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Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer

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World Journal of Clinical Oncology 2025年第2期16卷 63-75页

作者： Xu-fan zhang Qian Chen Qin Jiang Qiong-Ying Hu Department of Nuclear Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Mianyang Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC *** therapy may initially yield positive results,the development of drug resistance can result in treatment failure and cancer *** resistance is often attributed to the presence of cancer stem cells(CSCs).These CSCs not only contribute to therapeutic resistance but also play crucial roles in the initiation and development of tumor *** To investigate the antitumor effects of SH-4-54,which are mediated by targeting CSCs relative to treatment *** CSCs were enriched by culturing CRC cells in serum-free *** of stemness and IL-6/JAK2/STAT3 signaling were detected by Western *** of CSC malignancy,including proliferation,invasion,and tumor formation,were *** In this study,we employed SH-4-54,which exhibits anticancer activity in solid tumors through targeting the SH2 domain of both the signal transducer and activator of transcription(STAT)3 and the STAT5,and evaluated its effects on stemness and chemoresistance in colorectal *** expected,SH-4-54 treatment inhibited the phosphorylation of STAT3(p-STAT3)and decreased the percentage of ALDH1A1-positive CRC *** addition of SH-4-54 dissociated colorectal spheroids and decreased the expression of stemness markers,including ALDH1A1,CD44 and ***-4-54 treatment decreased IL-6/JAK2/STAT3 signaling by inhibiting p-STAT3 and thus inhibited spheroid formation by SW480 and LoVo ***,SH-4-54 treatment inhibited indicators of malignancy,including cell proliferation,invasion,and tumor formation,in CSCs in vitro and in ***,SH-4-54 treatment significantly increased chemosensitivity to *** Taken together,these results indicate that SH-4-54 is a promising molecule that exerts antitumor effects on colorectal CSCs by inhibiting STAT3 signaling.

关键词： SH-4-54 Colorectal cancer Cancer stem-like cells Stemness Chemosensitivity

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Strict finite-time sliding mode control for a tethered space net robot

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Chinese Journal of Aeronautics 2023年第12期36卷 325-335页

作者： Chen WANG fan zhang School of Construction Machinery Chang’an UniversityXi’an 710072China School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China

Tethered Space Net Robot(TSNR)is considered to be a promising approach for space debris removal,and accordingly it is also an interesting control problem due to its time-varying disturbances caused by an elastic and flexible net and a main connected *** this situation,the control scheme should be robust enough,low-frequency,and finite-time convergent in presence of external *** this paper,a robust controller with an advanced adaptive scheme is *** improve robustness,the disturbance is skillfully involved in the adaptive *** is strictly proven that the closed-loop system can converge to the desired trajectory in finite time in both reaching and sliding *** on the theoretical proof,adaptive gains and corresponding dynamic stability characteristics are further ***,the efficiency of the proposed control scheme is numerically proven via a *** proposed control scheme utilizes small and continuous control forces to compensate for the disturbance efficiently and track the desired trajectory quickly.

关键词： Modified adaptive supertwisting control Strict finite-time convergence Tethered space net robot(TSNR) Time-varying disturbance Underactuated system

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Rational design of self-powered sensors with polymer nanocomposites for human–machine interaction

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Chinese Journal of Aeronautics 2022年第11期35卷 155-177页

作者： Hailong HU fan zhang School of Aeronautics and Astronautics Central South UniversityChangsha 410083China Research Center in Intelligent Thermal Structures for Aerospace Central South UniversityChangsha 410083China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China

Smart sensors are becoming one of the necessities for connecting and detecting surrounding stimuli with tremendous convenience, especially when exploiting a single powerful sensor with multifunctionality. To successfully accomplish the design of a self-powered sensor, serving power is becoming a critical issue because of its continuously consumed energy required by electronics. A variety of nanogenerators aiming for the rational design of self-powered system are reviewed and compared, followed by their recent advances with polymer nanocomposites for self-powered sensors. More importantly, the proposed conceptual design of a self-powered unit/device with triboelectric nanogenerator has been emphasized to eventually realize the practical activities towards multiple detections and human–machine interaction. Finally, challenges and new prospects of rational design of self-powered polymer composite sensors in achieving human–machine interaction/interface are discussed.

