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Interracial differences in prostate cancer progression among patients from the United States, China and Japan

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Asian Journal of Andrology 2013年第6期15卷 705-707页

作者： Haiyen E Zhau Qinlong Li leland WK Chung Department of Medicine Samuel Oschin ComprehensiveCancer Institute Cedars-Sinai Medical Center LosAngeles CA 90048 USA

Although previous studies indicate interracial differences in prostate can-cer epidemiology based on gene expression profiles among patients from the United States, China and Japan, evidence at the ge- netic and phenotypic levels that these diffe-rences exist and manifest along ethnic lines has been sparse. Recent studies, however, suggest that genetic differences, such as the lower incidence of Chinese pros-tate cancers harboring TMPRSS2-ERG translocations compared to patients from Western countries, should be carefully con-sidered in the context of genotypic and phenotypic differences among interracial groups. New, more efficient technologies need to be developed to validate genetic, gene expression and/or phenotypic differ-ences associated with prostate cancer tissue specimens obtained from interracial groups, to establish reliable clinical standards that take racial/ethnic data into account to improve the diagnosis, prognosis and treat-ment of patients with prostate cancer.

关键词： ENDOTHELIAL GROWTH-fACTOR QUANTUM DOTS RACIAL-DIffERENCES MORTALITY-RATES MEN TRENDS TRANSITION PATTERNS BLACK ASIA

Impaired Cognition and Stroke Rehabilitation Outcomes: Are They Related?

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 101-116页

作者： Eric f. Tanlaka Torri Trojand faculty of Nursing University of Windsor Windsor Canada

Background: Stroke survivors who exhibit impaired cognition at admission to inpatient rehabilitation may experience participation challenges and poorer functional outcomes than those without impaired cognition. Differences in functional outcomes between stroke survivors with and without impaired cognition may be attributed to age, level of cognitive impairment, and severity of stroke. Materials and Methods: A retrospective secondary data analysis was conducted using health-related administrative data acquired from a Southwestern Ontario hospital’s stroke rehabilitation database. The aim was to explore potential linkages between post-stroke impaired cognition and functional gains, rehabilitation stays, and living settings after discharge from rehabilitation. Results: An aggregate sample of 393 males and 314 females subclassified as experiencing mild, moderate, and severe stroke was analyzed. At inpatient rehabilitation admission, 21.5% (n = 152) of these patients had no impaired cognition, 33.7% (n = 238) had mild impaired cognition, 22.2% (n = 157) had moderate impaired cognition, and 22.6% (n = 160) had severe impaired cognition. Cognitively impaired stroke patients were significantly (p 0.001) older, had (mostly) moderate to severe stroke with significantly (p = 0.012) more moderate cognitive impairment, had significantly (p 0.001) longer rehabilitation stays, and a high propensity for being discharged to longer-term care facilities compared to non-cognitively impaired patients. Conclusion: Presence of significant dissimilarity in rehabilitation stays and post-discharge destinations among stroke survivors with and without cognitive impairment is attributed to the age of the patient, level of cognitive impairment, and rigorous rehabilitation interventions.

关键词： Stroke Impaired Cognition Inpatient Rehabilitation functional Outcomes

Scalable Jet-Based fabrication of PEI-Hydrogel Particles for CO_(2)Capture

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Energy & Environmental Materials 2024年第6期7卷 351-358页

作者： Jieke Jiang Eline van Daatselaar Hylke Wijnja Tessa de Koning Gans Michel Schellevis Cornelis H.Venner Derk W.f.Brilman Claas Willem Visser Engineering fluid Dynamics Group Department of Thermal and Fluid EngineeringFaculty of Engineering TechnologyUniversity of Twente7500AEEnschedeThe Netherlands Sustainable Process Technology Faculty of Science and TechnologyUniversity of Twente7500AEEnschedeThe Netherlands

