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Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions

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World Journal of Clinical Cases 2023年第17期11卷 3932-3948页

作者： Panagiotis Papamichalis Katerina G Oikonomou Asimina Valsamaki Maria Xanthoudaki Periklis Katsiafylloudis evangelia Papapostolou Apostolia-Lemonia Skoura Michail Papamichalis Marios Karvouniaris Antonios Koutras Eleni Vaitsi Smaragdi Sarchosi Antonios Papadogoulas Dimitrios Papadopoulos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Department of Transfusion Medicine University Hospital of LarissaLarissa 41110ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit AHEPA University HospitalThessaloniki 54636Greece 1^(st) Department of Obstetrics and Gynecology General Hospital of Athens“ALEXANDRA”National and Kapodistrian University of AthensAthens 11528Greece Department of Anesthesiology University Hospital of LarissaLarissa 41110ThessalyGreece

Clinically,it is highly challenging to promote recovery in patients with acute liver failure(ALF)and acute-on-chronic liver failure(ACLF).Despite recent advances in understanding the underlying mechanisms of ALF and ACLF,standard medical therapy remains the primary therapeutic *** transplantation(LT)is considered the last option,and in several cases,it is the only intervention that can be ***,this intervention is limited by organ donation shortage or exclusion criteria such that not all patients in need can receive a *** option is to restore impaired liver function with artificial extracorporeal blood purification *** first such systems were developed at the end of the 20th century,providing solutions as bridging therapy,either for liver recovery or *** enhance the elimination of metabolites and substances that accumulate due to compromised liver *** addition,they aid in clearance of molecules released during acute liver decompensation,which can initiate an excessive inflammatory response in these patients causing hepatic encephalopathy,multiple-organ failure,and other complications of liver *** compared to renal replacement therapies,we have been unsuccessful in using artificial extracorporeal blood purification systems to completely replace liver function despite the outstanding technological evolution of these *** middle to high-molecular-weight and hydrophobic/protein-bound molecules remains extremely *** majority of the currently available systems include a combination of methods that cleanse different ranges and types of molecules and ***,conventional methods such as plasma exchange are being re-evaluated,and novel adsorption filters are increasingly being used for liver *** strategies are very promising for the treatment of liver ***,the best method,system,or device has not been developed yet,and its probability of

关键词： Liver failure Transplantation Blood purification Liver replacement therapy Artificial extracorporeal systems Transplant-free survival

Chemical characterisation of particulate matter in urban transport modes

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Journal of Environmental Sciences 2021年第2期33卷 51-61页

作者： Vania Martins Carolina Correia Ines Cunha-Lopes Tiago Faria evangelia Diapouli Manousos Ioannis Manousakas Konstantinos Eleftheriadis Susana Marta Almeida Centro de Ciencias e Tecnologias N ucleares Instituto Superior TecnicoLisbonPortugal Institute of Nuclear and Radiological Sciences and Technology Energy and SafetyN.C.S.R.'Demokritos'AthensGreece

Traffic is a main source of air pollutants in urban areas and consequently daily peak exposures tend to occur during *** exposure to particulate matter(PM)was monitored while cycling and travelling by bus,car and metro along an assigned route in Lisbon(Portugal),focusing on PM_(2.5) and PM_(1)0(PM with aerodynamic diameter<2.5 and 10μm,respectively)mass concentrations and their chemical *** vehicles,the indoor-outdoor interplay was also *** PM_(2.5) mean concentrations were 28±5,31±9,34±9 and 38±21μg/m 3 for bus,bicycle,car and metro modes,*** carbon concentrations when travelling by car were 1.4 to 2.0 times higher than in the other transport modes due to the closer proximity to exhaust *** are marked differences in PM chemical composition depending on transport *** particular,Fe was the most abundant component of metro PM,derived from abrasion of rail-wheel-brake *** concentrations of Zn and Cu in cars and buses were related with brake and tyre wear particles,which can penetrate into the *** the motorised transport modes,Fe,Zn,Cu,Ni and K were correlated,evidencing their common traffic-related *** average,the highest inhaled dose of PM_(2.5) was observed while cycling(55μg),and the lowest in car travels(17μg).Cyclists inhaled higher doses of PM_(2.5) due to both higher inhalation rates and longer journey times,with a clear enrichment in mineral *** presented results evidence the importance of considering the transport mode in exposure assessment studies.

