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Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2054-2064页

作者： Chun-Juan Zhao Chao Ren zhen Yuan Guo-Hui Bai Jin-Yu Li Long Gao Jin-Hui Li Ze-Qi Duan Dui-Ping feng Hui Zhang College of Medical Imaging Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Radiology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Occupational Health School of Public HealthShanxi Key Laboratory of Environmental Health Impairment and PreventionNHC Key Laboratory of PneumoconiosisMOE Key Laboratory of Coal Environmental Pathogenicity and PreventionShanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Oncological and Vascular Intervention The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Provincial Clinical Research Center for Interventional Medicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina First Clinical Medical College Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Shanxi Key Laboratory of Intelligent Imaging and Nanomedicine The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Intelligent Imaging Big Data and Functional Nano-imaging Engineering Research Center of Shanxi Province The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Portal shunt and immune status related to the spleen are related to the occurrence of hepatic encephalopathy(HE).It is unknown whether spleen volume before transjugular intrahepatic portosystemic shunt(TIPS)is related to postoperative *** To investigate the relationship between spleen volume and the occurrence of *** This study included 135 patients with liver cirrhosis who underwent TIPS,and liver and spleen volumes were elevated upon computed tomography *** Kaplan-Meier curve was used to compare the difference in the incidence rate of HE among patients with different spleen *** and multivariate Cox regression analyses were performed to identify the factors affecting overt HE(OHE).Restricted cubic spline was used to examine the shapes of the dose-response association between spleen volumes and OHE *** The results showed that 37(27.2%)of 135 patients experienced OHE during a 1-year follow-up *** with preoperative spleen volume(901.30±471.90 cm3),there was a significant decrease in spleen volume after TIPS(697.60±281.0 cm^(3))in OHE *** the severity of OHE increased,the spleen volume significantly decreased(P<0.05).Compared with patients with a spleen volume≥782.4 cm^(3),those with a spleen volume<782.4 cm^(3) had a higher incidence of HE(P<0.05).Cox regression analysis showed that spleen volume was an independent risk factor for post-TIPS OHE(hazard ratio=0.494,P<0.05).Restricted cubic spline model showed that with an increasing spleen volume,OHE risk showed an initial increase and then decrease(P<0.05).CONCLUSION Spleen volume is related to the occurrence of OHE after *** spleen volume is an independent risk factor for post-TIPS OHE.

关键词： Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Spleen volume Portal hypertension Cirrhosis

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胃复安联合膳食改善对治疗ICU患者晚期胃癌化疗患者免疫功能及生活质量的影响

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中国生化药物杂志 2017年第6期37卷 251-253页

作者：庞彩珍范国峰天台县人民医院营养科浙江台州317200 台州市中心医院营养科浙江台州318000

目的探讨胃复安联合膳食改善对治疗ICU患者晚期胃癌化疗患者免疫功能及生活质量的影响.方法回顾性分析天台县人民医院70例Ⅲ-Ⅳ期晚期胃癌患者临床病历资料与治疗情况;按照随机数字表法将其分为对照组（采用OLF方案化疗治疗）与观察... 详细信息

目的探讨胃复安联合膳食改善对治疗ICU患者晚期胃癌化疗患者免疫功能及生活质量的影响.方法回顾性分析天台县人民医院70例Ⅲ-Ⅳ期晚期胃癌患者临床病历资料与治疗情况;按照随机数字表法将其分为对照组（采用OLF方案化疗治疗）与观察组（化疗联合胃复安联合膳食改善）,各35例,统计2组治疗4个疗程后临床疗效及不良反应情况,用卡氏生活质量（KPS）评分评价2组患者治疗前、后生存质量;检测2组患者治疗前后免疫功能.结果观察组临床疾病控制率68.57%与对照组60.0%比较差异无统计学意义;观察组与对照组治疗后KPS评分,明显高于治疗前,且观察组KPS评分明显高于对照组,差异有统计学意义（P〈0.05）.2组治疗前各项免疫功能指标相比较差异无统计学意义;对照组CD4＋细胞、CD4＋/CD8＋及NK细胞水平较治疗前明显下降,差异有统计学意义（P〈0.05）;且与观察组比较（P〈0.05）.观察组不良反应率37.14%明显低于对照组68.57%,差异有统计学意义（P〈0.05）.结论胃复安联合膳食改善可减少不良反应,有助于改善患者免疫功能及生活质量.

