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Temporomandibular joint damage in K/BxN arthritic mice

International Journal of Oral Science 2020年第1期12卷 59-67页

作者： Sabine Kuchler-Bopp Alexandre Mariotte Marion Strub Chrystelle Po Aurore De Cauwer Georg Schulz Xavier Van Bellinghen Florence Fioretti Francois Clauss Philippe Georgel Nadia Benkirane-Jessel fabien Bornert INSERM(French National Institute of Health and Medical Research) UMR 1260Regenerative NanoMedicine(RNM)FMTSStrasbourgFrance INSERM UMR 1109Immuno Rhumatologie Moléculaire(IRM)FMTSStrasbourgFrance Fédération Hospitalo-Universitaire(FHU)OMICARE Universitéde StrasbourgStrasbourgFrance Facultéde Chirurgie Dentaire Universitéde Strasbourg(UDS)8 rue Ste ElisabethStrasbourgFrance Pole de Médecine et Chirurgie Bucco-Dentaires Hopitaux Universitaires de Strasbourg(HUS)1 place de l’HopitalStrasbourgFrance ICube UMR 7357 Universitéde StrasbourgCNRSFMTS4 rue KirschlegerStrasbourgFrance Department of Biomedical Engineering Core Facility Micro-and NanotomographyBiomaterials Science Center(BMC)University of BaselGewerbestrasse 144123AllschwilSwitzerland

Rheumatoid arthritis(RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/Bx N mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint(TMJ)inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging(μMRI)and micro-computed tomography(μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/Bx N animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes(FLSs)isolated from the TMJ of K/Bx N mice secreted inflammatory cytokines(IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases(MMPs). K/Bx N mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.

关键词： damage alterations inflammation

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Thermal Shock Resistance of Ladle Castables

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China's Refractories 2018年第2期27卷 7-12页

作者： Christoph WOHRMEYER GAO Jianying Magali SZEPIZDYN fabien SIMONIN Imerys Aluminates Oberhausen 46047Germany Imerys Aluminates Tianjin 300457P.Ro China Imerys Technology Center Vaulx-Milieu 38090France

High purity alumina - spinel （ A - MA ） and alumina- magnesia （A -M） castables are widely used in steel ladles due to their resistance against slag penetration and corrosion. With a calcium magnesium alumihate bond （ CMA ） excellent slag penetration resistance can be achieved which results in high wear resistance due to reduced structural spalling. This paper investigates the impact of matrix eompositions and CMA-binder content of A -MA and A -M castables on thermal shock resistance（TSR）. Standardized thermal shock tests have been applied with sample quenching from 950 ℃ down to room temperature. Results show that all castables are significantly damaged after 5 cycles despite their differences in microstructure. However, the mix with 12% CMA gave TSR that is at similar good level as the reference mix with 6% CAC （70% alumina cement ）. While a similar strength level was achieved before and after the thermal cycling, the Jormulation with 12% CMA contains 0. 6% less total CaO. The A - MA castables perform better on average than the A - M mixes with this test method. Within the group of A - M castables the mix with 18% CMA and 0. 5% SiO2 gave superior TSR, similar good as castables of the A - MA group. The introduction of CMA in an A - M tastable allows reduction of free MgO and SiO2-addition. The reduction of SiO2 has been found beneficial for the TSR. This was also found during a thermal cycling trial at high temperature between 1100 and 1 500 ℃. Here the A -M mix with 18% CMA and 0. 5% SiO2 performed better than the SiO2-free A -MA castable.

