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Chinese Physics B 2024年第4期33卷 237-243页

作者：穆文英庄波邱芳 Shandong Engineering Research Center of Aeronautical Materials and Devices Shangdong University of AeronauticsBinzhou 256600China School of Information Engineering Shangdong University of AeronauticsBinzhou 256600China School of Science Shangdong University of AeronauticsBinzhou 256600China

We develop a policy of observer-based dynamic event-triggered state feedback control for distributed parameter systems over a mobile sensor-plus-actuator *** is assumed that the mobile sensing devices that provide spatially averaged state measurements can be used to improve state estimation in the *** the purpose of decreasing the update frequency of controller and unnecessary sampled data transmission, an efficient dynamic event-triggered control policy is *** an event-triggered system, when an error signal exceeds a specified time-varying threshold, it indicates the occurrence of a typical *** global asymptotic stability of the event-triggered closed-loop system and the boundedness of the minimum inter-event time can be *** on the linear quadratic optimal regulator, the actuator selects the optimal displacement only when an event occurs.A simulation example is finally used to verify that the effectiveness of such a control strategy can enhance the system performance.

关键词： distributed parameter systems event-triggered control mobile sensors mobile actuators

Effect on serum metabolomics of rats with premature ovarian insufficiency by Zhibian(BL54) through Shuidao(ST28) acupuncture

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Journal of Traditional Chinese Medicine 2024年第4期44卷 722-733页

作者： YAN Jing FENG Huimin qiu fang WANG Haijun YIN Luyun JIN Xiaofei ZHAO Jiyu WANG Hongyang YAN Xiaoqin Second Clinical College of Shanxi University of Traditional Chinese Medicine Jinzhong 030619China Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Cervical and Lumbar Vertebral Diseases Jinzhong Hospital Affiliated to Shanxi University of Traditional Chinese MedicineJinzhong 030600China

OBJECTIVE:To analyze the serum metabolic targets of the"Zhibian(BL54)through Shuidao(ST28)"acupuncture technique in cyclophosphamide(CTX)-induced premature ovarian insufficiency(POI)model rats and to elucidate the potential molecular mechanism of acupuncture in improving ***:We used an intraperitoneal injection of CTX to establish the POI rat model(POI group)and compared serum hormone levels and ovarian histopathological changes to evaluate the effect of the Zhibian(BL54)through Shuidao(ST28)technique(ZS+POI group)on ovarian ***,nontargeted metabolomics was performed using rat serum by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF/MS).RESULTS:After acupuncture intervention,the serum hormone levels and ovarian pathological morphology of POI rats were effectively ***,UPLC-Q-TOF/MS results showed that the ZS+POI group showed a significant reversal of the levels of 6 differential *** them,the levels of four serum metabolic markers,divanillyltetrahydrofuran ferulate,trans-ferulic acid,tryptamine,and neuraminic acid,increased *** analysis of biological effects showed that all metabolites were involved in the regulation of reproductive hormone levels and antioxidant and antiapoptotic ***:The"Zhibian(BL54)through Shuidao(ST28)"acupuncture method may improve the ovarian function of POI rats by regulating serum metabolite markers to exert antioxidant and antiapoptotic effects,which provides a theoretical basis for the clinical application of acupuncture in the treatment of POI.

关键词： acupuncture premature ovarian insufficiency metabolomics ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry Zhibian(BL54)through Shuidao(ST28)

Abiotic stress treatment reveals expansin like A gene OfEXLA1 improving salt and drought tolerance of Osmanthus fragrans by responding to abscisic acid

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Horticultural Plant Journal 2024年第2期10卷 573-585页

作者： Bin Dong Qianqian Wang Dan Zhou Yiguang Wang Yunfeng Miao Shiwei Zhong qiu fang Liyuan Yang Zhen Xiao Hongbo Zhao School of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhouZhejiang 311300China Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants HangzhouZhejiang 311300China Key Laboratory of National Forestry and Grassland Administration on Germplasm Innovation and Utilization for Southern Garden Plants HangzhouZhejiang 311300China

