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Antiphospholipid syndrome with renal and splenic infarction after blunt trauma:A case report

World Journal of Clinical Cases 2022年第26期10卷 9404-9410页

作者： Na-A Lee eui-sung jeong Hyun-Seok Jang Yun-Chul Park Ji-Hyoun Kang Jung-Chul Kim Young-Goun Jo Division of Trauma Department of SurgeryChonnam National University Medical School and HospitalGwangju 61469South Korea Division of Rheumatology Department of Internal MedicineChonnam National University Medical School and HospitalGwangju 61469South Korea

BACKGROUND In trauma patients,bleeding is an immediate major *** the same time,there are few cases of acute vascular occlusion after blunt trauma,and it is unclear what assessment and diagnosis should be considered for these ***,we describe a patient diagnosed with antiphospholipid syndrome after a hypercoagulable workup for acute renal and splenic vascular occlusion due to blunt *** SUMMARY A 20-year-old man was admitted to the emergency department with abdominal pain after hitting a tree while riding a sled 10 h *** had no medical *** investigations revealed occlusion of the left renal artery with global infarction of the left kidney and occlusion of branches of the splenic artery with infarction of the central portion of the *** revascularization of the left renal artery occlusion through percutaneous transluminal angioplasty failed due to difficulty in passing the wire through the total *** the presence of acute multivascular occlusions in a young man with low cardiovascular risk,additional laboratory tests were performed to evaluate *** results suggested a high possibility of antiphospholipid *** with a subcutaneous injection of enoxaparin was started and changed to oral warfarin after two *** diagnosis was confirmed,and he continued to visit the rheumatology outpatient clinic while taking *** A hypercoagulable workup can be considered in trauma patients with acute multivascular occlusion,especially in young patients with low cardiovascular risk.

关键词： Wounds and injuries Wounds Nonpenetrating Antiphospholipid syndrome Renal artery obstruction Splenic infarction Case reports

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun jeong Lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok Hwang Hyo-jeong Jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

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A novel electrospinning method for self-assembled tree-like fibrous scaffolds:Microenvironment-associated regulation of MSC behavior and bone regeneration

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Journal of Materials Science & Technology 2022年第20期115卷 52-70页

作者： jeong In Kim Ju Yeon Kim sung-Ho Kook jeong-Chae Lee Cluster for Craniofacial Development and Regeneration Research Institute of Oral Biosciences and School of DentistryJeonbuk National UniversityJeonju 54896Republic of Korea Department of Bionanosystem Engineering Jeonbuk National UniversityJeonju 54896Republic of Korea Department of Bioactive Material Sciences Research Center of Bioactive MaterialsJeonbuk National UniversityJeonju 54896Republic of Korea

Numerous studies highlight advantages of electrospun scaffolds in bone tissue engineering,in which cellular behavior is tightly affected by fiber topographical cues of ***,the classic electrospinning setup limits a desired presentation of biomimetic fibrous microenvironments that sense mechanosignaling and regulate stem cell *** aims of this study were to fabricate advanced asspun scaffolds presenting tree-like microfiber/nanonet networks and to evaluate their regulatory potentials on behavior of human mesenchymal stem cells(h MSCs)and bone *** we developed a novel electrospinning setup that allowed the presentation of patterned Trunk microfibers(TMF)and/or branched nanonet fibers(BNn Fs)in biomimetic fibrous *** the cellular mechanisms,anisotropichierarchical topography of TMF controlled behavior of h MSCs through focal adhesion formation and Yesassociated protein(YAP)induction,whereas BNn F disturbed such mechanosensing responses in the *** fiber microenvironment-related expression and nuclear localization of YAP *** correlated with the potentials of as-spun scaffolds to enhance osteogenic differentiation of the h MSCs and alveolar bone defect healing in an animal ***,this study provides an advanced approach of the modified electrospinning setup for presentation of biomimetic fibrillar microenvironments in as-spun scaffolds along with their application in stem cell behavior regulation and regenerative tissue engineering.

