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不同档位脊神经后支低温等离子消融术治疗慢性关节突关节源性腰痛

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中国疼痛医学杂志 2024年第8期30卷 585-591页

作者：林鹋苗羽朱谦毛鹏司马蕾樊碧发福建省立医院疼痛科福建医科大学省立临床医学院福州大学附属省立医院福州350001 中日友好医院疼痛科北京100029

目的:探讨不同档位的低温等离子消融术(low-temperature plasma radiofrequency ablation,LTPRA)治疗慢性关节突关节源性腰痛的临床疗效及安全性,为临床提供理论依据。方法:纳入2021年2月至2022年2月在中日友好医院疼痛科接受LTPRA治疗... 详细信息

目的:探讨不同档位的低温等离子消融术(low-temperature plasma radiofrequency ablation,LTPRA)治疗慢性关节突关节源性腰痛的临床疗效及安全性,为临床提供理论依据。方法:纳入2021年2月至2022年2月在中日友好医院疼痛科接受LTPRA治疗的92例慢性关节突关节源性腰痛住院病人,根据LTPRA治疗的档位分为1档组(平均功率13 W,术区温度40℃左右,51例)与3档组(平均功率49 W,术区温度60℃左右,41例)。分别对两组术前、术后第2周、1、3、6、12个月的疼痛数字分级评分法(numerical rating scale,NRS)评分、Oswestry功能障碍指数(Oswestry disability index,ODI)、非甾体抗炎药(nonsteroidal antiinflammatory drugs,NSAIDs)和/或阿片类药物的使用情况、手术相关并发症进行随访评估以及统计学分析。结果:与术前相比,术后2周、1、3、6、12个月两组NRS评分和ODI评分均明显下降;药物使用率显著下降。组间比较发现,术后1个月至12个月3档组NRS评分均低于1档组,术后2周以及术后6个月至术后12个月,3档组ODI评分均低于1档组,差异有统计学意义。3档组中更多比例病人出现术后短期轻度并发症,但差异无统计学意义。结论:针对慢性关节突关节源性腰痛,1档、3档治疗均有效,3档的治疗效果更优、持续时间更长,术后短期可能出现轻度的并发症,但术后并发症与1档相比无明显差异。

关键词：慢性关节突关节源性腰痛低温等离子消融术不同档位 NRS评分 Oswestry功能障碍指数

Change of Electronic Structure and Magnetic Properties with MgO and Fe Thicknesses in Fe/MgO/Fe Magnetic Tunnel Junction

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Chinese Journal of Aeronautics 2006年第B12期19卷 151-155页

作者： YANG fan bi Xiao-fang School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics 100083 Beijing China

The effects of the thickness of MgO and Fe on the electronic structure and magnetic properties of Fe/MgO/Fe magnetic tunnel junction was studied using the first principle method. Two series of models with MgO of different thicknesses： Fe（3）MgO（t）Fe（3）（t-=1,3,5,7） and with Fe of varied thicknesses： Fe（t）MgO（3）Fe（t）（t=3,4,5,6,7） were established. Calculated results show that in all the models the magnetic moment of Fe increases at the Fe/MgO interface and surface as compared with that of the inner layers. The mag- netic moment of each Fe layer was found to be independent of MgO thicknesses, while the spin-polarization of Fe layer at the interface shows a slight change in function of the MgO thicknesses. The tunneling magnetoresistance （TMR） ratio estimated by the Julliere model has the same change tendency as the spin-polarization has, and the largest value is obtained at the MgO thickness of 5 atomic layers. When the Fe thickness increases, the spin-polarization of interface Fe layer follows up an increase with a decrease. The highest TMR value is achieved when the Fe thickness is of 4 atomic layers.

关键词： Fe/MgO/Fe electronic structure tunnel magnetoresistance thicknesses

Wave Effect on the Ocean Circulations Through Mass Transport and Wave-Induced Pumping

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Journal of Ocean University of China 2014年第2期13卷 175-182页

作者： bi fan WU Kejian Physical Oceanography Laboratory Ocean University of China

The wave Coriolis-Stokes-Force-modified ocean momentum equations are reviewed in this paper and the wave Stokes transport is pointed out to be part of the ocean circulations. Using the European Centre for Medium-Range Weather Forecasts 40-year reanalysis data(ERA-40 data) and the Simple Ocean Data Assimilation(SODA) version 2.2.4 data, the magnitude of this transport is compared with that of wind-driven Sverdrup transport and a 5-to-10-precent contribution by the wave Stokes transport is found. Both transports are stronger in boreal winter than in summers. The wave effect can be either contribution or cancellation in different seasons. Examination with Kuroshio transport verifies similar seasonal variations. The clarification of the efficient wave boundary condition helps to understand the role of waves in mass transport. It acts as surface wind stress and can be functional down to the bottom of the ageostrophic layer. The pumping velocities resulting from wave-induced stress are zonally distributed and are significant in relatively high latitudes. Further work will focus on the model performance of the wave-stress-changed-boundary and the role of swells in the eastern part of the oceans.

