Iron/B_(2)pin_(2)catalytic system enables the generation of alkyl radicals from inert alkyl C-O bonds for amine synthesis

作     者：Yanqing Zhu Shuai Chen Zhen Zhou Yun He Zhengli Liu Yang Liu Zhang Feng Yanqing Zhu;Shuai Chen;Zhen Zhou;Yun He;Zhengli Liu;Yang Liu;Zhang Feng

作者机构：Chongqing Key Laboratory of Natural Product Synthesis and Drug ResearchSchool of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Department of Medicinal ChemistrySchool of PharmacyFujian Medical University(FMU)Fuzhou 350005China Affiliated Hospital of North Sichuan Medical College and Medical Imaging Key Laboratory of Sichuan ProvinceNanchong 637503China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第1期

页      面：227-232页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support from National Natural Science Foundation of China(Nos.22271031,22201026),Natural Science Foundation of Chongqing(No.CSTB2022NSCQ-MSX1065) Chongqing Postdoctoral Science Foundation(No.cstc2020jcyj-bshX0052) Medical Imaging Key Laboratory of Sichuan Province(Nos.MIKL202201 and MIKL202202) Affiliated Hospital of North Sichuan Medical College(No.2022JB001) Youth Project of Science and Technology Research Program of Chongqing Education Commission of China(No.KJQN201900112) 

主　　题：C-N bond formation Reductive amination Borane reagent Iron catalysis Green chemistry 

摘      要：A method for the generation of alkyl radicals from inert alkyl C-o bonds has been developed via an iron/borane reagent/alkoxide catalytic system,which can be employed for the synthesis of amines from nitroarenes with excellent *** reductive amination features good functional group compatibility and enables the late-stage amination of bio-relevant compounds,thus providing good opportunities for applications in medicinal *** mechanistic studies reveal that the amine synthesis may be involving a Fe/Li cation-assisted single electron transfer pathway to form alkyl radicals,and the low-valent iron speciesmaybetheactive intermediates.