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Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer:Where are we now in the era of the next generation proteomics?

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World Journal of Gastroenterology 2014年第37期20卷 13466-13476页

作者： Jong-Min Park Na Young Han Young-Min Han Mi Kyung Chung Hoo Keun Lee Kwang Hyun Ko eun-Hee Kim Ki Baik Hahm cha Cancer Prevention Research Center CHA University Gachon University College of Pharmacy Digestive Disease Center CHA University Bundang Medical Center

Recent advances in genomic medicine have opened up the possibility of tailored medicine that may eventually replace traditional "one-size-fits all" approaches to the treatment of inflammatory bowel disease(IBD). In addition to exploring the interactions between hosts and microbes, referred to as the microbiome, a variety of strategies that can be tailored to an individual in the coming era of personalized medicine in the treatment of IBD are being investigated. These include prompt genomic screening of patients at risk of developing IBD, the utility of molecular discrimination of IBD subtypesamong patients diagnosed with IBD, and the discovery of proteome biomarkers to diagnose or predict cancer risks. Host genetic factors influence the etiology of IBD, as do microbial ecosystems in the human bowel, which are not uniform, but instead represent many different microhabitats that can be influenced by diet and might affect processes essential to bowel metabolism. Further advances in basic research regarding intestinal inflammation may reveal new insights into the role of inflammatory mediators, referred to as the inflammasome, and the macromolecular complex of metabolites formed by intestinal bacteria. Collectively, knowledge of the inflammasome and metagenomics will lead to the development of biomarkers for IBD that target specific pathogenic mechanisms involved in the spontaneous progress of IBD. In this review article, our recent results regarding the discovery of potential proteomic biomarkers using a label-free quantification technique are introduced and on-going projects contributing to either the discrimination of IBD subtypes or to the prediction of cancer risks are accompanied by updated information from IBD biomarker research.

关键词： Inflammatory bowel disease Biomarker Proteomics Ta

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从实心与时代精神看韩国阳明学

贵阳学院学报（社会科学版） 2018年第6期13卷 13-19页

作者：金世贞忠南大学人文学院哲学系韩国大田34134

韩国阳明学的主要特点是"实心"与"时代精神"。"实心"这一单词在阳明王守仁(1472—1529年)的《传习录》中并未提到过,也未提到过实效、实行。然而从张维、崔鸣吉、郑齐斗、江华学派到郑寅普,韩国的阳明学者们在表达上都非常重视实心、实... 详细信息

韩国阳明学的主要特点是"实心"与"时代精神"。"实心"这一单词在阳明王守仁(1472—1529年)的《传习录》中并未提到过,也未提到过实效、实行。然而从张维、崔鸣吉、郑齐斗、江华学派到郑寅普,韩国的阳明学者们在表达上都非常重视实心、实行、实功、实效。所以不管是实心这一术语的使用,还是对"实心"的重视,都是韩国阳明学的主要特点。实心这一概念是朝鲜中期以后,是时只重视形式、名分及义理的虚伪、虚饰及伪善的行为进行的一种批判和对应理论。张维、崔鸣吉、郑齐斗、江华学派、郑寅普等人重视实心,为了解决当时自己所处时代存在的问题,朴殷植虽然没有提及实心,但他也是想根据阳明学来解决当时的时代问题。围绕他们表现的"实心"与"时代精神",沿着韩国阳明学的发展历程,分析了韩国阳明学的特点和特性。

关键词：韩国阳明学实心时代精神江华学派

Quality of healing of gastric ulcers: Natural products beyond acid suppression

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World Journal of Gastrointestinal Pathophysiology 2014年第1期5卷 40-47页

作者： Napapan Kangwan Jong-Min Park eun-Hee Kim Ki Baik Hahm cha Cancer Prevention Research Center CHA Cancer InstituteCHA University College of Pharmacy CHA University Department of Gastroenterology CHA University Bundang Medical Center

Gastric ulcer is a chronic disease featured with unexpected complications, including bleeding, stenosis and perforation, as well as a high incidence of recurrence. Clinical treatments for gastric ulcer have allowed the rapid development of potent anti-ulcer drugs during the last several decades. Gastric ulcer healing is successful with conventional treatments including H2-receptor antagonists, and proton pump inhibitors(PPIs) have been essential for ulcer healing and prevention of complications. Additionally, Helicobacter pylori eradication therapy is effective in reducing ulcer recurrence and leads to physiological changes in the gastric mucosa which affect the ulcer healing process. However, in spite of these advancements, some patients have suf-fered from recurrence or intractability in spite of continuous anti-ulcer therapy. A new concept of the quality of ulcer healing(QOUH) was initiated that considers the reconstruction of the mucosal structure and its function for preventing ulcer recurrence. Although several gastroprotection provided these achievements of the QOUH, which PPI or other acid suppressants did not accomplish, we found that gastroprotection that originated from natural products, such as a newer formulation from either Artemisia or S-allyl cysteine from garlic, were very effective in the QOUH, as well as improving clinical symptoms with fewer side effects. In this review, we will introduce the importance of the QOUH in ulcer healing and the achievements from natural products.

