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Evaluation of anatomical considerations in the posterior maxillae for sinus augmentation

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World Journal of Clinical Cases 2014年第11期2卷 683-688页

作者： Ji-eun Lee Seong-Ho jin Youngkyung Ko Jun-Beom Park Department of Periodontics Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea Seoul 137-701South Korea

The edentulous posterior maxilla is considered a clinical challenge during dental implant treatment for many dental practitioners. This is because its insufficient bone quality, deficient alveolar ridge, spiny ridges, undercuts, and sinus pneumatization are often encountered after tooth loss. To overcome these problems, several approaches have been developed and are currently used, including sinus augmentation and bone augmentation. Today, two main procedures of sinus floor elevation for dental implant placement are in use: a two-stage technique using the lateral window approach, and a onestage technique using a lateral or a crestal approach. In this study, we deal with the anatomic relations ofthe structures of the maxillary sinus during sinus augmentation. These anatomical findings can help in complications and potential injuries of the maxillary sinus procedures. It can be suggested that pre-operative evaluation is helpful for diagnosis and treatment planning and minimizing complication during the surgery.

关键词： Anatomy Intraoperative complications Sinus floor augmentation

The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges

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Asian Journal of Urology 2016年第4期3卷 203-210页

作者： eun-jin Yun U-Ging Lo Jer-Tsong Hsieh Department of Urology UT Southwestern Medical CenterDallasTXUSA

Prostate cancer(PCa)is the most common cause of malignancy in males and the second leading cause of cancer mortality in United *** treatments for PCa include surgery,radiotherapy,and androgen-deprivation ***,PCa relapses to an advanced castration-resistant PCa(CRPC)that becomes a systematic disease and ***,identifying cellular components and molecular mechanisms that drive aggressive PCa at early stage is critical for disease prognosis and therapeutic *** potential strategy for aggressive PCa is to target cancer stem cells(CSCs)that are identified by several unique characteristics such as immortal,self-renewal,and ***,CSC is believed to be a major factor contributing to resistance to radiotherapy and conventional ***,CSCs are thought to be the critical cause of metastasis,tumor recurrence and cancer-related death of multiple cancer types,including *** this review,we discuss recent progress made in understanding prostate cancer stem cells(PCSCs).We focus on the therapeutic strategies aimed at targeting specific surface markers of CSCs,the key signaling pathways in the maintenance of self-renewal capacity of CSCs,ATP-binding cassette(ABC)transporters that mediate the drug-resistance of CSCs,dysregulated microRNAs expression profiles in CSCs,and immunotherapeutic strategies developed against PCSCs surface markers.ª2016 Editorial Office of Asian Journal of *** and hosting by Elsevier *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).

关键词： Prostate cancer Cancer stem cell Normal stem cell

Effects of Wind Fences on the Wind Environment around Jang Bogo Antarctic Research Station

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Advances in Atmospheric Sciences 2017年第12期34卷 1404-1414页

作者： Jang-Woon WANG Jae-jin KIM Wonsik CHOI Da-Som MUN Jung-eun KANG Hataek KWON jin-Soo KIM Kyung-Soo HAN Department of Environmental Atmospheric Sciences Pukyong National University 45Yongso-ro Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Department of Spatial Information Engineering Pukyong National University 45Yongso-ro

This study investigated the flow characteristics altered by Jang Bogo Antarctic Research Station using computational fluid dynamics(CFD) modeling. The topography and buildings around Jang Bogo Station were constructed with computeraided-design data in the CFD model domain. We simulated 16 cases with different inflow directions, and compared the flow characteristics with and without Jang Bogo Station for each inflow direction. The wind data recorded by the site’s automatic weather station(AWS) were used for comparison. Wind rose analysis showed that the wind speed and direction after the construction of Jang Bogo Station were quite different from those before construction. We also investigated how virtual wind fences would modify the flow patterns, changing the distance of the fence from the station as well as the porosity of the fence. For westerly inflows, when the AWS was downwind of Jang Bogo Station, the decrease in wind speed was maximized(-81% for west-northwesterly). The wind speed reduction was also greater as the distance of the fence was closer to Jang Bogo Station. With the same distance, the fence with medium porosity(25%–33%) maximized the wind speed *** results suggest that the location and material of the wind fence should be selected carefully, or AWS data should be interpreted cautiously, for particular prevailing wind directions.

