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Molecular basis of cranial suture biology and disease:Osteoblastic and osteoclastic perspectives

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Genes & Diseases 2014年第1期1卷 120-125页

作者： Maureen Beederman evan M.Farina Russell R.Reid Section of Plastic&Reconstructive Surgery Department of SurgeryThe University of Chicago Medical Center5841 South Maryland AvenueMC 6035ChicagoIL 60637USA Pritzker School of Medicine and The Laboratory of Craniofacial BiologyUniversity of Chicago MedicineChicagoIL 60637USA

The normal growth and development of the skull is a tightly regulated process that occurs along the osteogenic interfaces of the cranial ***,the borders of the calvarial bones and neighboring tissues above and below,function as a *** coordinated remodeling efforts of bone deposition and resorption,the cranial sutures maintain a state of patency from infancy through early adulthood as the skull continues to grow and accommodate the developing brain’s demands for ***,when this delicate balance is disturbed,a number of pathologic conditions ensue;and if left uncorrected,may result in visual and neurocognitive impairments.A prime example includes craniosynostosis,or premature fusion of one or more cranial and/or facial suture(s).At the present time,the only therapeutic measure for craniosynostosis is surgical correction by cranial vault ***,elegant studies performed over the past decade have identified several genes critical for the maintenance of suture patency and induction of suture *** deeper understandings of the pathogenesis and molecular mechanisms that regulate suture biology may provide necessary insights toward the development of non-surgical therapeutic alternatives for patients with cranial suture *** this review,we discuss the intricate cellular and molecular interplay that exists within the suture among its three major components:dura mater,osteoblastic related molecular pathways and osteoclastic related molecular pathways.

关键词： Cranial sutures Craniosynostosis Dura mater Osteoblasts Osteoclasts

PRESERVATION AND PROSPERITY--Traditional arts contribute to poverty alleviation in Tibet

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Beijing Review 2020年第37期63卷 24-25页

作者： evan Li 不详

Tsamjo,a former farm worker,is from Tsethang in Tibet Autonomous Region in southwest *** town is known for a traditional art that goes back for centuries,serge ***,durable and static free,the Tsethang serge,a kind of cashmere unique to the area,is considered to be the finest of all Tibetan *** dates back to the Tang Dynasty(618-907)and was used to make the robes of the nobles because of its ornate patterns and elaborate weaving that takes 18 procedures.

关键词： China. southwest Tibetan

Polymersomes scalably fabricated via flash nano- precipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration

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Nano Research 2018年第10期11卷 5689-5703页

作者： Sean D. Allen Yu-Gang Liu Sharan Bobbala Lei Cai Peter I. Hecker Ryan Temel evan A. Scott Interdisciplinary Biological Sciences Northwestern University IL 60208 USA Department of Biomedical Engineering Northwestern University IL 60208 USA Saha Cardiovascular Research Center University of Kentucky KY40506 USA Department of Pharmacology and Nutritional Sciences University of Kentucky KY40506 USA

Vesicular nanocarrier formulations confer the ability to deliver hydrophobic and hydrophilic cargos simultaneously to cells of interest in vivo. While liposomal formulations reached the clinic long ago, younger technologies such as polymeric vesicles （polymersomes） have yet to make the transition to clinical approval and use, in part due to difficulties in ensuring their safe and scalable production. In this work, we demonstrate the scalable production of poly（ethylene glycol）-block-poly（propylene sulfide）（PEG-bl-PPS） polymersomes via flash nanoprecipitation, and further show the safe administration of these nanocarriers to mice and non-human primates. In mice, PEG-bl-PPS polymersomes were found to be well tolerated at up to 200 mg/（***）. Following the administration of a more relevant 20 mg/（***） dosage in non-human primates, polymersomes were found to associate with numerous phagocytic immune cell populations, including a remarkable 68% of plasmacytoid dendritic cells and 〉 95% of macrophages in the spleen, while showing no toxicity or abnormalities in the liver, kidney, spleen, or blood. Despite the presence of a dense PEG corona, neither anti-PEG antibodies nor complement activation were detected. This work provides evidence of the translatability of PEG-bI-PPS polymersomes into the clinic for therapeutic applications in humans.

