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Encapsulated Fe(IV)Molecular Complex for Photoacoustic Imaging

CCS Chemistry 2024年第5期6卷 1184-1197页

作者： Ye Xu Chao Li Zhong-Yu Yu Jiamin Wang Zhaoyang Liu Chao Jiang zhen-feng Chen Xiaoyu Wu Ming-Xing Li Hong Yang Zhao-Xi Wang Jonathan L.Sessler Department of Chemistry Center for Supramolecular Chemistry and CatalysisInnovative Drug Research CenterShanghai UniversityShanghai 200444 College of Chemistry and Materials Science Shanghai Key Laboratory of Rare Earth Functional MaterialsShanghai Frontiers Science Center of Biomimetic CatalysisShanghai Normal UniversityShanghai 200234 Sijing Community Health Service Center of Songjiang District Shanghai 201601 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuilin 541004 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224

stable neutral Fe(IV)complex(Fe-HDCL),readily accessible on the g scale,was found to possess high water solubility and good stability(<5%degradation over 4 h upon photoirradiation).Fe-HDCL is green and absorbs light effectively in the visible region(500–800 nm)with aλmax at 650 nm(ɛ=7830 M^(−1)cm^(−1)).Fe-HDCL also exhibits photothermal(PT)behavior comparable to single-wall carbon nanotubes in the solid *** aqueous solution,high PT conversion(η=72.6%)is achieved,and a strong hyperthermia-based inhibition of cell growth is observed upon subjecting Fe-HDCL to near-infrared 730 nm laser *** biological studies in vitro and in vivo confirmed that Fe-HDCL is biocompatible,clears readily,and allows the visual detection of blood *** subjecting mice to intravenous injection at low doses(e.g.,50μmol·kg^(−1)),Fe-HDCL also permits the photoacoustic(PA)imaging of kidneys and the evaluation of renal fibrosis in mouse *** addition,Fe-HDCL allows PA-based imaging of brain tissues,presumably reflecting its ability to pass through the blood-brain *** thus propose that Fe-HDCL has a role to play as PT agent and as a photodiagnostic.

关键词： stable Fe(IV)complex blood-brain barrier molecular cage photoacoustic imaging renal fibrosis

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Pain and immune function in patients undergoing gastric cancer surgery following stellate ganglion block with total intravenous anesthesia

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2961-2967页

作者： zhen Wu Hong-Qin Cai Chun-feng Wang Xiang-Yuan Yu Jie-Qiong Wang Department of Anesthesiology The Kunshan Second People’s HospitalKunshan 215300Jiangsu ProvinceChina

BACKGROUND Stellate ganglion block is a commonly used sympathetic nerve block technique that restores the balance of the sympathetic and vagal nervous systems of the body and inhibits sympathetic nerve *** To analyze the effect of a stellate ganglion block combined with total diploma intravenous anesthesia on postoperative pain and immune function in patients undergoing laparoscopic radical gastric cancer(GC)surgery to provide a refe-rence basis for the formulation of anesthesia protocols for radical GC *** This study included 112 patients who underwent laparoscopic radical surgery for GC between January 2022 and March *** was no restriction on *** patient grouping method used was a digital random table method,and the num-ber of cases in each group was *** control group was administered total intravenous anesthesia,and the observation group compounded the stellate gan-glion block according to the total intravenous anesthesia *** hemodynamics,pain levels,and immune indices were compared between the *** The heart rate and mean arterial pressure in the observation group after in-tubation were lower than those in the control group(P0.05).The number of CD3+,CD4+,and CD4+/CD8+cells at the end of surgery was higher in the observation group than in the control group,and the number of CD8+cells was lower in the observation group than in the control group(P0.05).CONCLUSION The application of a stellate ganglion block combined with total intravenous anesthesia had no significant effect on postoperative pain levels in patients undergoing laparoscopic radical GC ***,it can safely reduce the effect of surgery on the immune function

