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Seasonal dynamics of airborne biomolecules influence the size distribution of Arctic aerosols

Environmental Science and Ecotechnology 2024年第6期22卷 245-255页

作者： Eunho Jang Ki-Tae Park young Jun Yoon Kyoung-Soon Jang Min Sung Kim Kitae Kim Hyun young chung Mauro Mazzola David Cappelletti Bang Yong Lee Korea Polar Research Institute(KOPRI) Incheon21990Republic of Korea University of Science and Technology(UST) Daejeon34113Republic of Korea Department of Environmental Sciences and Biotechnology Hallym UniversityChuncheonGangwon-do24252Republic of Korea Korea Basic Science Institute(KBSI) Cheongju28119Republic of Korea National Research Council of Italy Institute of Polar Sciences(CNR-ISP)Via Gobetti 101Bologna40129Italy Department of Chemistry Biology and BiotechnologyUniversity of PerugiaVia Elce di Sotto 8Perugia06123Italy

Organic matter is crucial in aerosol-climate interactions,yet the physicochemical properties and origins of organic aerosols remain poorly *** we show the seasonal characteristics of submicron organic aerosols in Arctic Svalbard during spring and summer,emphasizing their connection to transport patterns and particle size ***-derived organic matter(MOM)and terrestrial-derived organic matter(TOM)accounted for over 90%of the total organic mass in Arctic aerosols during these seasons,comprising carbohydrate/protein-like and lignin/tannin-like compounds,*** spring,aerosols showed high TOM and low MOM intensities due to biomass-burning influx in the central *** contrast,summer exhibited elevated MOM intensity,attributed to the shift in predominant atmospheric transport from the central Arctic to the biologically active Greenland *** and TOM were associated with Aitken mode particles(100 nm diameter),*** association is linked to the molecular size of biomolecules,impacting the number concentrations of corresponding aerosol *** findings highlight the importance of considering seasonal atmospheric transport patterns and organic source-dependent particle size distributions in assessing aerosol properties in the changing Arctic.

关键词： Organic aerosol FT-ICR MS Particle size distribution Atmospheric transport pattern Biomolecule

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Measurement of stiffness and damping coefficient of rubber tractor tires using dynamic cleat test based on point contact model

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International Journal of Agricultural and Biological Engineering 2021年第1期14卷 157-164页

作者： Hogil Yoo Jooseon Oh Woo-Jin chung Hyun-Woo Han Ji-Tae Kim young-Jun Park Yoonna Park Department of Biosystems&Biomaterials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Global Smart Farm Convergence Major College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Sciences College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research and Development Institute Tongyang Moolsan Co.Ltd.Gongju 32530Republic of Korea

The ride vibration of a tractor is affected mostly by the stiffness and damping coefficient of the seat suspension,cabin suspension,cabin rubber mounts,and rubber ***,in the case of rubber tractor tires,the stiffnesses and damping coefficients have not been researched adequately thus far,and it is not simple to measure these *** this study,a method for measuring and analyzing the stiffnesses and damping coefficients of rubber tractor tires,which were the input parameters for the tractor ride vibration simulation,was *** cleat test,proposed in this study,did not require separate and complicated test equipment,unlike the conventional *** test was conducted simply by measuring acceleration under the driving conditions of the vehicle without detaching tires from the vehicle body or setting up additional test *** on the ground-vertical acceleration data obtained,the stiffness was calculated using the logarithmic decrement method,and the damping coefficient was calculated using least squares exponential curve *** result of the cleat test indicated that the front tires had stiffnesses of 486.08-570.69 kN/m and damping coefficients of 4.02-4.52 kN·s/m;the rear tires had stiffnesses of 409.42-483.79 kN/m and damping coefficients of 2.21-2.67 kN·s/*** the test,40 mm height cleats were installed on the track and the speed of the tractor was set to 7 and 10 km/h,which were the most common speeds during the *** study is meaningful in that it has presented a new method that improves the practicality of results,reduces cost,and simplifies the test process for measuring the stiffnesses and damping coefficients of rubber tractor tires.

关键词： ride vibration rubber tractor tire stiffness damping coefficient cleat test point contact model

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Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

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Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin Kwon Wei Li young Soo Kim Buyun Kim Hwan-Suck chung younghoon Go Hyun-Jeong Ko Jae-Hyoung Song young Ho Kim Chun Whan Choi Jang-Gi Choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD

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Clinical implication of FDG uptake of bone marrow on PET/CT in gastric cancer patients with surgical resection

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World Journal of Gastroenterology 2017年第13期23卷 2385-2395页

作者： Jeong Won Lee Moon-Soo Lee Il Kwon chung Myoung Won Son young Sin Cho Sang Mi Lee Department of Nuclear Medicine Institute of Integrative MedicineCatholic Kwandong University College of MedicineInternational St.Mary's Hospital Department of Surgery Soonchunhyang University Hospital Division of Gastroenterology Department of Internal MedicineSoonchunhyang University Hospital Department of Nuclear Medicine Soonchunhyang University Hospital