关键词： Jang Bogo Antarctic Research Station CFD model observation environment wind fence porosity

Acute myopathy associated with liver cirrhosis

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World Journal of Gastroenterology 2006年第14期12卷 2254-2258页

作者： Ok-Jae Lee Jee-Hyang Yoon eun-Jeong Lee Hyun-jin Kim Tae-Hyo Kim Department of Internal Medicine and Gyeongsang Institute of Health Science Gyeongsang National University College of Medicine JinjuRepublic of Korea

AIM： Many cirrhotic patients have muscular symptoms and rhabdomyolysis. However, myopathy associated with liver cirrhosis has not been established as a disease entity. We evaluated the clinical significance of acute myopathy associated with liver cirrhosis. METHODS： We retrospectively reviewed the medical records of 5440 cirrhotic patients who had been admitted to Gyeongsang National University Hospital from August 1997 to January 2003. Among these, 99 developed acute myopathies, and they were analyzed with respect to clinical and laboratory parameters, and outcomes. RESULTS： The Child-Pugh classification at the time of myopathy onset was A in 3（3.1%） cases, B in 33（33.3%）, and C in 63 （63.6%）. Infection was identified as the most predisposing factor to myopathy. Fifty percent of 18 idiopathic cases who were tested for influenza antibody were positive. Forty-two of the 99 cases were complicated by acute renal failure, and 25 （59.5%） of these expired. Apart from 6 cases lost to follow-up, 64 of 93 recovered, giving a mortality rate of 31.2%. Mortality was higher in Child-Pugh class C than in B or A. CONCLUSION： Acute myopathy can develop as a serious complication in liver cirrhosis. Its frequency, severity and mortality depend on underlying liver function, and are higher in decompensated liver cirrhosis. Influenza should be considered as an etiologic factor in idiopathic cases. It is proposed that acute myopathy associated with liver cirrhosis be called ＇hepatic myopathy; and that careful monitoring for hepatic myopathy is necessary in the patients with advanced liver cirrhosis.

关键词： Myopathy Rhabdomyolysis Liver cirrhosis

Outcome after endoscopic submucosal dissection for early gastric cancer in Korea

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World Journal of Gastroenterology 2011年第31期17卷 3591-3595页

作者： Jun Haeng Lee Su jin Hong Jae Young Jang Seong eun Kim Sang Young Seol Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine Department of Internal Medicine Digestive Disease CenterInstitute for Digestive ResearchSoon Chun Hyang University College of Medicine Department of Internal Medicine Kyung Hee University College of Medicine Department of Internal Medicine Ewha Womans University School of MedicineEwha Medical Research Institute Division of Gastroenterology and Hepatology Department of Internal MedicineInje University College of Medicine

Endoscopic treatment,such as endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD),has been established as one of the treatment options for selected cases with early gastric cancer(EGC).Most studies on this topic have been carried out by researchers in ***,the experience in EMR/ESD for EGC outside Japan is increasingly *** Korea,gastric cancer is the most common malignant disease,and the second leading cause of cancer ***,EMR for EGC is widely performed in many centers in *** results with a shortterm follow-up period are very promising in *** resection rate of EMR was 37.8%-94.3%,and that of ESD was 77.4%-93.1%.In this review,we will provide an overview of the outcomes of endoscopic treatments in Korea.

关键词： Early gastric cancer Endoscopic mucosal resection Endoscopic submucosal dissection Outcome

Morphology Control of Bi2S3 Nanostructures and the Formation Mechanism

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Chinese Journal of Chemistry 2013年第6期31卷 752-756页

作者： Heejin Kim Ji-eun Park Kyung Kim Mi-Kyung Han Sung-jin Kim Wooyoung Lee Department of Materials Science and Engineering Yonsei University Seou1120- 749 Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 120-750 Korea

Bismuthinite （Bi2S3）nanostructures were prepared by a hydrothermal method with sodium ethylenediamine- tetraacetate （EDTA-Na2）. The morphology of Bi2S3 nanostructures was changed from a nanorod to a nanoplate by presence of the EDTA-Na2. The altered morphology was caused by the capping effect of EDTA-Na2 with Bi3＋ ions, which induces the suboptimal growth direction due to partially blocking the preferential orientation direction. When the EDTA-Na2/Bi3＋ molar ratio= 1, the growth of Bi2S3 nanostructures was not allowed due to the chelating effect of EDTA-Na2. The obtained Bi2S3 nanorods, stacked nanorods, nanoplates and nanoparticles were characterized using X-ray diffraction （XRD）, transmission electron microscopy （TEM）, high-resolution transmission electron mi- croscopy （HRTEM） and selected area electron diffraction （SAED） pattern. A possible formation mechanism of these morphologies was proposed. The successful synthesis of various morphologies of nanostructured Bi2S3 may open up new possibilities for thermoelectric, electronic and optoelectronic uses of nanodevices based on Bi2S3 nanostructure.

关键词： bismuth sulfide (Bi2S3) hydrothermal nanorod nanoplate thermoelectric material

Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19

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World Journal of Gastroenterology 2021年第19期27卷 2341-2352页

作者： Byungchang jin Rajan Singh Se eun Ha Hannah Zogg Paul J Park Seungil Ro Department of Physiology and Cell Biology University of Nevada School of MedicineRenoNV 89557United States Department of Medicine Renown HealthRenoNV 89557United States

