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Hyperpolarization-activated cyclic nucleotide-gated 2 contributes to electroacupuncture analgesia on lumbar disc herniation-induced radicular pain through activation of microglia in spinal dorsal horn

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Journal of Traditional Chinese Medicine 2022年第3期42卷 372-378页

作者： QIN Qingguang CHEN Zujiang fan weimin LI Junhua LIAO Liqing LI Yikai School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China

OBJECTIVE:To explore the mechanisms of dorsal root ganglia and spinal microglia cascade cross in electroacupuncture(EA)analgesia in the treatment of lumbar disc ***:A rat model of lumbar disc herniation(LDH)was established,EA was administered at Huantiao(GB30)acupoint 30 min once a day,for 3 *** and after modeling,and after EA,mechanical allodynia thresholds were ***-activated cyclic nucleotide-gated 2(HCN2)in dorsal root ganglia was detected by quantitative polymerase chain reaction(qPCR)and Western blot.C-X3-C motif chemokine ligand 1(CX3CL1)and activity of microglia in spinal cord was observed separately via qPCR and immunofluorescence ***:The mechanical allodynia threshold of the right planta of model rats was significantly reduced(P<0.01),EA increased the mechanical pain threshold of rats(P<0.01),and decreased HCN2 mRNA,and protein expression,reduced the expression of CX3CL1 and the activation of ***7288(a blocker of HCN channel)reduced the analgesic effect of EA from 1.83±0.84 to 0.74±0.20(P<0.05),and the expression of CX3CL1 in the spinal cord decreased from 0.52±0.11 to 0.15±0.05(P<0.01).CONCLUSION:EA analgesia on the radicular pain of LDH is *** reduced the expression of HCN2 channel in the dorsal root ganglion,thereby decreasing the noxious stimulation entered to microglia in spinal dorsal *** work supports EA is an effective treatment for radicular pain of LDH.

关键词： intervertebral disc displacement radicular pain electroacupuncture ganglia,spinal hyperpolarization-activated cyclic nucleotide-gated channels microglia

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Preparation and self-assembly of amphiphilic polymer with aggregation-induced emission characteristics

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Science China Chemistry 2012年第5期55卷 772-778页

作者： QIN AnJun ZHANG Ya HAN Ning MEI Ju SUN JingZhi fan weimin TANG Ben Zhong MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Chemistry Zhejiang UniversityHangzhou 310027China College of Medicine Zhejiang UniversityHangzhou 310027China Department of Chemistry Institute of Molecular Functional MaterialsState Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science&TechnologyClear Water BayKowloonHong KongChina

An amphiphilic polymer bearing tetraphenylethene (TPE) moiety was synthesized by convenient reactions. The polymer exhibits unique aggregation-induced emission (AIE) characteristics and can self-assemble to size-tunable particles in DMF/water mixtures. The polymer nanoparticles can be used for cell imaging, which provides a potential stable fluorescent tool to monitor the distribution of drugs and bioconjugates in living cells.

关键词： amphiphilic polymer aggregation-induced emission tetraphenylethene self-assembly cell imaging

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Summary of 2000 Fujian Hui'an China Sculpture Art Festival

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China & The World Cultural Exchange 2000年第6期66卷 36-39页

作者： fan weimin

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Risk and Intellectual Property in Technical Standard Competition： A Game Theory Perspective

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China Communications 2014年第5期11卷 136-143页

作者： XU Chaofeng fan weimin WANG Changfeng XIN Zhanhong School of Economics and Management Beijing University of Posts and Telecommunications Beijing 100876 China

Technical standard is typically characterized by network *** key point for a technical standard is the consumers' choice,which is based on consumers' maximum *** a technical standard becomes a national standard,its interests have been integrated into the national *** interests are divided into economic profits and security *** the perspective of consumers' choice,this paper deals with the main factors which affect the result of technical standard competition- the risk and profits of intellectual property based on the assumption of bounded rationality and dynamic game theory.

关键词： standard competition risk intellectual property game theory

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Ferromagnetism in sp^(2) carbon

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Nano Research 2023年第12期16卷 12883-12900页

作者： Wenxiang Wang Julienne Impundu Jiyou Jin Zhisheng Peng Hui Liu Zheng Wei Yushi Xu Yu Wang Jiawang You weimin fan Yong Jun Li Lianfeng Sun CAS Key Laboratory of Nanosystem and Hierarchical Fabrication Nanofabrication laboratoryCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China The GBA National Institute for Nanotechnology Innovation Guangzhou 510700China

The bulk,pristine sp^(2) carbons,such as graphite,carbon nanotubes,and graphene,are usually assumed to be typical diamagnetic ***,over the past two decades,there have been many reports about the ferromagnetism in these sp^(2) carbon materials,which have attracted intense interest for basic research and potential *** this review,we focus on the evidence and developments of the emergent ferromagnetism in sp^(2) carbon revealed by nine kinds of experimental methods:magnetic force microscopy(MFM),magnetization measurements with physical property measurement system(PPMS),X-ray magnetic circular dichroism(XMCD),scanning tunneling microscopy(STM),miniaturized magnetic particle inspection(MPI),anomalous Hall effect(AHE),mechanical deflection of carbon nanotube cantilevers,magnetoresistance,and spin-related devices(spin field effect transistor and spin memory).The advantages,conclusions,challenges,and future of these methods are *** ferromagnetism in sp^(2) carbon will open a door to explore exotic physical phenomena and lay the basis for the development of integrated circuit of spintronics,which is fundamentally different from charge-based conventional electronics.