关键词： Stellate ganglion block Total intravenous anesthesia Laparoscopy Radical gastric cancer surgery Immune

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Whole exome sequencing identifies risk variants associated with intracranial epidermoid cyst deterioration:A case report

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World Journal of Clinical Oncology 2024年第11期15卷 1428-1434页

作者： Zhao-Na Song Yan Cheng Dan-Dan Wang Ming-Jun Li Xiang-Rong Zhao Fa-Wang Li zhen Liu Xiao-Ru Zhu Xiao-Dong Jia Yu-fang Wang feng-fan Liang Joint Laboratory for Translational Medicine Research Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Harbin Genars Technology Co. Ltd.Harbin 150060Heilongjiang ProvinceChina Department of Radiotherapy Liaocheng People's HospitalLiaocheng 252000Shandong ProvinceChina Department of Medical laboratory Qilu Hospital of Shandong University Dezhou HospitalDezhou 253600Shandong ProvinceChina

BACKGROUND Intracranial epidermoid cyst(IEC)transformation to malignant squamous cell carcinoma(SCC)is extremely rare,and its etiology is yet ***,SCC is treated by performing surgery,followed by a combination of radiotherapy and *** is crucial to identify efficient and trustworthy therapeutic targets for SCC to improve its diagnosis,prognosis,and *** SUMMARY In this study,we report the case of a 47-year-old female patient with SCC,which progressed from IEC in the left internal capsule *** patient was sought treatment at our hospital for severe diplopic vision,accompanied with speech disorder and memory *** on the clinical and postoperative pathology,this patient was finally diagnosed with *** identify disease-causing variants,whole exome sequencing(WES)was performed on the *** revealed two pathogenic missense mutations on Gap junction protein beta 2(GJB2)(c.257C>T)and Toll-like receptor 2(TLR2)(c.1039A>G),*** This study provided the first clinical evidence for demonstrating the role of GJB2 and TLR2 in IEC development and *** further confirmed WES as a robust and reliable technique for underlying rare and complex disease-related genetic factor identification.

关键词： Intracranial epidermoid cyst Squamous cell carcinoma Whole exome sequencing Variants Case report

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融合移位窗口注意力的光流计算方法

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计算机辅助设计与图形学学报 2024年第8期36卷 1255-1262页

作者：安峰戴军韩振苏州工业园区服务外包职业学院智能制造学院苏州215123 同济大学经济与管理学院上海210092

针对端到端的光流计算方法容易受限于运动模糊、遮挡和大位移的问题,通过引入注意力机制实现对遮挡像素进行更准确的预测,提出一种融合移位窗口注意力的光流计算方法.首先使用移位窗口注意力对原有的特征图进行特征增强,获取更具全局自... 详细信息

针对端到端的光流计算方法容易受限于运动模糊、遮挡和大位移的问题,通过引入注意力机制实现对遮挡像素进行更准确的预测,提出一种融合移位窗口注意力的光流计算方法.首先使用移位窗口注意力对原有的特征图进行特征增强,获取更具全局自相似性的特征,弥补了卷积特征的局部性特点;然后使用移位窗口注意力进行相关体解析,包括2D运动向量解析和光流增量的计算,获得更准确的光流增量;最后引入遮挡图作为位置编码,在计算注意力时考虑更多的像素位置关系.实验结果表明,在Sintel数据集上,端到端的误差达到1.33;在FlyingChairs数据集上,单帧计算时间为69 ms,比全局运动聚合方法减少4.2%,超过了常见光流计算方法的精度和效率.