Gastrointestinal(GI)symptoms,such as diarrhea,abdominal pain,vomiting,and anorexia,are frequently observed in patients with coronavirus disease 2019(COVID-19).However,the pathophysiological mechanisms connecting these GI symptoms to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections remain *** studies indicate that the entry of SARS-CoV-2 into intestinal cells leads to downregulation of angiotensin converting enzyme 2(ACE2)receptors resulting in impaired barrier *** intestinal ACE2 functions as a chaperone for the amino acid transporter B0AT1,the B0AT1/ACE2 complex within the intestinal epithelium acts as a regulator of gut microbiota composition and *** to the B0AT1/ACE2 complex lead to microbial dysbiosis through increased local and systemic immune *** studies have also suggested that altered serotonin metabolism may be the underlying cause of GI disorders involving *** findings of elevated plasma serotonin levels and high fecal calprotectin in COVID-19 patients with diarrhea indicate that the viral infection evokes a systemic inflammatory response that specifically involves the ***,the elevated proinflammatory cytokines correlate with elevated serotonin and fecal calprotectin levels further supporting the evidence of GI inflammation,a hallmark of functional GI ***,the finding that rectal swabs of COVID-19 patients remain positive for SARS-CoV-2 even after the nasopharynx clears the virus,suggests that viral replication and shedding from the GI tract may be more robust than that of the respiratory tract,further indicating fecal-oral transmission as another important route of viral *** review summarized the evidence for pathophysiological mechanisms(impaired barrier function,gut inflammation,altered serotonin metabolism and gut microbiota dysbiosis)underlying the GI symptoms in patients with COVID-19.

关键词： COVID-19 Gastrointestinal symptoms Gut microbiota dysbiosis Impaired barrier function Serotonin Angiotensin converting enzyme 2 receptor

β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh Kim Ji Min Kim eun Jeong Cho Chang Ohk Sung Joon Kim Se jin Jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University of Ulsan College of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea OncoClew Life Science Co. LtdSeoul 05505Republic of Korea

Dysregulation of the Hippo pathway has been frequently identified in various human cancers. The Hippo pathway is a highly complex pathway involving multiple types of proteins, and the activation of YAP by LATS kinase is the final effector step in the transcription process. In this study, we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathways such as GPCR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway, β-arrestins function as scaffold proteins that mediate the phosphorylation of key molecules, and their association with human cancers is a major research topic. In this study, we demonstrated that β-arrestin 2 inhibits YAP activation through the formation of the β-arrestin 2-LATS-YAP trimeric complex, which results in the promotion of the kinase activity of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation

Association of fluoride exposure with disease burden and neurodevelopment outcomes in children in South Korea

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World Journal of Pediatrics 2024年第10期20卷 1029-1042页

作者： Won Seok Lee Ju Hee Kim Boeun Han Gi Chun Lee Hye Ri Jung Ye jin Shin eun Kyo Ha eun Lee Soonchul Lee Man Yong Han Department of Pediatrics CHA Ilsan Medical CenterCHA University School of MedicineGoyangRepublic of Korea Department of Pediatrics Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea Department of Pediatrics CHA Bundang Medical CenterCHA University School of Medicine59 Yatap-RoBundang-GuSeongnam-siGyeonggi-do13496Republic of Korea Multi-Omics Research Center CHA Future Medicine Research InstituteSeongnamRepublic of Korea Department of Computer Science and Engineering Konkuk UniversitySeoulRepublic of Korea School of Medicine CHA UniversityPocheonRepublic of Korea Department of Pediatrics Hallym University Kangnam Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Pediatrics Chonnam National University HospitalChonnam National University Medical SchoolGwangjuRepublic of Korea Department of Orthopaedic Surgery CHA Bundang Medical CenterCHA University School of Medicine59 Yatap-RoBundang-GuSeongnam-siGyeonggi-do13496Republic of Korea

Background Community water fluoridation is an effective public health strategy for preventing dental caries,*** exist about potential health *** study explores associations between tap water fluoride levels and pediatric disease burden,as well as neurodevelopmental outcomes at 6 years of *** This nationwide population-based cohort study included children born in Korean cities with and without tap water fluoridation projects,between 2006 and 2012,aiming for a fluoride concentration of 0.8±0.2 mg/L in treated tap *** from the National Health Insurance Service were used,spanning from birth to *** relationship between exposure to fluoridated tap water and incidence of 16 childhood diseases that were previously identified as potentially linked to fluoride exposure were ***,we evaluated the neurodevelopmental outcomes across various domains,including gross motor,fine motor,cognition,language,social skills,and self-help *** assessments were performed using data from a comprehensive national health screening program for children aged six *** A fluoride-unexposed group included 22,881 children,whereas a fluoride-exposed group comprised 29,991 children(52%males).Children in the fluoride-exposed group had a decreased risk of dental caries and bone fractures[hazard ratio(95%confidence interval,CI),0.76(0.63–0.93)and 0.89(0.82–0.93),respectively]and increased risk of hepatic failures[1.85,(1.14–2.98)]compared to those in the unexposed ***,the risk ratio of abnormal neurodevelopmental screening outcomes increased by 9%,but this was statistically uncertain(95%CI,0.95–1.26).Conclusions Fluoridated tap water was associated with an increased risk of hepatic failure but a decreased risk of bone fractures in *** association between fluoridated tap water and neurodevelopmental screening outcomes at 6 years remains unclear,highlighting the need for further studies to clarify this associ

关键词： Children-Fluoride.Hepatic failure.Neurodevelopment