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地下水人工回灌气相堵塞特征的试验研究

水科学进展 2017年第5期28卷 756-762页

作者：束龙仓张永杰许杨吴佩鹏 Abunu Atlabachew esther Chifuniro Mabedi 河海大学水文水资源学院江苏南京210098 河海大学水文水资源与水利工程科学国家重点实验室江苏南京210098

地下水人工回灌可以高效地利用雨季丰沛的水量来缓解地下水过量开采造成的海水入侵、泉水断流等环境水文地质问题,但回灌堵塞一直是制约人工回灌效率的关键问题。针对雨洪水回灌携带的大量气泡问题,设计室内砂柱试验模拟装置,利用曝气... 详细信息

地下水人工回灌可以高效地利用雨季丰沛的水量来缓解地下水过量开采造成的海水入侵、泉水断流等环境水文地质问题,但回灌堵塞一直是制约人工回灌效率的关键问题。针对雨洪水回灌携带的大量气泡问题,设计室内砂柱试验模拟装置,利用曝气水进行人工回灌,定时记录试验过程中测压管读数及出流流量,利用达西定律计算各层渗透系数,研究气相堵塞的发展过程和规律。结果表明:回灌过程中由于气相堵塞导致含水层渗透系数随时间呈指数衰减,气相堵塞主要发生在介质浅表层(0~30 cm),且随时间有向下发展的趋势,堵塞速率随深度的增加逐渐减小,在回灌过程中适时停灌进行排气有利于减小气相堵塞对回灌效率的影响。

关键词：地下水人工回灌气相堵塞达西定律砂柱试验

Anthracycline-induced cardiotoxicity:A case report and review of literature

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World Journal of Cardiology 2021年第1期13卷 28-37页

作者： esther G Chong Eric H Lee Reena Sail Laura Denham Gayathri Nagaraj Chung-Tsen Hsueh Department of Medicine Loma Linda UniversityLoma LindaCA 92350United States Department of Hematology/Oncology Compassionate Cancer Care Medical GroupFountain ValleyCA 92708United States Department of Hematology/Oncology Scripps MD Anderson Cancer CenterSan DiegoCA 92121United States Department of Pathology and Human Anatomy Loma Linda UniversityLoma LindaCA 92350United States Division of Medical Oncology and Hematology Department of MedicineLoma Linda UniversityLoma LindaCA 92350United States

BACKGROUND Doxorubicin and other anthracycline derivatives inhibit topoisomerase II and is an important class of cytotoxic chemotherapy in cancer *** use of anthracycline is limited by dose-dependent cardiotoxicity,which may manifest initially as asymptomatic cardiac dysfunction with subsequent progression to congestive heart *** baseline assessment and periodic monitoring of cardiac function for patients receiving anthracycline agents,there are unmet needs in prediction and prevention of anthracycline-induced cardiotoxicity(AIC).CASE SUMMARY A 35-year-old African American female was found to have a 9-cm high-grade osteosarcoma of right femur and normal baseline cardiac function with left ventricular ejection fraction of approximately 60%-70%determined by transthoracic and dobutamine stress *** underwent perioperative doxorubicin and cisplatin chemotherapy with 3 cycles before surgery and 3 cycles after surgery,and received a total of 450 mg/m2 doxorubicin at the end of her treatment *** was evaluated regularly during chemotherapy without any cardiac or respiratory *** two months after her last chemotherapy,the patient presented to the emergency department with dyspnea for one week and was intubated for acute hypoxic respiratory *** showed an ejection fraction of 5%-10%with severe biventricular *** attempts to optimize cardiac function,the patient’s hemodynamic status continued to decline,and resuscitation was not successful on the seventh day of *** autopsy showed no evidence of osteosarcoma,and the likely cause of death was cardiac failure with the evidence of pulmonary congestion,liver congestion,and multiple body cavity *** We present a case of 35-year-old African American female developing cardiogenic shock shortly after receiving a cumulative dose of 450 mg/m2 doxorubicin over 9 *** monitoring and management of patients receivin

关键词： Anthracycline Cardiotoxicity Doxorubicin Troponin Brain natriuretic peptide Case report

Knowledge and awareness of glaucoma in Mexican patients with and without glaucoma diagnosis in an Ophthalmology Referral Center