Sweet osmanthus(Osmanthus fragrans) is a having general approval aromatic tree in China that is widely applied to landscaping and gardening. However, the evergreen tree adaptability is limited by many environmental stresses. Currently, limited information is available regarding the genetic analysis and functional identification of expansin genes in response to abiotic stress in sweet osmanthus. In this study, a total of 29 expansin genes were identified and divided into four groups by genome-wide analysis from the sweet osmanthus genome. Transcriptome and quantitative Real-time PCR analysis showed that the cell wall-localized protein expansin-like A(OfEXLA1) gene was significantly induced by salt and drought treatment. Histochemical GUS staining of transgenic Arabidopsis lines in which GUS activity was driven with the OfEXLA1 promoter, GUS activity was significantly induced by salt, drought, and exogenous abscisic acid(ABA). In yeast, we found OfEXLA1overexpression significantly improved the population of cells compared with wild-type strains after NaCl and polyethylene glycol(PEG)treatment. Additionally, OfEXLA1 overexpression not only promoted plant growth, but also improved the salt and drought tolerance in Arabidopsis. To gain insight into the role of ABA signaling in the regulation of OfEXLA1 improving abiotic tolerance in sweet osmanthus, four differentially expressed ABA Insensitive 5(ABI5)-like genes(OfABL4, OfABL5, OfABL7, and OfABL8) were identified from transcriptome, and dualluciferase(dual-LUC) and yeast one hybrid(Y1H) assay showed that OfABL4 and OfABL5 might bind to OfEXLA1 promoter to accumulate the OfEXLA1 expression by responding to ABA signaling to improve abiotic tolerance in sweet osmanthus. These results provide the information for understanding the molecular functions of expansin-like A gene and molecular breeding of sweet osmanthus in future.

关键词： Osmanthus fragrans Abiotic tolerance Expansin Abscisic acid

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

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Bone Research 2024年第2期12卷 421-437页

作者： Hongzhen Chen Xuekun Fu Xiaohao Wu Junyi Zhao fang qiu Zhenghong Wang Zhuqian Wang Xinxin Chen Duoli Xie Jie Huang Junyu Fan Xu Yang Yi Song Jie Li Dongyi He Guozhi Xiao Aiping Lu Chao Liang Department of Systems Biology School of Life SciencesSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Institute of Integrated Bioinfomedicine and Translational Science(IBTS) School of Chinese MedicineHong Kong Baptist UniversityHong Kong SAR 999077China Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Division of Immunology and Rheumatology Stanford UniversityStanfordCA 94305USA VA Palo Alto Health Care System Palo AltoCA 94304USA Institute of Plant and Food Science Department of BiologySouthern University of Science and TechnologyShenzhen 518055China Department of Rheumatology Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Computational Biology St.Jude Children’s Research HospitalMemphisTNUSA Department of Laboratory Medicine Peking University Shenzhen HospitalShenzhenChina Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou 510006China Shanghai University of Traditional Chinese Medicine Shanghai 200032China State Key Laboratory of Proteomics National Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics100850 BeijingChina

Rheumatoid arthritis(RA)is an autoimmune *** studies hold an opinion that gut microbiota is environmentally acquired and associated with RA ***,accumulating evidence demonstrates that genetics also shape the gut *** is known that some strains of inbred laboratory mice are highly susceptible to collagen-induced arthritis(CIA),while the others are resistant to ***,we show that transplantation of fecal microbiota of CIA-resistant C57BL/6J mice to CIA-susceptible DBA/1J mice confer CIA resistance in DBA/1J mice.C57BL/6J mice and healthy human individuals have enriched *** than DBA/1J mice and RA *** of *** prevents CIA in DBA/1J *** identify that *** mainly produces propionate and C57BL/6J mice and healthy human individuals have higher level of ***-like synoviocytes(FLSs)in RA are activated to undergo tumor-like *** disrupts HDAC3-FOXK1 interaction to increase acetylation of FOXK1,resulting in reduced FOXK1 stability,blocked interferon signaling and deactivation of *** treat CIA mice with propionate and show that propionate attenuates ***,a combination of propionate with anti-TNF etanercept synergistically relieves *** results suggest that *** or propionate could be an alternative or complementary approach to the current therapies.

