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Cholangiographic characteristics of common bile duct dilatation in children

World Journal of Gastroenterology 2015年第20期21卷 6229-6235页

作者： Seak Hee Oh Soo-Hee Chang Hyun Jin Kim Jin Min Cho Ji-Hee Hwang jung-Man Namgoong Dae Yeon Kim Young-Ah Cho Chong Hyun yoon Kyung Mo Kim Department of Pediatrics Asan Medical Center Children’s HospitalUniversity of Ulsan College of Medicine Department of Pediatric Surgery Asan Medical Center Children’s HospitalUniversity of Ulsan College of Medicine Department of Pediatric Radiology Asan Medical Center Children’s HospitalUniversity of Ulsan College of Medicine

AIM: To investigate whether children with congenital common bile duct dilatation(CBDD) differ from children with obstructive CBDD in cholangiographic ***: In this retrospective cohort study, the baseline data and the results of imaging analyses were reviewed among children who had endoscopic retrograde cholangiopancreatography(ERCP) due to CBDD. ERCP was performed on all pediatric patients by experienced pediatric endoscopists. The maximal transverse diameter of the common bile duct(CBD) was measured on ERCP. To assess whether ageadjusted CBDD could be used for differential diagnosis, a CBDD severity index(SI) was calculated by dividing the measured CBD diameter by the age-corrected maximal diameter of a normal CBD. RESULTS: A retrospective medical chart review revealed that 85 consecutive children under 16 years of age with hepatobiliary disease and CBDD were referred to Seoul Asan Medical Center. Fiftyfive(64.7%) children had congenital CBDD and 30(35.3%) had obstructive CBDD. The two groups did not differ significantly in terms of clinical characteristics except for sex. The congenital and obstructive CBDD groups did not differ significantly in terms of mean CBD diameter(19.3 ± 9.6 mm vs 12.2 ± 4.1 mm, P > 0.05). However, congenital CBDD cases had a significantly higher mean SI than obstructive CBDD cases(3.62 ± 1.64 vs 1.98 ± 0.71, P = 0.01). In multivariate analysis, an SI value ≥ 2.32 and comorbidity with anomalous union of pancreaticobiliary duct(APBDU) in ERCP independently predicted congenital ***: Measuring the CBD may aid the differential diagnosis of both CBDD and APBDU in children.

关键词： Endoscopic retrograde cholangiopancreatography Common bile duct Choledochal cyst Choledolithiasis Children

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韩国建筑师的60年

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城市环境设计 2013年第11期 36-39页

作者：郑东贤尹秀妸北京PLaT Architects 清华大学建筑学院

自1953年韩国战争停战以来,迄今已整整过了60年。韩国的建筑,以战后重建为新起点,经历了关于传统性的争论、国家经济的盛衰,以及建筑师自我反思等过程后,最终回归到将建筑归还给市民的新落脚点。在此过程中,建筑师的社会地位不停地转化... 详细信息

自1953年韩国战争停战以来,迄今已整整过了60年。韩国的建筑,以战后重建为新起点,经历了关于传统性的争论、国家经济的盛衰,以及建筑师自我反思等过程后,最终回归到将建筑归还给市民的新落脚点。在此过程中,建筑师的社会地位不停地转化,建筑的意义也随之不断地转变。精神支柱的倒塌2013年的新年之初,便出现了韩国近代建筑的精神支柱倒塌的事件。1月2日,空间建筑事务所(以

关键词：建筑师青年美术家韩国近代建筑史

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红带与镜带商场

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城市环境设计 2015年第5期92卷 124-131页

作者： Sung-ho Kim Chang-ho Shin Bok-ki Lee jung-hoon Lee eun-young Kim Kyung Rho WISE建筑事务所

建筑位于首尔江南区驿三洞618-2号,共两层,水平的条形镜带与垂直向的红色透明条互相重叠并且反射,营造出强烈的视觉错觉。沿着层间狭窄的楼梯往上走,反复的折射光和摇晃的不锈钢条使行走其中的人产生一种晕炫感。楼梯连接着地面和屋顶平... 详细信息

