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Increased salt sensitivity induced by sensory denervation: role of superoxide

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Acta Pharmacologica Sinica 2004年第12期25卷 60-66页

作者： Alex f CHEN,Donna H WANG Department of Medicine and Pharmacology & Toxicology Michigan State University East Lansing MI 48824 USA Department of Medicine and Pharmacology & Toxicology Michigan State University East Lansing MI 48824 USA

AIM: To test the hypothesis that production of superoxide in mesenteric resistance arteries is increased and con- tributes to the development of hypertension induced by sensory denervation plus high salt intake. METHODS: Newborn Wistar rats were given capsaicin 50 mg/kg sc on the 1st and 2nd d of life. After weaning, male rats were grouped as follows and treated for 3 weeks with: capsaicin pretreatment plus normal sodium diet (0.5 %, CAP-NS), CAP plus high sodium diet (4 %, CAP-HS), control plus NS (CON-NS), or CON-HS. Both tail-cuff systolic blood pressure and mean arterial pressure (MAP) were measured in each of the groups. Western blot analysis was used for measurement of manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) in the mesenteric resistance arteries. Lucigenin chemiluminescence assay was used for superoxide production in the mesenteric resistance arteries. The Griess method was used for measurement of nitrite/nitrate levels in plasma. RESULTS: Both tail-cuff pressure and MAP were higher in CAP-HS compared with CAP-NS, CON-HS, and CON- NS rats (Pfferent among 4 groups. Acute iv administration of tempol, a membrane-permeable superoxide scavenger, de- creased MAP in both CAP-HS and CON-HS when compared with their respective controls. However, the de- creases of MAP between these two groups were not different. Chronic treatment with tempol failed to prevent the development of hypertension in CAP-HS rats. Superoxideproduction in the mesenteric resistance arteries was increased in CAP-HS compared with CAP-NS, CON-HS, and CON-NS (Pf mesenteric superoxideproduction in CAP-HS rats. CONCLUSIONS: Regardless of increased vascular MnSOD levels, salt

关键词： superoxides tempol afferent neurons capsaicin denervation dietary sodium chloride nitric oxide

Battery prognostics and health management for electric vehicles under industry 4.0

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Journal of Energy Chemistry 2023年第9期84卷 30-33页

作者： Jingyuan Zhao Andrew f.Burke Institute of Transportation Studies University of California DavisDavisCA 95616USA

Transportation electrification is essential for decarbonizing transport. Currently, lithium-ion batteries are the primary power source for electric vehicles (EVs). However, there is still a significant journey ahead before EVs can establish themselves as the dominant force in the global automotive market. Concerns such as range anxiety, battery aging, and safety issues remain significant challenges.

关键词： Lithium-ion battery Prognostics and health management Machine learning Cloud Artificial intelligence Digital twins Lifelong learning

Generation and analysis of expressed sequence tags from the medicinal plant Salvia miltiorrhiza

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Science China(Life Sciences) 2010年第2期53卷 273-285页

作者： SPENCER David f Department of Biochemistry and Molecular Biology Dalhousie University

Salvia miltiorrhiza *** a well-known traditional Chinese *** roots have been formulated and used clinically for the treatment of various ***,little genetic information has so far been available and this fact has become a major obstacle for molecular *** address this lack of genetic information,an Expressed Sequence Tag (EST) library from whole plantlets of *** was *** the 12959 cDNA clones that were randomly selected and subjected to single-pass sequencing from their 5′ ends,10288 ESTs (with sizes≥100 bp) were selected and assembled into 1288 contigs,leaving 2937 singletons,for a total of 4225 *** were analyzed using BLASTX (against protein databases),RPS-BLAST (against a conserved domain database) as well as the web-based KEGG Automatic Annotation Server for metabolic enzyme *** on the metabolic enzyme assignment,expression patterns of 14 secondary metabolic enzyme genes in different organs and under different treatments were verified using real-time PCR ***,a total of 122 microsatellites were identified from the ESTs,with 89 having sufficient flanking sequences for primer *** set of ESTs represents a significant proportion of the *** transcriptome,and gives preliminary insights into the gene complement of *** will prove useful for uncovering secondary metabolic pathways,analyzing cDNA-array based gene expression,genetic manipulation to improve yield of desirable secondary products,and molecular marker identification.