关键词： polymersome non-human primate nanoprecipitation toxicity biodistribution

Spatiotemporal microRNA profile in peripheral nerve regeneration:miR-138 targets vimentin and inhibits Schwann cell migration and proliferation

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Neural Regeneration Research 2018年第7期13卷 1253-1262页

作者： Travis B.Sullivan Litchfield C.Robert Patrick A.Teebagy Shannon E.Morgan evan W.Beatty Bryan j.Cicuto Peter K.Nowd Kimberly M.Rieger-Christ David j.Bryan Department of Translational Research Lahey Hospital & Medical Center Tissue Engineering Laboratory Lahey Hospital & Medical Center Department of Plastic and Reconstructive Surgery Lahey Hospital & Medical Center

While the peripheral nervous system has regenerative ability,restoration of sufficient function remains a *** has been shown to be localized in axonal growth fronts and associated with nerve regeneration,including myelination,neuroplasticity,kinase signaling in nerve axoplasm,and cell migration;however,the mechanisms regulating its expression within Schwann cell（SC） remain *** aim of this study was to profile the spatial and temporal expression profile of micro RNA（mi RNA） in a regenerating rat sciatic nerve after transection,and explore the potential role of mi R-138-5 p targeting vimentin in SC proliferation and migration.A rat sciatic nerve transection model,utilizing a polyethylene nerve guide,was used to investigate mi RNA expression at 7,14,30,60,and 90 days during nerve *** levels of mi RNA expression were determined using microarray analysis and subsequently validated with quantitative real-time polymerase chain *** vitro assays were conducted with cultured Schwann cells transfected with mi RNA mimics and assessed for migratory and proliferative *** top seven dysregulated mi RNAs reported in this study have been implicated in cell migration elsewhere,and GO and KEGG analyses predicted activities essential to wound *** of one of these,mi RNA-138-5 p,into SCs reduced cell migration and *** R-138-5 p has been shown to directly target vimentin in cancer cells,and the luciferase assay performed here in rat Schwann cells confirmed *** results detail a role of mi R-138-5 p in rat peripheral nerve regeneration and expand on reports of it as an important regulator in the peripheral nervous system.

关键词： non-coding RNA neural regeneration nerve guide sciatic nerve transection peripheral nerve injury wound healing Gene Ontology processes Kyoto Encyclopedia of Genes and Genomes pathways microarray luciferase assay

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空中出租车热潮背后

科技纵览 2022年第3期 6-9页

作者： evan Ackerman Glenn Zorpette 不详

在12年前,企业家乔本.贝维尔特(joe-Ben Bevirt)创办了joby Aviation公司,当时joby Aviation只是他位于加州圣克鲁兹山脉的Sproutwerx牧场里的一系列另类科技项目之一。如今,joby Aviatin的员工已经超过了1000名,并拥有了近20亿美元的... 详细信息

在12年前,企业家乔本.贝维尔特(joe-Ben Bevirt)创办了joby Aviation公司,当时joby Aviation只是他位于加州圣克鲁兹山脉的Sproutwerx牧场里的一系列另类科技项目之一。如今,joby Aviatin的员工已经超过了1000名,并拥有了近20亿美元的资金。

关键词：出租车维尔特 job 企业家

Deciphering pitting behavior of lithium metal anodes in lithium sulfur batteries

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journal of Energy Chemistry 2020年第10期29卷 257-261页

作者： Fanyang Huang Shuai Wang Yulin jie evan Hansen Shiyang Wang Zhanwu Lei jian Liu Ruiguo Cao Genqiang Zhang Shuhong jiao Hefei National Laboratory for Physical Science at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026AnhuiChina School of Engineering Faculty of Applied ScienceUniversity of British ColumbiaKelownaBCV1V1V7Canada

Unambiguous understanding in lithium anode failure mechanism calls for a comprehensive methodology to investigate the coupled morphological,electrochemical and mechanical behaviors during the stripping *** this work,a mechanistic investigation of the pitting behavior of lithium metal in an electrolyte containing lithium polysulfides in lithium sulfur batteries was *** is found that lithium polysulfides could aggravate the nonuniform stripping of lithium electrodes.

关键词： Lithium anode Pitting behavior Failure mechanism Lithium sulfur batteries

Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser

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Light(Science & Applications) 2017年第1期6卷 400-407页

作者： evan P Perillo jeremy W jarrett Yen-Liang Liu Ahmed Hassan Daniel C Fernée john R Goldak Andrei Bonteanu David j Spence Hsin-Chih Yeh Andrew K Dunn Department of Biomedical Engineering The University of Texas at AustinTX 78712USA Department of Physics The University of Texas at AustinTX 78712USA MQ Photonics Department of Physics and AstronomyMacquarie UniversitySydneyNSW 2109Australia