关键词： Electrospinning Advanced biomimetic scaffolds Stem cell behavior Mechanosensing Bone tissue engineering

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Bioinspired magnetic cilia:from materials to applications

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Microsystems & Nanoengineering 2023年第6期9卷 107-128页

作者： Seongjin Park Geonjun Choi Minsu Kang Woochan Kim Jangho Kim Hoon eui jeong Department of Mechanical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea Department of Convergence Biosystems Engineering Chonnam National UniversityGwangju61186Republic of Korea Interdisciplinary Program in IT-Bio Convergence System Chonnam National UniversityGwangju61186Republic of Korea

Microscale and nanoscale cilia are ubiquitous in natural systems where they serve diverse biological *** artificial magnetic cilia have emerged as a highly promising technology with vast potential applications,ranging from soft robotics to highly precise *** this review,we comprehensively discuss the roles of cilia in nature and the various types of magnetic particles utilized in magnetic cilia;additionally,we explore the top-down and bottom-up fabrication techniques employed for their ***,we examine the various applications of magnetic cilia,including their use in soft robotics,droplet and particle control systems,fluidics,optical devices,and ***,we present our conclusions and the future outlook for magnetic cilia research and development,including the challenges that need to be overcome and the potential for further integration with emerging technologies.

关键词： magnetic overcome precise

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SARS-CoV-2 mutations, vaccines, and immunity: implication of variants of concern

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1638-1639页

作者： Ji Yun Noh Hye Won jeong eui-Cheol Shin Division of Infectious Diseases Department of Internal MedicineKorea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Division of Infectious Diseases Department of Internal MedicineChungbuk National University College of MedicineCheongjuRepublic of Korea The Center for Epidemic Preparedness KAISTDaejeonRepublic of Korea

In a recent study published in Nature,Wang et al.1 investigated the neutralizing activities of antibodies elicited by COVID-19 mRNA vaccines and natural infection with SARS-CoV-2 against SARS-CoV-2 *** devastating impact of the ongoing COVID-19 pandemic on public health,the economy,and society has made vaccine development a top priority for global ***,vaccine development is progressing at an unprecedented pace as an urgent response to COVID-19.

关键词： immunity vaccines variants

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Comparison of wrist motion classification methods using surface electromyogram

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Journal of Central South University 2013年第4期20卷 960-968页

作者： jeong eui-chul KIM Seo-jun SONG Young-rok LEE Sang-min Department of Electronic Engineering Inha University

The Gaussian mixture model (GMM), k-nearest neighbor (k-NN), quadratic discriminant analysis (QDA), and linear discriminant analysis (LDA) were compared to classify wrist motions using surface electromyogram (EMG). Effect of feature selection in EMG signal processing was also verified by comparing classification accuracy of each feature, and the enhancement of classification accuracy by normalization was confirmed. EMG signals were acquired from two electrodes placed on the forearm of twenty eight healthy subjects and used for recognition of wrist motion. Features were extracted from the obtained EMG signals in the time domain and were applied to classification methods. The difference absolute mean value (DAMV), difference absolute standard deviation value (DASDV), mean absolute value (MAV), root mean square (RMS) were used for composing 16 double features which were combined of two channels. In the classification methods, the highest accuracy of classification showed in the GMM. The most effective combination of classification method and double feature was (MAV, DAMV) of GMM and its classification accuracy was 96.85%. The results of normalization were better than those of non-normalization in GMM, k-NN, and LDA.

关键词： Gaussian mixture model k-nearest neighbor quadratic discriminant analysis linear discriminant analysis electromyogram (EMG) pattern classification feature extraction

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Unusual neural tract between injured fornix and pedunculopontine nucleus in a patient with traumatic brain injury

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Neural Regeneration Research 2017年第9期12卷 1559-1560页

作者： sung Ho Jang jeong Pyo Seo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

It has been known that four cholinergic nuclei are located in the septal region and basal forebrain （Ch 1： medial septal nucleus, Ch 2： vertical nucleus of the diagonal band, Ch 3： horizontal limb of the diagonal band and Ch 4： nucleus basalis of Meynert） and two are located in the brainstem （Ch 5： pedunculopontine nucleus and Ch 6： laterodorsal tegmental nucleus）（Selden et al., 1998; Lucas-Meunier et al., 2003; Mesulam, 2004; Nieuwenhuys et al., 2007）. The fornix transfers information on episodic mem- ory between the medial diencephalon and the medial temporal lobe （Afifi and Bergman, 2005; Wolk and Budson, 2010）. The fornix is known to obtain cholinergic innervation from Ch 1 and Ch 2, and to project to the hippocampal formation （Selden et al., 1998; Lucas-Meunier et al., 2003; Mesulam, 2004; Nieu- wenhuys et al., 2007; Dere et al., 2008; Naidich and Duvernoy, 2009; Isaacson and Pribram, 2013）.