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 990-996页

作者： Valeria Becerril-Ledezma Daniela Alvarez-Ascencio Clarisa esther del Hierro-Gutiérrez Alejandra Hernandez-Oteyza Jesús Jiménez-Román Association to Prevent Blindness in Mexico Private Assistance Institution(APEC)Mexico City 04030Mexico

AIM: To assess and compare knowledge and awareness of glaucoma in subjects with and without glaucoma diagnosis attending an Ophthalmology Referral ***: This cross-sectional study was conducted at Asociación Para Evitar la Ceguera in Mexico City, using a questionnaire formulated by a group of experts following the Delphi panel rules, and pre-tested in a pilot *** questionnaire was applied and compared between:glaucoma patients, relatives of glaucoma patients and patients without glaucoma. Socio-demographic data was collected to assess correlation with the level of knowledge using Logistic regression models, estimating the odds ratios(OR), 95% confidence intervals, and P<***: Three hundred and ninety-four subjects were enrolled;with a median age of 61y. One hundred and thirty-four(34%) were patients with glaucoma, 152(38.6%)patients without glaucoma, and 108(27.4%) relatives of patients with glaucoma. Two hundred and ninety-one(73.9%) participants were aware of the term “glaucoma”.Regarding knowledge 46.7% had moderate knowledge,37.8% had poor knowledge, and 15.5% good ***, relatives of glaucoma patients had the highest scores, and patients without glaucoma got the lowest scores. A positive correlation was found between better knowledge and frequent ophthalmological examinations OR 2.24(P=0.02), higher education level OR 4.17(P=0.00) and having a family member with glaucoma OR 3.28(P=0.00).CONCLUSION: Awareness and knowledge of glaucoma in subjects attending an Ophthalmology Referral Center is predominantly moderate or poor. This has important implications regarding attitudes that can result in lack of follow up in ophthalmological care.

关键词： glaucoma awareness knowledge vision loss treatment

A novel technique for unilateral dissection of the penile neurovascular bundle to prevent loss of penile sensation during treatment of Peyronie's disease-Initial results of a pilot study

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Current Urology 2023年第4期17卷 299-302页

作者： Alexandr M.Pinkhasov Matthew Beamer Daniel Shulman Rachel Yakubov esther Pinkhasov Sergey Kravchick Department of Urology SUNY Upstate Medical University HospitalSyracuseNY 13202USA

Background:Plaque incision/excision and grafting are surgical techniques used to treat patients with Peyronie's disease who are refractory to less invasive interventions,have severe penile curvature,or have an hourglass ***,the procedure carries the risk of penile sensory loss because of the need for dissection of the neurovascular bundle(NVB).The aim of this study was to assess the feasibility of a novel technique for unilateral NVB dissection and its ability to preserve penile sensitivity while maintaining adequate correction of the penile *** and methods:Charts of patients who underwent unilateral NVB dissection during Peyronie's plaque incision/excision and grafting were retrospectively *** patients received preprocedural intracavernosal injections of TriMix,and the curvature was measured to be>70 *** 3 cases,an incision and minimal excision of the plaque were performed at the point of maximum curvature on the concave side of the *** 3 cases,Tutoplast allografts(Coloplast US,Minneapolis,MN)were used,whereas autografts were used in 2 other *** patients were examined at 1,3,and 6 months after the procedure when curvature and penile sensation were ***:Five patients underwent this *** mean age of patients was 55 years(45-70 years).All plaques were dorsally *** mean preoperative curvature was 78 degrees(75-90 degrees).At the 6-month follow-up,all patients had<15 degrees residual curvature and were satisfied with their cosmetic *** 1 patient continued with phosphodiesterase-5 inhibitors to improve potency at the 6-month *** patients reported normal penile glans *** patients experienced decreased sensation at the site of NVB dissection,but this was only detected when compared with the contralateral *** 2 patients reported a difference after 6 months,and only a minor area of involvement was ***:Unilateral NVB dissection is a feasi

关键词： Peyronie's disease Neurovascular bundle dissection

The effect of selected hemp seed protein hydrolysates in modulating vascular function

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Food Bioscience 2022年第1期45卷 249-256页