关键词： Analytical modelling Electronic devices Interface Nanocomposites Self-powered sensors

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Optimization of microstructure design for enhanced sensing performance in flexible piezoresistive sensors

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Journal of Advanced Ceramics 2024年第6期13卷 711-728页

作者： Xinghao fan Hailong Hu Bin Liao Yaqi zhang fan zhang School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Research Institute of Aerospace Technology Central South UniversityChangsha 410083China

Flexible piezoresistive strain sensors have received significant attention due to their diverse applications in monitoring human activities and health,as well as in robotics,prosthetics,and human–computer interaction *** the various flexible sensor types,those with microstructure designs are considered promising for strain sensing due to their simple structure,high sensitivity,extensive operational range,rapid response time,and robust *** review provides a concise overview of recent advancements in flexible piezoresistive sensors based on microstructure design for enhanced strain sensing performance,including the impact of microstructure on sensing mechanisms,classification of microstructure designs,fabrication methods,and practical ***,this review delves into the analysis of piezoresistive sensor sensing mechanisms and performance parameters,exploring the relationship between microstructure design and performance ***,an in-depth discussion is presented,focusing on the primary themes of microstructure design classification,process selection,performance characteristics,and specific *** review employs mathematical modeling and hierarchical analysis to emphasize the directionality of different microstructures on performance enhancement and to highlight the performance advantages and applicable features of various microstructure *** conclusion,this review examines the multifunctionality of flexible piezoresistive sensors based on microstructure design and addresses the challenges that still need to be overcome and improved,such as achieving a wide range of stretchability,high sensitivity,and robust *** review summarizes the research directions for enhancing sensing performance through microstructure design,aiming to assist in the advancement of flexible piezoresistive sensors.

关键词： microstructure design sensing performance flexible piezoresistive strain sensors microsensing mechanism

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Seismic response of pile-supported structures considering the coupling of inertial and kinematic interactions in different soil sites

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1350-1361页

作者： Huiling ZHAO fan zhang Department of Civil Engineering Shanghai UniversityShanghai 200444China

Dynamic soil−pile−superstructure interaction is crucial for understanding pile behavior in earthquake-prone *** the safety of piles requires determining the seismic bending moment caused by combined inertial and kinematic interactions,which is *** paper addresses this problem through numerical simulations of piles in different soil sites,considering soil *** reveal that the period of the soil site significantly affects the interaction among soil,piles,and *** moments in soft and hard soil sites exceed those in medium soil sites by more than *** modes of piles exhibit distinct characteristics between hard and soft soil *** soil sites exhibit a singular inflection point,while hard soil sites show two inflection *** soft soil sites,pile-soil kinematic interaction gradually increases bending moment from tip to head,with minor influence from superstructure’s inertial *** hard soil sites,significant inertial effects from soil,even surpassing pile-soil kinematic effects near the tip,lead to reversed superposition bending ***’s inertial interaction notably impacts pile head in hard soil sites.A simplified coupling method is proposed using correlation coefficient to represent inertial and kinematic *** findings provide insights into complex seismic interactions among soil,piles,and structures.

关键词： pile seismic response soft soil inertial interaction kinematic interaction

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Iron homeostasis and tumorigenesis： molecular mechanisms and therapeutic opportunities

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Protein & Cell 2015年第2期6卷 88-100页

作者： Caiguo zhang fan zhang Department of Biochemistry and Molecular Genetics University of Colorado School of Medicine Aurora CO 80045 USA Orthopedics Department Changhai Hospital Affiliated to Second Military Medical University Shanghai 200433 China

Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replica- tion, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells, Thus, multiple therapeutic strategies based on iron deprivation have been developed in cancer therapy, During the past few years, our understanding of genetic association and molecular mechanisms between iron and tumorigenesis has expanded enormously. In this review, we briefly summarize iron homeostasis in mammals, and discuss recent progresses in understanding the aberrant iron metabolism in numerous cancer types, with a focus on studies revealing altered signal transduction in cancer cells.

