Progress in Research on the Role of Angiomotins in Cancer

作     者：XU Fei LI Wenhui CHEN Linjun FANG Wenjuan XU Fei;LI Wenhui;CHEN Linjun;FANG Wen juan

作者机构：Department of Microbiology and ImmunologyShanghai University of Medicine&Health SciencesShanghai 201318China Collaborative Irmovation CenterShanghai University of Medicine&Health SciencesShanghai 201318China 

出 版 物：《Wuhan University Journal of Natural Sciences》 (武汉大学学报（自然科学英文版）)

年 卷 期：2020年第25卷第5期

页      面：377-386页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：the National Natural Science Foundation of China(81804096) the Produce-Learn-Research Projects of Shanghai University of Medicine&Health Sciences(B1-0200-19-311144,B3-0200-20-311008-11) 

主　　题：Angiomotin Angiomotin-like 1 Angiomotin-like 2 Hippo cancer 

摘      要：Cancer is a major public health problem worldwide and its overall morbidity and mortality have been increasing every *** growth,invasion and metastasis of cancer are vital traits of malignancy causing extreme difficulties in therapeutic *** behavioral characteristics of cancer are closely related to tumor *** argument was put forward that tumorigenesis depended on the formation of new blood vessels,which gained insight into a promising treatment strategy for cancer based on the inhibition of tumor *** date,many new therapeutic strategies targeting tumor vessels are universally accepted and become a hotspot in oncology ***(Amot),encoded by Amot gene,is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the *** the formation of new blood vessels,Amot may play an inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth *** this review,we summarized the structure and function of Amot,and its mechanism and research progress in cancer.