The evolving landscape of prostate cancer stem cell: Therapeutic implications and future challenges
作者机构：Department of UrologyUT Southwestern Medical CenterDallasTXUSA
出 版 物：《Asian Journal of Urology》 (亚洲泌尿外科杂志（英文）)
年 卷 期：2016年第3卷第4期
页 面：203-210页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Prostate cancer Cancer stem cell Normal stem cell
摘 要：Prostate cancer(PCa)is the most common cause of malignancy in males and the second leading cause of cancer mortality in United *** treatments for PCa include surgery,radiotherapy,and androgen-deprivation ***,PCa relapses to an advanced castration-resistant PCa(CRPC)that becomes a systematic disease and ***,identifying cellular components and molecular mechanisms that drive aggressive PCa at early stage is critical for disease prognosis and therapeutic *** potential strategy for aggressive PCa is to target cancer stem cells(CSCs)that are identified by several unique characteristics such as immortal,self-renewal,and ***,CSC is believed to be a major factor contributing to resistance to radiotherapy and conventional ***,CSCs are thought to be the critical cause of metastasis,tumor recurrence and cancer-related death of multiple cancer types,including *** this review,we discuss recent progress made in understanding prostate cancer stem cells(PCSCs).We focus on the therapeutic strategies aimed at targeting specific surface markers of CSCs,the key signaling pathways in the maintenance of self-renewal capacity of CSCs,ATP-binding cassette(ABC)transporters that mediate the drug-resistance of CSCs,dysregulated microRNAs expression profiles in CSCs,and immunotherapeutic strategies developed against PCSCs surface markers.ª2016 Editorial Office of Asian Journal of *** and hosting by Elsevier *** is an open access article under the CC BY-NC-ND license(http://***/licenses/by-nc-nd/4.0/).
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