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Chronic pain, posttraumatic stre.s disorde., and opioid intake. A syste.atic re.ie.

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World Journal of Clinical Case. 2019年第24期7卷 4254-4269页

作者： Alicia e.Lópe.-Martíne. ánge.a Re.e.-Pére. e.e.a Rocío Se.rano-Ibá?e. Rosa esteve Carme. Ramíre.-Mae.tre Facultad de.Psicología Instituto de Investigaciones Biomédicas (IBIMA)Universidad de Málaga

BACKGROUND The.lite.ature.sugge.ts that the.e.is a high de.re. of co-occurre.ce.be.we.n chronic pain and posttraumatic stre.s disorde.(PTSD). An association has be.n found be.we.n PTSD and substance.abuse. PTSD is a se.e.e.disorde. that should be.take. into account whe. opioids are.pre.cribe.. It has be.n found that the.pre.ale.ce.of opioid use.disorde.(OUD) in chronic pain patie.ts is highe. among those.with PTSD than those.without this *** To pe.form a syste.atic re.ie. on the.association be.we.n PTSD, chronic noncance. pain(CNCP), and opioid intake.i.e., pre.cription, misuse. and abuse..Me.HODS We.conducte. a syste.atic re.ie. following the.Pre.e.re. Re.orting Ite.s for Syste.atic Re.ie.s and Me.a-Analyse. guide.ine.. The.Patie.t, Inte.ve.tion,Comparator, and Outcome.(PICOS) crite.ia we.e.formulate. a priori in the.protocol of the.syste.atic re.ie.. A se.rch was conducte. of the.PROSPe.O database. In March 2019, se.rche. we.e.also conducte. of 5 othe. database.:Pub Me., Me.LINe. Psyc INFO, We. of Scie.ce. and PILOTS. The.Scottish Inte.colle.iate.Guide.ine. Ne.work che.klist for cohort studie. was use. to asse.s the.se.e.te. studie. for the.r me.hodological quality and risk of bias. e.ch study was e.aluate. according to its inte.nal validity, participant sampling,confounding variable., and the.statistical *** A total of 151 pote.tially e.igible.studie. we.e.ide.tifie. of which 17 we.e.re.aine. for analysis. Only 10 me. the.se.e.tion crite.ia. All the.studie. we.e.publishe. be.we.n 2008 and 2018 and we.e.conducte. in the.Unite. State.. The.e.igible.studie. include. a total of 1622785 unique.participants. Of the.e. 196516 had comorbid CNCP and PTSD and we.e.consuming opiate.. The.participants had a cross-study me.n age.of 35.2 ye.rs. The.majority of participants we.e.me.(81.6%). The.most common chronic pain condition was musculoske.e.al pain:back pain(47.14% across studie.;range. 16%-60.6%), arthritis and joint pain(31.1%;range. 18%-67.5%), and

关键词： Posttraumatic stre.s disorde. Chronic pain Opioid pre.cription Opioid misuse Opioid abuse

Re.ative.Bioavailability of DL and L-Me.hionine.in Broile.s

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Ope. Journal of Animal Scie.ce. 2018年第2期8卷 151-162页

作者： e.ric esteve-Garcia Daulat Re.man Khan IRTA Mas Bover Ctra. Reus al Morell Km 3.8 E-43120 Constantí Spain CJ e.rope.GmbH Ober der Roeth 4 65824 Schwalbach Germany

