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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna Grant Keith evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert Wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Interplay between Perovskite Magic-Sized Clusters and Amino Lead Halide Molecular Clusters

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Research 2021年第1期2021卷 323-329页

作者： evan T.vickers Ziyi Chen Vivien Cherrette Tyler Smart Peng Zhang Yuan Ping Jin Z.Zhang department of Chemistry and Biochemistry University of CaliforniaSanta CruzCA 95064USA department of Chemistry Dalhousie UniversityHalifaxNSCanada B3H 4R2 department of Physics University of CaliforniaSanta CruzCA 95064USA

Recent progress has been made on the synthesis and characterization of metal halide perovskite magic-sized clusters(PMSCs)with ABX_(3)composition(A=CH_(3)NH_(3)^(+)or Cs^(+),B=Pb^(2+),and X=Cl^(−),Br^(−),or I^(−)).However,their mechanism of growth and structure is still not well *** our effort to understand their structure and growth,we discovered that a new species can be formed without the CH_(3)NH_(3)^(+)component,which we name as molecular clusters(MCs).Specifically,CH_(3)NH_(3)PbBr_(3)PMSCs,with a characteristic absorption peak at 424 nm,are synthesized using PbBr_(2)and CH_(3)NH_(3)Br as precursors and butylamine(BTYA)and valeric acid(VA)as ligands,while MCs,with an absorption peak at 402 nm,are synthesized using solely PbBr_(2)and BTYA,without ***,PMSCs are converted spontaneously overtime into *** isosbestic point in their electronic absorption spectra indicates a direct interplay between the PMSCs and ***,we suggest that the MCs are precursors to the *** spectroscopic and extended X-ray absorption fine structure(EXAFS)results,we propose some tentative structural models for the *** discovery of the MCs is critical to understanding the growth of PMSCs as well as larger perovskite quantum dots(PQds)or nanocrystals(PNCs).

关键词： perovskite absorption Magic

Load carrying capacity of a heterogeneous surface bearing

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Friction 2015年第4期3卷 287-293页

作者： evan THOMAS Mircea d PASCOVICI Romeo P GLOVNEA Tribology Laboratory Department of Engineering and DesignUniversity of SussexUnited Kingdom Machine Elements and Tribology division Politehnica University of BucharestBucharestRomania

It has been shown before that liquids can slip at a solid boundary,which prompted the idea that parallel-surfaces bearings can be achieved just by alternating slip and non-slip regions in the direction of fluid *** amount of slip at the wall depends on the surface tension at the liquid-solid interface,which in turn depends on the chemical state of the surface and its *** the present study a heterogeneous surface was obtained by coating half of a circular glass disc with a coating repellant to glycerol.A rotating glass disc was placed at a known/calibrated distance and the gap was filled with *** the mobile surface moving from the direction of slip to non-slip region it can be theoretically shown that a pressure build up can be *** pressure gradient in the two regions is constant,similar to that in a Rayleigh step bearing,with the maximum pressure at the separation *** heterogeneous disc was placed on a holder supported by a load cell thus the force generated by this pressure increase can be measured *** were carried out at different sliding speeds and gaps and the load carried was measured and subsequently compared with theoretical *** allowed the slip coefficient to be evaluated.

关键词： bearing slip heterogeneous load

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软件系统空间的概念

计算机科学 1984年第3期 75-77页

作者： Frank d.vickers 王春生

适应现代大规模的科学计算和信息处理的需要,建立起了种类繁多的软件系统。本文的目的是对这些软件系统进行透视,以确立一种软件系统空间的概念,还将阐述如何利用这个概念去描述各种计算机语言和各种软件系统的特性。一、系统空间参量... 详细信息

适应现代大规模的科学计算和信息处理的需要,建立起了种类繁多的软件系统。本文的目的是对这些软件系统进行透视,以确立一种软件系统空间的概念,还将阐述如何利用这个概念去描述各种计算机语言和各种软件系统的特性。一、系统空间参量计算机软件系统空间是一个抽象的空间,它包括所有的程序设计语言和软件系统。与其它空间概念一样,计算机软件系统空间也有确定的参量。所不同的是,这里的参量不能用通常的度量单位来计量。

关键词：计算机软件系统机器语言汇编语言程序语言概念思维形式

(Re)assessing Climate-Smart Agriculture practices for sustainable food systems outcomes in sub-Saharan Africa:The case of Bono East Region,Ghana

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Geography and Sustainability 2023年第2期4卷 112-126页

