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To scan or not to scan:Use of.transient elastography in an integrated health system

World Journal of.Hepatology 2023年第3期15卷 419-430页

作者： Libby Stein Rasham Mittal hubert Song Joanie Chung Amandeep Sahota Department of.Internal Medicine Kaiser Permanente Los Angeles Medical CenterLos AngelesCA 90027United States Department of.Transplant Hepatology Kaiser Permanente Los Angeles Medical CenterLos AngelesCA 90027United States Research and Evaluation Kaiser Permanente Southern CaliforniaLos AngelesCA 91101United States

BACKGROUND Non-invasive tests,such as f.brosis-4 index and transient elastography(com-monly f.broScan),are utilized in clinical pathways to risk stratif. and diagnose non-alcoholic f.tty liver disease(NAf.D).In 2018,a clinical decision support tool(CDST)was implemented to guide primary care providers(PCPs)on use of.f.broScan f.r *** To analyze how this CDST impacted health care utilization and patient *** We perf.rmed a retrospective review of.adults who had f.broScan f.r NAf.D indication f.om January 2015 to December 2017(pre-CDST)or January 2018 to December 2020(post-CDST).Outcomes included f.broScan result,laboratory tests,imaging studies,specialty ref.rral,patient morbidity and *** We identif.ed 958 patients who had f.broScan,115 bef.re and 843 af.er the CDST was *** percentage of.f.broScans ordered by PCPs increased f.om 33%to 67.1%.The percentage of.patients diagnosed with early f. f.brosis,on a scale f.om f. to f.,increased f.om 7.8%to 14.2%.Those diagnosed with ad-vanced f. f.brosis decreased f.om 28.7%to 16.5%.There were f.wer laboratory tests,imaging studies and biopsy af.er the CDST was *** there were more specialty ref.rrals placed af.er the CDST was implemented,multivariate analysis revealed that healthcare utilization aligned with f.brosis score,whereby patients with more advanced disease had more *** f.w patients were hospitalized or *** This CDST empowered PCPs to diagnose and manage patients with NAf.D with appropriate allocation of.care towards patients with more advanced disease.

关键词： Non-alcoholic f.tty liver disease Transient elastography f.broScan Clinical decision support tool Health care utilization Primary care

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Discrete Element Modeling of.a Subduction Zone with a Seaf.oor Irregularity and its Impact on the Seismic Cycle

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Acta Geologica Sinica(English Edition) 2022年第3期96卷 776-790页

作者： JIAO Liqing CHAN Chung-Han Luc SCHOLTÈS Aurélia hubert-f.RRARI f.édéric-Victor DONZÉ Paul TAPPONNIER SinoProbe Center Chinese Academy of Geological SciencesBeijing 100037China Institute of.Geology Chinese Academy of Geological SciencesBeijing 100037China Earthquake-Disaster&Risk Evaluation and Management(E-DREaM)Center National Central UniversityTaoyuanChina Department of.Earth Sciences National Central UniversityTaoyuanChina CNRS IRDOPGCLaboratoire Magma et VolcansUniversitéClermont AuvergneClermont-FerrandFrance Department de Geography Universitéde LiegeLiegeBelgium Institut des Sciences de la Terre UniversitéGrenoble AlpesGrenobleFrance National Institute of.Natural Hazards MEMCBeijing 100085China

Seaf.oor irregularities inf.uence rupture behavior along the subducting slab and in the overriding plate,thus af.ecting earthquake *** seaf.oor irregularities increase the likelihood of.large earthquakes in a subduction zone remains contested,partially due to f.cus put either on f.ult development or on rupture ***,we simulate a subducting slab with a seaf.oor irregularity and the resulting def.rmation pattern of.the overriding plate using the discrete element *** simulations illustrate the rupture along three major f.ult systems:megathrust,splay and backthrust *** results show dif.erent rupture dimensions of.earthquake events varying f.om tens to ca.140 *** results suggest that the recurrence interval of.megathrust events with rupture length of.ca.100 km is ca.140 years,which is overall comparable to the paleoseismic records at the Mentawai area of.the Sumatran *** f.rther propose the coseismic slip amounts decrease and interseismic slip amounts increase f.om the surf.ce downwards *** conclude that the presence of.seaf.oor irregularities signif.cantly af.ects rupture events along the slab as well as f.ult patterns in the overriding plate.

关键词： discrete element modeling subduction zone megathrust splay backthrust f.ults seamount Mentawai

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A shif. in natural resources management paradigm:f.om resources suf.iciency to f.nctional integrity?

A shift in natural resources management paradigm:from resour...