关键词： expressed sequence tags Salvia miltiorrhiza Bge. gene identification microsatellite

Development of Soda Residue Concrete Expansion Agent

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Journal of Wuhan University of Technology(Materials Science) 2003年第3期18卷 79-82页

作者：王宝民 M f Mohd Zain f C Lai Department of Civil Engineering Dalian University of Technology faculty of Engineering U.K.M (Malaysia)

A new type of concrete expansion agent has been successfully developed for the first time in the world by utilizing an industrial waste residue soda residue and an industrial *** 3%-6% of the agent into Portland cement enables a shrinkage compensating concrete to be *** and concrete containing this expansion agent have better shrinkage compensating and mechanical *** raw materials component,production process,technical properties,micro analysis of mortar made with this expansion agent,mechanism of expansion and research results are described in this *** experimental results show that the new type of concrete expansion agent accords with the standard and its main mineral component is xCaO ySO 3 zAl 2O 3.

关键词： industrial waste soda residue concrete expansion agent expansive concrete shrinkage compensating concrete

Nanocrystalline Ti49.2Ni50.8 shape memory alloy as orthopaedic implant material with better performance

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Journal of Materials Science & Technology 2019年第10期35卷 2156-2162页

作者： H.f.Li f.L.Nie Y.f.Zheng Y.Cheng S.C.Wei R.Z.Valiev Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 700877China Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Department of Oral and Maxillofacial Surgery School of StomatologyPeking UniversityBeijing 100081China Institute of Physics of Advanced Materials Ufa State Aviation Technical UniversityUfaRussia Saint Petersburg State University Universitetskiy prospekt 28PeterhofSt.Petersburg198504Russia

Ti Ni alloys, with their unique shape memory effects and super elastic properties, occupy an indispensable place in the family of metallic biomaterials. In the past years, surface treatment is the main technique to improve the bioinert nature of microcrystalline Ti Ni alloys and inhibit on the release of toxic nickel ions to obtain excellent osteogenesis and osseointegration function. In the present study, nanocrystalline Ti49.2Ni50.8 alloy has been fabricated via equal channel angular pressing(ECAP), and the in vitro and in vivo studies revealed that it had enhanced cell viability, adhesion, proliferation, ALP(Alkaline phosphatase)activity and mineralization, and increased periphery thickness of new bone, in comparison to the commercial coarse-grained counterpart. These findings indicate that the reduction of grain size is beneficial to increasing the biocompatibility of Ti49.2Ni50.8 shape memory alloy.

关键词： Nanocrystallines Shape memory alloys Metallic biomaterials Orthopaedic implants TiNi alloys

The viscous strip approach to simplify the calculation of the surface acoustic wave generated streaming

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 711-724页

作者： f.JAZINI DORCHEH M.GHASSEMI fuel Cells and Nano Systems(fCNS)Laboratory Department of Mechanical EngineeringK.N.Toosi University of TechnologyTehran 19697Iran

In recent decades,the importance of surface acoustic waves,as a biocompatible tool to integrate with microfluidics,has been proven in various medical and biological *** numerical modeling of acoustic streaming caused by surface acoustic waves in microchannels requires the effect of viscosity to be considered in the equations which complicates the *** this paper,it is shown that the major contribution of viscosity and the horizontal component of actuation is concentrated in a narrow region alongside the actuation *** the inviscid equations are considerably easier to solve,a division into the viscous and inviscid domains would alleviate the computational load *** particles'traces calculated by this approximation are excellently alongside their counterparts from the completely viscous *** is also shown that the optimum thickness for the viscous strip is about 9-fold the acoustic boundary layer thickness for various flow patterns and amplitudes of actuation.