关键词： Traffic Commuting Air pollution Particle chemistry Indoor-outdoor interplay Inhaled dose

Resurgence of the cotton bollworm Helicoverpa armigera in northern Greece associated with insecticide resistance

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Insect Science 2013年第4期20卷 505-512页

作者： George K. Mironidis Despina Kapantaidaki Maria Bentila evangelia Morou M. Savopoulou-Soultani John Vontas Laboratory of Applied Zoology and Parasitology Faculty of Agriculture Aristotle University of Thessaloniki Thessaloniki Faculty of Applied Biology and Biotechnology Department of Biology University of Crete Heraklion Greece

Helicoverpa armigera has been controlled effectively with chemical insec- ticides in the major cotton crop production areas of northern Greece for many years. However, a resurgence of the pest was observed in 2010, which significantly affected crop production. During a 4-year survey （2007-2010）, we examined the insecticide re- sistance status of 1-1. armigera populations from two major and representative cotton production areas in northern Greece against seven insecticides （chlorpyrifos, diazinon, methomyl, alpha-cypermethrin, cypermethrin, gamma-cyhalothrin and endosulfan）. Full dose-response bioassays on third instar larvae were performed by topical application. Lethal doses at 50% were estimated by probit analysis and resistance factors （RF） were calculated, compared to a susceptible laboratory reference stra^a. Resistance levels were relatively moderate until 2009, with resistance ratios below 10-fold for organophosphates and carbamates and up to 16-fold for the pyrethroid alpha-cypermethrin. However, resis- tance rose to 46- and 81-fold for chlorpyrifos and alpha-cypermethrin, respectively in 2010, when the resurgence of the pest was observed. None of the known pyrethroid resistance mutations were found in the pyrethroid-resistant insects. The possible association between resistance and H. armigera resurgence in Greece is discussed.

关键词： bioassay carbamates cotton field endosulfan organophospates pyrethroids

Spasm of the near reflex:a common diagnostic dilemma?

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 541-546页

作者： Eleni Papageorgiou Dimitrios Kardaras Eftychia Kapsalaki Efihymios Dardiotis Asimina Mataftsi evangelia E.Tsironi Department of Ophthalmology University Hospital of LarissaLarissa 41222Greece Department of Radiology University Hospital of LarissaLarissa 41222Greece Department of Neurology University Hospital of LarissaLarissa 41222Greece 2^(nd)Department of Ophthalmology Aristotle University of ThessalonikiThessaloniki 41222Greece

AIM:To report the clinical characteristics and diagnostic procedures used in patients with spasm of the near reflex(SNR),in order to present common investigation strategies and diagnostic ***:Retrospective case series of twenty-two patients,mainly children,with SNR or accommodation spasm(AS).AS was diagnosed on the basis of blurred vision and a difference of>2 dioptres between manifest and cycloplegic *** esotropia and miosis were present,the patients were diagnosed with *** patients underwent visual acuity testing,orthoptic evaluation,assessment of refraction before and after cycloplegia,and dilated *** diagnostic investigations,such as neuroimaging,lumbar puncture(LP),electrophysiology and blood tests,were also *** use among children was assessed in hours per ***:There were 19 female and 3 male patients(age range 7-33 y,median=10 y).Seventeen patients had AS and 5 patients had SNR,with episodic blurry vision and headaches being the most common *** neuroimaging was performed in six patients(27%),although only one had a history of brain *** of those patients underwent visual evoked potentials and three also underwent LP and received intravenous steroid *** majority of patients(90%)reported prolonged daily screen time(>2 h/d),and in 55%of cases there were concurrent social problems or psychological *** consisted of careful explanation of the condition,atropine1%eye drops and full cycloplegic correction by means of bifocal ***:The diagnosis of SNR and AS may be challenging,because symptoms are usually intermittent and nonspecific,and a large number of patients are often subjected to redundant and potentially time-consuming examinations and treatment,that may exaggerate the underlying psychological ***,detailed clinical testing and assessment of psychosocial profile is necessary,in order to avoid unnecessary *** sh

