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Early identification of stroke through deep learning with multi-modal human speech and movement data

Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the face Arm Speech Test(faST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the faST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,Slowfast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the faST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection faST screening stroke

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Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan ren Fei Zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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Additive effects on tin electrodepositing in acid sulfate electrolytes

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International Journal of Minerals,Metallurgy and Materials 2013年第5期20卷 472-478页

作者： fa-xin Xiao Xiao-ni Shen Feng-zhang ren Alex A. Volinsky School of Materials Science and Engineering Henan University of Science and Technology Department of Mechanical Engineering University of South Florida

The effects of additives on the stannous reduction of an acid sulfate bath were investigated using cyclic and linear sweep voltammetry, electrochemical impedance spectroscopy （EIS）, and microstructure analysis. In the absence of additives, tin coatings are rough, and the tin electrodepositing is a single-step reduction process accompanied by hydrogen gas evolution. The addition of tartaric acid produces a slight reduction in the peak current of stannous reduction and has an appreciably positive effect on the stability of the acidic tin bath. Both benzylidene acetone and polyoxyethylene octylphenol ether hinder the stannous reduction and greatly suppress the hydrogen gas evolution. Formaldehyde slightly decreases the peak current density of stannous reduction and serves as an auxiliary brightener in the acid sulfate bath. The presence of mixed additives greatly suppresses the stannous reduction and hydrogen gas evolution and consequently produces a significantly smoother and denser tin coating. The （112） crystal face is found to be the dominant and preferred orientation of tin deposits.

关键词： electrodepositing tin additives stannous reductiOn

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Mechanical and microstructural characterization of additive manufactured Inconel 718 alloy by selective laser melting and laser metal deposition

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Journal of Iron and Steel Research International 2022年第8期29卷 1322-1333页

作者： fa-yun Lu Hong-yuan Wan xin ren Li-ming Huang Hai-lin Liu xin Yi Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China

The direct comparison of the microstructure and tensile properties of Inconel 718 fabricated by selective laser melting (SLM) or laser metal deposition (LMD) has been carried out. In the as-built state, LMD-fabricated specimens show lower tensile yield strength and fracture elongation than SLM-fabricated specimens due to the coarser solidification microstructure, including grains, cellular dendrites and Laves phases. This is mainly because the cooling rate of the LMD process is 2 to 3 orders lower than that of the SLM process. Upon the same heat treatment, both yield strengths of SLMand LMD-fabricated specimens are enhanced significantly. Notably, LMD-fabricated specimens exhibit simultaneous improvement in the strength and ductility, which is mainly attributed to the presence of small granular Laves phases and uniformly distributed nanoscale c00 strengthening phases. The results could serve as a guidance for selecting suitable postheat treatment routes for specific additive manufacturing process to attain excellent strength-ductility synergy.

关键词： Inconel 718 alloy Selective laser melting Laser metal deposition Heat treatment Strength-ductility synergy

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Anatomical characteristics of patients with symptomatic severe aortic stenosis in China

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Chinese Medical Journal 2021年第22期134卷 2738-2740页

作者： Tian-Yuan Xiong Yi-Ming Li Yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei fang Jun Jin Guo-Sheng Fu Yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen Yi Li Yi-Bing Shao Yi Zhang Bo-Sen Yang Yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He fa-xin ren Jian-Cheng Xiu xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China State Key Lab of Hydraulics and Mountain River Engineering Sichuan UniversityChengduSichuan 610044China Department of Cardiology General Hospital of Northern Theater CommandShenyangLiaoning 110015China Department of Cardiology The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Cardiology Xinqiao Hospital of Third Military Medical UniversityChongqing 400037China Department of Cardiology Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhouZhejiang 310016China Department of Cardiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Department of Cardiovascular Surgery The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310009China Department of Cardiology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Cardiology Fujian Provincial HospitalFuzhouFujian 350013China Department of Cardiology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Cardiology Chinese People’s Liberation Army General Hospital(301 Hospital)Beijing 100853China Department of Cardiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Cardiology Qingdao Municipal HospitalQingdaoShandong 266071China Department of Cardiology Subei People’s HospitalYangzhouJiangsu 225001China Department of Cardiology Yantai Yuhuangding HospitalYantaiShandong 264000China Department of Cardiology Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Cardiovascular Surgery Qilu Hospital of Shandong UniversityJinanShandong 250063China Department of Cardiology Fujian Medical University Union HospitalFuzhouFujian 350001China Department of Cardiology

With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated.