建筑位于首尔江南区驿三洞618-2号,共两层,水平的条形镜带与垂直向的红色透明条互相重叠并且反射,营造出强烈的视觉错觉。沿着层间狭窄的楼梯往上走,反复的折射光和摇晃的不锈钢条使行走其中的人产生一种晕炫感。楼梯连接着地面和屋顶平台,提供了不同的行走体验,改变了过去首尔常见的商业体块模式。我们将这条红色反光镜组成的楼梯走道称为"非凡的建筑漫步通道"。最

关键词：商业建筑商场百货商店楼梯江南区镜面板走道屋顶平台

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Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis

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World Journal of Gastroenterology 2013年第16期19卷 2543-2549页

作者： Sang jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong jung Bora Keum yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu Department of Internal Medicine College of Medicine Korea University Department of Internal Medicine Cheju Halla General Hospital Department of Radiology College of Medicine Korea University Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Christian Hospital

AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis.

关键词： Acute hepatitis Cholestasis Computed tomography Prognosis Gallbladder

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Biopathologic features and clinical significance of micrometatasis in the lymph node of early gastric cancer

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World Journal of Gastroenterology 2015年第2期21卷 667-674页

作者： Min jung Jo Ji Yeon Park Joon Seon Song Myeong-Cherl Kook Keun Won Ryu Soo-Jeong Cho Jun Ho Lee Byung-Ho Nam eun Kyung Hong Il Ju Choi Young-Woo Kim Gastric Cancer Branch Research Institute and HospitalNational Cancer CenterGoyang-si 410-769South Korea Department of Pathology Research Institute and HospitalNational Cancer CenterGoyangsi 410-769South Korea Cancer Registration and Biostatistics Branch and Center for Clinical Trial National Cancer CenterGoyangsi 410-769South Korea

AIM: To evaluate the biopathologic features and clinical significance of nodal micrometastasis(MI) in early gastric cancer(EGC).METHODS: Among 1022 EGC patients who underwent gastrectomy with lymphadenectomy of D1 + β or more from March 2001 to December 2005 at the Korean National Cancer Center, available nodal metastasis was found in 90 p T1N1 patients. Nodal metastasis was confirmed by immunohistochemistry(IHC) with cytokeratin and patients were classified into MI and macrometastasis(MA) groups based on the main tumor burden according to the 6th International Union Against Cancer/American Joint Committee on Cancer staging system; the main tumor burden with a diameter of greater than 0.2 mm but no greater than 2 mm as MI, and greater than 2 mm as MA of the representative metastatic node. Proliferative and apoptotic activities of the primary tumor and the nodal metastasis were measured by IHC with Ki-67 and terminal deoxynucleotidyl transferase d UTP nick end labeling, respectively. Biopathologic and clinical features of the patients were analyzed and compared between MI and MA groups. Patients with recurrence were compared with those without recurrence to identify risk factors for ***: Thirty-seven patients showed MI and the other 53 patients revealed MA in the lymph node; the incidence of patients with MI and MA was 41.1% and 58.9%. The main tumor burden was 0.9 and 4.6 mm in the representative metastatic node, respectively. Japanese N2 stations were more frequently involved in MA group(20.9%) than in MI group(10.3%) butthe difference was not statistically different(P = 0.338). Proliferative and apoptotic activities of MI were decreased than those of MA(26.7% vs 40.5%, P = 0.004 and 1.0% vs 3.0%, P < 0.001, respectively). However, nodal MI in the current study showed a relatively high proliferative activity and an equivalent apoptotic activity compared to other cancers in the previously published studies. Recurrence was observed in 6 patients during

关键词： Early gastric cancer Sentinel node biopsy Lymphade

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Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction

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World Journal of Gastroenterology 2015年第30期21卷 9134-9141页