关键词：光流计算自注意力机制移位窗口注意力位置编码

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Generation and regulation of electromagnetic pulses generated by femtosecond lasers interacting with multitargets

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Nuclear Science and Techniques 2024年第1期35卷 96-107页

作者： Ya-Dong Xia De-feng Kong Qiang-You He zhen Guo Dong-Jun Zhang Tong Yang Hao Cheng Yu-Ze Li Yang Yan Xiao Liang Ping Zhu Xing-Long Xie Jian-Qiang Zhu Ting-Shuai Li Chen Lin Wen-Jun Ma Xue-Qing Yan State Key Laboratory of Nuclear Physics and Technology and Key Laboratory of HEDP of the Ministry of EducationCAPTPeking UniversityBeijing 100871China Beijing Laser Acceleration Innovation Center Beijing 101407China Institute of Guangdong Laser Plasma Technology Guangzhou 510540China National Laboratory on High Power Laser and Physics Shanghai Institute of Optics and FineChinese Academy of SciencesShanghai 201800China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China

Ultrashort and powerful laser interactions with a target generate intense wideband electromagnetic pulses(EMPs).In this study,we report EMPs generated by the interactions between petawatt(30 fs,1.4×10^(20) W/cm^(2))femtosecond(fs)lasers with metal flat,plastic flat,and plastic nanowire-array(NWA)*** analyses are conducted on the EMPs in terms of their spatial distribution,time and frequency domains,radiation energy,and *** results indicate that EMPs from metal targets exhibit larger amplitudes at varying angles than those generated by other types of targets and are enhanced significantly for NWA *** a plastic target holder and increasing the laser focal spot can significantly decrease the radiation energy of the ***,the composite shielding materials indicate an effective shielding effect against *** simulation results show that the NWA targets exert a collimating effect on thermal electrons,which directly affects the distribution of *** study provides guidance for regulating EMPs by controlling the laser focal spot,target parameters,and target rod material and is beneficial for electromagnetic-shielding design.

关键词： Electromagnetic pulses Laser plasma interaction Electromagnetic shielding Electron distribution

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Variable phenotypes and outcomes associated with the MMACHC c.482G>A mutation:follow-up in a large CblC disease cohort

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World Journal of Pediatrics 2024年第8期20卷 848-858页

作者： Sheng-Nan Wu Hui-Shu E Yue Yu Shi-Ying Ling Li-Li Liang Wen-Juan Qiu Hui-Wen Zhang Rui-Xue Shuai Hai-Yan Wei Chi-Ju Yang Peng Xu Xi-Gui Chen Hui Zou Ji-zhen feng Ting-Ting Niu Hai-Li Hu Kai-Chuang Zhang De-Yun Lu Zhu-Wen Gong Xia Zhan Wen-Jun Ji Xue-fan Gu Yong-Xing Chen Lian-Shu Han Department of Endocrinology and Metabolism Henan Key Laboratory of Children’s Genetics and Metabolic DiseasesChildren’s Hospital Affiliated to Zhengzhou UniversityHenan Children’s HospitalZhengzhou Children’s HospitalNo.255 Gangdu StreetZhengzhouChina Department of Pediatric Endocrinology and Genetics Fujian Children’s HospitalFuzhouChina The Center for Pediatric Liver Diseases Children’s HospitalFudan UniversityShanghaiChina Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric ResearchXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityNo.1665 Kongjiang RoadShanghaiChina Department of Pediatrics Second Affiliated Hospital of Naval Medical UniversityShanghaiChina Center of Neonatal Disease Screening Jining Maternal and Child Health Care HospitalJiningChina Center of Neonatal Disease Screening Jinan Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Shijiazhuang Maternal and Child Health Care HospitalShijiazhuangChina Center of Neonatal Disease Screening Shandong Maternal and Child Health Care HospitalJinanChina Center of Neonatal Disease Screening Hefei Maternal and Child Health Care HospitalHefeiChina