关键词： surface acoustic wave microfluidics numerical simulation particle tracing acoustic streaming

Monitoring spatiotemporal soil moisture changes in the subsurface of forest sites using electrical resistivity tomography (ERT)

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Journal of forestry Research 2022年第5期33卷 1649-1662页

作者： Julian fäth Julius Kunz Christof Kneisel Institute of Geography and Geology University of WürzburgAm Hubland97074 WürzburgGermany

The effects of drought on tree mortality at forest stands are not completely understood. for assessing their water supply, knowledge of the small-scale distribution of soil moisture as well as its temporal changes is a key issue in an era of climate change. However, traditional methods like taking soil samples or installing data loggers solely collect parameters of a single point or of a small soil volume. Electrical resistivity tomography (ERT) is a suitable method for monitoring soil moisture changes and has rarely been used in forests. This method was applied at two forest sites in Bavaria, Germany to obtain high-resolution data of temporal soil moisture variations. Geoelectrical measurements (2D and 3D) were conducted at both sites over several years (2015-2018/2020) and compared with soil moisture data (matric potential or volumetric water content) for the monitoring plots. The greatest variations in resistivity values that highly correlate with soil moisture data were found in the main rooting zone. Using the ERT data, temporal trends could be tracked in several dimensions, such as the interannual increase in the depth of influence from drought events and their duration, as well as rising resistivity values going along with decreasing soil moisture. The results reveal that resistivity changes are a good proxy for seasonal and interannual soil moisture variations. Therefore, 2D- and 3D-ERT are recommended as comparatively non-laborious methods for small-spatial scale monitoring of soil moisture changes in the main rooting zone and the underlying subsurface of forested sites. Higher spatial and temporal resolution allows a better understanding of the water supply for trees, especially in times of drought.

关键词： Geoelectrical monitoring forest ecology Hydrology Soil water content

Transportation of heat through Cattaneo-Christov heat flux model in non-Newtonian fluid subject to internal resistance of particles

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Applied Mathematics and Mechanics(English Edition) 2020年第8期41卷 1157-1166页

作者： M.I.KHAN f.ALZAHRANI Department of Mathematics Riphah International UniversityFaisalabad 38000Pakistan Nonlinear Analysis and Applied Mathematics(NAAM)-Research Group Department of MathematicsFaculty of SciencesKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Thermal conduction which happens in all phases(liquid,solid,and gas)is the transportation of internal energy through minuscule collisions of particles and movement of electrons within a working *** colliding particles comprise electrons,molecules,and atoms,and transfer disorganized microscopic potential and kinetic energy,mutually known as the internal *** engineering sciences,heat transfer comprises the processes of convection,thermal radiation,and sometimes mass ***,more than one of these procedures may happen in a given *** use the Cattaneo-Christov(CC)heat flux model instead of the fourier law of heat conduction to discuss the behavior of heat transportation.A mathematical model is presented for the Cattaneo-Christov double diffusion(CCDD)in the flow of a non-Newtonian nanofluid(the Jeffrey fluid)towards a stretched *** magnetohydrodynamic(MHD)fluid is *** behaviors of heat and mass transportation rates are discussed with the *** models are based on fourier’s and fick’s *** convective transportation in nanofluids is discussed,subject to thermophoresis and Brownian *** nonlinear governing flow expression is first altered into ordinary differential equations via appropriate transformations,and then numerical solutions are obtained through the built-in-shooting *** impact of sundry flow parameters is discussed on the velocity,the skin friction coefficient,the temperature,and the concentration *** is reported that the velocity of material particles decreases with higher values of the Deborah number and the ratio of the relaxation to retardation time *** temperature distribution enhances when the Brownian motion and thermophoresis parameters *** concentration shows contrasting impact versus the Lewis number and the Brownian motion *** is also noticed that the skin friction coefficient decreases when the ratio of the relaxation to retarda

关键词： Cattaneo-Christov double diffusion(CCDD) non-Newtonian fluid model(Jeffrey model) viscous dissipation magnetohydrodynamic(MHD) Brownian diffusion thermophoresis diffusion

Editorial Prerogative and the Plant Genome

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Journal of Genetics and Genomics 2016年第5期43卷 229-232页

作者： Daniel f.Voytas Department of Genetics Cell Biology & Development and Center for Genome EngineeringUniversity of Minnesota

In the coming decades,plant agriculture must produce the food needed to sustain the world＇s burgeoning *** challenge is made more daunting in light of a changing climate,scarcity of inputs such as water and fertilizer,and the need to grow more crops on increasingly marginal *** achieve food security,we will need to fully exploit plant genetics to develop new crop varieties that produce higher yields of healthier food.

关键词： agriculture fertilizer scarcity Genome breeding sustain exploit genetics editing template