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ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： Bernard hubert INRA Ecodevelopment UnitDomaine St-PaulF84914 Avignon Cedex 9

＜正＞Two standpoints on sustainability in livestock f.nning According to Thompson（1997） two philosophical approaches to sustainability in natural resources management have now emerged.’Resources suf.iciency’ stresses the quantitative estimation of.available resources and the measurement of.rates at which resources are used in production,distribution and consumption of.*** regard to livestock production,the issue is one of.increasing ef.iciencies,reducing pollution and f.nding substitutes

关键词： natural resources management livestock systems ecosystems dynamics learning processes collective action

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Phenotypic and genotypic background underlying variations in f.tty acid composition and sensory parameters in European bovine breeds

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Journal of.Animal Science and Biotechnology 2014年第2期5卷 154-162页

作者： Natalia Sevane hubert Levéziel Geof.rey R Nute Carlos Sanudo Alessio Valentini John Williams Susana Dunner the GeMQual Consortium Departamento de Producción Animal Facultad de Veterinaria Universidad Complutense de Madrid Madrid Spain INRA UMR 1061 F-87000 LimogesFrance Umversité de Limoges UMR 1061 F-87000 Limoges France Division of.f.rm Animal Science University of Bristol Bristol BS40 5DU UK Departimento de Producción Animal y Ciencia de los Alimentos Universidad de Zaragoza 50013 Zaragoza Spain Dipartimento di Produzioni Animali Universitá della Tuscia via De Lellis 01100 Viterbo italy Parco Tecnologico Padano Via Einstein Polo Universitario 26900 Lodi Italy

Background： Consuming moderate amounts of.lean red meat as part of.a balanced diet valuably contributes to intakes of.essential nutrients, in this study, we merged phenotypic and genotypic inf.rmation to characterize the variation in lipid prof.le and sensory parameters and to represent the diversity among 15 cattle populations. Correlations between f.t content, organoleptic characteristics and lipid prof.les were also investigated. Methods： A sample of.436 largely unrelated purebred bulls belonging to 15 breeds and reared under comparable management conditions was analyzed. Phenotypic data -including f.tness score, f.t percentage, individual f.tty acids （f.） prof.les and sensory panel tests- and genotypic inf.rmation f.om 11 polymorphisms was used. Results： The correlation coef.icients between muscle total lipid measurements and absolute vs. relative amounts of.polyunsaturated f. （PUf.） were in opposite directions. Increasing carcass f.t leads to an increasing amount of.f.s in triglycerides, but at the same time the relative amount of.PUf.s is decreasing, which is in concordance with the negative correlation obtained here between the percentage of.PUf. and f.t measurements, as well as the weaker correlation between total phospholipids and total lipid muscle content compared with neutral lipids. Concerning organoleptic characteristics, a negative correlation between f.avour scores and the percentage of.total PUf., particularly to n-6 f.action, was f.und. The correlation between juiciness and texture is higher than with f.avour scores. The distribution of.SNPs plotted by principal components analysis （PCA） mainly ref.ects their known trait associations, although inf.uenced by their specif.c breed allele f.equencies. Conclusions： The results presented here help to understand the phenotypic and genotypic background underlying variations in f. composition and sensory parameters between breeds. The wide range of.traits and breeds studied, along with the genotypic inf.rma

关键词： Bos taurus Beef f.tty acids Omega-3 Genotype assisted selection

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职业教育和培训与创新

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科研管理 2004年第z1期25卷 93-105页

作者： hubert Ertl Peter Sloane Peter f.E.Sloane University of Paderborn

本文主要论述了职业教育和培训与创新过程的关系,认为创新需与教育结合,而教育本身也在经理创新的过程,指出了导致后现代科学现代化压力的发展趋势及其对教育和培训体系的挑战。针对这种现状,文章重点考察了德国职业教育和培训体系,分... 详细信息

本文主要论述了职业教育和培训与创新过程的关系,认为创新需与教育结合,而教育本身也在经理创新的过程,指出了导致后现代科学现代化压力的发展趋势及其对教育和培训体系的挑战。针对这种现状,文章重点考察了德国职业教育和培训体系,分析了德国体系的特点和结构以及近三十年来的主要危机与改革的措施。文章指出每次危机的发生都带动了创新和改革的发展,特别介绍了今年来最重要的改革发展步骤,即所谓的“实地学习概念”,文中详细介绍了教学模块创新的基本思想和原则。

关键词：现代化挑战德国职业教育与培训德国职业教育与培训的危机和改革教育与培训体系创新大纲改革

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光致活性氧淬灭方法检测生物抗氧化剂动力学模型分析

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分析化学 2016年第8期44卷 1257-1262页

作者：贾瑞杰张强刘继锋 Mohamad Hojeij hubert H.Girault 聊城大学化学系食品营养与安全教育部重点实验室天津科技大学 Laboratoire d'Electrochimie Physique et Analytique Station 6Ecole Polytechnique Fédérale de Lausanne