AIM To determine the relationship between F-18 fluorodeoxyglucose(FDG) uptake of bone marrow(BM) on positron emission tomography/computed tomography(PET/CT) and clinical factors and to assess the prognostic value of FDG uptake of BM in gastric *** We retrospectively enrolled 309 gastric cancer patients who underwent staging FDG PET/CT and curative surgical resection. FDG uptake of primary tumor was visually classified as positive or negative FDG uptake. Mean FDG uptake of BM(BM SUV) and BM-to-liver uptake ratio(BLR) were measured. The relationships of BM SUV or BLR with clinical factors were evaluated. The prognostic values of BM SUV, BLR, and other clinical factors for predicting recurrence-free survival(RFS) and overall survival(OS) were *** Of 309 patients, 38 patients(12.3%) experienced cancer recurrence and 18 patients(5.8%) died. Patients with advanced gastric cancer, positive FDG uptake, and recurrence had higher values of BM SUV and BLR than those with early gastric cancer, negative FDG uptake, and no recurrence(P < 0.05). BM SUV and BLR were significantly correlated with hemoglobin level, neutrophil-to-lymphocyte ratio, and platelet-tolymphocyte ratio(P < 0.05). On multivariate analysis, multiple tumors, T stage, lymph node metastasis, tumor involvement of resection margin, and BLR were significantly associated with RFS(P < 0.05). T stage, lymph node metastasis, hemoglobin level, and BLR were significantly associated with OS(P < 0.05). CONCLUSION BLR on PET/CT was an independent prognostic factor for RFS and OS in gastric cancer patients with curative surgical resection.

关键词： F-18 fluorodeoxyglucose Positron emission tomography Prognosis Bone marrow Gastric cancer

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A perturbation-incremental scheme for studying Hopf bifurcation in delayed differential systems

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Science China(Technological Sciences) 2009年第3期52卷 698-708页

作者： chung Kwok Wai Department of Mathematics City University of Hong Kong Kowloon

A new method, called perturbation-incremental scheme (PIS), is presented to investigate the periodic solution derived from Hopf bifurcation due to time delay in a system of first-order delayed differential equations. The method is summarized as three steps, namely linear analysis at critical value, perturba- tion and increment for continuation. The PIS can bypass and avoid the tedious calculation of the center manifold reduction (CMR) and normal form. Meanwhile, the PIS not only inherits the advantages of the method of multiple scales (MMS) but also overcomes the disadvantages of the incremental harmonic balance (IHB) method. Three delayed systems are used as illustrative examples to demonstrate the validity of the present method. The periodic solution derived from the delay-induced Hopf bifurcation is obtained in a closed form by the PIS procedure. The validity of the results is shown by their consis- tency with the numerical simulation. Furthermore, an approximate solution can be calculated in any required accuracy.

关键词： delayed differential equation perturbation-incremental scheme Hopf bifurcation synchronization center manifold

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Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy

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Bioactive Materials 2022年第12期7卷 433-445页

作者： Hyo-Jin Yoon Songhyun Lee Tae young Kim Seung Eun Yu Hye-Seon Kim young Shin chung Seyong chung Suji Park Yong Cheol Shin Eun Kyung Wang Jihye Noh Hyun Jung Kim Cheol Ryong Ku Hong Koh Chang-Soo Kim Joon-Sang Park young Min Shin Hak-Joon Sung Department of Medical Engineering Yonsei University College of MedicineSeoul03722Republic of Korea School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Obstetrics and Gynecology Institution of Women’s Life Medical ScienceSeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Biomedical Engineering The University of Texas at AustinAustinTX78712USA Department of Internal Medicine EndocrinologyInstitute of Endocrine ResearchYonsei University College of MedicineSeoul03722Republic of Korea Department of Pediatrics GastroenterologySeverance HospitalYonsei University College of MedicineSeoul03722Republic of Korea Department of Computer Engineering Hongik UniversitySeoul04066Republic of Korea Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan31116Republic of Korea Numais Co. Ltd.Korea Seoul 04799Republic of Korea

All-in-one treatments represent a paradigm shift in future *** example,inflammatory bowel disease(IBD)is mainly diagnosed by endoscopy,which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable ***,molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free *** study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable *** properties enabled spraying of the hydrogel onto the intestinal walls during ***,peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adhesive gelation with subsequent moisturization of inflammatory lesions,specifically by *** peptide was designed to mimic the major component that mediates intestinal interaction with Bacillus subtilis flagellin during IBD ***,the peptide-guided efficient adhesion of the hydrogel nanomicelles onto Toll-like receptor 5(TLR5)as the main target of flagellin binding and *** peptide binding potently suppressed inflammatory signaling without drug loading,where TLR5 and Notch-1 operated collaboratively through downstream actions of tumor necrosis *** results were produced using a human colorectal cell line,clinical IBD patient cells,gut-on-a-chip,a mouse IBD model,and pig experiments to validate the translational utility.