关键词： HDAC3 cytes interferon

丹酚酸B对香烟烟雾提取物诱导的支气管上皮细胞凋亡的影响

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中国临床药理学杂志 2024年第6期40卷 825-829页

作者：胡秋芳吕秋菊乐山职业技术学院基础医学教研室四川乐山614000 乐山市人民医院内分泌科四川乐山614000

目的研究丹酚酸B对香烟烟雾提取物(CSE)诱导的支气管上皮细胞凋亡的影响及机制。方法将人支气管上皮细胞16HBE分成对照组、模型组(香烟烟雾提取物诱导)、实验低剂量组(烟雾诱导+11μmol·L^(-1)丹酚酸B处理)、实验中剂量组(烟雾诱导+22... 详细信息

目的研究丹酚酸B对香烟烟雾提取物(CSE)诱导的支气管上皮细胞凋亡的影响及机制。方法将人支气管上皮细胞16HBE分成对照组、模型组(香烟烟雾提取物诱导)、实验低剂量组(烟雾诱导+11μmol·L^(-1)丹酚酸B处理)、实验中剂量组(烟雾诱导+22μmol·L^(-1)丹酚酸B处理)、实验高剂量组(烟雾诱导+44μmol·L^(-1)丹酚酸B处理)、实验高剂量+Compound C组(烟雾诱导+44μmol·L^(-1)丹酚酸B+AMPK信号通路抑制剂Compound C处理)。用细胞计数试剂盒-8(CCK-8)实验检测细胞增殖情况,以蛋白质印迹法检测磷酸化腺苷—磷酸活化蛋白激酶(p-AMPK)、CCAAT/增强子结合蛋白同源蛋白(CHOP)、活化转录因子4(ATF4)蛋白表达,用PI单染法检测细胞周期,用Annexin V-FITC/PI双染法检测细胞凋亡情况,用分光光度法检测胱天蛋白酶-3(caspase-3)活性。结果对照组、模型组、实验低剂量组、实验中剂量组、实验高剂量组、实验高剂量+Compound C组的细胞增殖活性(OD值)分别为0.86±0.07、0.38±0.03、0.45±0.03、0.54±0.04、0.68±0.03和0.42±0.04,支气管上皮细胞中p-AMPK/AMPK蛋白表达量比值分别为0.41±0.03、0.13±0.03、0.20±0.02、0.28±0.04、0.36±0.04和0.22±0.02,G0/G1期细胞比例分别为(54.40±5.84)%、(82.93±4.50)%、(75.45±4.73)%、(67.41±2.70)%、(59.15±3.73)%和(69.80±6.59)%,细胞凋亡率分别为(3.21±0.49)%、(24.90±3.35)%、(20.56±1.73)%、(13.55±1.68)%、(9.20±1.07)%和(18.04±1.79)%;实验低剂量组、实验中剂量组、实验高剂量组与模型组相比,在统计学上差异均有统计学意义(均P<0.05);实验高剂量+Compound C组与实验高剂量组相比,在统计学上差异均有统计学意义(均P<0.05)。结论丹酚酸B通过激活AMPK信号通路影响内质网应激,减少香烟烟雾提取物诱导的支气管上皮细胞凋亡。

关键词：丹酚酸B 腺苷一磷酸活化蛋白激酶信号内质网应激支气管上皮细胞细胞周期阻滞

面向可持续生产中多任务调度的双重增强模因算法

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自动化学报 2024年第4期50卷 731-744页

作者：卢弘王耀南乔非方遒湖南大学电气与信息工程学院长沙410082 同济大学电子与信息工程学院上海201804

从经济、环境和社会3个维度,全面提升生产调度方案的可持续性具有重要意义.针对并行机生产场景,建立考虑机器指派、加工顺序、人员安排以及开关机控制等4种决策任务的调度模型.为实现对复杂决策空间的高效寻优,提出一种融合两种局部优... 详细信息

从经济、环境和社会3个维度,全面提升生产调度方案的可持续性具有重要意义.针对并行机生产场景,建立考虑机器指派、加工顺序、人员安排以及开关机控制等4种决策任务的调度模型.为实现对复杂决策空间的高效寻优,提出一种融合两种局部优化策略的双重增强模因算法(Dual-enhanced memetic algorithm, DMA)求解模型.从随机更新角度,针对不同决策任务,构造单步变邻域搜索(One-step variable neighborhood search, 1S-VNS)策略.从定向优化角度,分析目标和关键任务之间的匹配关系,提出一种可持续目标导向策略(Sustainable goals-oriented strategy, SGS).考虑到两种优化策略的不同特点,单步变邻域搜索策略作用于整个种群,目标导向策略强化种群中的精英个体,实现对输出解集的双重优化.仿真实验结果表明,双重优化策略能有效地增强算法性能,并且所提算法在非支配解的多样性和收敛性上具有优越性.