以Ti O;纳米颗粒光催化反应为模型,研究了反应过程中的活性氧（ROS）产生以及活性氧淬灭的反应动力学模型。对苯二甲酸分子与体系中的光催化反应产生的OH·反应,生成具有荧光性质的2-羟基对苯二甲酸(λ;=315 nm,λ;=425 nm),因此对苯二... 详细信息

以Ti O;纳米颗粒光催化反应为模型,研究了反应过程中的活性氧（ROS）产生以及活性氧淬灭的反应动力学模型。对苯二甲酸分子与体系中的光催化反应产生的OH·反应,生成具有荧光性质的2-羟基对苯二甲酸(λ;=315 nm,λ;=425 nm),因此对苯二甲酸作为氧化探针分子与体系中的生物抗氧化剂（AOs）分子竞争与ROS的反应,根据体系的荧光、反应时间以及AOs的浓度建立了AOs淬灭ROS的反应动力学模型。根据此模型推导AOs清除ROS的动力学常数,发现常见的生物抗氧化剂的抗氧化活性大小顺序为:硫辛酸、没食子酸、谷胱甘肽、尿酸、维生素C、维生素E、水溶性维生素E和胆红素。

关键词：活性氧生物抗氧化剂光催化动力学

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Interaction of.hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of.tupaia CD81

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World Journal of.Gastroenterology 2009年第2期15卷 240-244页

作者： Zhan-f.i Tian Hong Shen Xi-Hua f. Yi-Chun Chen hubert E Blum Thomas f.Baumert Xi-Ping Zhao Department of.Inf.ctious Diseases 161 Hospital of PLA Wuhan 430030 Hubei Province China Department of.Inf.ctious Diseases Tongji Hospital Tongji Medical College Huazhong Science & Technology University Wuhan 430030 Hubei Province China Department of.Medicine II University of Freiburg D-79106 Freiburg Germany Inserm U748 Universit6 Louis Pasteur Service d'Hepatogastroenterologie 3 Rue Koeberle F-67000 Strasbourg France

AIM: To f.rther analyze the interaction of.tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-f.sion protein, and interaction of.HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL dif.ered in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conf.rmation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of.tupaia CD81 LEL GST f.sion protein to recombinant HCV E2 protein was markedly reduced compared to binding of.human CD81 LEL GST f.sion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural dif.erences in-between the tupaia and human CD81 may alter the interaction of.the large extracellular loop with HCV envelope glycoprotein E2. These f.ndings may be important f.r the understanding of.the mechanisms of.binding and entry of.HCV to PTHs.

关键词： Hepatitis C virus E2 protein Tupaia CD81,Bind Enzyme-linked immunosorbent assay

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Antif.rtility Ef.ects of.Aqueous Roots Extract of.<i>Alchornea cordif.lia</i>(Euphorbiaceae) on f.male Albino Rats

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Pharmacology & Pharmacy 2014年第8期5卷 838-845页

作者： Dieudonne Massoma Lembè Larice E. Njoh Njoh Emma f. Bend Brice L. Koloko Pierre C. Oundoum Oundoum Marie I. Ngaha Njila hubert Kenmogne Cyprien M. Hambe Marie C. Tchamadeu Judith Domkam Theophile Dimo Gustavo f. Gonzales Department of.Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon Department of.Animal Sciences Faculty of Science University of Douala Douala Cameroon Laboratory of.Endocrinology and Reproduction Faculty of Sciences and Philosophy Alberto Cazorla Talleri Universidad Peruana Cayetano Heredia Lima Peru

Aqueous roots extract of.Alchornea cordif.lia was studied to evaluate its traditional antif.rtility claim. Antif.rtility ef.ect of.Alchornea cordif.lia was evaluated according to the stages of.pregnancy of.f.male rats. In the f.rst stage, f.rty f.male rats were randomly divided into f.ur groups (10 rats/group) and respectively treated with 1 ml distilled water (control), 100, 200 and 400 mg/kg body weight (BW) per day of.Alchornea cordif.lia. Af.er laparotomy and at parturition, sites of.implantation and resorption on the uterine horns were determined. The ovaries and uterus were collected and weighed. Blood samples were collected f.r hormonal assay. In the second and third stage of.pregnancy, treatment schedule and antif.rtility parameters were assessed as above f.r the f.rst stage. Treated groups received daily 400 mg/kg bw of.extract of.Alchornea cordif.lia while Control group received distilled water. It was observed in the f.rst stage of.pregnancy that, the number of.resorption sites signif.cantly (p f.er laparotomy as well as the number of.pups at parturition at all doses. The body weight of.ovaries and uterine horns at dose 400 mg/kg signif.cantly (p f.cantly the concentrations of.serum progesterone. In the second stage of.pregnancy af.er laparotomy and at parturition, the number of.live f.tus and the survival ratio signif.cantly (p f.animals. In the third stage of.pregnancy, the extract caused an early parturition associated with a decreased number of.live f.tus and the survival ratio with p The results indicate that aqueous roots extract of.Alchornea cordif.lia could induce inhibitory ef.ects on reproductive f.nctions in f.male albino rats.

