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Chinese Chemical Letters 2011年第7期22卷 831-834页

作者： fan Lei Wei fan Xian Kun li Shan Wang li Hai Yong Wu Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University Chengdu 610041 China

A series of glucose-cholesterol derivatives 8a-8e as ligands for brain targeting liposomes were synthesized. The preparation of compound 6 involved temporary protection of glucose with chlorotrimethylsilicane and hexamethyldisilazane followed by selectively hydrolyzed. The known cholesteryl tosylate 1 were coupled to ethylene glycols to afford alcohol 2a-2e. Substitution and deprotection of alcohol 2a-2e furnished the acids 4a-4e, which was condensed with compound 6 to get compounds 7a-7e, and then was deprotected in tetrahydrofuran with TFA to obtain the title compounds. As a model drug, tegafur was entrapped by liposomes coupled with 8b, and preliminary in vivo evaluation shown 8b could enhance the ability of liposomes delivering tegafur across the blood brain barrier.

关键词： liposome ligands Brain target GLUTt transporter Tegafur Synthesis

Influence of TiCl_4 treatment on performance of dye-sensitized solar cell assembled with nano-TiO_2 coating deposited by vacuum cold spraying

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Rare Metals 2006年第z1期25卷 163-168页

作者： fan Shengqiang li Changjiu YANG Guanjun ZHANG lingzi State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049China State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049China State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049China State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi''an Jiaotong University Xi''an 710049China

Titanium tetrachloride (TiCl4) treatment was employed to TiO2 coating deposited on fluoride-doped tin oxide (FTO) conducting glass and indium oxide doped tin oxide (ITO) conducting glass, respectively. The nano-crystalline TiO2 coating was deposited using a composite powder composed of polyethylene glycol (PEG) and 25 nm TiO2 particles by vacuum cold spraying (VCS) process. A commercial N-719 dye was used to adsorb on the surface of TiO2 coating to prepare TiO2 electrode, which was applied to assemble dye-sensitized solar cell (DSC). The cell performance was measured under simulated solar light at an intensity of 100 mW·cm-2. Results show that with an FTO substrate the DSC composed of a VCS TiO2 electrode untreated by TiCl4 gives a short-circuit current density of 13.1 mA·cm-2 and an open circuit voltage of 0.60 V corresponding to an overall conversion efficiency of 4.4%. It is found that after TiCl4 treatment to the VCS TiO2 electrode with an FTO substrate, the short circuit current density of the cell increases by 31%, the open-circuit voltage increases by 60 mV and a higher conversion yield of 6.5% was obtained. However, when an ITO substrate is used to deposit TiO2 coating by VCS, after TiCl4 treatment, the conversion efficiency of the assembled cell reduces slightly due to corrosion of the conducting layer on the ITO glass by TiCl4.

关键词： titanium tetrachloride treatment vacuum cold spraying dye-sensitized solar cell nano-crystalline TiO2 coating

Decomposed input-output stability analysis and enhancement of integrated power systems

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Science China(Technological Sciences) 2018年第3期61卷 427-437页

作者： li fan CHEN Ying QIN BoYu SHEN Chen Department of Electrical Engineering Tsinghua University State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical Engineering Xi'an Jiaotong University

The integrated power system(IPS) is a foundation of all-electrical ships and vessels. The stability of IPS becomes a prerequisite of complicated cruise tasks. Thus, advanced stability analysis and regulation methods for IPS are of great importance. In this paper, a novel method is proposed for analyzing and enhancing transient stability of IPS, which is regarded as a cyber-physical system comprising of subsystems and connections. Criterions for determining input-output stability of such a system are firstly derived. Then, the stability analysis of IPS can be performed in the following two steps: 1) evaluating local input-output stability features of each subsystem independently through simulations. 2) Checking stability criterions with system topology and subsystem stability features. Moreover, synthetic approaches are proposed for stabilization and stability enhancement of IPS. To avoid system in-stability after major failures or topology changes, the optimal emergency control is performed to reconfigure subsystems. The other optimal regulation is used to strengthen system stability by adjusting subsystems' control parameters during normal operation conditions. Case studies on a typical IPS validate the proposed stability analysis and enhancement approach.