关键词：胃复安膳食改善晚期胃癌 OLF方案化疗生活质量

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Integrated and holistic knowledge map of phase change materials for pavement: A scientometric analysis and bibliometric review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Jiasheng Dai feng Ma zhen Fu Chen Li Yingjie Hou Yalu Wen Yanzhe Zou Dongdong Yuan Wenhao Dong Ke Shi Key Laboratory for Special Area Highway Engineering of Ministry of Education， Chang'an University School of Material and Science Engineering， Chang'an University

Elevated pavement temperatures contribute to the urban heat island effect and pose a risk of thermal damage to pavement. Thus， regulating pavement temperature is paramount to ensure its longevity， enhance traffic safety， and preserve the environment. Phase change materials (PCMs) with the latent heat characteristic can store and release thermal energy via phase transitions. PCMs can effectively control pavement structure temperatures within a relatively narrow range， mitigating thermal stress on asphalt pavements. This research aims to explore the current status and emerging trends in PCM Integrated Pavement Engineering (PCMIPE) using the CiteSpace visual analysis tool. Relevant publications were systematically curated from the Web of Science core database， spanning 2011 to 2023. Subsequently， the co-authorships network maps (country， institution， author)， co-cited network maps (co-cited journals， authors， and references)， and keyword co-occurrence network maps were constructed to analyze the principal contributions in the PCMIPE field comprehensively. This analysis provides an understanding of the field's strengths， research domains， and knowledge structure and identifies current research focal points and emerging frontiers. The findings reveal that research within the PCMIPE field is still in its early stages， with a predominant emphasis on material design and performance assessment. Additionally， future research is anticipated to expand into economic analyses and exploration of environmental effects when integrating PCMs into pavement engineering. Furthermore， there is an emerging interest in investigating the synergy of PCMs with other functional pavement technologies. These results underscore the potential of the PCMIPE field and emphasize the importance of future research endeavors.

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大直径盾构隧道下穿既有高速公路桥涵影响分析

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现代隧道技术 2024年第1期61卷 137-145页

作者：张庆甄文战封坤中铁二院工程集团有限责任公司成都610031 西南交通大学交通隧道工程教育部重点实验室成都610031

为进一步研究大直径盾构隧道掘进时对周边建(构)筑物的影响,依托成都某铁路工程大直径盾构隧道小间距、浅覆土下穿高速公路桥涵工程,采用数值模拟分析方法,考虑桩-土-隧道相互作用,建立三维有限元计算模型,分析盾构隧道施工引起地表、... 详细信息

为进一步研究大直径盾构隧道掘进时对周边建(构)筑物的影响,依托成都某铁路工程大直径盾构隧道小间距、浅覆土下穿高速公路桥涵工程,采用数值模拟分析方法,考虑桩-土-隧道相互作用,建立三维有限元计算模型,分析盾构隧道施工引起地表、桥桩、人行地道及隔离桩位移变化趋势。结果表明:盾构隧道开挖卸荷在地表形成了明显的沉降槽,但隔离桩能有效阻断土体变形,减小地表沉降;地表横向沉降曲线在隔离桩位置出现突变,隔离桩前及背后的地表沉降量降幅分别达27%及40%~50%;地表纵向沉降曲线在隔离桩范围数值减小且呈W形分布。桥桩受盾构隧道开挖卸荷影响,产生向隧道侧的附加变形及弯矩,洞身范围其变形值从下至上先增大后减小,且较小直径盾构隧道对桥桩竖向影响范围大;同时盾构隧道下穿人行地道引起结构底板附加变形较大,沉降最大值达7.5 mm;上述相关数值计算结果与现场实测结果较为吻合,验证了数值模拟结果的准确性。

关键词：盾构隧道高速桥涵数值分析隔离桩沉降槽

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Unveiling the early stage evolution of local atomic structures in the crystallization process of a metallic glass

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Chinese Physics B 2024年第3期33卷 58-64页

作者：马琳杨晓东杨锋周鑫嘉武振伟 Institute of Nonequilibrium Systems School of Systems ScienceBeijing Normal UniversityBeijing 100875China

The early stage evolution of local atomic structures in a multicomponent metallic glass during its crystallization process has been investigated via molecular dynamics *** is found that the initial thermal stability and earliest stage evolution of the local atomic clusters show no strong correlation with their initial short-range orders,and this leads to an observation of a novel symmetry convergence phenomenon,which can be understood as an atomic structure manifestation of the ***,in our system we have quantitatively proved that the crucial factor for the thermal stability against crystallization exhibited by the metallic glass is not the total amount of icosahedral clusters,but the degree of global connectivity among them.