关键词： Quality of ulcer healing Natural products Gastric ulcers Acid suppression S-allyl cysteine Artemisia isopropanol extract

固体氧化物燃料电池离子-电子混合传导性Ni/ScSZ燃料极的制备以及性能分析

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集成技术 2018年第6期7卷 81-87页

作者：崔仁源刘元钟李相勋苏芝玄柳相凤金有圣郑圆烨郑春花车硕源张翼滉首尔大学机械工程系首尔151742 中国科学院深圳先进技术研究院深圳518055 圆光大学机械汽车工程系益山54538

在薄膜固体氧化物燃料电池中,为增加发生电化学反应的三相界面面积,燃料极和空气极通常制备成离子-电子混合传导性质的多孔形态。该研究将燃料极电化学反应(氢氧化反应)的催化剂——镍(Ni)和氧离子传导性好的氧化钪稳定的氧化锆(ScSZ)... 详细信息

在薄膜固体氧化物燃料电池中,为增加发生电化学反应的三相界面面积,燃料极和空气极通常制备成离子-电子混合传导性质的多孔形态。该研究将燃料极电化学反应(氢氧化反应)的催化剂——镍(Ni)和氧离子传导性好的氧化钪稳定的氧化锆(ScSZ)混合制备成离子-电子混合传导燃料极。实验结果显示,与纯Ni燃料极相比,所制备的Ni/ScSZ燃料极因其三相界面面积的增加,可显著降低极化电阻,但同时欧姆电阻也显著增加,从而最终导致燃料电池单池性能总体下降。

关键词：薄膜固体氧化物燃料电池离子-电子混合传导氧化钪稳定的氧化锆欧姆电阻

钆塞酸二钠增强MRI对壶腹周围癌病人肝微脓肿和转移瘤鉴别诊断的价值

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国际医学放射学杂志 2017年第6期 746-746页

作者： S.Y.Choi Y.K.Kim J.H.Min D.I.cha W.K.jeong W.J.Lee 李欣然 Department of Radiology Soonchunhyang University College of Medicine Bucheon Hospital

摘要目的采用钆塞酸二钠增强MRI对壶腹周围癌病人检查,旨在识别能够鉴别的肝微脓肿和转移瘤的影像特征。方法共纳入72例病人(31例病人有83处肝微脓肿灶,

关键词：壶腹周围癌钆塞酸二钠 MRI 转移瘤

Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies

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World Journal of Gastroenterology 2015年第38期21卷 10874-10882页

作者： Hyoung Su Kim Hyung Joon Yim Myoung Kuk Jang Ji Won Park Sang Jun Suh Yeon Seok Seo Ji Hoon Kim Bo Hyun Kim Sang Jong Park Sae Hwan Lee Sang Gyune Kim Young Seok Kim Jung Il Lee Jin-Woo Lee In Hee Kim Tae Yeob Kim Jin-Wook Kim Sook-Hyang jeong Young Kul Jung Hana Park Seong Gyu Hwang Department of Internal Medicine Hallym University College of Medicine Department of Internal Medicine Korea University Ansan Hospital Department of Internal Medicine Korea University Medical College Department of Internal Medicine Bundang Jesaeng Hospital Department of Internal Medicine Soon Chun Hyang University College of Medicine Department of Internal Medicine Inha University School of Medicine Department of Internal Medicine Chonbuk National University Medical School Department of Internal Medicine Hanyang University College of Medicine Department of Internal Medicine Seoul National University College of Medicine Department of Internal Medicine Gachon University School of Medicine Department of Internal Medicine CHA Bundang Medical CenterCHA University

AIM: To evaluate the long-term efficacy adefovir(ADV)-based combination therapies in entecavir(ETV)-resistant chronic hepatitis B(CHB) patients. METHODS: F i fty CHB pat ient s wi t h genotypic resistance to ETV at 13 medical centers in South Korea were included for the analysis. All the patients received rescue therapy with the combination of ADV plus ETV(ADV/ETV,n = 23) or ADV plus lamivudine(LMV)(ADV/LMV,n = 27) for more than 12 mo. Patients were monitored at least every 3-4 mo during ADV-based combination therapy by clinical examination as well as biochemical and virological assessments. Hepatitis B virus(HBV) DNA levels were measured by realtime PCR and logarithmically transformed for analysis. Cumulative rates of virologic response(VR; HBV DNA < 20 IU/m L) were calculated using the Kaplan-Meier method,and the difference was determined by a logrank test. Multivariate logistic regression and Cox proportional hazards models were used to identify independent risk factors significantly associated with short-term and long-term VR,***: Baseline median HBV DNA levels were 5.53(2.81-7.63) log10 IU/m L. The most commonly observed ETV genotypic mutation sites were rt184 and rt202. Patients were treated for a median of 27(12-45) mo. Overall,cumulative VR rates at 6,12,24,and 36 mo were 26%,36%,45%,and 68%,respectively. Patients treated with the ADV/ETV combination showed higher cumulative VR rates(35%,43%,65%,and 76%,respectively) than those with the ADV/LAM combination(18%,30%,30%,and 62%,respectively; P = 0.048). In the multivariate analysis,low baseline HBV DNA levels(< 5.2 log10 IU/m L) and initial virologic response at 3 mo(IVR-3; HBV DNA < 3.3 log10 IU/m L after 3 mo) were independent predictive factors for VR. Patients with favorable predictors achieved cumulative VR rates up to 90% at 36 mo. During the same period,the cumulative incidence of virologic breakthrough was as low as 6% in patients with the both favorable ***: If tenof

关键词： Adefovir Chronic hepatitis B Entecavir Lamivudine