关键词： input-output stability stability criteria stability enhancement integrated power systems

Dual characteristic of trace rare earth elements in a commercial casting Al-Cu-X alloy

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Rare Metals 2015年第5期34卷 308-313页

作者： li fan Qi-Tang Hao Wen-Ke Han State Key Laboratory of Solidification Processing Northwestern Polytechnical University School of Materials Science and Engineering Northwestern Polytechnical University

The effect of rare earth elements on microstructure and mechanical properties of casting Al-Cu-X alloy （X = Mn, Ti, V, Cd, Zr） was investigated in as-cast and T6 conditions. Microstructure evolution was characterized by optical microscopy, scanning electron microscopy, and transmission electron microscopy. RE-containing intermetallic compounds （IMCs） formed in this alloy were indentified by X-ray diffraction （XRD） and energy dispersive spectroscopy （EDS）. It is shown that the additions of RE （60Ce-40La, wt%） result in the formation of Ce-rich blocky-shaped A12o（Ti, V）2RE and La-rich skeletal-shaped A18Cu4RE. Tensile results of samples after T6 treatment indicate that the strength and ductility increase slightly to 480 MPa and 9.7 %, respectively, with RE content increasing from 0 wt% to 0.3 wt%. This is due to the combinative hardening effects of reduced grain size, enhanced precipitation of 0＇（Al2Cu） phase and Al20 Cu2Mn3 dispersed particles, and minor La-rich IMCs at the grain boundaries of α-Al dendrites. The decrease of strength of 0.5 wt% RE-added sample is ascribed to the aggregation of Al20（Ti, V）2RE IMCs inside the grains. The dual characteristic of rare earth elements was also discussed in terms of its positive and negative effects on mechanical properties.

关键词： Aluminum alloys Rare earth Microstructure Mechanical property Intermetallic compounds

Laser-enhanced thermal effect of moderate intensity focused ultrasound on bio-tissues

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Science China(Physics,Mechanics & Astronomy) 2017年第9期60卷 28-36页

作者： JinYu Zhao ShuYi Zhang XiuJi Shui li fan Laboratory of Modern Acoustics Institute of Acoustics Collaborative Innovation Center of Advanced Microstructures Nanjing University

For avoiding extra-damage to healthy tissues surrounding the focal point during high intensity focused ultrasound(HIFU) treatment in medical therapy, to reduce the ultrasonic intensity outside the focal point is expected. Thus, the heating processes induced by moderate intensity focused ultrasound(MIFU) and enhanced by combined irradiation of laser pulses for bio-tissues are studied in details. For fresh bio-tissues, the enhanced thermal effects by pulsed laser combined with MIFU irradiation are observed experimentally. To explore the mechanisms of these effects, several tissue-mimicking materials composed of agar mixed with graphite powders are prepared and studied for comparison, but the laser-enhanced thermal effects in these mimicking materials are much less than that in the fresh bio-tissues. Therefore, it is suggested that the laser-enhanced thermal effects may be mainly attributed to bio-activities and related photo-bio-chemical effects of fresh tissues.

关键词： bio-tissue focused ultrasound laser pulse irradiation thermal effect

Recent Progress in Donor-Acceptor Type Conjugated Polymers for Organic Field-effect Transistors

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Chinese Journal of Polymer Science 2023年第5期41卷 652-670,I0006页

作者： Yi-fan li Yun-Long Guo Yun-Qi liu Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic solidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The recent progress in the design and synthesis of high-performance donor-acceptor conjugated polymeric semiconducting materials is reviewed from the perspective of multiscale *** multiscale of conjugated polymers is from the primary one-dimensional polymer molecular scale to the secondary polymer-chains interaction scale,and then to the tertiary polymer aggregate *** review focuses on the design and synthesis of polymer molecules,proposes new classification rules,and rationally summarizes the design strategies and modulation methods of *** describe the recent progress from these three aspects:(1)the modification ofπ-conjugated backbone,(2)the evolution of the polymerization methods,and(3)the regulation of aggregate-state structure.

关键词： Conjugated polymers Donor-acceptor Organic field-effect transistors Multiscale optimization

Electrochemical response of MoS_(2) nanosheets/SiO_(2)-NH_(2) nanoparticles modified glassy carbon electrode to phenylacetic acid

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Rare Metals 2023年第12期42卷 4142-4152页

作者： Tian-Yao Qi Zhen-Yu Yuan fan-li Meng College of Information Science and Engineering Northeastern UniversityShenyang 110819China Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology Qinhuangdao 066004China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationShenyang 110819China

Phenylacetic acid(PAA)is a primary raw material for illegal Methamphetamine(MATM)synthesis under the strong precursor chemicals supervisions of safrole and ***,trace detection of PAA at ultra-low concentration is a strategic technique and an urgent issue in the field of drug *** this paper,trace determination of PAA at sub-nmol-L-1 concentration level is achieved by hydrogen bond adsorption and electrochemical catalysis through the prepared aminated SiO_(2)nanoparticles(SiO_(2)-NH_(2) NPs)and MoS_(2) nanosheets(NSs)modified glassy carbon electrode(GCE).The prepared MoS_(2) NS s/SiO_(2)-NH_(2) NPs modified electrode represents a detecting limit of 0.0989 nmol·L^(-1)and an obvious increasing linear range before the concentration increasement up to 60 nmol·L^(-1)in square wave voltammetry(SWV)responses of *** SWV response of the modified electrode to PAA in the concentration range within 100 nmol·L^(-1)is higher than phenol,acetic acid(HOAc)and benzoic Acid(BEN).This electrochemical method for trace detection of PAA in aqueous solution with desired performance provides a feasible scheme for the detection of other drugs and aromatic precursor chemicals.