关键词： Stokes transport Sverdrup transport wave pumping velocity western boundary currents

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邮轮烟囱排气消声器选型及结构设计

船海工程 2024年第2期53卷 76-80页

作者：郭正扬樊创碧张帆王志强王金朝中国船舶集团公司第七二五研究所洛阳双瑞橡塑科技有限公司河南洛阳471023

针对邮轮主机正常运转排气时对排气消声器的声学性能及空气动力性能的要求,以某型邮轮烟囱排气消声器为研究对象,基于主机排气噪声源特性开展声场、流场特性分析,对比多个方案结果表明,当消声器内插管孔隙率不变,仅改变孔径大小及数量... 详细信息

针对邮轮主机正常运转排气时对排气消声器的声学性能及空气动力性能的要求,以某型邮轮烟囱排气消声器为研究对象,基于主机排气噪声源特性开展声场、流场特性分析,对比多个方案结果表明,当消声器内插管孔隙率不变,仅改变孔径大小及数量对消声器声学性能几乎没有影响;适当减小孔径大小并增加孔径数量可以有效改善消声器流场性能,以保证主机正常运作的经济性和动力性。

关键词：消声器流场声学性能空气动力性能

The effect of Stokes drift on Ekman transport in the open sea

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Acta Oceanologica Sinica 2012年第6期31卷 12-18页

作者： bi fan WU Kejian ZHANG Yuming Physical Oceanography Laboratory Ocean University of ChinaQingdao 266100China

By introducing the wave-induced Coriolis-Stokes forcing into ageostrophic motion equation, th1 Eulerian transport is modified by the wave-induced Stokes drift. The long-term mean contributions of the Stokes transport with remotely generated swells being included to the ageostrophic transport are analyzed using the ECMWF （European Centre for Medium-Range X,Veather Forecasts） reanalysis data. The ratio of Stokes transport to Ekman transport in north-south （N-S） direction can reach maximum of over 50% in the subtropical region. The preliminary influence of the Stokes transport on the North Pacific gyre is all year persistent, while the effect on the North Atlantic gyre is only obvious in boreal winter and early spring.

关键词： Stokes transport Ekman transport ocean swell ocean gyres

基于网络药理学及分子对接探讨枳实-白芍药对镇痛的作用机制

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中国疼痛医学杂志 2024年第7期30卷 501-508,514页

作者：刘春华樊碧发张媛婧胡慧敏李晨李怡帆张毅毛鹏北京中医药大学研究生院北京2100029 中日友好医院疼痛科北京100029

目的:运用网络药理学和分子对接分析枳实-白芍药对镇痛的作用机制。方法:利用中药系统药理学数据库和分析平台检索枳实、白芍的有效成分及对应靶点,GeneCards、DisGeNet以及OMIM数据库检索疼痛相关基因靶点,取两者交集靶点,借助STRING... 详细信息

目的:运用网络药理学和分子对接分析枳实-白芍药对镇痛的作用机制。方法:利用中药系统药理学数据库和分析平台检索枳实、白芍的有效成分及对应靶点,GeneCards、DisGeNet以及OMIM数据库检索疼痛相关基因靶点,取两者交集靶点,借助STRING数据库构建蛋白互作网络图,应用Cytoscape3.9.1软件筛选核心靶点,构建“药物-成分-靶点”网络图。通过DAVID数据库对共同靶点进行GO和KEGG通路富集分析。通过AutoDock 1.5.7对主要成分和核心靶点进行分子对接。结果:经筛选获得药物有效成分16个,药物与疾病共同靶点75个,其中肿瘤坏死因子(tumor necrosis factor,TNF)、白细胞介素-6(interleukin-6,IL-6)、丝氨酸/苏氨酸蛋白激酶1(serine/threonine-protein kinase 1,AKT1)、血管内皮生长因子A(vascular endothelial growth factorA,VEGFA)、肿瘤蛋白P53(tumor protein P53,TP53)等17个核心靶点可能是枳实-白芍药对镇痛的关键靶点。GO生物学过程主要涉及基因表达正调控、对外源性刺激的反应、脂多糖介导的信号通路等,KEGG信号通路主要涉及TNF信号通路、磷脂酰肌醇3-激酶(phosphoinositide 3 kinase,PI3K)/丝氨酸-苏氨酸激酶(serine-threonine kinase,Akt)信号通路、癌症通路等。分子对接结果显示主要成分与核心靶点结合较好。结论:枳实-白芍药对中的木犀草素、山柰酚、柚皮素等有效成分可能通过作用于TNF、IL-6、AKT1、VEGFA、TP53等靶点来调节TNF信号通路、PI3K-Akt信号通路、癌症通路等通路发挥镇痛作用。

关键词：枳实白芍疼痛网络药理学分子对接

The temporal and spatial variations in the Pacific wind and wave fields for the period 2002–2011

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Acta Oceanologica Sinica 2017年第3期36卷 26-36页