关键词： ferromagnetism sp^(2)carbon anomalous Hall effect spin devices magnetoresistance

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Morphological MRI and T2 mapping of cartilage repair tissue after mosaicplasty with tissue-engineered cartilage in a pig model

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The Journal of Biomedical Research 2014年第4期28卷 309-319页

作者： Qichun Chen Qiang Zuo Qianqian Hu Yang Feng Weiding Cui weimin fan Yuefen Zou Department of Radiology the Second Hospital of Anhui Medical University Department of Orthopedics the First Affiliated Hospital of Nanjing Medical University Department of Radiology the First Affiliated Hospital of Nanjing Medical University

The aim of this study was to evaluate the efficacy of mosaicplasty with tissue-engineered cartilage for the treatment of osteochondral defects in a pig model with advanced MR technique. Eight adolescent miniature pigs were used. The right knee underwent mosaicplasty with tissue-engineered cartilage for treatment of focal osteochondral defects, while the left knee was repaired via single mosaicplasty as controls. At 6, 12, 18 and 26 weeks after surgery, repair tissue was evaluated by magnetic resonance imaging （MRI） with the cartilage repair tissue （MOCART） scoring system and T2 mapping. Then, the results of MRI for 26 weeks were compared with findings of macroscopic and histologic studies. The MOCART scores showed that the repaired tissue of the tissue-engineered cartilage group was statistically better than that of controls （P 〈 0.001）. A significant correlation was found between macroscopic and MOCART scores （P 〈 0.001）. Comparable mean T2 values were found between adjacent cartilage and repair tissue in the experimental group （P 〉 0.05）. For zonal T2 value evaluation, there were no significant zonal T2 differences for repair tissue in controls （P 〉 0.05）. For the experimental group, zonal T2 variation was found in repair tissue （P 〈 0.05）. MRI, macroscopy and histology showed better repair results and bony incorporation in mosaicplasty with the tissue-engi- neered cartilage group than those of the single mosaicplasty group. Mosaicplasty with the tissue-engineered cartilage is a promising approach to repair osteochodndral defects. Morphological MRI and T2 mapping provide a non-invasive method for monitoring the maturation and integration of cartilage repair tissue in vivo.

关键词： cartilage repair mosaicplasty tissue engineering magnetic resonance imaging T2 mapping

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Effects of bone morphogenetic protein on the osseointegration of porous-surfaced implants:An experimental study in rabbits

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Journal of Nanjing Medical University 2006年第6期20卷 335-340页

作者： Yimin Ma weimin fan Yu Zhang Department of Orthopedic Surgery the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Objective： Research on enhancing early osseointegration of cementless implants to improve early fixation and reducing of risk of loosening. Methods ： Thirty New Zealand rabbits were divided into two groups at random. BMP combined with DBM 30 mg was inserted around the prosthesis in 15 rabbits as experimental group, the remaining rabbits were served as control group. After 4, 8, and 12 weeks, five rabbits were sacrificed in each group. The humerus with the implants were retrieved. Bone ingrowth was analyzed by none-decalcification bone ground section and biomechanical test. Results： At the end of 4 and 8 weeks the osseointegration rates of BMP group were higher than those of control （P 〈 0.05）. The ultimate shear strength between BMP treated implantation and the control was the same as the results in osseointegration rates at 4, 8 weeks （P 〈 0.05）. However, there was no difference between the treated and untreated group in the osseointegration rate and ultimate shear strength at 12 weeks （P 〉 0.05）. Conclusion： BMP combination can enhance bone growth into gaps around cementless implants, especially in the early postoperative period.

关键词： osseointegration BMP implant fixation rabbit

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通痹七物方对痛风性关节炎NLRP3炎症小体、线粒体自噬蛋白的影响

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中药新药与临床药理 2020年第7期31卷 769-774页

作者：范为民皖南医学院弋矶山医院中医科安徽芜湖241001 南方医科大学中医药学院广东广州510515

目的探讨通痹七物方对痛风性关节炎(Gouty Arthritis,GA)大鼠的防治作用及对NOD样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎症小体、线粒体自噬蛋白的影响。方法将36只大鼠随机分为空白对照组,模型组,秋水仙碱组,通痹七物方低、... 详细信息