作者： Philip Tetteh Quarshie Seidu Abdulai evan d.G.Fraser deparment of Geography Environment and Geomatics&Guelph Institute of Development StudiesCollege of Social and Applied Human ScienceUniversity of Guelph50 Stone Rd EGuelphON N1H 2W1 Canada Global Agri-Business Solutions INC.54-480 Grey Street BrantfordON N3S 7S5 Canada deparment of Food Agricultural and Resource Economics Ontario Agriculture CollegeUniversity of Guelph50 Stone Rd EGuelphON N1G 2W1 Canada department of Geography Environment and Geomatics&Arrell Food InstituteUniversity of Guelph50 Stone Rd EGuelphON N1H 2W1 Canada

This research paper assesses the reality of Climate-Smart Agriculture(CSA)practices’potential to promote the outcomes of sustainable food systems(SFS)within Ghana’s smallholding agriculture *** study demon-strates that rural farmers generally perceive CSA’s contribution to‘food and nutrition security’and‘economic performance’as more important than CSA’s contribution to‘social equity’and‘environmental stewardship’.From a narrow perspective,the study demonstrates that farmers perceive CSA’s potential to‘prevent pest and disease outbreaks’and‘increase human capital information’as the most important contribution of CSA to SFS *** contrast,CSA’s potential to promote environmental stewardship is perceived as the least important among Ghana’s rural *** enormity of displacement of smallholders’perceptions at large is motivated by de-mographic,socioeconomic and ecological ***,the CSA for SFS outcomes narratives is driven by farmers’self-apprise,social networks and other local information dissemination ***,research findings suggest farmers’awareness of CSA practices and interventions is deficient owing to unmet training and information needs for approximately 82%of the CSA practices and *** situation elucidates the dichotomy of CSA practices’narratives as tools for attaining food,nutrition security and economic performance to the detriment of critical issues such as increasing awareness and building farmers’capacity to engage with CSA practices while also managing socio-ecological trade-offs that emerge over time due to engagement with ***(re)orientation is needed across the scale to drive CSA practices and interventions that confine cli-mate adaptation and food production practices within safe planetary boundaries without undermining social,economic,food and nutrition security needs.

关键词： Climate adaptation Climate-Smart Agriculture Ghana Smallholder farmers Sustainable food systems Sub-Saharan Africa

Polymersomes scalably fabricated via flash nano- precipitation are non-toxic in non-human primates and associate with leukocytes in the spleen and kidney following intravenous administration

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Nano Research 2018年第10期11卷 5689-5703页

作者： Sean d. Allen Yu-Gang Liu Sharan Bobbala Lei Cai Peter I. Hecker Ryan Temel evan A. Scott Interdisciplinary Biological Sciences Northwestern University IL 60208 USA department of Biomedical Engineering Northwestern University IL 60208 USA Saha Cardiovascular Research Center University of Kentucky KY40506 USA department of Pharmacology and Nutritional Sciences University of Kentucky KY40506 USA

Vesicular nanocarrier formulations confer the ability to deliver hydrophobic and hydrophilic cargos simultaneously to cells of interest in vivo. While liposomal formulations reached the clinic long ago, younger technologies such as polymeric vesicles （polymersomes） have yet to make the transition to clinical approval and use, in part due to difficulties in ensuring their safe and scalable production. In this work, we demonstrate the scalable production of poly（ethylene glycol）-block-poly（propylene sulfide）（PEG-bl-PPS） polymersomes via flash nanoprecipitation, and further show the safe administration of these nanocarriers to mice and non-human primates. In mice, PEG-bl-PPS polymersomes were found to be well tolerated at up to 200 mg/（***）. Following the administration of a more relevant 20 mg/（***） dosage in non-human primates, polymersomes were found to associate with numerous phagocytic immune cell populations, including a remarkable 68% of plasmacytoid dendritic cells and 〉 95% of macrophages in the spleen, while showing no toxicity or abnormalities in the liver, kidney, spleen, or blood. despite the presence of a dense PEG corona, neither anti-PEG antibodies nor complement activation were detected. This work provides evidence of the translatability of PEG-bI-PPS polymersomes into the clinic for therapeutic applications in humans.

