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Chinese Journal of Chemistry 1993年第1期11卷 53-58页

作者： YAN,Lin fang,yi-wei Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080 Institute of Chemistry Chinese Academy of Sciences Beijing 100080

The negative secondary ion mass spectrometry,in combination with the stereoselective derivatizations with substituted boronic acid RB(OH)_2,was used in the analysis of fourteen oligosac- *** mass spectra of the derivatives provide information on their linkage Positions and iso- merism of the individual monoscaccharide *** results indicated that among the derivatives of the oligosaccharides analyzed,those with 1—4 and 1—6 linkages all presented the ion peaks at m/z 287,sometimes one more peak at m/z ***,a relationship was found between the linkage positions and the intensity orders of the derivative ***,the derivatives of the disaccharides with a galactose presented an intense ion peak at m/z 347,and those of oligosaccharides with 1—6 linkage to a galactose at terminal presented the ion at m/z *** the case of oligosaccharides with a fructose residue,characteristic ion of m/z 155 was *** conditions of stereoselective derivatizations and mass spectrometry were studied,in order to obtain a better reproducibility of the mass spectra.

关键词： Analysis of the linkage positions and isomers of monosaccharide units in oligosaccharides by negative secondary ion mass spectrometry in combination with the stereoselective reaction with substituted boronic acid acid

Recurrent acute myocardial infarction after 32 months： very late stent thrombosis after sirolimus-eluting stent implantation

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Chinese Medical Journal 2009年第19期122卷 2399-2400页

作者： HOU Xu-min QIU Xing-biao fang wei-yi Department of Cardiology Shanghai Chest Hospital Shanghai 200030 China

Recent analyses have suggested that implantation of drug-eluting stents （DES） is associated with a higher rate of very late stent thrombosis when compared with bare metal stents （BMS）. According to Academic Research Consortium （ARC） definition,1 very late stent thrombosis refers to events occurring more than 12 months following stent placement. This complication is evident with sirolimus-eluting stents （SES） as well as polymer-based paclitaxel-eluting stents （PES）,

关键词： stent myocardial infarction thrombosis

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网络化控制系统的故障诊断

系统工程与电子技术 2006年第12期28卷 1858-1862页

作者：方华京方翌炜杨方华中科技大学控制科学与工程系湖北武汉430074 华中科技大学电子与信息工程系湖北武汉430074

网络化控制系统与传统结构的控制系统相比具有许多优点,但经网络传输的控制信号所带来的随机时延、丢包、异步等问题会影响闭环控制系统的性能,因此需要发展可在网络环境工作的系统的控制理论和技术。故障诊断与容错控制对于控制工程实... 详细信息

网络化控制系统与传统结构的控制系统相比具有许多优点,但经网络传输的控制信号所带来的随机时延、丢包、异步等问题会影响闭环控制系统的性能,因此需要发展可在网络环境工作的系统的控制理论和技术。故障诊断与容错控制对于控制工程实践特别是对安全性有严格要求的控制系统是十分重要的。近年来,我们较为系统地开展了网络化控制系统故障诊断与容错控制的研究工作从而可对故障诊断的主要研究结果进行概述。

关键词：网络化控制系统故障诊断时延系统

Multiple aortico-cameral tunnels associated with bicuspid aortic valve in aged： a case report

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Chinese Medical Journal 2009年第18期122卷 2184-2185页

作者： QIU Xing-biao SHI Hong-yu LIU Lan CHEN Hui WU wei-hua QIU Zhao-kun ZHANG wei fang wei-yi Department of Cardiology Shanghai Chest Hospital Jiao Tong University Shanghai 200030 China Department of Cardiac Surgery Shanghai Chest Hospital Jiao Tong University Shanghai 200030 China Department of Echocardiology Shanghai Chest Hospital Jiao Tong University Shanghai 200030 China

Aortico-cameral tunnel is a rare congenital cardiac .anomaly, which arises from the right coronary sinus and enters the left ventricle, occasionally the right ventricle and right atrium. However, more than one tunnel are seldom seen simultaneously in one patient. Here we present a case of multiple aortico-cameral tunnels associated with the bicuspid aortic valve in a 63-year-old man.