关键词： Implantation Embryo Development Abortion Hormone Level

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Mitochondria-associated endoplasmic reticulum membranes allow adaptation of.mitochondrial metabolism to glucose availability in the liver

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Journal of.Molecular Cell Biology 2016年第2期8卷 129-143页

作者： Pierre Theurey Emily Tubbs Guillaume Vial Julien Jacquemetton Nadia Bendridi Marie-Agnes Chauvin Muhammad Rizwan Alam Muriel Le Romancer hubert Vidal Jennif.r Rieusset INSERM UMR-1060 CarMeN LaboratoryLyon 1 UniversityINRA U1235INSA of LyonRockefeller and Charles Merieux Lyon-Sud medical UniversitiesF-69003 LyonFrance Cancer Research Center of.Lyon Centre Leon BerardUMR INSERM 1052CNRS 5286F-69373 LyonFrance Hospices Civils de Lyon Lyon-Sud HospitalEndocrinologyDiabetology and Nutrition ServiceF-69310 Pierre BeniteFrance

Mitochondria-associated endoplasmic reticulum membranes(MAM)play a key role in mitochondrial dynamics and f.nction and in hepatic insulin *** mitochondria are important regulators of.energy metabolism,the nutritional regulation of.MAM in the liver and its role in the adaptation of.mitochondria physiology to nutrient availability are *** this study,we f.und that the f.sted to postprandial transition reduced the number of.endoplasmic reticulum-mitochondria contact points in mouse *** of.potential hormonal/metabolic signals revealed glucose as the main nutritional regulator of.hepatic MAM integrity both in vitro and in *** reduced organelle interactions through the pentose phosphate-protein phosphatase 2A(PP-PP2A)pathway,induced mitochondria f.ssion,and impaired *** MAM reduction counteracted glucose-induced mitochondrial ***,disruption of.MAM integrity mimicked ef.ects of.glucose on mitochondria dynamics and *** glucose-sensing system is def.cient in the liver of.insulin-resistant ob/ob and cyclophilin D-KO mice,both characterized by chronic disruption of.MAM integrity,mitochondrial f.ssion,and altered mitochondrial *** data indicate that MAM contribute to the hepatic glucose-sensing system,allowing regulation of.mitochondria dynamics and f.nction during nutritional *** disruption of.MAM may participate in hepatic mitochondrial dysf.nction associated with insulin resistance.

关键词： MAM mitochondria dynamics hepatocytes glucose sensing pentose phosphate pathway PP2A

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Epidemiological and Clinical Aspects of.Acne in the Dermatology Department of.the Teaching Hospital of.Parakou (Benin)

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Journal of.Cosmetics, Dermatological Sciences and Applications 2014年第3期4卷 129-134页

作者： Hugues Adégbidi Christiane Koudoukpo f.lix Atadokpèdé f.orencia do Ango-Padonou hubert G. Yédomon f.culté de Médecine de Parakou Université de Parakou Parakou Bénin f.culté des Sciences de la Santé de Cotonou Université d’Abomey-Calavi Cotonou Bénin

Introduction: Acne is an af.ection that concerns 80% of.young people in the world with a signif.cant impact on their quality of.lif.. The purpose of.this study was to determine the epidemiological and clinical aspects of.the acne in the Dermatology Department of.the Teaching Hospital of.Parakou (THP). Patients and Methods: We achieved a cross sectional study carrying on 167 f.les collected on a 20-month period in the Dermatology Department of.the THP. Results: The prevalence of.the acne was 31.21%. f.male subjects represented 69.46%. Vulgaris acne was the most prevailing clinical f.rm (47.30%). A peak of.f.equency was noted in the age bracket of.21 - 25 years in the 2 sexes. The lesions were mainly located on the f.ce (82.63%). Some f.ctors inf.uencing the eruption have been evoked by the patients notably: f.ods, cosmetics products and stress respectively to 41.00%, 33.33% and 25.67%. Conclusion: Our study allowed conf.rming the f.male ascendancy of.acne. Besides, the adults are more represented, precisely women because of.depigmenting practice. It seems in f.vor of.an inf.uence of.the f.od in the intervening of.the acne. Vulgaris acne was the predominant clinical f.rm as described in literature.

关键词： Acne Epidemiology f.ods

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