关键词： metallic glass crystallization molecular dynamics simulation local atomic clusters

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Iron/B_(2)pin_(2)catalytic system enables the generation of alkyl radicals from inert alkyl C-O bonds for amine synthesis

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Chinese Chemical Letters 2024年第1期35卷 227-232页

作者： Yanqing Zhu Shuai Chen zhen Zhou Yun He zhengli Liu Yang Liu Zhang feng Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Department of Medicinal Chemistry School of PharmacyFujian Medical University(FMU)Fuzhou 350005China Affiliated Hospital of North Sichuan Medical College and Medical Imaging Key Laboratory of Sichuan Province Nanchong 637503China

A method for the generation of alkyl radicals from inert alkyl C-o bonds has been developed via an iron/borane reagent/alkoxide catalytic system,which can be employed for the synthesis of amines from nitroarenes with excellent *** reductive amination features good functional group compatibility and enables the late-stage amination of bio-relevant compounds,thus providing good opportunities for applications in medicinal *** mechanistic studies reveal that the amine synthesis may be involving a Fe/Li cation-assisted single electron transfer pathway to form alkyl radicals,and the low-valent iron speciesmaybetheactive intermediates.

关键词： C-N bond formation Reductive amination Borane reagent Iron catalysis Green chemistry

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Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis

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Frontiers of Medicine 2024年第1期18卷 68-80页

作者： Yanling Liu Xi He Yanchun Yuan Bin Li zhen Liu Wanzhen Li Kaixuan Li Shuo Tan Quan Zhu zhengyan Tang feng Han Ziqiang Wu Lu Shen Hong Jiang Beisha Tang Jian Qiu zhengmao Hu Junling Wang Department of Neurology Xiangya HospitalCentral South UniversityJiangxiNational Regional Center for Neurological DiseasesNanchang330038China Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease Department of UrologyXiangya HospitalCentral South UniversityChangsha410078China Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhou310002China Department of Neurology Xiangya HospitalCentral South UniversityChangsha410078China National Clinical Research Center for Geriatric Diseases Xiangya HospitalCentral South UniversityChangsha410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangsha410008China Center for Medical Genetics School of Life SciencesCentral South UniversityChangsha410008China Engineering Research Center of Hunan Province in Cognitive Impairment Disorders Central South UniversityChangsha410078China Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases Changsha410078China Hunan Key Laboratory of Molecular Precision Medicine Xiangya HospitalCentral South UniversityChangsha410078China

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons,and it demonstrates high clinical heterogeneity and complex genetic architecture.A variation within TRMT2B(c.1356G>T;p.K452N)was identified to be associated with ALS in a family comprising two patients with juvenile ALS(JALS).Two missense variations and one splicing variation were identified in 10 patients with ALS in a cohort with 910 patients with ALS,and three more variants were identified in a public ALS database including 3317 patients with ALS.A decreased number of mitochondria,swollen mitochondria,lower expression of ND1,decreased mitochondrial complex I activities,lower mitochondrial aerobic respiration,and a high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2B interfering HEK293 ***,TRMT2B variations overexpression cells also displayed decreased *** conclusion,a novel JALS-associated gene called TRMT2B was identified,thus broadening the clinical and genetic spectrum of ALS.

关键词： TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species

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Efficacy and safety of Qingfei Huatan formula in the treatment of acute exacerbation of chronic obstructive pulmonary disease:A multi-centre,randomised,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 561-569页

作者： Hui-zhi Zhu Cheng-yi Li Liang-ji Liu Jia-bing Tong Zhi-hui Lan Shu-guang Tian Qiao Li Xiang-li Tong Ji-feng Wu zhen-gang Zhu Su-yun Li Jian-sheng Li Department of Respiratory Medicine the First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Graduate School Anhui University of Traditional Chinese MedicineHefei 230012Anhui ProvinceChina Department of Respiratory Medicine Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Respiratory Diseases the First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Pulmonary Diseases Taihe Hospital of Traditional Chinese Medicine Affiliated to Anhui University of Traditional Chinese MedicineFuyang 236600Anhui ProvinceChina Department of Respiratory and Critical Care Medicine Jiangxi Province Hospital of Integrated Chinese and Western MedicineNanchang 330002Jiangxi ProvinceChina Department of Respiratory Medicine the First Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province Zhengzhou 450046Henan ProvinceChina