关键词： accommodative spasm bifocal glasses convergence spasm pseudomyopia spasm of the near reflex screen time

Assessment of the Bemisia tabaci C YP6CM l vQ transcript and protein levels in laboratory and field-derived imidacloprid-resistant insects and cross-metabolism potential of the recombinant enzyme

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Insect Science 2011年第1期18卷 23-29页

作者： Emmanouil Roditakis evangelia Morou Anastasia Tsagkarakou Maria Riga Ralf Nauen Mark Paine Shai Morin John Vontas Laboratory of Entomology and Agricultural Zoology Plant Protection Institute of Heraklion National Agricultural Research Foundation Heraklion (N.AG.RE.F.) Heraklio Greece Faculty of Applied Biology and Biotechnology Department of Biology University of Crete Heraklion Greece Vector Group Liverpool School of Tropical Medicine Liverpool UK Bayer CropScience AG Research Insecticides Insect Toxicology and Resistance Monheim Germany Department of Entomology Faculty of Agricultural Food and Environmental Quality Sciences Hebrew University of Jerusalem Rehovot Israel

Over-expression of the cytochrome P450 CYP6CM1 gene has been associated with imidacloprid resistance in a number of Q and B biotype Bemisia tabaci laboratory strains from distinct geographical origins worldwide. We recently demonstrated that the Q biotype version of the CYP6CM 1 protein （CYP6CMlvQ） is capable of metabolizing imida- cloprid. Here, we show that the levels of BtCYP6CMlvQ were also elevated in laboratory- resistant strains and field-derived populations, with variable imidacloprid resistance levels, collected in Crete. High levels of CYP6CMlvQ transcripts were also determined in survivors of a heterogeneous field population, after exposure to discriminating imidacloprid dosage. Using peptide antibody-based detection assays, we demonstrated that in line with transcriptional data, the CYP6CMlvQ protein levels were higher in imidacloprid-resistant insects, which further implicates the gene as the causal factor of resistance. Finally, assess- ment of the cross-metabolism potential of CYP6CMlvQ against additional neonicotinoid molecules used for B. tabaci control revealed that clothianidin and thiacloprid, but not acetamiprid or thiamethoxam, are metabolized by the recombinant enzyme in vitro.

关键词： detoxification neonicotinoids peptide antibodies P450

Recurrence of keratoconus after deep anterior lamellar keratoplasty following pregnancy

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 1011-1013页

作者： Zisis Gatzioufas Georgios D.Panos evangelia Gkaragkani Stylianos Georgoulas Romesh Angunawela Moorfields Eye Hospital Department of Ophthalmology Ipswich Hospital NHS Trust

Keratoconus is a progressive, non-inflammatory disease of the cornea, which is characterized by marked cornealsteepening and thinningrll. It induces myopia and irregular astigmatism leading frequently to severe visual impairmentu. Although several aetiological factors have been implicated in its pathophysiology, the exact mechanisms underlying keratoconus are not fully elucidated yet. Corneal crosslinking is the treatment of choice in order to inhibit the progression of keratoconus, whereas advanced cases require penetrating or lamellar keratolalasty for visual restoration.

关键词： deep on of OS Recurrence of keratoconus after deep anterior lamellar keratoplasty following pregnancy or OD

Complex posttraumatic stress disorder: The need to consolidate a distinct clinical syndrome or to reevaluate features of psychiatric disorders following interpersona trauma?