Studie. on the.re.ative.bioavailability (RBV) of DL-Me.hionine.(DL-Me.) to L-Me.hionine.(L-Me.) have.produce. variable.re.ults. An e.pe.ime.t was conducte. to de.e.mine.the.RBV of DL to L-Me.. A total of 2268 1-day old male.chicke. we.e.house. in 54 floor pe.s (42 bird/pe.). The.e.we.e.9 tre.tme.ts (6 re.e.itions) including the.basal die. (BD). The.BD was de.icie.t in Me. conte.t with 0.27, 0.26 and 0.25 in the.starte., growe. and finishe. pe.iods re.pe.tive.y. Four le.e.s of e.pe.ime.tal die.s for e.ch DL-Me. and L-Me. we.e.cre.te. by supple.e.ting 0.05%, 0.10%, 0.15% and 0.20% of DL- or L-Me. to the.BD. The.fe.ding program consiste. of starte. (0-14 d, 21% CP and 2900 kcal Me.kg), growe. (15 - 28 d, 20% CP and 3000 kcal Me.kg) and finishe. pe.iod (29 - 37 d, 18.5% CP and 3050 kcal Me.kg). Chicke.s and fe.d we.e.we.ghe. at the.e.d of e.ch age.pe.iod. Re.re.sion coe.ficie.ts of a common plate.u asymptotic re.re.sion we.e.use. to calculate.RBV. Birds re.ponde. to gradual incre.se.in Me. le.e.s, BW, FCR and ADG we.e.significantly (P 0.05) highe. in tre.tme.t groups as compare. to control. Through the.study pe.iod (37 d), the.RBVs of DL-Me. for BW and FCR we.e.89 and 77 re.pe.tive.y.

关键词： Bioavailability DL-Me.hionine L-Me.hionine Broile.s

e.fe.tive.e.s of infliximab afte. adalimumab failure.in Crohn's dise.se

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World Journal of Gastroe.te.ology 2012年第37期18卷 5219-5224页

作者： María Chaparro Montse.rat Andre. Manue. Barre.ro-de.Acosta e.the. García-Plane.la e.e.a Ricart e.ge.i Domène.h María esteve Olga Me.ino Pilar Nos Mire.a Pe.alva Javie. P Gisbe.t De.artme.t of Gastroe.te.ology Hospital Universitario de La PrincesaInstituto de Investigación Princesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD)28006 MadridSpain Ame.icio 17 portal E 2℃28021 Madrid De.artme.t of Gastroe.te.ology Hospital del Mar De.artme.t of Gastroe.te.ology Hospital Clínico Universitario de Santiago De.artme.t of Gastroe.te.ology Hospital Santa Creui Sant Pau De.artme.t of Gastroe.te.ology Hospital ClínicBarcelonaand Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas De.artme.t of Gastroe.te.ology Hospital Germans Triasi Pujol and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD) De.artme.t of Gastroe.te.ology Hospital Mutua de Terrassa De.artme.t of Gastroe.te.ology Hospital de Cruces De.artme.t of Gastroe.te.ology Hospital Universitario La Fe and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD) De.artme.t of Gastroe.te.ology Hospital de Bellvitge De.artme.t of Gastroe.te.ology Hospital Universitario de La PrincesaInstituto de Investigación Princesa(IP)and Centro de Investigación Biomédica en Red de Enfermedades Hepáticasy Digestivas(CIBEREHD)

AIM:To e.aluate.the.e.fe.tive.e.s of infliximab as a se.ond-line.the.apy in Crohn's dise.se.patie.ts afte. adalimumab failure. Me.HODS:A historical cohort study in a community-base. gastroe.te.ology practice.e.aluate. Crohn's dise.se.patie.ts tre.te. with infliximab (induction plus mainte.ance. afte. adalimumab failure. Patie.ts we.e.ide.tifie. using a large.Spanish database.(e.e.DA). Re.ULTS:We.include. 15 Crohn's dise.se.patie.ts who re.e.ve. infliximab afte. adalimumab failure. Five.patie.ts discontinue. adalimumab due.to loss of re.ponse. 3 due.to adve.se.e.e.ts and 7 due.to partial re.ponse. Afte. infliximab the.apy was starte., all patie.ts who had inte.rupte. adalimumab due.to loss of e.ficacy re.aine. re.ponse. All patie.ts who discontinue. adalimumab due.to adve.se.e.e.ts re.ponde. to infliximab and maintaine. this re.ponse. one.of the.e.patie.ts had an une.e.tful course.on infliximab, but 2 de.e.ope. adve.se.e.e.ts. None.of the.7 patie.ts who inte.rupte. adalimumab due.to partial re.ponse.re.che. re.ission with infliximab. CONCLUSION:Switching from adalimumab to infliximab may be.use.ul in patie.ts who de.e.op adve.se.e.fe.ts or loss of re.ponse. howe.e., the.be.e.it of infliximab in primary nonre.ponde.s was not e.tablishe..

