Anthracycline-induced cardiotoxicity:A case report and review of literature
作者机构：Department of MedicineLoma Linda UniversityLoma LindaCA 92350United States Department of Hematology/OncologyCompassionate Cancer Care Medical GroupFountain ValleyCA 92708United States Department of Hematology/OncologyScripps MD Anderson Cancer CenterSan DiegoCA 92121United States Department of Pathology and Human AnatomyLoma Linda UniversityLoma LindaCA 92350United States Division of Medical Oncology and HematologyDepartment of MedicineLoma Linda UniversityLoma LindaCA 92350United States
出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第1期
页 面：28-37页
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
主 题：Anthracycline Cardiotoxicity Doxorubicin Troponin Brain natriuretic peptide Case report
摘 要：BACKGROUND Doxorubicin and other anthracycline derivatives inhibit topoisomerase II and is an important class of cytotoxic chemotherapy in cancer *** use of anthracycline is limited by dose-dependent cardiotoxicity,which may manifest initially as asymptomatic cardiac dysfunction with subsequent progression to congestive heart *** baseline assessment and periodic monitoring of cardiac function for patients receiving anthracycline agents,there are unmet needs in prediction and prevention of anthracycline-induced cardiotoxicity(AIC).CASE SUMMARY A 35-year-old African American female was found to have a 9-cm high-grade osteosarcoma of right femur and normal baseline cardiac function with left ventricular ejection fraction of approximately 60%-70%determined by transthoracic and dobutamine stress *** underwent perioperative doxorubicin and cisplatin chemotherapy with 3 cycles before surgery and 3 cycles after surgery,and received a total of 450 mg/m2 doxorubicin at the end of her treatment *** was evaluated regularly during chemotherapy without any cardiac or respiratory *** two months after her last chemotherapy,the patient presented to the emergency department with dyspnea for one week and was intubated for acute hypoxic respiratory *** showed an ejection fraction of 5%-10%with severe biventricular *** attempts to optimize cardiac function,the patient’s hemodynamic status continued to decline,and resuscitation was not successful on the seventh day of *** autopsy showed no evidence of osteosarcoma,and the likely cause of death was cardiac failure with the evidence of pulmonary congestion,liver congestion,and multiple body cavity *** We present a case of 35-year-old African American female developing cardiogenic shock shortly after receiving a cumulative dose of 450 mg/m2 doxorubicin over 9 *** monitoring and management of patients receivin
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