关键词： Nanomicelle Injectable hydrogel Peptide display Theranostic All-in-one treatment Inflammatory bowel disease

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Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus

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World Journal of Gastroenterology 2013年第41期19卷 7089-7096页

作者： Nam Seok Ham Jae young Jang Sung Woo Ryu Ji Hye Kim eui Ju Park Woong Cheul Lee Kwang Yeun Shim Soung Won Jeong Hyun Gun Kim Tae Hee Lee Sung Ran Jeon Jun Hyung Cho Joo young Cho So young Jin Ji Sung Lee Institution for Digestive Research Digestive Disease CenterDepartment of Internal MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Pathology Soonchunhyang University HospitalSeoul 140-743South Korea Biostatistical Consulting Unit Soonchunhyang University HospitalSeoul 140-743South Korea

AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×*** magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s ***,a 0.5%solution of methylene blue(MB)was sprayed over columnar *** patterns of the magnified image and MB staining were *** were obtained from the regions previously observed by magnifying endoscopy and MB ***:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.

关键词： Short-segment Barrett’s esophagus Magnifying endoscopy Methylene blue chromoendoscopy Specialized intestinal metaplasia Dysplasia Esophageal adenocarcinoma Diagnosis

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Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection

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World Journal of Gastroenterology 2014年第21期20卷 6547-6553页

作者： Woo Chul chung Sung Hoon Jung Jung Hwan Oh Tae Ho Kim Dae young Cheung Byung Wook Kim Sung Soo Kim Jin Il Kim Eun young Sin Department of Internal Medicine the Catholic University of KoreaSeoul 130-709South Korea The Research Institute of St. Vincent Hospital the Catholic University of KoreaSuwon 442-723South Korea

AIM: To investigate whether tissue samples processed by the rapid urease test (RUT) kit are suitable for dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) to detect Helicobacter pylori (... 详细信息

关键词： Helicobacter pylori Diagnosis Dual-priming oligonucleotide-based multiplex polymerase chain reaction

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Risk factors for tuberculosis after gastrectomy in gastric cancer

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World Journal of Gastroenterology 2016年第8期22卷 2585-2591页

作者： Won Jai Jung young Mok Park Joo Han Song Kyung Soo chung Song Yee Kim Eun young Kim Ji Ye Jung Moo Suk Park young Sam Kim Se Kyu Kim Joon Chang Sung Hoon Noh Ji Yeong An young Ae Kang Division of Respiratory and Critical Care Medicine Department of Internal Medicine Korea University College of Medicine Division of Pulmonology Department of Internal Medicine Severance Hospital Institute of Chest Diseases Yonsei University College of Medicine Department of Surgery Yonsei University College of Medicine

AIM: To examine incidence of tuberculosis(TB) in gastrectomy patients and investigate the risk factors for developing TB after gastrectomy in patients with gastric ***: A retrospective cohort study of gastrectomy patients with gastric cancer was performed at a university-affiliated hospital in Seoul, South Korea between January 2007 and December 2009. We reviewed patient medical records and collected data associated with the risk of TB, surgery, and gastric cancer. Standardized incidence ratios(SIRs) of TB were calculated to compare the incidence of TB in gastrectomy patients with that in the general Korean population, and risk factors for TB after gastrectomies were ***: Among the 1776 gastrectomy patients, 0.9%(16/1776) developed post-gastrectomy TB, with an incidence of 223.7 cases per 100000 patients per year. The overall incidence of TB in gastrectomy patients, adjusted by sex and age, was significantly higher thanthat in the general population(SIR = 2.22, 95%CI: 1.27-3.60). Previous TB infection [odds ratio(OR) = 7.1, P < 0.001], lower body mass index(BMI)(kg/m2; OR = 1.21, P = 0.043) and gastrectomy extent(total gastrectomy vs subtotal gastrectomy)(OR = 3.48, P = 0.017) were significant risk factors for TB after gastrectomy in a multivariate ***: TB incidence after gastrectomy is higher than that in the general population. Previous TB infection, lower BMI, and total gastrectomy are risk factors for TB after gastrectomy in patients with gastric cancer.

关键词： Tuberculosis Gastrectomy Body mass index Risk factor Gastric cancer

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Central retinal artery occlusion in eosinophilic granulomatosis with polyangiitis(Churg-Strauss Syndrome):the first case report in South Korea

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International Journal of Ophthalmology(English edition) 2021年第6期14卷 948-951页

作者： Jungyul Park Up Huh Hee-young Choi Seunggeun Lee Miyeun Han Sungwoon chung Hyerim Kim Department of Ophthalmology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Thoracic and Cardiovascular Surgery Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Rheumatology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Nephrology Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea Department of Laboratory Medicine Pusan National University School of MedicineBiomedical Research InstitutePusan National University HospitalBusan 49241Republic of Korea

Dear Editor,I am *** Park from the Department of Ophthalmology,Pusan National University Hospital,Busan,Korea.I am writing to present a case of eosinophilic granulomatosis with polyangiitis(EGPA)with central retinal artery occlusion(CRAO).It provides important information about the relationship between ANCA and CRAO in a patient who was diagnosed with EGPA who had ophthalmic *** believe that our study makes a significant contribution to the literature because to our knowledge,the literature of EGPA with CRAO are rare worldwide and this is even the first case of EGPA with CRAO in Republic of Korea.

关键词： granuloma occlusion eosinophilic

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