The capture,regeneration,and conversion of CO_(2)from ambient air and flue gas streams are critical aspects of mitigating global *** sorbents for CO_(2)absorption are very promising as they have high mass transfer areas without energy input and reduce emissions and minimize corrosion as compared to liquid ***,precisely tunable solid CO_(2)sorbents are difficult to ***,we demonstrate the high-throughput production of hydrogel-based CO_(2)-absorbing particles via liquid *** wrapping a liquid jet consisting of an aqueous solution of cross-linkable branched polyethylenimine(PEI)with a layer of suspension containing hydrophobic silica nanoparticles,monodisperse droplets with a silica nanoparticle coating layer was formed in the air.A stable Pickering emulsion containing PEI droplets was obtained after these ejected droplets were collected in a heated oil *** droplets turn into mm-sized particles after thermal curing in the *** diameter,PEI content,and silica content of the particles were systematically varied,and their CO_(2)absorption was measured as a function of *** regeneration of the particles enabled cyclic testing,revealing a CO_(2)absorption capacity of 6.5±0.5 mol kg^(−1)solid PEI in pure CO_(2)environments and 0.7±0.3 mol kg^(−1)solid PEI for direct air *** thousands of particles were produced per second at a rate of around 0.5 kg per hour,with a single *** process can be further scaled by *** complete toolbox for the design,fabrication,testing,and regeneration of functional hydrogel particles provides a powerful route toward novel solid sorbents for regenerative CO_(2)capture.

关键词： CO_(2)capture droplet hydrogel liquid jet particle steam regeneration

Thin-Shell Wormholes Admitting Conformal Motions in Spacetimes of Embedding Class One

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International Journal of Astronomy and Astrophysics 2024年第3期14卷 162-171页

作者： Peter K. f. Kuhfittig Department of Mathematics Milwaukee School of Engineering Milwaukee USA

This paper discusses the feasibility of thin-shell wormholes in spacetimes of embedding class one admitting a one-parameter group of conformal motions. It is shown that the surface energy density σis positive, while the surface pressure is negative, resulting in , thereby signaling a violation of the null energy condition, a necessary condition for holding a wormhole open. for a Morris-Thorne wormhole, matter that violates the null energy condition is referred to as “exotic”. for the thin-shell wormholes in this paper, however, the violation has a physical explanation since it is a direct consequence of the embedding theory in conjunction with the assumption of conformal symmetry. These properties avoid the need to hypothesize the existence of the highly problematical exotic matter.

关键词： Thin-Shell Wormholes Conformal Symmetry Embedding Class One Exotic Matter

Radiofrequency ablation versus microwave ablation for colorectal liver metastases:long-term results of a retrospective cohort surgical experience

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 759-770,I0001页

作者： Ali Gunduz Sarioglu Chase J.Wehrle Ege Akgun Arturan Ibrahimli James f.Bena Eren Berber Department of Endocrine Surgery Cleveland ClinicClevelandOHUSA Department of General Surgery Cleveland ClinicClevelandOHUSA Department of Quantitative Health Sciences Cleveland ClinicClevelandOHUSA

Background:Ablation is an alternative treatment modality for selected patients with colorectal liver metastases(CRLMs).Although initially widely performed via radiofrequency ablation(RfA),more recently,microwave ablation(MWA)is being preferred due to its perceived superiority in creating the ablation *** aim of this study is to compare the long-term efficacy of these two modalities performed ***:Patients undergoing surgical liver ablation from 2005-2023 at a tertiary center by a single surgeon for CRLM were included in a retrospective institutional review board-approved *** were compared using Wilcoxon,Chi-square,Kaplan-Meier,and Cox multivariate regression *** data are presented as median(interquartile range).Results:There were a total of 242 *** RfA was done in 121 patients with 303 lesions and laparoscopic MWA in 121 patients with 300 *** was no difference between the groups regarding operative time(161 vs.147 minutes,respectively,P=0.4),perioperative morbidity(3%vs.8%,respectively,P=0.2)or hospital stay(1 vs.1 day,P=0.05).Local recurrence(LR)per lesion with at least 1 year of imaging follow-up was 29%in the RfA and 13%in the MWA group(Pf *** control these variables,direct matching was *** cohort included 189 ***-Meier analysis of these cohorts showed increased LR-free survival in the MWA group *** RfA group(P=0.005).Conclusions:This large study confirms our initial observation that local tumor control rate is better after MWA ***.