关键词：可持续生产多任务调度优化策略模因算法

同方期刊数据库博看期刊评论

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跨通道迁移及其认知神经机制

生物化学与生物物理进展 2024年第1期51卷 94-110页

作者：孙莹孙洵伟王一帆付秋芳中国科学院心理研究所脑与认知科学国家重点实验室北京100101 中国科学院大学心理学系北京100049 北京大学心理与认知科学学院北京100871

跨通道迁移是指将在一种感觉通道获得的知识应用于另一感觉通道的能力。跨通道迁移的相关研究探索了大脑表征不同感觉通道信息的方式,为减少重复学习、提高认知加工效率提供了新的见解。为较好地概括跨通道迁移的特点和机制,本文首先介... 详细信息

跨通道迁移是指将在一种感觉通道获得的知识应用于另一感觉通道的能力。跨通道迁移的相关研究探索了大脑表征不同感觉通道信息的方式,为减少重复学习、提高认知加工效率提供了新的见解。为较好地概括跨通道迁移的特点和机制,本文首先介绍了在物体识别、类别学习和时间知觉等不同领域对跨通道迁移效应的实验研究,之后介绍了支持跨通道迁移的表征类型和相关理论,梳理了跨通道迁移产生的理论及采用事件相关电位(ERP)和功能磁共振成像(fMRI)等技术探讨跨通道迁移神经机制的研究进展,并指出了影响跨通道迁移的因素。最后,对目前跨通道迁移研究成果及其潜在应用进行了总结,并对这一领域未来的研究问题进行了展望。

关键词：跨通道迁移多通道表征跨通道识别通道优势元通道理论

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连翘苷对呼吸道合胞病毒感染小鼠的治疗作用

中国临床药理学杂志 2024年第15期40卷 2202-2206页

作者：胡秋芳李凡敏乐山职业技术学院基础医学教研室四川乐山614000 乐山市人民医院呼吸科四川乐山614000

目的探讨连翘苷对呼吸道合胞病毒(RSV)感染小鼠Toll样受体4(TLR4)/髓样分化因子88(MyD88)信号通路的影响。方法用RSV滴鼻感染法构建呼吸道感染模型,将RSV感染小鼠随机分为模型组、实验组及阳性对照组,另对照组小鼠给予等量的DMEM培养基... 详细信息

目的探讨连翘苷对呼吸道合胞病毒(RSV)感染小鼠Toll样受体4(TLR4)/髓样分化因子88(MyD88)信号通路的影响。方法用RSV滴鼻感染法构建呼吸道感染模型,将RSV感染小鼠随机分为模型组、实验组及阳性对照组,另对照组小鼠给予等量的DMEM培养基滴鼻。实验组小鼠灌胃给予200 mg·kg^(-1)·d^(-1)连翘苷,阳性对照组小鼠灌胃给予27.6 mg·kg^(-1)·d^(-1)利巴韦林,对照组与模型组均灌胃给予等量0.9%NaCl,连续干预14 d。用酶联免疫吸附试验法检测肺泡灌洗液(BALF)中白细胞介素-4(IL-4)、IL-13及γ-干扰素(INF-γ)水平,用实时荧光定量聚合酶链反应法检测肺组织TLR4、MyD88 mRNA的转录水平,用免疫组织化学法检测肺组织TLR4、MyD88蛋白的阳性表达情况。结果对照组、模型组、实验组及阳性对照组小鼠BALF中IL-4水平分别为(490.63±27.45)、(1382.37±41.28)、(970.32±36.01)和(738.41±30.27)pg·mL^(-1),IL-13水平分别为(4.02±2.63)、(18.33±5.62)、(12.97±3.73)和(7.51±2.74)pg·mL^(-1),INF-γ水平分别为(54.42±2.68)、(30.26±4.68)、(42.80±3.36)和(45.01±3.82)pg·mL^(-1),肺组织TLR4 mRNA相对表达水平分别为0.43±0.06、1.63±0.12、0.98±0.10和0.86±0.06,肺组织MyD88 mRNA相对表达水平分别为0.56±0.09、1.78±0.15、1.02±0.07和0.75±0.06,肺组织TLR4蛋白平均光密度值分别为0.02±0.00、0.11±0.02、0.06±0.01和0.03±0.00,MyD88蛋白平均光密度值分别为0.01±0.00、0.09±0.02、0.05±0.01和0.03±0.01。模型组的上述指标与对照组比较,实验组和阳性对照组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.05)。结论连翘苷可减轻RSV感染小鼠的肺损伤,可能与调节免疫细胞的平衡,抑制TLR4/MyD88信号通路有关。