作者： Raiyan Mahbub esther Callcott Shiwangni Rao Omid Ansari Daniel L.E.Waters Christopher L.Blanchard Abishek B.Santhakumar Graham Centre for Agricultural Innovation Charles Sturt UniversityWagga WaggaNew South Wales2650Australia School of Dentistry and Medical Sciences Faculty of Science and HealthCharles Sturt UniversityWagga Wagga2650New South WalesAustralia School of Animal and Veterinary Sciences Faculty of ScienceCharles Sturt UniversityWagga Wagga2650New South WalesAustralia Agriculture Victoria Research HorshamVictoria3400Australia Ecofibre Limited VirginiaQueensland4014Australia Ananda Food New South Wales2322Australia Ananda Hemp Ltd CynthianaKYUSA

Reduced bioavailability of nitric oxide along with an increase in inflammatory cytokines,reactive oxygen species,cell adhesion molecules,and platelet hyperactivity are underlying causes of endothelial *** peptides derived from various plants have been shown to attenuate biomarkers of endothelial *** objective of this study was to determine the effects of hemp seed protein hydrolysates(HSPH)in modulating biomarkers of endothelial dysfunction using an in vitro cell culture model and an ex vivo platelet activity *** cells were treated with HSPH from commercial variant X and ECO-commercial variant Y,followed by hydrogen peroxide to simulate oxidative stress and *** of endothelial dysfunction were then measured to determine the protective properties of *** samples collected from healthy volunteers were used to determine the effect of the HSPH on ADP and hydrogen peroxide-induced platelet activity,using flow *** HSPH reduced the production of reactive oxygen species,inflammatory cytokines IL-8,IL-12p70 and IL-1β,and adhesion molecule vascular cell adhesion molecule ***,treatment with HSPH also reduced platelet activation marker CD62P ex *** results obtained from this study suggest HSPH alleviates biomarkers of endothelial dysfunction by reducing oxidative stress,inflammation and platelet activation.

关键词： Hemp seed Protein hydrolysates Endothelial dysfunction Platelet activity Inflammation Antioxidant properties

Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid

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Journal of Integrative Plant Biology 2010年第2期52卷 244-251页

作者： María Josefa López Núez-Flores Jorge Gutirrez Laura V.Gómez-Ros esther Novo Uzal Mariana Sottomayor Alfonso Ros Barceló Department of Plant Biology University of MurciaE-30100MurciaSpain Department of Plant Biology University of La CoruaE-15071La CorunaSpain IBMC University of Porto4150 PortoPortugal

Hypocotyl formation during the epigeal germination of seedlings is under strict hormonal regulation. In a 3 d old Zinnia elegans seedling system, gibberellic acid （GA3） exerts an opposite effect to that exerted by light on hypocotyl photomorphogenesis because GAz promotes an etiolated-like growth with an inhibition of radial （secondary） growth. For this reason, the effect of GA3 on the basic peroxidase isoenzyme from Z. elegans （ZePrx）, an enzyme involved in hypocotyl lignin biosynthesis, was studied. The results showed that GA3 reduces ZePrx activity, similarly to the way in which it reduces seedling secondary growth. This hormonal response is supported by the analysis of the ZePrx promoter, which contains four types of GA3-responsive ***： the W Box/O2S; the Pyr Box; the GARE; and the Amy Box. Taken together, these results suggest that ZePrx is directly regulated by GA3, with this effect matching the inhibitory effect of GA on the hypocotyl secondary growth.

关键词： GA Downregulation of the Basic Peroxidase Isoenzyme from Zinnia elegans by Gibberellic Acid cis Figure

Field-effect passivation on silicon nanowire solar cells

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Nano Research 2015年第2期8卷 673-681页

作者： Anna Dalmau Mallorqui esther Alarcon-Llado Ignasi Canales Mundet Amirreza Kiani Benedicte Demaurex Stefaan De Wolf Andreas Menzel Margrit Zacharias Anna Fontcuberta i Morra Laboratoire des Materiaux Semiconducteurs Ecole Polytechnique Federale de Lausanne 1015 Lausanne Switzerland Photovoltaics and Thin Film Electronics Laboratory Institute o fMicroengineering (IMT) E-cole Polytechnique Federale de Lausanne 2000 Neuchotel Switzerland Nanotechnology Institute of Microsystems Engineering(IMTEK) Albert-Ludwigs-University 79110 Freiburg Germany

