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Altered Mental Status and Hyperammonemia after Overdose of Valproic Acid with Therapeutic Valproic Acid Concentrations

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International journal of Clinical Medicine 2014年第10期5卷 546-549页

作者： evan S. Schwarz Mark Thoelke Department of Medicine Washington University School of Medicine St. Louis USA Division of Emergency Medicine Washington University School of Medicine St. Louis USA

Valproic acid is used in the treatment of multiple disorders. Adverse effects from valproic acid include hepatotoxicity, hypotension, metabolic acidosis, and decreased mental status. Valproic acid also causes hyperammonemia. Many physicians assume that this is due to a supratherapeutic valproic acid concentration;when in fact, it can occur with therapeutic valproic acid concentrations. This is because the hyperammonemia may be related to carnitine deficiency and disruption of the urea cycle, which can both occur with therapeutic valproic acid concentrations. We report a patient presented to the emergency department with alteration of mental status after ingesting valproic acid for recreational purposes, who developed hyperammonemia with a therapeutic valproic acid concentration.

关键词： Valproic Acid L-Carnitine Levocarnitine Overdose Toxicity

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Insight from in situ microscopy into which precipitate morphology can enable high strength in magnesium alloys

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journal of Materials Science & Technology 2018年第7期34卷 1061-1066页

作者： Bo-Yu Liu Nan Yang jian Wang Matthew Barnett Yun-Chang Xin Di Wu Ren-Long Xin Bin Li R. Lakshmi Narayan jian-Feng Nie ju Li evan Ma Zhi-Wei Shan Center for Advancing Materials Performance from the Nanoscale (CAMP-Nano) & Hysitron Applied Research Center in China (HARCC) State Key Laboratory for Mechanical Behavior of Materials Xi' an Jiaotong University Xi' an 710049. People's Republic of China Mechanical and Materials Engineering University of Nebraska-Lincoln Lincoln NE 68588 USA Institute for Frontier Materials Deakin University Geelong Victoria 3216 Australia College of Materials Science and Engineering Chongqing University Chongqing 400045 People's Republic of China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 People's Republic of China Department of Chemical and Materials Engineering University of Nevada Reno USA Department of Materials Science and Engineering Carnegie Mellon University Pittsburgh PA 15213 USA Department of Materials Science and Engineering Monash University Melbourne Victoria 3800 Australia Department of Nuclear Science and Engineering and Department of Materials Science and Engineering Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA Department of Materials Science and Engineering Johns Hopkins University Baltimore MD 21218 USA

Magnesium alloys, while boasting light weight, suffer from a major drawback in their relatively low strength. Identifying the microstructural features that are most effective in strengthening is therefore a pressing challenge. Deformation twinning often mediates plastic yielding in magnesium alloys. Unfortunately, due to the complexity involved in the twinning mechanism and twin-precipitate interactions, the optimal precipitate morphology that can best impede twinning has yet to be singled out. Based on the understanding of twinning mechanism in magnesium alloys, here we propose that the lamellar precipitates or the network of plate-shaped precipitates are most effective in suppressing deformation twinning. This has been verified through quantitative in situ tests inside a transmission electron microscope on a series of magnesium alloys containing precipitates with different morphology. The insight gained is expected to have general implications for strengthening strategies and alloy design. 2018 Published by Elsevier Ltd on behalf of The editorial office of journal of Materials Science ＆ Technology.

关键词： Precipitate selection criterionIn-situ TEM Mg alloy Mechanical property Deformation twinning

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直肠癌根治术中的盆腔自主神经保护:30年变迁

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Gastroenterology Report 2016年第3期4卷 173-185,I0001页

作者： Min-Hoe Chew Yu-Ting Yeh evan Lim Francis Seow-Choen Department of Colorectal Surgery Singapore General HospitalSingapore Singhealth Academy Singapore General HospitalSingapore Seow-Choen Colorectal Centre Singapore

全直肠系膜切除(TME)理念及微创技术(如腹腔镜结直肠手术和机器人手术)的出现大大提高直肠癌的外科疗效。然而,术后排尿功能和性功能障碍率仍然较高,从而给患者造成巨大的痛苦,同时也会给手术医生带来困扰。新辅助和辅助放疗应用的增多... 详细信息