关键词： Phenylacetic acid detection Modified electrode MoS_(2)nanosheet Square wave voltammetry

UAVs cooperative task assignment and trajectory optimization with safety and time constraints

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Defence Technology（防务技术） 2023年第2期20卷 149-161页

作者： Duo Zheng Yun-fei Zhang fan li Peng Cheng UAV Autonomous Control Institute Beijing Institute of TechnologyBeijing100081China Shanghai Institute of Mechanical and Electrical Engineering Shanghai201100China CASIC Research Institute of Intelligent Decision Engineering Wuhan100074China

This paper proposes new methods and strategies for Multi-UAVs cooperative attacks with safety and time constraints in a complex *** triangle is designed to construct a map of the complex flight environment for aerial ***-Map,Safe Flight Corridor(SFC),and Relative Safe Flight Corridor(RSFC)are applied to ensure each UAV flight trajectory's *** using such techniques,it is possible to avoid the collision with obstacles and collision between ***-curve is further developed to ensure that multi-UAVs can simultaneously reach the target at the specified time,and the trajectory is within the flight *** trajectory tracking controller is also designed based on model predictive control to track the planned trajectory *** simulation and experiment results are presented to verifying developed strategies of Multi-UAV cooperative attacks.

关键词： Multi-UAV Cooperative attacks Task assignment Trajectory optimization Safety constraints

Identification of reference genes provides functional insights into meiotic recombination suppressors in Gerbera hybrida

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Horticultural Plant Journal 2022年第1期8卷 123-132页

作者： fan li Ying Cheng Lulin Ma Shenchong li Jihua Wang Floriculture Research Institute Yunnan Academy of Agricultural SciencesNational Engineering Research Center for Ornamental HorticultureKey Laboratory for Flower Breeding of Yunnan ProvinceKunming 650200China School of Agriculture Yunnan UniversityKunming 650504China

Gerbera Hybrida is one of the important cut flowers across the *** novel traits are the primarily market requirements and the breeding targets,mainly determined by the degree of genetic variation after ***,meiotic recombination is highly conserved in most eukaryotes which suppressed the crossover formation and limited the genetic ***,several meiotic recombination suppressors have been identified and characterized in plants,whereas it remains elusive in *** order to characterize the expression patterns of these suppressors in ***,20 candidate reference genes were identified from the transcriptome datasets of ***,and their expression stabilities during plant development were evaluated by geNorm,NormFinder and *** the most stable reference genes were variable in different softwares,comprehensive ranking revealed that PGK2 was the most stable reference gene and GAPDH was the most unstable *** expression patterns of fanCM,FIGL1,RECQ4,RM1,and FliP further validated that PGK2 was suitable for normalization of gene *** study identified a reliable reference gene for gene expression during meiotic recombination,and provided functional insights into meiotic recombination suppressors in ***.

关键词： erbera hybrida Reference gene Gene expression Meiotic recombination suppressor

Identification and Expression of TOP3αin Gerbera hybrida

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Horticultural Plant Journal 2021年第2期7卷 167-173页

作者： Shenchong li Ying Cheng Dan Sun Lulin Ma Mingyang li fan li College of Horticulture and Landscape Architecture Southwest UniversityChongqing 400715China Key Laboratory for Flower Breeding of Yunnan Province National Engineering Research Center for Ornamental HorticultureFloriculture Research InstituteYunnan Academy of Agricultural SciencesKunming 650200China School of Agriculture Yunnan UniversityKunming 650504China

Meiotic recombination and the resulting novel allele combinations are fundamental to plant breeding and the identification of superior ***,the rate of meiotic crossovers is naturally suppressed below its potential ability,which prevents plant breeding *** suppressors of meiotic recombination have been identified in the model plant Arabidopsis and in other crop *** in these genes can lead to increased recombination frequency and could therefore potentially be used to create hyper-recombinant lines for ornamental *** Gerbera hybrida,the anti-crossover factors remain *** this study,we isolated and cloned TOP3αfrom flower buds of ***,and it encoded 935 amino acids with three conserved domains TOPRIM,TOP1Ac and ***,TOP3αwas the highest expressed at the flower bud stage,which coincided with the occurrence of meiotic recombination,suggesting that TOP3αis associated with the regulation of meiotic recombination in ***.

关键词： Gerbera hybrida meiotic recombination TOP3α gene expression ornamental breeding