腹股沟假瘤:天疱疮15年缓解后复发

作     者：Esteve E. Kerdraon R. Martin L. 田中伟 

作者机构：Service de Dermatologie H.opi tal Porte Madeleine BP 2439 45032 Orl'Cedex France 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第5期

页      面：52-53页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：假瘤 棘层松解 棘细胞层 右侧腹股沟 直接免疫荧光 间接免疫荧光 增殖型 糖皮质激素 表皮细胞 增殖性 

摘      要：Introduction. Pemphigus vegetans (PV) is a rare type of pemphigus vulgaris. We report a patient with pemphigus vulgaris relapsing as an isolated vegetative tu mour. Case report. A 59year-old man was seen in February 2001 for a tumour on t he right groin. He had received systemic corticosteroids and cyclophosphamide fo r pemphigus vulgaris from 1974 to 1985, and he had been in complete remission si nce 1985. At the time of evaluation,a10 ×5 ×5cm,smooth vegetative tumour was s een on the right groin. Biopsies showed spongiosis, acanthosis and some acanthol ysis. Direct immunofluorescence showed strong deposition of immunoglobulin C wit hin the intercellular substance of the epidermis. Indirect immunofluorescence re vealed anti-intercellular antibodies at a titer of 1/800. Immunoblot analysis s howed reactivity with the 130 kD pemphigus vulgaris antigen. PVg was diagnosed. Local corticosteroid treatment was initiated. The patient was disease-free at f ollow-up three years later. Discussion. Localised forms of pemphigus are very r are. Twenty four other cases have been reported among them just one case of loca lised PV. Our case report is very unusual because of the variability of the expr ession of the disease, the high antibody level, the absence of trigger factors, and the efficacy of the local corticosteroid treatment.