关键词：连翘苷呼吸道合胞病毒 Toll样受体4 髓样分化因子88 炎症反应

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转杯纺分梳排杂区气流场的多维数值模拟对比

纺织学报 2024年第10期45卷 64-71页

作者：张定眺王倩茹邱芳李凤艳天津工业大学纺织科学与工程学院天津300387 江苏中纺联检验技术服务有限公司江苏苏州215228 天津工业大学先进纺织复合材料教育部重点实验室天津300387

为探讨转杯纺分梳排杂区二维与三维模型气流场数值模拟结果的准确度与差异性,采用COMSOL仿真模拟软件建立分梳排杂区的二维与三维几何模型,对气流场进行数值模拟并进行比较。结果表明:与二维模型模拟结果相比,三维模型输纤通道出口处速... 详细信息

为探讨转杯纺分梳排杂区二维与三维模型气流场数值模拟结果的准确度与差异性,采用COMSOL仿真模拟软件建立分梳排杂区的二维与三维几何模型,对气流场进行数值模拟并进行比较。结果表明:与二维模型模拟结果相比,三维模型输纤通道出口处速度高,分梳腔速度、压强与湍动能分布更均匀,且排杂区的气流与湍动能分布结果更加准确;引入杂质颗粒后的运动结果也证明,三维模型中大部分杂质颗粒随气流运动及时排除,仅有少部分杂质进入输纤通道内,对流场细节和颗粒分布情况的模拟展现得更加准确直观,适合指导实际生产与优化转杯纺机构的设计。

关键词：转杯纺分梳排杂数值模拟气流场三维模型二维模型

牺牲桩截面特性对圆柱桥墩局部冲刷的影响试验研究

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土木与环境工程学报（中英文） 2024年第5期46卷 152-159页

作者：魏凯冉彭鑫裘放洪杰西南交通大学桥梁智能与绿色建造全国重点实验室成都611756

墩前牺牲桩防护是减小桥墩局部冲刷的主要措施之一,现有的牺牲桩防护桥墩局部冲刷研究主要集中在圆形截面,关于牺牲桩截面特性对桥墩局部冲刷的影响关注较少。通过单向流循环水槽构建冲刷环境,开展不同直径与不同截面牺牲桩防护单桩桥... 详细信息

墩前牺牲桩防护是减小桥墩局部冲刷的主要措施之一,现有的牺牲桩防护桥墩局部冲刷研究主要集中在圆形截面,关于牺牲桩截面特性对桥墩局部冲刷的影响关注较少。通过单向流循环水槽构建冲刷环境,开展不同直径与不同截面牺牲桩防护单桩桥墩局部冲刷物理模型试验,并通过水下高清摄像以及倾斜摄影测量技术实现对局部冲刷深度发展历程和冲刷平衡时刻冲刷坑形态的精准测量,进而探究牺牲桩直径与截面形式对单桩桥墩局部冲刷防护效果的影响规律。试验表明:牺牲桩直径与截面形状是影响桥墩局部冲刷防护效果的关键因素,牺牲桩的防护效果随牺牲桩直径的增大而增强,相比方形和圆形截面牺牲桩,菱形截面牺牲桩对桥墩的冲刷防护效果更好;牺牲桩防护会影响后方桥墩冲刷坑变化的剧烈程度,防护效果越好,后方冲刷坑变化越平缓;牺牲桩防护会缩短冲刷达到平衡状态的时间,牺牲桩直径越大,到达冲刷平衡状态的时间越短。采用牺牲桩开展桥墩局部冲刷防护时,应合理确定牺牲桩尺寸和截面特性,从而提高冲刷防护效果。

关键词：桥墩局部冲刷冲刷防护牺牲桩水槽试验

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