Background Chronic obstructive pulmonary disease(COPD),a common respiratory disease,can be effectively treated by traditional Chinese medicine(TCM).Qingfei Huatan,a TCM formula,has been reported to effectively alleviate the clinical symptoms of COPD ***,there is a lack of multi-centre,randomised,double-blind,controlled clinical trials documenting the clinical efficacy and safety of this formula in the treatment of acute exacerbation of COPD(AECOPD).Objective This study evaluated the efficacy and safety of Qingfei Huatan formula in the treatment of AECOPD,thereby providing high-quality clinical ***,setting,participants and interventions A total of 276 patients with AECOPD were included in this multi-centre,randomised,double-blind,placebo-controlled trial and were randomised into treatment and control groups at a ratio of 1:*** in the treatment and control groups took Qingfei Huatan granules or simulated Qingfei Huatan granules twice a day,for 14 days,in addition to Western medicine *** patients were followed up for 3 *** outcome measures The primary outcome was time taken to symptom *** secondary outcomes included duration of antibiotic use,clinical symptom and sign score,TCM syndrome score,dyspnoea score,and quality of life(QOL)***,the safety of the formula was assessed through routine urine and stool tests,electrocardiograms,liver and kidney function tests,and the observation of adverse events throughout the *** The time taken for effective stabilisation(P<0.05)and obvious stabilisation(P<0.01),and the duration of antibiotic use(P<0.05)were significantly shorter in the treatment group than in the control *** days 6,9,12 and 14 of treatment,clinical symptom and sign score decreased in both groups,particularly in the treatment group(P<0.01).On days 9,12 and 14 of treatment,the TCM syndrome scores of both groups were reduced(P<0.01),with more significant reductions in the treatm

关键词： Acute exacerbation of chronic obstructive pulmonary disease Clinical trial Syndrome of phlegm-heat congesting lung Qingfei Huatan formula Traditional Chinese medicine

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基层综合执法改革的合法性及规范展开

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江苏行政学院学报 2024年第3期 130-136页

作者：张峰振江苏师范大学法学院江苏徐州221116

基层综合执法改革经历了地方探索、中央推动、法律确认三个阶段。行政处罚权下放制度为基层综合执法改革提供了合法性。省级人大及其常委会、省级人民政府均有权决定基层综合执法改革,但考虑到下放权力的动态调整需求和行政效率因素,由... 详细信息

基层综合执法改革经历了地方探索、中央推动、法律确认三个阶段。行政处罚权下放制度为基层综合执法改革提供了合法性。省级人大及其常委会、省级人民政府均有权决定基层综合执法改革,但考虑到下放权力的动态调整需求和行政效率因素,由省级人民政府行使决定权更有优势。为确保基层综合执法改革的合法性,应准确理解并严格执行改革的决定主体、适用条件、程序要求等制度。

关键词：基层综合执法改革行政处罚权下放合法性

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多端交通视频分析任务卸载决策

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控制与决策 2024年第8期39卷 2773-2782页

作者：温震宇胡慧峰钱滨洪榛俞立浙江工业大学网络空间安全研究院杭州310023 浙江工业大学信息工程学院杭州310023 纽卡斯尔大学计算机学院纽卡斯尔NE45TG

针对智慧交通中多点位监控视频分析时出现的计算任务繁重、设备之间资源利用不均衡的问题,提出一种基于云控制的视频分析卸载方案.首先,针对客户端算力不足而无法完成视频分析任务的问题,使用一种视频卸载框架,将部分视频分析任务切块... 详细信息

针对智慧交通中多点位监控视频分析时出现的计算任务繁重、设备之间资源利用不均衡的问题,提出一种基于云控制的视频分析卸载方案.首先,针对客户端算力不足而无法完成视频分析任务的问题,使用一种视频卸载框架,将部分视频分析任务切块卸载至云服务器处理;其次,针对服务器与多客户端之间的算力资源竞争问题,提出一种阶段优化卸载算法,平衡设备之间负荷,提高资源利用率;最后,针对不同点位的客户端需求不同的问题,在算法中加入精度和能耗偏好,满足不同客户端的需求.与其他卸载方案对比的实验表明,所提出方案能够更好地对视频分析任务进行合理分配,提高系统收益,并通过扩展实验验证所提出系统的扩展能力.

关键词：多端视频分析任务卸载资源竞争卸载决策智慧交通

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