关键词： polymersome non-human primate nanoprecipitation toxicity biodistribution

Optimization of Artificial Viscosity in Production Codes Based on Gaussian Regression Surrogate Models

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1521-1550页

作者： Vitaliy Gyrya evan Lieberman Mark Kenamond Mikhail Shashkov Applied Mathematics and Plasma Physics Theoretical DivisionMail Stop B284Los Alamos National LaboratoryLos AlamosNM 87545USA Continuum Models and Numerical Methods Group X-Computational Physics DivisionMail Stop F644Los Alamos National LaboratoryLos AlamosNM 87545USA Lagrangian Codes Group X-Computational Physics DivisionMail Stop T086Los Alamos National LaboratoryLos AlamosNM 87545USA

To accurately model flows with shock waves using staggered-grid Lagrangian hydrodynamics, the artificial viscosity has to be introduced to convert kinetic energy into internal energy, thereby increasing the entropy across shocks. determining the appropriate strength of the artificial viscosity is an art and strongly depends on the particular problem and experience of the researcher. The objective of this study is to pose the problem of finding the appropriate strength of the artificial viscosity as an optimization problem and solve this problem using machine learning (ML) tools, specifically using surrogate models based on Gaussian Process regression (GPR) and Bayesian analysis. We describe the optimization method and discuss various practical details of its implementation. The shock-containing problems for which we apply this method all have been implemented in the LANL code FLAG (Burton in Connectivity structures and differencing techniques for staggered-grid free-Lagrange hydrodynamics, Tech. Rep. UCRL-JC-110555, Lawrence Livermore National Laboratory, Livermore, CA, 1992, 1992, in Consistent finite-volume discretization of hydrodynamic conservation laws for unstructured grids, Tech. Rep. CRL-JC-118788, Lawrence Livermore National Laboratory, Livermore, CA, 1992, 1994, Multidimensional discretization of conservation laws for unstructured polyhedral grids, Tech. Rep. UCRL-JC-118306, Lawrence Livermore National Laboratory, Livermore, CA, 1992, 1994, in FLAG, a multi-dimensional, multiple mesh, adaptive free-Lagrange, hydrodynamics code. In: NECdC, 1992). First, we apply ML to find optimal values to isolated shock problems of different strengths. Second, we apply ML to optimize the viscosity for a one-dimensional (1d) propagating detonation problem based on Zel’dovich-von Neumann-doring (ZNd) (Fickett and davis in detonation: theory and experiment. dover books on physics. dover Publications, Mineola, 2000) detonation theory using a reactive burn model. We compare re

关键词： Optimization Artificial viscosity Gaussian regression surrigate model

Witten's d_4 Integrable Hierarchies Conjecture

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 175-192页

作者： Huijun FAN Amanda FRANCIS Tyler JARVIS evan MERRELL Yongbin RUAN School of Mathematical Sciences Peking University department of Mathematics Brigham Young University department of Mathematics University of Michigan Ann Arbor the Yangtz Center of Mathematics at Sichuan University

The authors prove that the total descendant potential functions of the theory of Fan-Jarvis-Ruan-Witten for d4 with symmetry group J and for d4T with symmetry group Gmax, respectively, are both tau-functions of the d4 Kac-Wakimoto/drinfeld-Sokolov hierarchy. This completes the proof, begun in the article by Fan-Jarvis-Ruan（2013）, of the Witten Integrable Hierarchies Conjecture for all simple（AdE） singularities.

关键词： Quantum cohomology Frobenius manifolds Singularity theory Integrable hierarchies

COVId-19 status quo:Emphasis on gastrointestinal and liver manifestations

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World Journal of Gastroenterology 2021年第46期27卷 7969-7981页

作者： Abhishek Bhurwal Carlos d Minacapelli evan Orosz Kapil Gupta Christopher Tait Ishita dalal Clark Zhang Eric Zhao Vinod K Rustgi department of Medicine Division of Gastroenterology and HepatologyRutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States Center for Liver diseases and Masses Rutgers Robert Wood Johnson School of MedicineNew BrunswickNJ 08901United States department of Internal Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States

The coronavirus disease 2019(COVId-19)has caused one of the worst public health crises in modern *** though severe acute respiratory syndrome coronavirus 2 primarily affects the respiratory tract,gastrointestinal manifestations are well described in *** review will discuss the epidemiology,virology,manifestations,immunosuppressant states,and lessons learned from ***:At the time of writing,COVId-19 had infected more than 111 million people and caused over 2.5 million deaths *** medical comorbidities including obesity,pre-existing liver condition and the use of proton pump inhibitor have been described as risk factor for severe ***-19 most frequently causes diarrhea(12.4%),nausea/vomiting(9%)and elevation in liver enzymes(15%-20%).The current data does not suggest that patients on immunomodulators have a significantly increased risk of mortality from *** current guidelines from American Gastroenterological Association and American Association for the Study of Liver diseases do not recommend pre-emptive changes in patients on immunosuppression if the patients have not been infected with *** and relevance:The COVId-19 pandemic has prompted a change in structure and shape of gastroenterology departmental *** should be performed only when necessary and with strict protective *** consultations in the form of telehealth services and home drug deliveries have revolutionized the field.

关键词： COVId-19 Status quo Epidemiology Virology Gastrointestinal manifestations Liver manifestations Immunosuppressed states