目的探讨通痹七物方对痛风性关节炎(Gouty Arthritis,GA)大鼠的防治作用及对NOD样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎症小体、线粒体自噬蛋白的影响。方法将36只大鼠随机分为空白对照组,模型组,秋水仙碱组,通痹七物方低、中、高剂量组,每组6只。空白对照组、模型组给予同体积生理盐水,秋水仙碱组给予秋水仙碱0.3 mg·kg^-1水溶液,通痹七物方低、中、高剂量组分别给予通痹七物方浓缩配方颗粒800、1600、3200 mg·kg^-1水溶液。上述各组连续灌胃给药7 d。第5天给药后,除空白对照组外,其余各组大鼠右膝关节腔注射0.1 mL单钠尿酸盐(Monosodium urate,MSU)结晶溶液,进行模型制备。以上各组在模型制备24 h、48 h后进行步态评分,实验结束观察病理组织形态,检测血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)的含量,检测NLRP3、半胱氨酸蛋白酶1(Caspase-1)、白细胞介素1β(IL^-1β)、自噬微管相关蛋白轻链3B(Autophagy microtubule associated protein light chain 3B,LC3B)、P62、抗增殖蛋白2(PHB2)蛋白的表达。结果与空白对照组比,模型组的步态评分明显上升,滑膜病理提示细胞增生、间质高度水肿伴大量中性粒细胞浸润,血清TNF-α、IL-6水平升高。滑膜NLRP3、Caspase-1、IL^-1β、LC3B、P62、PHB2蛋白表达量不同程度增加,差异有统计学意义(P<0.01,P<0.05)。与模型组相比,秋水仙碱组,通痹七物方低、中、高剂量组上述指标均有不同程度的改善,差异有统计学意义(P<0.01,P<0.05)。结论通痹七物方能够防治痛风性关节炎,其作用机制可能与调控线粒体自噬,抑制NLRP3炎症小体激活有关。

关键词：通痹七物方痛风性关节炎 NLRP3 炎症小体线粒体自噬大鼠

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Dietary Cadmium Intake and Risks of Adverse Pregnancy Outcomes in Rural Women of Jiangxi Province

Dietary Cadmium Intake and Risks of Adverse Pregnancy Outcom...

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第十七届中国科协年会——分12　新时代下大营养观专题论坛

作者： WANG Yanyan FU Junjie HE Jiafen fan weimin YANG Yan Department of Nutrition School of Public Health Sun Yat-sen University (Northern Campus) Jiangxi Province Center for Disease Control and Prevention

Cadmium(Cd) is a ubiquitous toxic metal that has been shown to be teratogenic and embryotoxic after long-term exposure. The diet is the main source of Cd exposure in non-smokers. However, the relationships between dietary Cd intake and adverse pregnancy outcomes haven’t been studied before. Therefore, we evaluated the association of dietary Cd intake and adverse pregnancy outcome, spontaneous abortion, stillbirth and birth defects by the cross-sectional study in Jiangxi province, China. Sociodemographic information, pregnancy experience and dietary habit information were collected from 1346 fertile women, who were 25-54 years old. Local food samples were directly collected from local farmland, and Cd concentrations were determined by flame atomic absorption spectrophotometry. Non-conditional binary logistic regression models were used to model the associations between dietary Cd intake and adverse pregnancy outcomes. The results showed that the median(quartile range) Cd intake was 24.766(13.228-56.819) μg/d. Based on the full adjusted models, the ORs(95% CIs) for adverse pregnancy outcome and spontaneous abortion, comparing the highest quartile versus the lowest quartile of dietary Cd intake, were 1.700(95%CI: 1.056, 2.735) and 2.173(95%CI: 1.239, 3.813), while the ORs(95% CIs) for stillbirth and birth defects were 1.472(95%CI: 0.551, 3.932) and 0.565(95%CI: 0.164, 1.953), respectively. Dietary Cd intake was significantly positively associated with adverse pregnancy outcome and spontaneous abortion(P=0.008, 0.010, respectively), nevertheless, the linear trends didn’t observed in fully adjusted models using stillbirth and birth defects as the dependent *** conclusion, dietary Cd intake is positively associated with adverse pregnancy outcome and spontaneous abortion, however, no significant associations are observed with stillbirth and birth defects. Additional work should to be done to explore the causal relationship between dietary Cd intake and adverse pre

关键词： dietary Cd exposure adverse pregnancy outcome spontaneous abortion stillbirth birth defects

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FLOOD SIMULATION IN DONGTING LAKE DRAINAGE AREA AND ITS FLOOD CONTROL

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Geotectonica et Metallogenia 1998年第Z1期22卷 90-96页

作者： Huang Huaiyong Du Guoquan fan weimin and Chen Guanghao(Changsha Institute of Geotectonics, Academia Sinica, Changsha 410013)

On the basis of water-balance equation in Dongting Lake and Xiang Zi Yuan-Li River drainage areas, a possib1e flood height relating to the rainfall precipitation in these areas has been inferred. According to the flood simulation, some synthetic maintenance strategies to prevent future catastrophic f1oods in Dongting Lake drainage area have been also presented.

关键词： Dongting Lake drainage area flood simulation synthetic maintenance

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