Two-color multiphoton microscopy through wavelength mixing of synchronized lasers has been shown to increase the spectral window of excitable fluorophores without the need for wavelength ***,most currently available dual output laser sources rely on the costly and complicated optical parametric generation *** this report,we detail a relatively simple and low cost diamond Raman laser pumped by a ytterbium fiber amplifier emitting at 1055 nm,which generates a first Stokes emission centered at 1240 nm with a pulse width of 100 *** two excitation wavelengths of 1055 and 1240 nm,along with the effective two-color excitation wavelength of 1140 nm,provide an almost complete coverage of fluorophores excitable within the range of 1000–1300 *** compared with 1055 nm excitation,two-color excitation at 1140 nm offers a 90%increase in signal for many far-red emitting fluorescent proteins(for example,tdKatushka2).We demonstrate multicolor imaging of tdKatushka2 and Hoechst 33342 via simultaneous two-color two-photon,and two-color three-photon microscopy in engineered 3D multicellular *** further discuss potential benefits and applications for two-color three-photon *** addition,we show that this laser system is capable of in vivo imaging in mouse cortex to nearly 1 mm in depth with two-color excitation.

关键词： microscopy nonlinear processes three-dimensional imaging ultrafast lasers

Optimizing Surgical Conditions with the Use of a Modified Spontaneous Respiration, Intravenous Anesthesia and High-Flow Nasal Oxygen for Pediatric Laser Laryngeal Surgery

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Open journal of Anesthesiology 2023年第11期13卷 234-240页

作者： Dennis E. Feierman Daniel Escobar Kim T. Lam Mark Kronenfeld jacob Sutton evan P. Salant Maimonides Medical Center Department of Anesthesiology Brooklyn NY USA Northwell Staten Island University Hospital New York USA

The use of SponTaneous Respiration using IntraVEnous anesthesia and High-flow nasal oxygen (STRIVE-Hi) in laryngeal surgery has become more widely reported. This method eliminates the endotracheal tube as a fuel for a potential fire. However, little has been published on its use in the pediatric population. Our case report describes its use in a 2-year-old undergoing micro-direct laryngoscopy with CO2 assisted supraglottoplasty and rigid bronchoscopy for airway obstruction from congenital laryngomalacia. The STRIVE-Hi technique was modified for the pediatric patient by using a lower flow through the nasal cannula (4 L). No major changes in SpO2 were detected during the 30-minute procedure. With back up airway safety equipment in place, STRIVE is proving to be a safe technique with major advantages when used in this unique scenario.

关键词： STRIVE Pediatric Direct Laryngoscopy Laryngomalacia

Predictive value of SYNTAX score II for clinical outcomes in octogenarian undergoing percutaneous coronary intervention

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journal of Geriatric Cardiology 2016年第9期13卷 733-739页

作者： evan Kurniawan Feng-Hua DING Qi ZHANG Zhen-Kun YANG jian HU Wei-Feng SHEN Rui-Yan ZHANG Department of Cardiology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China

为了评估句法的预兆的价值，为经皮的冠的干预(一种总线标准) 获得 II (SS-II ) 在八十至八十九岁(80 岁) 从 Ruijin 医院从八十至八十九岁的经历的一种总线标准的三连续的年经历 *** 与 ResultsData (上海，中国) 回顾地被收集(n = 308... 详细信息

为了评估句法的预兆的价值，为经皮的冠的干预(一种总线标准) 获得 II (SS-II ) 在八十至八十九岁(80 岁) 从 Ruijin 医院从八十至八十九岁的经历的一种总线标准的三连续的年经历 *** 与 ResultsData (上海，中国) 回顾地被收集(n = 308 ) 。包括所有原因死亡，心脏的死亡和主要不利心血管、脑血管的事件(MACCE ) 在一年在临床的数据上面列在后面被收集。病人们为一种总线标准根据 SS-II 的 tertiles 被成层：SS-II 26 (n = 104 ) ， SS-II：27-31 (n = 102 ) ， SS-II > 31 (n = 102 ) 。在为使因素惊讶的调整以后，为一种总线标准的 SS-II 是独立风险为所有原因死亡的因素(机会比率：2.77， 95% CI：1.13-8.06；P = 0.04 ) 。Kaplan-Meier 曲线为一种总线标准在 SS-II 的更高的 tertile 为所有原因死亡和心脏的死亡显示出更高的事件率(木头等级测试 P = 0.002 并且 P = 0.001，分别地) 。为一种总线标准的 SS-II 在经历 *** 的八十至八十九岁的人口预言了一年死亡八十至八十九岁，与 angiographic 解剖变量合并了临床的变量的 SS-II 在风险成层并且在一年预言临床的结果是合适的。

关键词：临床的研究老风险层化