Background The aim of this study was to characterize the variable phenotypes and outcomes associated with the methylmalonic aciduria and homocystinuria type C protein gene(MMACHC)c.482G>A mutation in 195 Chinese cases with CblC *** We carried out a national,retrospective multicenter study of 195 Chinese patients with CblC disease attributable to the MMACHC c.482G>A variant either in a homozygous or compound heterozygous *** control group consisted of 200 patients diagnosed with CblC disease who did not possess the c.482G>A *** features,including disease onset,symptoms,biochemical metabolites,gene mutation,and follow-up outcomes were reviewed and analyzed in *** median follow-up period spanned 3 years and 8 months,with a range of 1 year and 2 months to 12 years and 10 *** Among 195 patients carrying the c.482G>A variant,125(64.1%)cases were diagnosed by newborn screening(NBS),60(30.8%)cases were detected due to disease onset,and 10(5.1%)cases were identified from sibling *** hundred and seventeen(93.6%)individuals who were diagnosed by NBS,and nine patients who came from sibling diagnoses remained asymptomatic in this *** 69 symptomatic patients of the c.482G>A group,more patients presented with later onset,and the top six common clinical symptoms at disease onset were developmental delay(59.4%),lower limb weakness and poor exercise tolerance(50.7%),cognitive decline(37.7%),gait instability and abnormal posture(36.2%),seizures(26.1%),and psychiatric and behavioral disturbances(24.6%).In the 159 symptomatic patients lacking c.482G>A variants,the most frequently observed clinical manifestations at disease onset included developmental delay(81.8%),lethargy and feeding difficulty(62.9%),lower limb weakness and poor exercise tolerance(54.7%),prolonged neonatal jaundice(51.6%),vomiting(47.2%),and seizures(32.7%).Before treatment,the levels of blood propionylcarnitine,propionylcarnitine/acetylcarnitine ratio

关键词： c.482G>A CblC disease MMACHC gene Newborn screening Outcome Use our pre-submission checklist Avoid common mistakes on your manuscript.

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Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan Zhu Tao Jiang Ying Gao Nan Ling Na Wang John Shi Wei-Chun Pan Qi-zhen Du Jun-feng Yin Tea Research Institute Chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture College of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research Center， Agriculture and Agri-Food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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Modulation of gut microbiota and serum metabolome by Apostichopus japonicus derived oligopeptide in high-fructose diet-induced hyperuricemia in mice

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Food Science and Human Wellness 2024年

作者： Jun Zhou Ziyan Wang Zhixuan Zhang Jiaojiao Han Ying feng Jing Zhang zhen Zhang Ye Li Tinghong Ming Chenyang Lu Rixin Wang Xiurong Su School of Marine Science， Ningbo University Faculty of Food Science， Zhejiang Pharmaceutical College Key Laboratory of Aquacultural Biotechnology Ministry of Education， Ningbo University College of Life Sciences， Tonghua Normal University State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Ningbo University

Fructose consumption has risen dramatically in recent decades due to the use of sucrose and high fructose corn syrup in beverages and processed foods， contributing to rising rates of hyperuricemia. The purpose of this experiment was to explore the anti-hyperuricemia effects of an active oligopeptide (GPSGRP) derived from sea cucumber in fructose induced hyperuricemia mouse model， and to clarify the underlying mechanism in sight of gut microbiota and serum metabolites. Peptide GPSGRP treatment rebalanced uric acid metabolism and alleviated inflammatory response in mice. In addition， treatment with GPSGRP decreased the abundance of Bacteroides and Proteobacteria at the phylum level， Muribaculum， Prevotella and Bacteroides at the genus level， and inhibited the related pathways of purine metabolism and glycolysis/gluconeogenesis metabolism. Moreover， serum metabolites， including linoleic acid， indole and its derivatives， arachidonic acid and uridine， as well as related metabolic pathways， such as tricarboxylic acid cycle， ketone production and sugar production， were altered in response to GPSGRP treatment. This study provides a valuable reference for the application and development of marine biological peptides in uric acid management.