关键词： thermal shock ladle eastable calcium magnesium aluminate binder

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Study of the Influence of a Young Synthetic Leachate on the Hydromechanical Properties of a Swelling Clay

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Journal of Environmental Science and Engineering(B) 2017年第11期6卷 569-581页

作者： Hamma fabien Yonli David Yemboini Kader Toguyeni Moussa Sougoti Department of Physics the University Ouaga I Pr Joseph KI-ZERBO BP 7021 Ouagadougou 03 Burkina Faso Department of Civil Engineering the University of Fada N'Gourma BP 46 Fada N'Gourma Burkina Faso

Despite the developments of sectors which aim at valorizing recyclable materials, landfills remain essential in integrated waste management. The construction of such infrastructures is an engineering challenge that must be proven over the long term. The purpose of this study is to understand the modification of the hydromechanical properties of bottom liners of landfills that may occur during their exploitation under leachate action. To do so, on the basis of its parameters of nature, a swelling clay from Burkina Faso is selected from soils of seven localities in Burkina Faso （West Africa）. Laboratory tests carried out with distilled water and then with a young synthetic leachate show a degradation of the permeability of this clay from 2.42 × 10^-10 m/s to 1.01 × 10^-9 m/s. In addition, leachate leads to an inhibition of the swelling and a remarkable increase of its compressibility, inducing significant settlement. With the increase in permeability, the primary consolidation settlement is increasing faster. Changes in the hydromechanical behavior can be attributed to the clays mineralogy, mainly cation exchange and the development of the diffuse double layer.

关键词： Bottom liner leachate hydraulic conductivity compressibility consolidation.

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"In-situ Recycling" :Monolithic Ladle Repair with Shotcreting

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China's Refractories 2015年第1期24卷 44-50页

作者： Christoph WHRMEYER Christopher PARR fabien SIMONIN Bin LI Susan Li Simon GAO Magali SZEPIZDYN Jim FARRELL Scott KNIGHTON Kemeos S.A. Paris-Neuilly92521 France & Beijing 100027China Blastcrete Equipment Company

The service life of refractories in ladle walls is limited by corrosion,abrasion,thermal shock and structural spalling mechanisms. When the ladle is lined with bricks they typically need to be completely removed after a certain number of heats to be replaced by new bricks of the same size as the original bricks. Not so for monolithic ladle linings. At the end of their service life the remains of the castable can almost completely be recycled as they can in fact stay in place. Only the worn-out part of the lining has to be replaced by a new castable. 20%-50% of the initial ladle lining can be recycled ＂insitu＂. The installation can efficiently be done by shotcreting technics. But it requires a castable that resists slag penetration very well. Castables based on a calcium magnesium aluminate bond provide the required penetration resistance. Pumping and shotcreting is very well adapted for repairs of blast furnace shafts,torpedo cars,hot metal and steel ladle linings[1]. However,very little is published about how a good pumping and shotcreting performance can be achieved when the installation has to be done under extreme weather conditions. At high ambient temperature the challenge is to ensure a good pumping result without early castable stiffening. Blockage of the pump would be the consequence. At low ambient temperature the difficulty is to de-activate the highly efficient deflocculant fast enough with a gelling agent added intothe wet mix at the nozzle to prevent the gunned material slipping off the wall. This paper studies strategies how to achieve good installed properties even at extreme ambient temperatures. The interactions between deflocculants,retarders,gelling agents,and calcium magnesium aluminate binder as a function of temperature are studied for an alumina- spinel ladle castable. Beside a new gelling agent for this castable type also a special stabilizer to reduce the temperature sensitivity has been investigated. It will be highlighted how the use of t

关键词： steel ladle slag penetration alumina spinel castable shotcreting recycling calcium magnesium aluminate gelling agent

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活性染料竭染染色的配伍性研究

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印染 2003年第2期29卷 1-4页

作者：姜秀增朱泉 fabien Roland 东华大学化学与化工学院 200051 法国里昂纺织化工学院

活性染料的拼色染色以其可靠的染色结果而得到广泛应用。本文给出了一种直观、简便的可视化新方法 ,为活性染料的应用提供了可靠的参考依据。选用MCT MCT双活性基染料 ,按一定的工艺处方染纯棉织物 ,作其上染和固色曲线 ,并测试具有代... 详细信息