作者： Seung Han Kim Hoon Jai Chun In Kyung Yoo Jae Min Lee Seung Joo Nam Hyuk Soon Choi eun Sun Kim Bora Keum Yeon Seok Seo yoon Tae Jeen Hong Sik Lee Soon Ho Um Chang Duck Kim Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of Medicine

AIM:To investigate the predictive factors of selfexpandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS:A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS:Self-expandable metallic stent placement was technically successful in all patients(100%),and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model,carcinoembryonic antigen(CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio(a HR)= 2.92,95%CI:1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency(P = 0.009; a HR = 0.27,95%CI:0.10-0.72).CONCLUSION:CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

关键词： Malignant gastroduodenal obstruction Stent Patency Predictive factor Carcinoembryonicantigen

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Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status

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中国肺癌杂志 2011年第1期14卷 33-38页

作者： Sun Young jung Su Jin YOO Ji Young SHIN Ji Won PARK Jeong eun LEE Hee Sun PARK Ju Ock KIM Sun Young KIM Department of Internal Medicine Chungnam National University Hospital

Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner(NSCLC) in progression after first-line *** evaluated the activity and feasibility of pemetrexed in previously treated *** Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March *** patients had relapsed or progressed after prior chemotherapy ***(500 mg/m2) was administered intravenously once every 3 weeks after progression to prior *** tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of *** A total 61 patients were eligible for *** status of them(100%) was over *** response rate and disease control rate were 14.7% and 37.7% ***-squamous cell carcinoma histology was significantly associated with a superior response rate(P=0.045) and disease control rate(P=0.008).The median survival time and the median progression free survival(PFS) time were 6.11 months and 2.17 months,*** the efficacy of pemetrexed in these two settings [second-line versus(12/61) more than third(49/61)],there was no significant difference in regard to median survival(11.18 months vs 11.46 months,P=0.922,5),but PFS was more longer in third-or further-line groups than second-line group(1.39 months vs 2.25 months,P=0.015,3).Conclusion Pemetrexed is a feasible regimen in previously treated NSCLC with poor performance status.

关键词：肺癌症状化学疗法临床治疗

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Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis

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World Journal of Gastroenterology 2013年第29期19卷 4679-4688页

作者： Do Seon Song Si Hyun Bae Myeong Jun Song Sung Won Lee Hee Yeon Kim Young Joon Lee jung Suk Oh Ho Jong Chun Hae Giu Lee Jong Young Choi Seung Kew yoon Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul 137-040 South Korea Department of Radiology College of Medicine The Catholic University of Korea Seoul 137-040 South Korea

AIM: To evaluate the prognostic factors and efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis. METHODS: Fifty hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) were treated using hepatic arterial infusion chemotherapy (HAIC) via a subcutaneously implanted port. The epirubicin-cisplatin-5-fluorouracil (ECF) chemotherapeutic regimen consisted of 35 mg/m 2 epirubicin on day 1, 60 mg/m 2 cisplatin for 2 h on day 2, and 500 mg/m 2 5-fluorouracil for 5 h on days 1-3. The treatments were repeated every 3 or 4 wk. RESULTS: Three (6%) of the 50 patients achieved a complete response (CR), 13 (26%) showed partial responses (PR), and 22 (44%) had stable disease (SD).The median survival and time to progression were 7 and 2 mo, respectively. After 2 cycles of HAIC, CR was achieved in 1 patient (2%), PR in 10 patients (20%) and SD in 26 patients (52%). Significant pre-treatment prognostic factors were a tumor volume of < 400 cm 3 (P = 0.01) and normal levels of protein induced by vitamin K absence or antagonist (PIVKA)-Ⅱ (P = 0.022). After 2 cycles of treatment, disease control (CR + PR + SD) (P = 0.001), PVTT response (P = 0.003) and α-fetoprotein reduction of over 50% (P = 0.02) were independent factors for survival. Objective response (CR + PR), disease control, PVTT response, and combination therapy during the HAIC were also significant prognostic factors. Adverse events were tolerable and successfully managed. CONCLUSION: HAIC may be an effective treatment modality for advanced HCC with PVTT in patients with tumors < 400 cm 3 and good prognostic factors.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Portal vein tumor thrombosis