关键词： Iron tumorigenesis p53 Wnt DNA repair,cell cycle

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Evasion strategies of a three-player lifeline game

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Science China(Information Sciences) 2018年第11期61卷 144-154页

作者： fan zhang Wenzhong ZHA School of Automation Beijing Institute of Technology State Key Laboratory of Intelligent Control and Decision of Complex System Information Science Academy China Electronics Technology Group Corporation

This study examines a multi-player pursuit-evasion game, more specifically, a three-player lifeline game in a planar environment, where a single evader is tasked with reaching a lifeline prior to capture. A decomposition method based on an explicit policy is proposed to address the game qualitatively from two main aspects:(1) the evader’s position distribution to guarantee winning the game(i.e., the escape zone),which is based on the premise of knowing the pursuers’ positions initially, and(2) evasion strategies in the escape zone. First, this study decomposes the three-player lifeline game into two two-player sub-games and obtains an analytic expression of the escape zone by constructing a barrier, which is an integration of the solutions of two sub-games. This study then explicitly partitions the escape zone into several regions and derives an evasion strategy for each region. In particular, this study provides a resultant force method for the evader to balance the active goal of reaching the lifeline and the passive goal of avoiding capture. Finally,some examples from a lifeline game involving more than one pursuer are used to verify the effectiveness and scalability of the evasion strategies.

关键词： lifeline game three-player pursuit-evasion game barrier evasion strategy game of kind

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An exciting time for gravitational wave astronomy

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Science Bulletin 2016年第3期61卷 187-189页

作者： fan zhang Gravitailonal Wave and Cosmology Laboratory Department ofAstronomy Beijing Normal University Beijing 100875 China Department of Physics and Astronomy West VirginiaUniversity Morgantown WV 26506 USA

This year marks the centenary of Einstein’s general relativity(GR),a theory whose intrinsic mathematical beauty is only matched by its *** the past 100 years,GR has stood the challenges of numerous weak and strong field *** remaining crown jewel is the direct detection of gravitational waves(GW),or ripples of spacetime *** from testing GR,modified gravity theories,and a host of related fundamental

关键词：引力波天文学广义相对论爱因斯坦直接探测时空曲率引力理论鲁棒性

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Computing knots by quadratic and cubic polynomial curves

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Computational Visual Media 2020年第4期6卷 417-430页

作者： fan zhang Jinjiang Li Peiqiang Liu Hui fan School of Computer Science and Technology Shandong Technology and Business UniversityYantai 264005China Co-Innovation Center of Shandong Colleges and Universities:Future Intelligent Computing Yantai 264005China

A new method is presented to determine parameter values(knot)for data points for curve and surface *** four adjacent data points,a quadratic polynomial curve can be determined uniquely if the four points form a convex *** the four data points do not form a convex polygon,a cubic polynomial curve with one degree of freedom is used to interpolate the four points,so that the interpolant has better shape,approximating the polygon formed by the four data *** degree of freedom is determined by minimizing the cubic coefficient of the cubic polynomial *** advantages of the new method are,firstly,the knots computed have quadratic polynomial precision,i.e.,if the data points are sampled from a quadratic polynomial curve,and the knots are used to construct a quadratic polynomial,it reproduces the original quadratic ***,the new method is affine invariant,which is significant,as most parameterization methods do not have this ***,it computes knots using a local *** show that curves constructed using knots computed by the new method have better interpolation precision than for existing methods.

关键词： knot interpolation polynomial curve affine invariant

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Recent progress in NIR-Ⅱ emitting lanthanide-based nanoparticles and their biological applications

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Journal of Rare Earths 2020年第5期38卷 451-463页

作者： Suwan Ding Lingfei Lu Yong fan fan zhang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of Polymers and iChemFudan UniversityShanghai 200433China

The second near-infrared(NIR-Ⅱ,1000-1700 nm)window provides a superior optical platform with high resolution,deep penetration and high signal-to-noise ratios(SNRs),which results from the intrinsic low scattering and auto fluorescence in biological *** one of the promising NIR-Ⅱemitting probes,lanthanide based nanoparticles(LnNPs)exhibit high photo stability and chemostability,long photoluminescence lifetimes,low long-term cytotoxicity and narrow emission *** these merits have spurred the evolution of related bio-optics and a variety of biomedical applications of *** mini-review discusses the most recent advances in both the design-the composition and surface modifications-and the applications of NIR-Ⅱemitting LnNPs in bioimaging,disease diagnosis and *** also summarize the current limits and challenges facing the applications of LnNPs as well as discuss the directions of future development.

关键词： Lanthanide nanoparticles Second near infrared window Fluorescence imaging Diagnose Therapy Rare earths

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