关键词： TBI Unusual neural tract between injured fornix and pedunculopontine nucleus in a patient with traumatic brain injury

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Coronary sinus endocarditis in a hemodialysis patient:A case report and review of literature

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World Journal of Clinical Cases 2021年第17期9卷 4348-4356页

作者： Hui-jeong Hwang sung-Wook Kang Department of Cardiology Kyung Hee University Hospital at GangdongKyung Hee University College of MedicineSeoul 05278South Korea Department of Pulmonary Allergy and Critical Care MedicineKyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND Infective endocarditis is more common in hemodialysis patients than in the general population and is sometimes difficult to *** coronary sinus(CS)vegetation is extremely rare and has a good prognosis,but complicated CS vegetation may have a poorer clinical *** report a case of CS vegetation accidentally found via echocardiography in a hemodialysis patient with undifferentiated *** CS vegetation may have been caused by endocardial denudation due to tricuspid regurgitant jet and subsequent *** SUMMARY A 91-year-old man with dyspnea and hypotension was transferred from a nursing *** was on regular hemodialysis and had a history of severe grade of tricuspid *** was no leukocytosis or fever upon *** and sequential blood cultures revealed absence of microorganism *** computed tomography showed lung consolidation and a large pleural effusion.A mobile band-like mass on the CS,suggestive of vegetation,was observed on *** diagnosed him with infective endocarditis involving the CS,pneumonia,and septic shock based on echocardiographic,radiographic,and clinical *** of broad-spectrum antibiotics,fluid resuscitation,inotropic support,and ventilator care were ***,the patient died from uncontrolled infection and septic *** CS vegetation can be fatal in hemodialysis patients with impaired immune systems,especially when it delays the diagnosis.

关键词： Coronary sinus Endocarditis Renal dialysis Echocardiography Diagnosis,differential Case report

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Progress in light-to-frequency conversion circuits based on low dimensional semiconductors

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Nano Research 2021年第9期14卷 2938-2964页

作者： Seung Gi Seo Seung Yeob Kim Jinheon jeong sung Hun Jin Department of Electronic Engineering Incheon National UniversityAcademy-ro 119Yeongsu-guIncheon 22012Republic of Korea

As the scaling down of Si devices in the range less than few nm has been expedited up to a physical limit of Si,low dimensional materials have been regarded as one of next generation *** a variety of applications,studies on photodetectors have been actively investigated with their novel optical properties as well as astonishing electrical ***,most of research has focused on single device-type photodetector(i.e.,photo-diode or photo-transistor).Contrary to common photodetector,light-to-frequency circuits(LFCs)are based on frequency reading with photosensitive ring oscillators,which has better noise immunity and reduced system complexity,thus,can be utilized to novel application even in internet of things(loT)and bio&medical *** this review,low dimensional materials based circuit level photodetectors,which are core elements as the form of either inverters or ring oscillators for demonstration of LFCs,are *** with the introduction of low dimensional materials and their optical properties for optoelectronics,a fundamental concept for LFCs is specifically ***,research progress on low dimensional material based photosensitive inverters is addressed according to the types of ***,as one of practical method for the improvement of photodetector performance,molecular doping technology is ***,complete system of LFCs and its digitization for demonstration of production level,and potential application in the respective four aspects,(i)medical SpO_(2) detection,(ii)biological fluidic system,(iii)auto-lighting in agriculture,and(iv)optical feedback and sensing systems,are presented as systematic way to address the envisioned practical applications for the future displays including virtual reality and augmented reality,and *** a remark,LFCs based on low dimensional semiconductors are expected to be one of core components in trillion’s sensor area.

关键词： photodetector light-to-frequency conversion circuit transition metal dichalcogenide carbon nanotube

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