数据库的建立

安徽农业科学 2024年第20期52卷 173-178页

作者：方志娟李晓芹沈麒亮何新叶王伟金萍张雪婧苏州市食品检验检测中心江苏苏州215104 苏州市产品质量监督检验院江苏苏州215104

[目的]研究江浙地区不同产地(阳澄湖、太湖、洪泽湖、固城湖)中华绒螯蟹氨基酸组成差异,配合先进化学计量学分析,建立用于鉴别不同产地中华绒螯蟹氨基酸图谱数据库。[方法]样品用盐酸水解,净化后用氨基酸分析仪测定样品中氨基酸成分。采... 详细信息

[目的]研究江浙地区不同产地(阳澄湖、太湖、洪泽湖、固城湖)中华绒螯蟹氨基酸组成差异,配合先进化学计量学分析,建立用于鉴别不同产地中华绒螯蟹氨基酸图谱数据库。[方法]样品用盐酸水解,净化后用氨基酸分析仪测定样品中氨基酸成分。采用ChemPattern软件对不同产地中华绒螯蟹氨基酸图谱进行化学计量学分析,建立识别模型。[结果]阳澄湖、太湖、洪泽湖、固城湖4个不同产地之间中华绒螯蟹氨基酸组成具有明显差异;建立了分类识别模型将不同产地中华绒螯蟹准确鉴别。[结论]该研究建立的不同产地(阳澄湖、太湖、洪泽湖、固城湖)中华绒螯蟹鉴定系统具有简便、稳定、准确、重现性好的优点,为江浙地区中华绒螯蟹的产地判别提供科学的方案。

关键词：中华绒螯蟹氨基酸图谱数据库江浙地区

Relationship between clinical belonging,professional identity,and nursing information ability among nursing interns:Model construction

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World Journal of Clinical Cases 2024年第13期12卷 2210-2217页

作者： Gai Zhang Shao-juan Huang Shu-fang Li Department of Nursing Foshan Hospital of Traditional Chinese MedicineFoshan 528000Guangdong ProvinceChina

BACKGROUND Clinical belonging refers to the feeling that clinical medical staff feel recognized and accepted by others or *** level of clinical belonging of nursing interns affects students’learning motivation and confidence,which in turn affects their clinical practice *** To explore the effects of professional identity and nursing information ability on clinical belonging among nursing interns and establish a relationship model for these *** The researchers used the convenience sampling method to select 682 nursing interns from *** survey was conducted using a general information questionnaire,clinical sense of belonging scale,nursing information ability self-assessment scale,and a nursing student professional identity *** mediating effect of nursing information ability between their professional identity and clinical sense of belonging was analyzed using SPSS 21.0 and the path analysis in structural equation *** The total scores of clinical belonging,professional identity,and nursing information ability of nursing interns were(104.29±13.11)points,(57.89±7.16)points,and(70.29±6.20)points,*** information ability had a direct effect on the clinical sense of belonging(effect value=0.46,P<0.05).Occupational identity had a direct effect(effect value=0.52,P<0.05)and an indirect effect(effect value=0.21,P<0.05)on clinical *** Nursing administrators in nursing colleges and hospitals should take effective measures to improve the professional identity and nursing information ability of nursing interns,as well as the clinical sense of belonging among nursing interns.

关键词： Belongingness Nursing Education Undergraduate Information literacy Models

小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿细胞免疫功能和炎性因子的影响

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现代生物医学进展 2024年第6期24卷 1191-1194页

作者：张文童仁香房红娟陈倩柳娜娜徐文付合肥市第二人民医院儿科安徽合肥230011

目的:观察小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿细胞免疫功能和炎性因子的影响。方法:选择合肥市第二人民医院2019年10月到2023年1月期间收治的110例急性上呼吸道感染患儿,按照随机数字表法分为对照组(n=55)和研究... 详细信息

目的:观察小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿细胞免疫功能和炎性因子的影响。方法:选择合肥市第二人民医院2019年10月到2023年1月期间收治的110例急性上呼吸道感染患儿,按照随机数字表法分为对照组(n=55)和研究组(n=55),对照组患儿接受注射用头孢西丁钠治疗,研究组患儿接受小儿青翘颗粒联合注射用头孢西丁钠治疗。对比两组疗效、临床症状恢复情况、细胞免疫功能指标、炎性因子水平,同时观察两组不良反应发生情况。结果:研究组的临床总有效率为96.36%高于对照组80.00%(P0.05)。结论:小儿青翘颗粒联合注射用头孢西丁钠治疗急性上呼吸道感染患儿,可有效缓解临床症状,改善患儿的细胞免疫功能和炎性因子水平。

关键词：小儿青翘颗粒注射用头孢西丁钠急性上呼吸道感染细胞免疫功能炎性因子

Strategies to advance thermoelectric performance of PbSe and PbS materials

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Rare Metals 2024年第9期43卷 4099-4114页

作者： Zheng-Hao Hou Xin Qian Qiu-juan Cui Shu-fang Wang Li-Dong Zhao Shijiazhuang Key Laboratory of Low Carbon Energy Materials College of Chemical EngineeringShijiazhuang UniversityShijiazhuang 050035China Hebei Key Lab of Optic-Electronic Information and Materials College of Physics Science and TechnologyHebei UniversityBaoding 071002China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Thermoelectric materials possess the unique capability to convert thermal energy into electric energy and vice versa,making them promising for waste heat recovery and efficient cooling ***,extensively investigated thermoelectric materials such as Bi2Te3,PbTe and GeTe exhibit superior thermoelectric properties at room temperature and medium temperature ***,the broad application of these thermoelectric materials has been impeded by the high cost and restricted accessibility of Te and Ge in the earth's *** the past few years,researchers have shown increasing interest in PbSe-and PbS-based materials,primarily attributed to their abundant elemental supply and relatively low *** assessment of research progress and a comprehensive overview of optimization strategies in time can significantly contribute to further improving the thermoelectric *** strategies include optimizing carrier concentration(aliovalent doping,dynamic doping and defect state),enhancing density-of-state effective mass(band convergence,band flattening and energy filtering effect),optimizing carrier mobility(band sharpening and band alignment)and reducing lattice thermal conductivity(all-scale hierarchical defect structures designing).This systematic summary and analysis provide novel insights and perspectives for the development of thermoelectric materials.

关键词： PbSe and PbS thermoelectric materials Carrier concentration Density-of-state effective mass Carrier mobility Lattice thermal conductivity