作者： XU Yao bi fan SONG Jinbao HE Hailun Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China North China Sea Marine Forecasting Center of State Oceanic Administration Qingdao 266061China Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China Ocean College Zhejiang UniversityHangzhou 310058China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic AdministrationHangzhou 310012China

The temporal and spatial variations in the wind and wave fields in the Pacific Ocean between 2002 and 2011 are analyzed using a third-generation wave model（WAVEWATCH III）. The model performance for a significant wave height is validated using in situ buoy data. The results show that the wave model effectively hindcasts the significant wave height in the Pacific Ocean, but the errors are relatively large in the mid- and low-latitude regions. The spatial distributions and temporal variations in a wind speed and the significant wave height in the Pacific Ocean are then considered after dividing the Pacific Ocean into five regions, which show meridional differences and seasonal cycles. Regional mean values are used to give yearly average time series for each separate zone. The high latitude region in the Southern Hemisphere had a stronger significant wave height trend in the model results than regions at other latitudes. The sources and sinks of wave energy are then investigated. Their regional mean values are used to quantify variations in surface waves. Finally, the spectral analyses of the daily mean wind speeds and the significant wave heights are obtained. The significant wave height and the wind speed spectra are found to be connected in some ways but also show certain differences.

关键词： the Pacific Ocean wind speed significant wave height temporal and spatial variations WAVEWATCH Ⅲ

Evaluation of the simulation capability of the Wavewatch Ⅲ model for Pacific Ocean wave

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Acta Oceanologica Sinica 2015年第9期34卷 43-57页

作者： bi fan SONG Jinbao WU Kejian XU Yao Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences College of Physical and Environmental Oceanography Ocean University of China Ocean College Zhejiang University Key Laboratory of Physical Oceanography (Ocean University of China) Ministry of Education

Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model （v3.14 and v4.18） are compared and assessed in this study through comprehensive observations, including altimeter significant wave height, advanced synthetic aperture radar swell, and buoy wave parameters and spectrum. In addition to the evaluation of typically used integral parameters, the spectra partitioning method contributes to the detailed wave system and wave maturity validation. The modified performance evaluation method （PS） effectively reduces attribute numbers and facilitates the overall assessment. To avoid possible misleading results in the root mean square error-based validations, another indicator called HH （indicating the two authors） is also calculated to guarantee the consistency of the results. The widely used Tolman and Chalikov （TC） package is still generally efficient in determining the integral properties of wave spectra but is physically deficient in explaining the dissipation processes. The ST4 package performs well in overall wave parameters and significantly improves the accuracy of wave systems in the open ocean. Meanwhile, the newly published ST6 package is slightly better in determining swell energy variations. The two packages （ACC350 and biA） obtained from Wavewatch III v3.14 exhibit large scatters at different sea states. The three most ideal packages are further examined in terms of reproducing wave- induced momentum flux from the perspective of transport. Stokes transport analysis indicates that ST4 is the closest to the NDBC-buoy-spectrum-based transport values, and TC and ST6 tend to overestimate and underestimate the transport magnitude, respectively, in swell mixed areas. This difference must be considered, particularly in air-wave-current coupling research and upper ocean analysis. The assessment results provide guidance for the selection of ST4 for use in a backgrou

关键词： Wavewatch III evaluation Pacific Ocean source and sink term packages wave-induced flux Stokes transport

Long-term trend analysis of wave characteristics in the Bohai Sea based on interpolated ERA5 wave reanalysis from 1950 to 2020

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Acta Oceanologica Sinica 2022年第7期41卷 97-112页

作者： Jichao Wang Peidong Sun Zhihong Liao fan bi Guiyan Liu College of Science China University of PetroleumQingdao266580China National Meteorological Information Center Beijing100081China North China Sea Marine Forecasting Center of State Oceanic Administration Qingdao266061China Shandong Provincial Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao266061China

Reasonably understanding of the long-term wave characteristics is very crucial for the ocean engineering.A feedforward neural network is operated for interpolating ERA5 wave reanalysis in this study,which embodies a detailed record from 1950 *** spatiotemporal variability of wave parameters in the Bohai Sea,especially the significant wave height(SWH),is presented in terms of combined wave,wind wave and swell by employing the 71 years(1950–2020)of interpolated ERA5 *** mean SWH decreases at−0.12 cm/a estimated by Theil-Sen estimator and 95th percentile SWH reflecting serve sea states decreases at−0.20 cm/***-seasonal analysis shows SWH of wind wave has steeper decreasing trend with higher slopes than that of swell,especially in summer and winter,showing the major decrease may attribute to the weakening of *** inner Bohai Sea reveals a general decreasing trend while the intersection connecting with the Yellow Sea has the lower significance derived by Mann-Kendall ***,95th percentile SWH decreases at a higher rate while with a lower significance in comparison with the mean *** frequencies of mean wave directions in sub-sector are statistically calculated to find the seasonal prevailing ***,the dominant directions in summer and winter are south and north.A similar variation concerning to SWH,the trend of the mean wave period is provided,which also shows a decrease for decades.

关键词： wave characteristic wind wave swell long-term trend Bohai Sea