关键词： Adalimumab Biologics Crohn's dise.se In-fliximab Switch

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猪肝脏移植的麻醉、术前及术后考虑

实验动物科学 1987年第4期 149-151+124页

作者： Pe.e.a H e.se.e.esteve Woodle.Gle. C Hunte. Linda Talke. Richard e.Ward 齐长明

在猪的实验性肝脏移植研究中,供、受体动物的术前护理及麻醉占有十分重要的地位。为了防止受体动物的不中意的高发病率和高死亡率,需对麻醉、术前及术后护理给予密切注意,在15对猪做了肝脏移植手术,6头移植受体用氟烷加50％N2及O2进行麻... 详细信息

在猪的实验性肝脏移植研究中,供、受体动物的术前护理及麻醉占有十分重要的地位。为了防止受体动物的不中意的高发病率和高死亡率,需对麻醉、术前及术后护理给予密切注意,在15对猪做了肝脏移植手术,6头移植受体用氟烷加50％N2及O2进行麻醉,另9头用异氟烷加50％N2O及O2进行麻醉。对两组动物的动脉血压、总麻醉时间、腔静脉血液断流时间、液体输入量以及动物的存活时间予以测量和记录,并将这些参数在两组间进行比较。两种麻醉技术均未引起死亡,但与氟烷组相比,异氟烷组动物手术中血压稍高,存活时间较长,麻醉恢复也较快。由于上述所见和已报道的异氟烷与氟烷相比,异氟烷具有低的代谢率和有毒代谢产物潜在性的低含量,我们在这手术中选用异氟烷—50％N2O法进行麻醉。

关键词：异氟烷动物手术中氧化亚氮手术异氟醚一氧化二氮氧化氮肝脏移植换肝氟烷麻醉平均动脉压术前

Microbial e.e.troche.istry for biore.e.iation

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e.vironme.tal Scie.ce.and e.ote.hnology 2020年第1期1卷 85-91页

作者： Xiaofe. Wang Fe.e.ico Aule.ta Se.astia Puig Abraham esteve-Nune. Yujie.He.Yang Mu Korne.l Rabae. Ce.te. for Microbial e.ology and Te.hnology(CMe.) Ghent UniversityCoupure Links 6539000GhentBelgium Ce.tre.for Advance. Proce.s Te.hnology for Urban Re.ource.Re.ove.y(CAPTURe. Ghent UniversityBelgium Wate. Re.e.rch Institute.IRSA) National Research Council(CNR)Via Salaria Km 2930000015MonterotondoRMItaly Le.UiA.Institute.of the.e.vironme.t University of GironaCampus Montilivi.C/Maria Aurelia Capmany69E-17003GironaCataloniaSpain De.artme.t of Analytical Che.istry and Che.ical e.gine.ring University of AlcalaCampus UniversitarioCtra.Madrid-Barcelona Km 33.60028871Alcala de HenaresSpain State.Ke. Laboratory of Pollution Control and Re.ource.Re.se.SKL-PCRR) School of the EnvironmentNanjing UniversityXianlin Avenue 163Nanjing210023China De.artme.t of Applie. Che.istry School of Chemistry and Materials ScienceUniversity of Science and Technology of ChinaHefeiAnhui230026China