全直肠系膜切除(TME)理念及微创技术(如腹腔镜结直肠手术和机器人手术)的出现大大提高直肠癌的外科疗效。然而,术后排尿功能和性功能障碍率仍然较高,从而给患者造成巨大的痛苦,同时也会给手术医生带来困扰。新辅助和辅助放疗应用的增多也带来了更多的功能问题。在本文中,我们对盆腔神经解剖的目前认识进行了评价,将盆腔神经分为肠系膜下动脉根部、侧盆壁及泌尿生殖器官周围等区域,探讨了在这些区域如何进行手术操作。同时,我们也讨论了过去30年不同手术方式(包括开腹、腹腔镜和机器人)的功能状况。

关键词：全直肠系膜切除术盆腔自主神经保护排尿功能障碍性功能障碍

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(U-Th)／He年龄不一致及可能影响原因

(U-Th)／He年龄不一致及可能影响原因

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中国矿物岩石地球化学学会第11届学术年会

作者：吴堑虹 BrentiA McInnes Noreen evan 中南大学澳大利亚科学与工业研究组织澳大利亚科学与工业研究组织

＜正＞（U-Th）／He定年技术自上世纪90年代后期已开始实际应用。作者注意到一些单颗粒矿物或颗粒组间（U-Th）／He年龄的不一致性,目前人们对这种现象尚未给予足够认识,多将不同颗粒年龄值平均后作为样品年龄值。了解（U-Th）／He年龄... 详细信息

＜正＞（U-Th）／He定年技术自上世纪90年代后期已开始实际应用。作者注意到一些单颗粒矿物或颗粒组间（U-Th）／He年龄的不一致性,目前人们对这种现象尚未给予足够认识,多将不同颗粒年龄值平均后作为样品年龄值。了解（U-Th）／He年龄的不一致现象及形成原因,确定其应用适用条件,应为人们所重视。

关键词： (U-Th)/He年龄不一致年龄原因

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Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCδ

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World journal of Biological Chemistry 2017年第3期8卷 163-174页

作者： Amy L Samuels Alison Louw Reza Zareie evan Ingley Cell Signalling Group Harry Perkins Institute of Medical Research and Centre for Medical Researchthe University of Western Australia Proteomics International Laboratories Ltd Proteowa Pty Ltd SABCMurdoch University Cell Signalling Group School of Veterinary and Health SciencesMurdoch University

AIM To identify and characterize the effect of phosphorylation on the subcellular localization of *** HEK293 T cells were treated with calyculin A, staurosporin or phorbol 12-myristate 13-acetate(PMA). Cells were transfected with eG FP-tagged Ankrd54 with or without Lyn tyrosine kinase(wild-type, Y397 F mutant, or Y508 F mutant). The subcellular localization was assessed by immunofluorescence imaging of cells, immunoblotting of subcellular fractionations. The phosphorylation of Ankrd54 was monitored using Phos-tagT M gel retardation. Phosphorylated peptides were analysed by multiplereaction-monitoring(MRM) proteomic *** Activation of PKC kinases using PMA promoted nuclear export of Ankrd54 and correlated with increased Ankrd54 phosphorylation, assayed using Phos-tag TM gel retardation. Co-expression of an active form of the PKCδisoform specifically promoted both phosphorylation and cytoplasmic localization of Ankrd54, while PKCδ, Akt and PKA did not. Alanine mutation of several serine residues in the amino-terminal region of Ankrd54(Ser14, Ser17, Ser18, Ser19) reduced both PMA induced cytoplasmic localization and phosphorylation of Ankrd54. Using MRM proteomic analysis, phosphorylation of the Ser18 residue of Ankrd54 was readily detectable in response to PMA stimulation. PMA stimulation of cells co-expressing Ankrd54 and Lyn tyrosine kinase displayed increased coimmunoprecipitation and enhanced co-localization in the *** We identify phosphorylation by PKCδ as a major regulator of nuclear-cytoplasmic shuttling of Ankrd54, and its interaction with the tyrosine kinase Lyn.