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World Journal of Psychiatry 2018年第1期8卷 12-19页

作者： evangelia Giourou Maria Skokou Stuart P Andrew Konstantina Alexopoulou Philippos Gourzis Eleni Jelastopulu Department of Psychiatry School of Medicine University of Patras Department of Public Health School of Medicine University of Patras Specialist Care Team Limited School of Medicine University of Patras

Complex posttraumatic stress disorder(Complex PTSD)has been recently proposed as a distinct clinical entity in the WHO International Classification of Diseases,11^(th) version, due to be published, two decades after its first initiation. It is described as an enhanced version of the current definition of PTSD, with clinical features of PTSD plus three additional clusters of symptoms namely emotional dysregulation, negative self-cognitions and interpersonal hardship, thus resembling the clinical features commonly encountered in borderline personality disorder(BPD). Complex PTSD is related to complex trauma which is defined by its threatening and entrapping context, generally interpersonal in nature. In this manuscript, we review the current findings related to traumatic events predisposing the above-mentioned disorders as well as the biological correlates surrounding them, along with their clinical features. Furthermore, we suggest that besides the present distinct clinical diagnoses(PTSD; Complex PTSD; BPD), there is a cluster of these comorbid disorders, that follow a continuum of trauma and biological severity on a spectrum of common or similar clinical features and should be treated as such. More studies are needed to confirm or reject this hypothesis, particularly in clinical terms and how they correlate to clinical entities' biological background, endorsing a shift from the phenomenologically only classification of psychiatric disorders towards a more biologically validated classification.

关键词： Complex posttraumatic stress disorder Posttraumatic stress disorder Borderline personality disorder Trauma Complex trauma

Women in Hotel Management and Leadership： Diamond or Glass？

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Journal of Tourism and Hospitality Management 2014年第1期2卷 18-25页

作者： evangelia Marinakou Royal University for Women Riffa Kingdom of Bahrain

Although the hospitality industry shows growth, only few women are found in high managerial positions. The hotel sector is dominated by women with an average 55.5% of the workforce, but is managed by men, as women are mainly found in positions that are stereotypically ascribed to their gender, such as directors of sales, housekeeping, and marketing. Fifteen male and 15 female managers in 5-star hotels in Greece were interviewed to explore their management and leadership styles, as well as any challenges they face in the career ladder in hotel management. The findings of this study suggest that women are equally capable to their male counterparts and they acquire skills that are considered to be more effective in the context of the hospitality industry. They are nurturing, better at communicating with people, they are caring, and they adopt supporting behaviors. This paper proposes that hotels that have women in managerial positions are more successful in facing the increasing competitiveness and adapt to changes more efficiently.

关键词：旅游业旅游经济旅游市场旅游景点服务业酒店管理

IgY technology: Methods for developing and evaluating avian immunoglobulins for the in vitro detection of biomolecules

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World Journal of Methodology 2021年第5期11卷 243-262页

作者： Chrysoula-evangelia Karachaliou Vyronia Vassilakopoulou evangelia Livaniou Institute of Nuclear&Radiological Sciences&Technology Energy&SafetyNational Centre for Scientific Research“Demokritos”Athens 15310Greece

The term“IgY technology”was introduced in the literature in the mid 1990s to describe a procedure involving immunization of avian species,mainly laying hens and consequent isolation of the polyclonal IgYs from the“immune”egg yolk(thus avoiding bleeding and animal stress).IgYs have been applied to various fields of medicine and *** present article will deal with specific aspects of IgY technology,focusing on the currently reported methods for developing,isolating,evaluating and storing polyclonal *** topics such as current information on isolation protocols or evaluation of IgYs from different avian species are also *** advantages of IgY technology(e.g.,novel antibody specificities that may emerge via the avian immune system)will also be *** in vitro applications of polyclonal egg yolk-derived IgYs to the field of disease diagnosis in human and veterinary medicine through in vitro immunodetection of target biomolecules will be ***,ethical aspects associated with animal well-being as well as new promising approaches that are relevant to the original IgY technology(e.g.,development of monoclonal IgYs and IgY-like antibodies through the phage display technique or in transgenic chickens)and future prospects in the area will also be mentioned.

关键词： Animal welfare Polyclonal IgYs Egg yolk IgY technology Relevant-to-IgYtechnology approaches In vitro immunodetection techniques