Surface recombination represents a handicap for high-efficiency solar cells. This is especially important for nanowire array solar cells, where the surface-to-volume ratio is greatly enhanced. Here, the effect of different passivation materials on the effective recombination and on the device performance is experimentally analyzed. Our solar cells are large area top-down axial n-p junction silicon nanowires fabricated by means of Near-Field Phase-Shift Lithography （NF-PSL）. We report an efficiency of 9.9% for the best cell, passivated with a SiO2/SiNx stack. The impact of the presence of a surface fixed charge density at the silicon/oxide interface is studied.

关键词： field-effect passivation nanowire surface recombination solar cell

Farmers＇ Perception of Soil Erosion Control Measures： Implications for Sustainable Development in Agriculture and Environment in South East, Nigeria

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Journal of Life Sciences 2016年第3期10卷 161-169页

作者： Simeon Okpoto Eze esther Etenmugonwa Osahon DepartmentofRuralSociologyandExtension MichaelOkparaUniversityofAgricultureUmudikeUmuahiaPMB7267AbiaStateNigeria

The study investigated farmers＇ perception of soil erosion control measures and highlighted implications for sustainable development in agriculture and environment in southeast, Nigeria. Purposive, multistage and random sampling techniques were employed in selecting a sample size of two hundred and forty （240） respondents. Structured interview schedule was used for data collection, while percentages, mean ratings and factor analysis techniques were employed for analysis. The findings show that majority （64.6%） of farmers were within the ages of 40-59, while majority （67.9%） had either FSLC or WASCE/SSCE/GCE/OL qualifications. The farmers reported that the major soil erosion control measures used were strip cropping （M = 4.8） and making of ridges against slopes （M = 4.7）. The study reported that poor group affinity, inadequate institutional support and inadequate technical knowhow were constraints to soil erosion control in southeast, Nigeria. The study highlighted implications for sustainable development in agriculture and environment on organizational overhaul in extension, participatory extension policy on farmers groups and institutional re-orientation and synergy between Universities, Agricultural Development Programme （ADP）, Ministry of Agriculture （MOA） and Local Government Councils. In conclusion, success in soil erosion control and sustainable development in agriculture and environment in southeast, Nigeria depends on the extent issues raised and implications highlighted can be addressed. The study recommends improved funding support to extension, participatory extension training and contacts with farmers＇ groups and groups＇ resources management.

关键词： Farmers erosion control sustainable development Nigeria.

Overview of the CHILL-ICE 2021 Science Experiments and Research Campaign

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Space(Science & Technology) 2022年第1期2022卷 27-35页

作者： David J.K.Smith Charlotte R.Pouwels Marc Heemskerk Benedetta M.Cattani esther Konijnenberg Robert Heemskerk Sebasthian Ogalde ICEE Space Netherlands EuroMoonMars An Initiative of ILEWG(International Lunar Exploration Working GroupThe Netherlands)Netherlands Vrije Universiteit Amsterdam Netherlands Lunar Zebro Delft University of TechnologyNetherlands Heemskerk Innovative Technology Netherlands

The main objective of the CHILL-ICE(Construction of a Habitat Inside a Lunar-analogue Lava tube—Iceland;a campaign by ICEE Space and EuroMoonMars)prototype mission was to deploy an inflatable habitat and its systems inside a lunar analogue lava *** took place during an 8-hour extra vehicular activity(EVA)with three analogue astronauts as part of a threeday ***-ICE 2021 was carried out in July/August 2021 and consisted of two missions and was accomplished through successful collaboration of nonprofit research organizations,agencies,companies,and universities across 16 *** pilot campaign successfully reached its main objective:the testing of emergency equipment designed to help astronauts survive when first arriving to a new celestial body and to perform experiments similar to those that would be carried out *** article is a review of the scientific research experiments carried out during and after the mission:SpotNet,an artificial intelligence(AI)astronaut detection vision system;training for studies of the geological surroundings examined during EVAs;astronaut vigilance experiments carried out before,during,and after the mission;and Lunar Zebro,a legged rover intended to assist the crew in traversing and exploring harsh terrain.

关键词： ICE companies planet