关键词： Ankrd54 PKC Lyn Btk Phosphorylation

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Increased competitive ability and herbivory tolerance in the invasive plant Sapium sebiferum

Increased competitive ability and herbivory tolerance in the...

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第一届全国生物入侵学术研讨会

作者： William E.Rogers evan Siemann Department of Ecology and Evolutionary Biology Rice UniversityHoustonTX 77005USA Department of Rangeland Ecology and Management Texas A&M UniversityCollege StationTX 77843USA

The evolution of increased competitive ability(EICA) hypothesis predicts that release from natural enemies in the introduced range favors exotic plants evolving to have greater competitive ability and lower herbivore resistance than conspecifics from the native *** tested the EICA hypothesis in a common garden experiment with Sapium sebiferum in which seedlings from native(China) and invasive(USA) populations were grown in all pairwise combinations in the native range(China) in the presence of *** paired seedlings were from the same continent,shoot mass and leaf damage per seedling were significantly greater for plants from invasive populations than those from native *** more damage from herbivores,plants from invasive populations still outperformed those from native populations when they were grown *** competitive ability and higher herbivory damage of invasive populations relative to native populations of S. sebiferum support the EICA *** of biomass against percent leaf damage showed that plants from invasive populations tolerated herbivory more effectively than those from native *** results of this study suggest that *** has become a faster-growing,less herbivore-resistant and more herbivore-tolerant plant in the introduced *** implies that increased competitive ability of exotic plants may be associated with evolutionary changes in both resistance and tolerance to herbivory in the introduced *** these evolutionary changes has important implications for biological control strategies targeted at problematic invaders.

关键词： biological invasions biological control EICA hypothesis enemy release herbivore resistance herbivore tolerance

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A history of music in Western culture 2nd ed.

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2006年

作者： Bonds Mark evan.

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富锂巨星的观测研究

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天文学进展 2012年第4期30卷 453-466页

作者：符晓婷邓李才 Kirby evan N Guhathakurta Puragra 中国科学院光学天文重点实验室北京100012 中国科学院国家天文台北京100012 中国科学院研究生院北京100049 California Institute of Technology 1200 E.California Blvd.MC 249-17PasadenaCA 91125USA Hubble Fellow University of California Observatories/Lick Observatory University of California1156 High St.Santa CruzCA 95064USA

锂在温度达到T〉2．5×10^6K时即参与’Li（p，a）4He反应燃烧，经典恒星理论推测，当恒星演化到红巨星阶段时，由于向内非常延伸的对流包层的存在，锂的丰度A（Li）=12＋lg[n（Li）／n（H）1应为A（Li）〈0．5。但是，陆续有处于不同... 详细信息

锂在温度达到T〉2．5×10^6K时即参与’Li（p，a）4He反应燃烧，经典恒星理论推测，当恒星演化到红巨星阶段时，由于向内非常延伸的对流包层的存在，锂的丰度A（Li）=12＋lg[n（Li）／n（H）1应为A（Li）〈0．5。但是，陆续有处于不同光谱型、不同演化阶段的富锂巨星被发现，其中一些巨星的锂丰度甚至远超出宇宙大爆炸的原初锂丰度，给经典恒星演化模型带来了难题。回顾了从恒星主序到巨星支的锂丰度观测研究历史，并详细介绍了我们对银河系矮星系中富锂巨星的最新发现，总结了所有富锂巨星的观测证据，以及为解决此难题所提出的理论解释。

关键词：恒星演化巨星元素丰度锂

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中文版Microsoft Access 2000VBA基础

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1999年

作者： evan Callahan 马朝斌谢应科林琳魏武译

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水下发射火箭研究综述

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飞航导弹 1993年第7期 11-13页

作者： evan K Lawsenc 郭福涛

综述了目前水下发射火箭研究进展情况,比较了海军军械实验室与其它研究机构在这一领域进行的研究工作,讨论了以过膨胀喷管工作产生的各种现象对水下火箭工作性能的影响。

关键词：水下发射导弹潜射巡航导弹分离流

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