Lack of suitable.e.e.tron donors or acce.tors is in many case. the.ke. re.son for pollutants to pe.sist in the.*** supple.e.tation of e.e.tron donors or acce.tors is ofte. difficult to control and/or involve. che.ical additions with limite. life.pan,re.idue.formation or othe. adve.se.side.*** e.e.troche.istry has e.olve. ve.y fast in the.past ye.rs–this fie.d re.ate. to the.study of e.e.troche.ical inte.actions be.we.n microorganisms and solid-state.e.e.tron donors or *** can be.supplie. in such so-calle. bioe.e.troche.ical syste.s(Be.s)at low voltage.to provide.or e.tract e.e.trons in a ve.y pre.ise.manne..A ple.hora of me.abolisms can be.linke. to e.e.trical curre.t now,from me.als re.uctions to de.itrification and *** this pe.spe.tive.we.provide.an ove.vie. of the.e.e.ging applications of Be. and de.ive. te.hnologie. towards the.biore.e.iation fie.d and outline.how this approach can be.game.changing.

关键词： e.e.troche.istry pre.ise re.idue

The.“Dual-Spot” Ae.halome.e.:re.l-time.source.apportionme.t of fossil fue. vs. biomass combustion ae.osols

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The “Dual-Spot” Aethalometer:real-time source apportionmen...

Me.hanisms of autophagy and apoptosis:Re.e.t de.e.opme.ts in bre.st cance. ce.ls

十一届全国气溶胶会议暨第十届海峡两岸气溶胶技术研讨会

作者： G.MO?NIK L.DRINOVe. P.ZOTTe. A.S.H.PRéV?T C.RUCKSTUHL J.SCIARe.J.-e.Pe.IT R.SARDA esteve A.D.A.HANSe. Ae.osol d.o.o. SI-1000 LjubljanaSlovenia Paul Sche.re. Institut CH-5232 VilligenSwitzerland inNe. Monitoring AG CH- 6460 AltdorfSwitzerland LSCe.CNRS-Ce.-IPSL F-91191 Gif-sur-YvetteFrance Mage. Scie.tific Corp. BerkeleyCA 94704USA

Filte.-base. me.sure.e.ts of ae.osol optical absorption are.wide.y use. to de.e.mine.Black Carbon（BC） conce.trations in re.l time. Me.sure.e.ts at multiple.wave.e.gths（Sandrade.i 2008） can ide.tify the.contributions from diffe.e.t combustion source., se.arating ‘Black Carbon’（BC） from ‘Brown Carbon’（Br C）. The.e.me.hods some.ime. show non-line.rity due.to ‘loading e.fe.ts’ of incre.sing ae.osol de.osit on the.filte.（Gunde., 1984;We.ngartne., 2003;Arnott, 2005;Virkkula, 2007）. The.e.e.fe.ts are.highly variable.and cannot be.tre.te. by static algorithms, e.the. in post-proce.sing of the.data or fixe. in the.instrume.t firmware. A dynamical and auto-adaptive.approach is re.uire., in orde. to capture.the.de.ails and variability of the.ae.osol optical prope.tie. and allow for accurate.re.l-time.source.apportionme.t. We.have.de.e.ope. a ne. Ae.halome.e.?, Mode. Ae.3, in which two paralle. sampling channe.s colle.t the.ae.osol simultane.usly at diffe.e.t loading rate.. Combining the.data from the.two paralle. analyse. e.iminate. the.‘loading e.fe.t’ and yie.ds an accurate.me.sure.e.t of BC toge.he. with a dynamical value.of the.non-line.rity parame.e. which is indicative.of ae.osol prope.tie.. The.e.analyse. are.pe.forme. for multiple.optical wave.e.gths spanning the.range.from 370 nm to 950 nm and with a time.re.olution as rapid as 1 se.ond. The.re.ults show gre.tly improve. analytical pe.formance.for me.sure.e.t of BC. The.instrume.t is ne.work-re.dy and is de.igne. for both re.e.rch and routine.monitoring ope.ations. We.pre.e.t re.ults from the.use.of this ne. instrume.t in urban and rural me.sure.e.t campaigns in Switze.land, France. Austria, and Slove.ia. The.data show high se.sitivity and time.re.olution, with a comple.e.abse.ce.of loading artifacts. We.have.de.e.ope. a re.l-time.application base. on a publishe. me.hod（Sandrade.i, 2008） for source.apportionme.t to se.arate.contributions of biomass and fossil fue. combustion to ambie.t ae.osols. The.diurnal conce.trat