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一款含植物组合发酵物精华露的皮肤改善效果评价

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日用化学品科学 2021年第3期44卷 26-30页

作者： Lee Joon Ho Goh eun Ji jung Hae Min Jeong Eui Taek 张彬锋 Maeng Yoo Jae 乐金生活健康化妆品研发(上海)有限公司上海200233 LG生活健康股份有限公司技术研究院首尔07795韩国

通过分析植物组合发酵物发酵前后的氨基酸、有机酸含量变化和对胶原蛋白的合成提高率的影响,并对一款含有该植物组合发酵物的精华露采用测定受试志愿者使用前后皮肤含水量、皮肤平滑度和光泽度等客观指标,结合问卷调查收集受试者使用感... 详细信息

通过分析植物组合发酵物发酵前后的氨基酸、有机酸含量变化和对胶原蛋白的合成提高率的影响,并对一款含有该植物组合发酵物的精华露采用测定受试志愿者使用前后皮肤含水量、皮肤平滑度和光泽度等客观指标,结合问卷调查收集受试者使用感受等主观指标进行了人体功效评价。结果表明,植物组合发酵物与发酵前比较,氨基酸和有机酸的含量增加,同时胶原蛋白合成率提高。含有该植物组合发酵物的精华露能显著提高皮肤含水量,改善皮肤平滑度和光泽度。使用4周后97.2%的受试者对该产品整体效果表示满意,实验过程中无受试者出现不良反应。研究结果显示,该款产品具有一定的皮肤改善效果。

关键词：发酵精华露胶原蛋白皮肤改善含水量光泽度平滑度

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A feasible modified biopsy method for tissue diagnosis of gastric subepithelial tumors

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World Journal of Gastroenterology 2013年第29期19卷 4752-4757页

作者： jung Ho Kim Jun-Won Chung Minsu Ha Min Young Rim Jong Joon Lee jungsuk An yoon Jae Kim Kyoung Oh Kim Kwang An Kwon Dong Kyun Park Yeon Suk Kim Duck Joo Choi Department of Internal Medicine Gachon University Gil Medical Center Incheon 405-760 South Korea Department of Pathology Gachon University Gil Medical Center Incheon 405-760 South Korea

AIM: To evaluate the diagnostic yield and safety of a modified technique for the histological diagnosis of subepithelial tumors (SETs). METHODS: A retrospective review of patients who underwent a modified technique for the histological diagnosis of gastric SETs, consisting of a mucosal incision with a fixed flexible snare (MIF) and deep-tissue biopsy under conventional endoscopic view, from January 2012 to January 2013 was performed. Eleven patients with gastric SETs 10-30 mm in diameter and originating from the third or fourth layer on endoscopic ultrasonography were included. RESULTS: The mean age was 59.8 (range, 45-76) years, and 5 patients were male. The mean size of the SETs was 21.8 (range, 11-30) mm. The number of biopsy specimens was 6.3 (range 5-8). The mean procedure time was 9.0 min (range, 4-17 min). The diagnostic yield of MIF biopsies was 90.9% (10/11). The histological diagnoses were leiomyoma (4/11, 36.4%), aberrant pancreas (3/11, 27.3%), gastrointestinal stromal tumors (2/11, 18.2%), an inflammatory fibrinoid tumor (1/11, 9.1%); one result was non-diagnostic (1/11, 9.1%). There were six mesenchymal tumors; the specimens obtained in each case were sufficient for an immunohistochemical diagnosis. There was no major bleeding, but one perforation occurred that was successfully controlled by endoscopic clipping. CONCLUSION: The MIF biopsy was simple to perform, safe, and required a shorter procedure time, with a high diagnostic yield for small SETs.

关键词： Subepithelial tumors Stomach Biopsy Endoscopy Diagnostic techniques

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