Laser-enhanced thermal effect of moderate intensity focused ultrasound on bio-tissues

作     者：JinYu Zhao ShuYi Zhang XiuJi Shui Li Fan 

作者机构：Laboratory of Modern Acoustics Institute of Acoustics Collaborative Innovation Center of Advanced Microstructures Nanjing University 

出 版 物：《Science China(Physics,Mechanics & Astronomy)》 (中国科学：物理学、力学、天文学（英文版）)

年 卷 期：2017年第60卷第9期

页      面：28-36页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 070206[理学-声学] 0802[工学-机械工程] 100215[医学-康复医学与理疗学] 0702[理学-物理学] 10[医学] 

基　　金：supported by the Special Funds for Quality Supervision Inspection and Quarantine Research in Public Interest of China(Grant No.201510068) 

主　　题：bio-tissue focused ultrasound laser pulse irradiation thermal effect 

摘      要：For avoiding extra-damage to healthy tissues surrounding the focal point during high intensity focused ultrasound(HIFU) treatment in medical therapy, to reduce the ultrasonic intensity outside the focal point is expected. Thus, the heating processes induced by moderate intensity focused ultrasound(MIFU) and enhanced by combined irradiation of laser pulses for bio-tissues are studied in details. For fresh bio-tissues, the enhanced thermal effects by pulsed laser combined with MIFU irradiation are observed experimentally. To explore the mechanisms of these effects, several tissue-mimicking materials composed of agar mixed with graphite powders are prepared and studied for comparison, but the laser-enhanced thermal effects in these mimicking materials are much less than that in the fresh bio-tissues. Therefore, it is suggested that the laser-enhanced thermal effects may be mainly attributed to bio-activities and related photo-bio-chemical effects of fresh tissues.