活性染料的拼色染色以其可靠的染色结果而得到广泛应用。本文给出了一种直观、简便的可视化新方法 ,为活性染料的应用提供了可靠的参考依据。选用MCT MCT双活性基染料 ,按一定的工艺处方染纯棉织物 ,作其上染和固色曲线 ,并测试具有代表性的染色特征值使其可视化 ,以选择理想的三原色组合进行拼色染色 ,并与染料生产厂家推荐的其他类型三原色进行比较。

关键词：纯棉织物活性染料竭染染色配伍性上染率固色率三原色

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Elaboration and Characterization of a Plaster Reinforced with Fibers from the Stem of Cola lepidota for Industrial Applications

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World Journal of Engineering and Technology 2022年第4期10卷 824-842页

作者： Zogo Tsala Simon Armand Noah Pierre Marcel Anicet Ayissi Zacharie Merlin Betene Ebanda fabien Nkenne Youmba Judide Kenmogne fabien Atangana Ateba Department of Civil Engineering ENSET University of Ebolowa Ebolowa Cameroon Department of Mechanical Engineering ENSET University of Douala Douala Cameroon Laboratory of Mechanics University of Douala Cameroon Douala Cameroon Laboratory of Energy Materials Modelisation and Method University of Douala Douala Cameroon Department of Civil Engineering ENSET University of Douala Douala Cameroon

Current environmental and eco-design issues require the use of environmentally friendly materials. These make up a large share of the building materials market. Natural fibers are already used in various types of materials, such as plastics, concrete and lime-based products. They exhibit different attributes like the right combination of mechanical, thermal and acoustic properties, allowing these types of materials to be used for different applications. The main disadvantage associated with plaster is its fragility, especially under mechanical stress. Therefore, it becomes interesting to study different methods that could improve the mechanical properties of plaster. The addition of fibers to the plaster to obtain a composite material is already recognized as a means of improving the behavior of the product, in particular after the rupture of the matrix. The aim of this work was to study the effects of the addition of natural fibers from the stem of Cola lepidota (CL), on the physical properties and the mechanical behavior of the composite matrix. This study highlights the effects of fiber size and volume fraction. It has been shown that the mass of composites decreases as the percentage and length of fibers increases. The mechanical properties of composite materials are also discussed. Even at low addition rates, CL stem fibers achieved slightly higher values of flexural properties.

关键词： Cola lepidota Vegetable Fiber Plaster Composite Retting Characterization

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Optimizing the Interpretation of Sub-surface Resistivity in Relation with Borehole Productivity in Basement Area Applied to Seno Province （Burkina Faso）

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Journal of Environmental Science and Engineering(B) 2016年第12期5卷 563-580页

作者： Mahamadou Koita Hamma fabien Yonli Delwende Guy Christian Nikiema Department of Civil Engineering and Hydraulics the International Institute for Water and Environmental Engineering BP 594 Ouagadougou 01 Burkina Faso Department of Physics and Environmental Chemistry the University of Ouaga 1 Pr Joseph K1 ZERBO BP 7021 Ouagadougou 03Burkina Faso

This study aims at identifying possible correlations between shapes, types of geophysical anomalies and borehole productivity according to geological and hydrogeotogical contexts. The methodology adopted was a two-pronged one--the first step sought to：（1） interpret the electrical resistivity values from horizontal profiling and vertical electrical sounding implemented in Seno province that preceded the drilling of 513 boreholes; （ii） interpret data from pumping tests carried out on boreholes having a discharge superior to 1 m3/h （＂positive borehole＂） by using Cooper-Jacob＇s method. In the second step, according to geology, authors tried to identify possible correlations between each of the qualitative geophysical parameters： ~shape of anomaly〉〉, tttype of anomaly〉〉 and ~〈type curve〉〉 on the one hand, and hydrogeological parameters such as discharge, alteration thickness, transmissivity and saturated level on the other. The results of this study have shown that the chances of having a positive borehole in Seno province are higher when the type of anomaly is TCC （80%）, shape of anomaly is ＂W＂ and when type curve is ＂H＂（80%） for all geological formations. Granitic formations are those that record higher discharges while schists record high transmissivity values.

