Iron homeostasis and tumorigenesis： molecular mechanisms and therapeutic opportunities

作     者：Caiguo Zhang Fan Zhang 

作者机构：Department of Biochemistry and Molecular Genetics University of Colorado School of Medicine Aurora CO 80045 USA Orthopedics Department Changhai Hospital Affiliated to Second Military Medical University Shanghai 200433 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2015年第6卷第2期

页      面：88-100页

核心收录：

学科分类：0710[理学-生物学] 080503[工学-材料加工工程] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：Iron tumorigenesis p53 Wnt DNA repair,cell cycle 

摘      要：Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replica- tion, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells, Thus, multiple therapeutic strategies based on iron deprivation have been developed in cancer therapy, During the past few years, our understanding of genetic association and molecular mechanisms between iron and tumorigenesis has expanded enormously. In this review, we briefly summarize iron homeostasis in mammals, and discuss recent progresses in understanding the aberrant iron metabolism in numerous cancer types, with a focus on studies revealing altered signal transduction in cancer cells.