关键词： aortico-cameral tunnels," aged bicuspid aortic vavle

Percutaneous repair of inadvertent subclavian artery cannulation： a case report

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Chinese Medical Journal 2009年第9期122卷 1117-1118页

作者： SHI Hong-yu QIU Xing-biao CHEN Hui LIU Zhi-gang YE ying fang wei-yi Department of Cardiology Shanghai Chest Hospital Shanghai JiaoTong University Shanghai 200030 China

Although catheterization of the subclavian vein is a common procedure, it might be associated with life-threatening complications including accidental cannulation of subclavian artery. Rash sheath removal could result in fatal hemorrhage. We report a case of inadvertent 6F sheath cannulation of the right subclavian artery during a radiofrequency catheter ablation procedure and successful repair of the cannulation by Angio-Seal STS plus （St. Jude Medical, St. Paul, MN, US）, a collagen-base vascular closure device.

关键词： percutaneous repair angio-seal inadvertent subclavian artery cannulation subclavian vein catheterization

QT hysteresis in long-QT syndrome children with exercise testing

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Chinese Medical Journal 2007年第3期120卷 179-182页

作者： GAO Dong-sheng fang wei-yi Christine Chiu-Man Joel Kirsh Gil Gross Robert M. Hamilton Department of Cardiology Shanghai Chest Hospital Shanghai200030 China Department of Cardiology Hospital for Sick Children Universityof Toronto Ontario M5G 1X8 Canada

Background Congenital long QT syndrome （LQTS） is an inherited ion channel disorder resulting in abnormal cardiac repolarization that can cause syncope and sudden death associated with a prolonged rate-corrected QT interval and polymorphic ventricular tachycardia. Several studies in adults showed that LQTS patients have altered QT adaptation to heart rate changes compared with normal subjects which forming a ＂hysteresis loop＂ in the QT-circle length plot. This study was to observe the QT interval changing during exercise testing in children long QT syndrome （LQTS） patients, explore the new diagnosis methods of LQTS. Methods The subjects were divided into 3 groups according to 1993 LQTS diagnostic criteria. Group 1： LQTS group （n=17） who scored 〉 or = 4 points indicating definite LQTS. Group 2： Middle group （n=16）, patients who have prolonged QT interval but scored 1.5 to 3.5. Group 3： Normal control group （n=18）. The average age of all study population is （12.3±5.8） years. No case had beta-adrenergic antagonists administration before exercise testing. All subjects were underwent tread mill exercise testing and electrocardiograph in whole exercise testing and recovery were recorded. QT and heart rate changing during whole exercise testing period were recorded. /kQT, the QT interval at 1, 2, 4, 6 minutes into recovery subtract from the QT interval at a similar heart rate during exercise, were calculated. Results In all three groups, QT intervals were shortening with the increasing of heart rate, but QTc had no significant change. ΔQT at 1 minute （（45±11） ms）, 2 minutes （（37±15） ms）, 4 minutes （（23±12） ms） into recovery in LQTS group were significantly greater than that of the other two groups （P〈0.05, P〈0.01, P〈0.01, respectively）. There was no ΔQT significant difference between middle group and normal control group at recovery time. During the recovery phase in LQTS group, the QT interval remained shortened despite a decelerating heart rate, forming a hysteresis ＂lo

关键词： long QT syndrome QT hysteresis exercise testing children

透明质酸修饰的白蛋白纳米粒的制备及抗肿瘤作用的初步评价

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四川大学学报（医学版） 2011年第4期42卷 480-484,502页

作者：方奕巍尹宗宁四川大学华西药学院药剂学教研室成都610041

目的制备透明质酸修饰的白蛋白纳米粒,对其修饰程度和载药性能进行考察,并初步评价其抗肿瘤作用。方法用去溶剂化法制备白蛋白纳米粒,并用透明质酸修饰纳米粒表面,以表面活性氨基的减少作为评价透明质酸修饰的白蛋白纳米粒的修饰程度的... 详细信息

目的制备透明质酸修饰的白蛋白纳米粒,对其修饰程度和载药性能进行考察,并初步评价其抗肿瘤作用。方法用去溶剂化法制备白蛋白纳米粒,并用透明质酸修饰纳米粒表面,以表面活性氨基的减少作为评价透明质酸修饰的白蛋白纳米粒的修饰程度的指标,并筛选最佳处方;考察pH和载药量及包封率的关系。使用噻唑蓝比色法(MTT)测定纳米粒对人肝癌细胞株HepG2的抑制率。结果制备所得的透明质酸修饰的白蛋白纳米粒的平均粒径为396 nm,Zeta电位-19.7 mV,表面氨基减少率为34.28%;透明质酸修饰的米托蒽醌白蛋白纳米粒载药量11.13%,包封率94.64%,平均粒径为398 nm,Zeta电位-17.9 mV,且具有明显的缓释作用。透明质酸修饰的米托蒽醌白蛋白纳米粒比米托蒽醌水溶液具有更强的细胞抑制率(P<0.05)。结论所用制备工艺稳定,可用于制备透明质酸修饰的白蛋白纳米粒。透明质酸修饰的米托蒽醌白蛋白纳米粒具有不低于药物溶液的活性。