关键词： Basement rocks sub-surface resistivity borehole anomaly productivity Seno province Burkina.

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The transcription factor Fl08 mediates CO2 sensing in the human fungal pathogen Candida albicans

The transcription factor Fl08 mediates CO2 sensing in the hu...

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2012年中国菌物学会学术年会

作者： fabien Cottier Fritz A.Mühlschlegel School of Biosciences University of KentCanterburyKentCT2 7N JUK Clinical Microbiology Service East Kent Hospitals University NHS Foundation TrustAshfordKentTN24 0LZUK

Physiological levels of CO

关键词： Candida albicans Flo8 cAMP/PKA pathway CO2

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Inclusion Control and Long Sequence Casting

Inclusion Control and Long Sequence Casting

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技术创新与循环经济——第二届宝钢学术年会

作者： Marc BURTY Leo PEETERS fabien RUBY Sidmar Arcelor groupBelgium Arcelor Research France

＜正＞The clogging of CC nozzle means higher production cost,increased safety risk,higher internal downgrading and finally customer *** has detrimental consequences on ***,the problem occurs variably on one given strand,one sequence,a specific period,on some *** development has evidenced critical process parameters influencing *** many parameters act on clogging, details of the steelmaking process matter;injection of argon,refractory quality and the inclusion population. We have developed and used some powerful new techniques to better understand the clogging *** content and type can be quickly characterized with SEM and PDA *** have thus specifically tracked the harmful inclusion *** - oxidation with Mg - bearing aluminum leads to the formation of spinel *** are smaller than alumina and form looser *** negative impact is found concerning castability.

关键词： clogging inclusions calcium magnesium oxides spinel

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双调蛋白反义核酸表达对裸鼠乳腺癌血管生成的抑制作用

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中华肿瘤杂志 2005年第9期27卷 521-523页

作者：马林 SEROVA Maria PODGORNIAK Marie Pierre BERTHOIS Yolande MOURAH Samia CALVO fabien 解放军总医院放射治疗科北京100853 法国巴黎INSERMEMI-0334实验室法国马赛北医学院实验肿瘤学实验室

目的研究双调蛋白(AR)反义RNA表达对乳腺癌血管生成的抑制作用。方法乳腺癌NS2T2A1细胞经AR反义cDNA质粒转染后,经筛选获得表达AR反义RNA的AR-AS1及AR-AS3克隆,转染空载体获得NS2T2A1V对照细胞,接种裸鼠皮下形成肿瘤。研究条件培养液对... 详细信息

目的研究双调蛋白(AR)反义RNA表达对乳腺癌血管生成的抑制作用。方法乳腺癌NS2T2A1细胞经AR反义cDNA质粒转染后,经筛选获得表达AR反义RNA的AR-AS1及AR-AS3克隆,转染空载体获得NS2T2A1V对照细胞,接种裸鼠皮下形成肿瘤。研究条件培养液对人微血管内皮细胞(HMEC)增殖的影响,以ELISA法测定细胞血管内皮生长因子(VEGF)分泌量。以定量RT-PCR分析肿瘤组织的VEGF表达水平。以免疫组化法标记CD31研究肿瘤内血管数量。结果HMEC在AR-AS1和AR-AS3细胞条件培养液中的增殖比例明显降低。AR-AS1和AR-AS3细胞VEGF分泌量亦降低。AR-AS1和AR-AS3肿瘤的血管数量仅有对照组的50%左右,且VEGF表达显著降低。结论AR反义RNA表达可有效抑制乳腺癌的血管生成,应作为新治疗靶点进一步研究。

关键词：双调蛋白反义血管生成乳腺肿瘤反义RNA 抑制作用乳腺癌血管内皮生长因子(VEGF) 核酸表达裸鼠

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