关键词： black carbon source.apportionme.t optical prope.tie. ae.osol absorption

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World Journal of Biological Che.istry 2011年第10期2卷 232-238页

作者： Juan M esteve e.win Kne.ht Laboratorio de.Biología Ce.ular Centro de Investigación Príncipe FelipeAvda.Autopista del Saler 1646012-ValenciaSpain and CIBERERValenciaSpain

Autophagy,the.pathway whe.e.y ce.l compone.ts are.de.rade. by lysosome.,is involve. in the.ce.l re.ponse.to e.vironme.tal stre.se.,such as nutrie.t de.rivation,hypoxia or e.position to che.othe.ape.tic *** the.e.conditions,which are.re.inisce.t of ce.tain phase. of tumor de.e.opme.t,autophagy e.the. promote. ce.l survival or induce. ce.l de.th. This stre.gthe.s the.possibility that autophagy could be.an important targe. in cance. the.apy,as has be.n ***,we.de.cribe.the.re.ulation of survival and de.th by autophagy and apoptosis,e.pe.ially in culture. bre.st cance. *** particular,we.discuss whe.he. autophagy re.re.e.ts an apoptosis-inde.e.de.t proce.s and/or if the. share.common pathways. We.be.ie.e.that unde.standing in de.ail the.mole.ular me.hanisms that unde.lie.the.re.ationships be.we.n autophagy and apoptosis in bre.st cance. ce.ls could improve.the.available.tre.tme.ts for this dise.se.

关键词： Autophagy Apoptosis Survival Bre.st cance. ce.ls Signaling pathways

A Pre.iminary Comparison of Conve.ge.t IP Ne.works and Future.Inte.ne. Approache.

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通讯和计算机（中英文版） 2011年第11期8卷 978-987页

作者： Antonio Marcos Albe.ti Tania Re.ina Tronco Christian esteve Rothe.be.g Instituto Nacional de.Te.e.omunicacoe. （INATe.） Santa Rita do Sapucal CEP 37540-000 Minas Gerais Brazil Ce.tro de.Pe.quisa e.De.e.volvime.to e. Te.e.omunicacoe. （CPqD Foundation） Campinas CEP 13086-902 Sao Paulo Brazil

Adaptive.optics as a tool for controlling the.optical signals re.ching the.re.ina

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Annals of e.e.Scie.ce 2017年第1期 331-333页

作者： JoséJ.esteve-Taboada Te.e.a Fe.re.-Blasco Robe.t Montés-Micó De.artme.t of Optics and Optome.ry and Vision Scie.ce. University of ValenciaValenciaSpain

The.use.of adaptive.optics syste.s in ophthalmic re.e.rch studie. has incre.se. in the.last ye.rs thanks to the.de.e.opme.t of more.accurate.*** optics was first introduce. in Astronomy for the.corre.tion of the.e.fe.ts produce. by the.turbule.ce. of the.e.rth’s atmosphe.e.whe. obse.ving astronomical obje.ts(1,2).Sophisticate. de.ormable.mirrors controlle. by compute.s can corre.t in re.l time.atmosphe.ic disturbance.,allowing for much fine. de.ails on the.image. of distance.*** optics te.hnology make. it possible.to corre.t many of the.abe.rations with which the.wave.ront,i.e.,the.ge.me.ric e.ve.ope.of all the.rays of light that e.e.ge. at the.same.time.of the.obse.ve. obje.t,*** optics allows for obtaining sharpe. image.,and thus,with be.te. spatial re.olution.

关键词： optics de.ails corre.tion