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Novel transcatheter aortic heart valves exhibiting excellent hemodynamic performance and low-fouling property

Journal of Materials Science & Technology 2019年第1期35卷 207-215页

作者： f.guo K.Jiao Y.Bai J.guo Q.Chen R.Yang X.Zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China School of Textile and Material Engineering Dalian Polytechnic University Lumenous Peiertech

Transcatheter aortic heart valves(TAHVs) have been widely used for aortic valve replacements, with less trauma and lower clinical risk compared with traditional surgical heart valve replacements. In the present study, composites of poly(ethylene glycol) diacrylate(PEGDA) hydrogels and anisotropic highshrinkage polyethylene terephthalate/polyamide6(PET-PA6) fabric(PEGDA/PET-PA6) were fabricated as artificial heart valve leaflets. Dynamic mechanical analyses(DMA) indicated that PEGDA/PET-PA6 composites possessed anisotropic mechanical properties(i.e., storage moduli ~23.30 ± 1.36 MPa parallel to the aligned fabric fibers and ~9.68 ± 0.90 MPa perpendicular to the aligned fibers at 1 Hz) that were comparable to aortic valve leaflets. The PEGDA/PET-PA6 composites with smooth surfaces were highly hydrophilic(contact angle ~41.6°± 3.8°) and had low-fouling properties without platelet adhesion,suggesting a low risk of thrombogenicity when they interacted with blood. furthermore, transcatheter aortic heart valves were fabricated using nitinol self-expanding frames and PEGDA/PET-PA6 composites as artificial leaflets, which presented excellent hemodynamic performance with a large orifice area(1.75cm2) and low regurgitation(3.41%), thus meeting the requirements of ISO 5840-3 standard. Therefore,PEGDA/PET-PA6 composites had suitable mechanical properties, good biocompatibility, and low-fouling properties, indicating that they might be used for TAHVs in the future.

关键词： Transcatheter aortic heart valve Textile fabric Poly(ethylene glycol)diacrylate Anti-fouling

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Effects of absorbing media on relative optical interference intensity ROII technique

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Science China Mathematics 2001年第S1期44卷 431-435页

作者： P.L.Wong f.guo Department of Manufacturing Engineering and Engineering Management City University of Hong Kong83 Tat Chee

The optical interference intensity ROll technique, which enables measurements of filmthickness of magnitude below half of the wavelength of the incident light, is widely used in thestudy of thin film lubrication (TfL). However, the absorbing characteristics of the metallic compo-nents which are for generating suitable amount of reflectance to facilitate optimum inference im-ages has never been taken into consideration. This paper presents a theoretical analysis of theabsorbing characteristics. Results indicate that without acknowledging the absorbing effects, sig-nificant errors in film thickness measurements can be induced.

关键词： relative optical interference intensity optics of metal film thickness

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Study the Teaching Mode of the Integration of Theory and Real Equipment——Take the Teaching Mode Reform of Aircraft Spares Sequestration Course as an Example

Study the Teaching Mode of the Integration of Theory and Rea...

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International Conference on Industrial Technology and Management Science(ITMS 2015)

作者： f.guo D.X.WANG C.Y.LIU B.ZHOU X.X.guo S.Q.ZHANG Naval Aeronautical Engineering Institute Qingdao Branch

In view of the problem that aircraft spares sequestration course gave priority to theory and minor attention to practice, used the teaching mode of the integration of theory and real equipment to make the curriculum reform of aircraft spares sequestration course, put foreward the teaching ideas, teaching design, practice teaching and appraisal method based on the teaching mode of the integration of theory and real equipment. The teaching mode reform practice of aircraft spares sequestration course shows that the application effect of the teaching mode of the integration of theory and real equipment is significant.

关键词： Integration of theory and real equipment Teaching mode Practice teaching Aircraft spares sequestration

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基于自由呼吸质子MRI和深度卷积神经网络生成的肺通气图

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国际医学放射学杂志 2021年第2期44卷 236-237页

作者： D.P.I.Capaldi f.guo L.Xing G.Parraga 杨柳

摘要超极化惰性气体有助于测量肺通气功能,但临床转化仍然有限。自由呼吸质子MRI或许能够利用现有的MRI技术在无需对比剂的情况下辅助量化肺功能,提供肉眼

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慢性阻塞性肺部疾病气体残留和肺气肿的肺部影像生物标记:3He MRI和CT参数化响应图

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国际医学放射学杂志 2016年第4期 434-435页

作者： D.P.I.Capaldi N.Zha f.guo D.Pike D.G.McCormack M.Kirby 杨心悦 Imaging Research Laboratories Robarts Research Institute

摘要目的直接比较MRI和CT参数化响应图(PRM)评估伴或不伴有慢性阻塞性肺部疾病(COPD)戒烟者的气体残留和肺气肿。材料与方法受试者签署知情同意书,该协议经当地伦理委员会及加拿大卫生部通过,并遵循HIPAA(机构审查委员会Reg.#00000940)... 详细信息

摘要目的直接比较MRI和CT参数化响应图(PRM)评估伴或不伴有慢性阻塞性肺部疾病(COPD)戒烟者的气体残留和肺气肿。材料与方法受试者签署知情同意书,该协议经当地伦理委员会及加拿大卫生部通过,并遵循HIPAA(机构审查委员会Reg.#00000940)。该前瞻性设计研究收集了

关键词：慢性阻塞性肺部疾病 PRM 病人肺气肿肺疾病 COPD MRI 参数化 CT

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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple Tin Compounds Modified Carbon fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(Cf)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/Cf composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/Cf epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： fei-Yu Zhao guo-Wei Si Nian-Song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

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