关键词： Colorectal cancer liver metastasis liver ablation radiofrequency ablation(RfA) microwave ablation(MWA) local recurrence(LR)

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

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Journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.fattahi Christopher Zaro Janice J.Chung Richard f.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA Jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

A Preliminary Comparative Study on the Centering Algorithms for CassiniISS NAC Images

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Research in Astronomy and Astrophysics 2024年第10期24卷 58-65页

作者： T.Liang Q.-f.Zhang G.-M.Liu W.-H.Zhu C.-S.Wang Department of Computer Science Jinan UniversityGuangzhou 510632China Sino-french Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China School of Computer Science Guangdong University of EducationGuangzhou 510303China

Obtaining high precision is an important consideration for astrometric studies using images from the Narrow Angle Camera(NAC)of the Cassini Imaging Science Subsystem(ISS).Selecting the best centering algorithm is key to enhancing astrometric *** this study,we compared the accuracy of five centering algorithms:Gaussian fitting,the modified moments method,and three point-spread function(PSf)fitting methods(effective PSf(ePSf),PSfEx,and extended PSf(x PSf)from the Cassini Imaging Central Laboratory for Operations(CICLOPS)).We assessed these algorithms using 70 ISS NAC star field images taken with CL1 and CL2 filters across different stellar *** ePSf method consistently demonstrated the highest accuracy,achieving precision below 0.03 pixels for stars of magnitude *** to the previously considered best,the modified moments method,the e PSf method improved overall accuracy by about 10%and 21%in the sample and line directions,***,the xPSf model provided by CICLOPS had lower precision than the ***,the ePSf exhibits an improvement in measurement precision of 23%and 17%in the sample and line directions,respectively,over the *** discrepancy might be attributed to the xPSf focusing on photometry rather than *** findings highlight the necessity of constructing PSf models specifically tailored for astrometric purposes in NAC images and provide guidance for enhancing astrometric measurements using these ISS NAC images.

关键词： methods:analytical techniques:image processing stars:imaging astrometry

Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Tharwat Elabbasy Mohamed R.Atteya Mai A.Samak Mousa Abdelrahman Tahani AlMahmoud M.A.El-Morsy A.A.Menazea M.f.H.Abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),fourier transform infrared spectroscopy(fTIR),Raman,and scanning electron microscopy(SEM),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

Development of an ultrathin liquid sheet target for laser ion acceleration at high repetition rates in the kilohertz range

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High Power Laser Science and Engineering 2024年第3期12卷 134-145页

作者： M.füle A.P.Kovács T.Gilinger M.Karnok P.Gaál S.figul G.Marowsky K.Osvay National Laser-Initiated Transmutation Laboratory University of SzegedSzegedHungary Department of Experimental Physics University of SzegedSzegedHungary ELI ALPS ELI-HU Non-Profit Ltd.SzegedHungary Department of Optics and Quantum Electronics University of SzegedSzegedHungary Advanced Microfluidic Systems GmbH GöttingenGermany

A colliding microjet liquid sheet target system was developed and tested for pairs of round nozzles of 10,11 and 18μm in *** sheet's position stability was found to be better than a few *** interaction with 50 mJ laser pulses,the 18μm jet has a resonance amplitude of 16μm at a repetition rate of 33 Hz,while towards 100 Hz it converges to 10μm for all nozzles.A white-light interferometric system was developed to measure the liquid sheet thickness in the target chamber both in air and in vacuum,with a measurement range of 182 nm±1μm and an accuracy of±3%.The overall shape and 3D shape of the sheet follow the Hasson±Peck model in *** vacuum versus air,the sheet gradually loses 10%of its thickness,so the thinnest sheet achieved was below 200 nm at a vacuum level of 10±4mbar,and remained stable for several hours of operation.

关键词： diagnostics laser ion acceleration nanometric liquid sheet targets vacuum test