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长三角城市群一体化对旅游产业效率的空间溢出效应研究

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长江流域资源与环境 2024年第7期33卷 1397-1411页

作者：王兆峰邱梦真湖南师范大学旅游学院湖南长沙410081

客观审视区域一体化对旅游产业效率的作用,对推进长三角城市群经济社会高质量发展意义显著。采用熵值法与线性加权法、超效率SBM模型,依次测度2008~2020年长三角城市群的一体化发展水平与旅游产业效率,并借助空间杜宾模型揭示两者之间... 详细信息

客观审视区域一体化对旅游产业效率的作用,对推进长三角城市群经济社会高质量发展意义显著。采用熵值法与线性加权法、超效率SBM模型,依次测度2008~2020年长三角城市群的一体化发展水平与旅游产业效率,并借助空间杜宾模型揭示两者之间的内在关系和空间效应。研究发现:(1)区域一体化水平指数从2008年的0.304增长到2020年的0.490,整体呈现稳健上升趋向;空间上呈“东南高、西北低”态势,且具有显著的“高—高”“低—低”簇状集聚演化特征。(2)旅游产业效率值呈现小幅度波动下降态势,谷值出现在2020年;空间分布呈“东高西低,中部高—南北两翼低”的格局,高效率城市数量逐渐增加并向东南方向拓展。(3)区域一体化水平对旅游产业效率存在显著的空间溢出作用;政府调控、城镇化水平、信息化水平、交通便利程度、对外开放程度、科技发展水平对本地旅游产业效率均具有显著的直接促进作用;城镇化水平、信息化水平对邻地旅游产业效率具有正向溢出效应,政府调控、交通便利程度则表现出负向溢出效应。

关键词：区域一体化旅游产业效率空间溢出效应区域协调发展长三角城市群

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A versatile framework for analyzing galaxy image data by incorporating Human-in-the-loop in a large vision model

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Chinese Physics C 2024年第9期48卷 176-187页

作者： Ming-Xiang Fu Yu Song Jia-Meng Lv Liang Cao Peng Jia Nan Li Xiang-Ru Li Ji-feng Liu A-Li Luo Bo Qiu Shi-Yin Shen Liang-Ping Tu Li-Li Wang Shou-Lin Wei Hai-feng Yang zhen-Ping Yi Zhi-Qiang Zou National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Key lab of Space Astronomy and Technology National Astronomical ObservatoriesBeijing 100101China School of Computer Science South China Normal UniversityGuangzhou 510631China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China University of Chinese Academy of Sciences NanjingNanjing 211135China University of Science and Technology Beijing Beijing 100083China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Computer and Information Dezhou UniversityDezhou 253023China Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China School of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 30024China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China Nanjing University of Posts&Telecommunications Nanjing 210023China School of Science University of Science and Technology LiaoningAnshan 114051China

The exponential growth of astronomical datasets provides an unprecedented opportunity for humans to gain insight into the ***,effectively analyzing this vast amount of data poses a significant *** response,astronomers are turning to deep learning techniques,but these methods are limited by their specific training sets,leading to considerable duplicate *** overcome this issue,we built a framework for the general analysis of galaxy images based on a large vision model(LVM)plus downstream tasks(DST),including galaxy morphological classification,image restoration object detection,parameter extraction,and *** the low signal-to-noise ratios of galaxy images and the imbalanced distribution of galaxy categories,we designed our LVM to incorporate a Human-in-the-loop(HITL)module,which leverages human knowledge to enhance the reliability and interpretability of processing galaxy images *** proposed framework exhibits notable fewshot learning capabilities and versatile adaptability for all the abovementioned tasks on galaxy images in the DESI Legacy Imaging *** particular,for the object detection task,which was trained using 1000 data points,our DST in the LVM achieved an accuracy of 96.7%,while ResNet50 plus Mask R-CNN reached an accuracy of 93.1%.For morphological classification,to obtain an area under the curve(AUC)of~0.9,LVM plus DST and HITL only requested 1/50 of the training sets that ResNet18 *** addition,multimodal data can be integrated,which creates possibilities for conducting joint analyses with datasets spanning diverse domains in the era of multi-messenger astronomy.

关键词： artificial intelligence large vision model human-in-the-loop astronomy galaxies

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