关键词： patients aortic younger

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Constitutive Modeling for Elevated Temperature Flow Behavior of30Cr2Ni4MoV Ultra-super-critical Rotor Steel

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Journal of Iron and Steel Research International 2014年第5期21卷 521-526页

作者： Fei CHEN fa-cai ren Zhen-shan CUI xin-min LAI Institute of Forming Technology and Equipment Shanghai Jiao Tong University School of Mechanical Engineering Shanghai Jiao Tong University

In order to perform numerical simulation of forging and determine the hot deformation processing parameters for 30Cr2Ni4MoV steel, the compressive deformation behaviors of 30Cr2Ni4MoV steel were investigated at the temperatures from 970 to 1270 ℃ and strain rates from 0. 001 to 0.1 s-1 on a Gleeble-3500 thermo-mechanical simulator. The flow stress constitutive equations of the work hardening-dynamical recovery period and dynamical recrystallization period were established for 30Cr2Ni4MoV steel. The stress-strain curves of 30Cr2Ni4MoV steel predicted by the proposed model well agreed with experimental results, which confirmed that the proposed equations can be used to determine the hot deformation processing parameters for 30Cr2Ni4MoV steel.

关键词： 30Cr2Ni4MoV steel hot compression dynamical recrystallization flow stress

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Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao ren Cheng Xu Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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Novel aluminum-based fuel:facile preparation to improve thermal reactions

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Defence Technology（防务技术） 2022年第10期18卷 1852-1862页

作者： fa-yang Guan Hui ren Wan-jun Zhao xin-zhou Wu Qing-jie Jiao State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

To improve the thermal properties of aluminum(Al)in the energetic system,a coated structure with ammonium perchlorate(AP)was prepared by a facile *** N,N-Dimethylformamide(DMF)was chosen as an ideal solvent based on heterogeneous nucleation theory and molecular dynamics *** coated structure could enlarge the contact area and improve the reaction environment to enhance the thermal *** addition of AP could accelerate oxidation temperature of Al with around 17.5°*** the heat release of 85@15 composition rises to 26.13 k J/g and the reaction degree is97.6%with higher peak pressure(254.6 k Pa)and rise rate(1.397 MPa/s).An ideal ratio with 15 wt%AP was probed *** high energy laser-induced shockwave experiment was utilized to simulate the reaction behavior in hot *** the larger activated mixture of coated powder could release more energy to promote the growth of shockwave with higher speed up to 518.7±55.9 m/*** conclusion,85@15 composition is expected to be applied in energetic system as a novel metal fuel.

关键词： Aluminum-based fuel Heterogeneous nucleation Molecular dynamics simulation Thermal reaction High energy laser-induced shockwave experiment

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Role of trivalent antimony in the removal of As, Sb, and Bi impurities from copper electrolytes

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International Journal of Minerals,Metallurgy and Materials 2013年第1期20卷 9-16页

作者： fa-xin Xiao Dao Cao Jian-wei Mao Xiao-ni Shen Feng-zhang ren School of Materials Science and engineering Henan University of Science and Technology Henan Key Laboratory of Advanced Nonferrous Metal Materials

The role of trivalent antimony was investigated in removing As, Sb, and Bi impurities from a copper electrolyte. Puri- fication experiments were carried out by adding a various concentrations of Sb（III） ions in a synthetic electrolyte containing 185 g/L sulfuric acid, 45 g/L Cu2＋, 10 g/L As, and 0.5 g/L Bi under stirring at 65℃ for 2 h. The electrolyte was filtered, and the structure, morphology and composition of the precipitate were analyzed by means of chemical analysis, scanning electron mi- croscopy （SEM）, X-ray diffraction （XRD）, transmission electron microscopy （TEM）, and IR spectroscopy. The precipitate is composed of irregular lumps which are agglomerated by fine dendritic and floccus particles, and it mainly consists of As, Sb, Bi, and O elements. Characteristic bands in the IR spectra of the precipitate are As-OX （X=As, Sb, Bi）, Sb-OY （Y=Sb, Bi）, O-As-O1 As-OH, Sb-OH, and O-H. The precipitate is a mixture of microcrystalline SbAsQ, （Sb,As）203, and amorphous phases. As, Sb, and Bi impurities are effectively removed from the copper electrolyte by Sb（III） ions attributing to these pre- cipitates.

关键词： copper metallurgy electrorefining electrolytes impurities removal antimony arsenic bismuth

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