关键词：透明质酸白蛋白纳米粒

内皮祖细胞在经皮冠状动脉介入治疗后内皮损伤修复中的作用

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上海交通大学学报（医学版） 2011年第3期31卷 256-260页

作者：方唯一张敏上海交通大学附属胸科医院心内科上海200030

经皮冠状动脉介入治疗(PCI)显著地改善了冠心病患者的心肌供血和临床预后。虽然冠状动脉内支架设计已得到不断改进,支架术后强效抗血小板药物治疗也越来越普及,但是PCI术后并发症的发生率仍然较高。内皮再生是PCI导致血管损伤反应的重... 详细信息

经皮冠状动脉介入治疗(PCI)显著地改善了冠心病患者的心肌供血和临床预后。虽然冠状动脉内支架设计已得到不断改进,支架术后强效抗血小板药物治疗也越来越普及,但是PCI术后并发症的发生率仍然较高。内皮再生是PCI导致血管损伤反应的重要组成部分。新近研究发现,内皮祖细胞(EPC)可以通过再内皮化促进血管修复,从而在血管损伤反应中起到重要作用。PCI内皮损伤后循环EPCs的作用可能成为促进内皮修复的一种新的治疗措施。因此,深入了解EPC的生物学特性及它在PCI相关的血管损伤中的作用机制将为介入并发症的治疗提供一种新的思路。

关键词：经皮冠状动脉介入治疗内皮祖细胞血管损伤内皮修复

辛伐他汀对CD40L介导的ECV-304细胞E选择素表达及粘附功能的影响

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中国药理学通报 2007年第12期23卷 1658-1662页

作者：张敏袁方陈晖方唯一上海交通大学附属胸科医院心内科上海200030

目的研究在人脐静脉内皮细胞中3-羟-3-甲基戊二酰辅酶A(HMG-CoA)还原酶对CD40/CD40L系统介导的粘附分子表达的影响,及对淋巴细胞与内皮细胞的粘附功能的影响。方法采用人脐静脉内皮细胞株ECV-304,CD40L干预,使之与其表面的CD40作用,用... 详细信息

目的研究在人脐静脉内皮细胞中3-羟-3-甲基戊二酰辅酶A(HMG-CoA)还原酶对CD40/CD40L系统介导的粘附分子表达的影响,及对淋巴细胞与内皮细胞的粘附功能的影响。方法采用人脐静脉内皮细胞株ECV-304,CD40L干预,使之与其表面的CD40作用,用不同浓度辛伐他汀或辛伐他汀(5μmol.L-1)+甲羟戊酸干预,流式细胞术和RT-PCR检测干预前后E选择素(E-Selectin)的表达,流式细胞术检测CD40L介导的淋巴细胞与内皮细胞的粘附功能。结果不同浓度辛伐他汀可下调CD40L介导的E-Selectin的表达,并呈一定的剂量依赖性。甲羟戊酸(400μmol.L-1)抑制了辛伐他汀(5μmol.L-1)对E-Selectin表达的下调作用。辛伐他汀可降低CD40L介导的淋巴细胞与内皮细胞的粘附功能。结论他汀类药物的抗炎作用与抑制CD40-CD40L系统有关,其机制是通过抑制HMG-CoA还原酶而发挥作用的。

关键词： E选择素辛伐他汀粘附功能内皮细胞动脉粥样硬化

Spontaneous resolution of iatrogenic coronary artery to right ventricular fistula secondary to percutaneous coronary intervention

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Chinese Medical Journal 2013年第11期126卷 2195-2196页

作者： QIU Xing-biao LIU Lan HOU Xu-min HAN Wen-zheng YE ying DAI Jin-jie SHI Hong-yu fang wei-yi Department of Cardiology Shanghai Chest Hospital Shanghai JiaoTong University Shanghai 200030 China Department of Cardiovascular Surgery Shanghai Institute ofCardiovascular Disease Zhongshan Hospital Fudan UniversityShanghai 200032 China

Iatrogenic coronary artery fistula （ICAF） is a rare .complication and could happen during endomyocardialbiopsy, open heart surgery or percutaneous coronary intervention. The treatment of ICAF is not well established and is dependent upon the patient＇s haemodynamic situation. Here we report a case of spontaneous resolution of ICAF during such angioplasty.

关键词： coronary arteryperforation iatrogenic coronary arteryfistula percutaneous coronary intervention