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Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical studies

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Current Medical science 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir ZinetÇöl Ömer ertürk Department of Internal Medicine Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and Genetics Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“hTert-HPNE”,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(G/C-Ms).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(Pstatistically significant decrease was detected in the apoptosis caused by vildagliptin/metformin hydrochloride with the supplementation of Anzer honey,pollen and propolis in hTert-HPNE cells(Psion This study can contribute to other studies testing the healing properties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.

关键词： cell viability hTert-HPNE Anzer bee products drug side effect diabetes mellitus

The Troubled Road in Russia: Putin’s Impasse

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International Relations and Diplomacy 2020年第9期8卷 377-391页

作者： sait Yilmaz Muzaffer ertürk Esenyurt University Esenyurt/IstanbulTurkey NişantaşıUniversity IstanbulTurkey

After the collapse of the soviet Union,Russia,which is sustaining a new recovery process with Putin,is at the crossroads of a new turning ***,the face of the country's deep state,may hold the presidency for another two terms,in line with new constitutional *** new constitution predicts handing over some of the presidential authority to the Russian Parliament,the *** changes in the constitution involve new alignments in the Russian decision-making system rather than promoting internal *** the other hand,the conventional energy resources of Russia,representing the predominant part of the national income,are in a decreasing *** explored energy reserves are either too expensive for extraction or too far from the center of the *** inevitably has to develop additional sources for export other than energy to balance her *** COVID-19,the vulnerability of the Russian state system and revenues came into the *** the coming decades,Russia needs to make critical decisions to sustain her ambition to be a major ***,being aware of this,is planning a transition period,behind which he will personally stand during the changeover.

关键词： Putin Russia Duma energy constitution

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Effect of Water Concentration on the Characterization of sprayed Cd_(0.5)Zn_(0.5)s Films

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Chinese Physics Letters 2011年第6期28卷 237-240页

作者： sur s Öztürk Z Öztaş.M Bedir M Özdemir Y Department of Engineering Physics University of GaziantepGaziantepTurkey Chemical and Process Engineering Department Yalova UniversityYalovaTurkey

Cd_(0.5)Zn_(0.5)s film samples are prepared by a spray pyrolysis technique using aqueous solutions of CdC_(l2),ZnC_(l2),sC(NH2)2 and deionized water,which are atomized using compressed air as the carrier gas onto glass substrates with different water(H2O)concentrations.H2O is used as the *** prepared films are characterized by means of XRD and UV−VIs *** results reveal that the structures and properties of the films are greatly affected by the H2O *** in a certain range of concentrations promotes the formation of the Cd_(0.5)Zn_(0.5)s films and improves the properties of the films.

关键词： spectroscopy pyrolysis

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Calculation of Elastic scattering Properties in an Ultra-Cold ^85Rb-^85Rb Vapour

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Chinese Physics Letters 2004年第12期21卷 2395-2398页

作者： M.KemalOEztürk süleymanOEzcelik DepartmentofPhysics UniversityofGazi06500TeknikokullarAnkaraTurkey

We report the calculation of the same-species elastic scattering properties for the ultracold rubidium--rubidium (85Rb--85Rb) system and the results are compared with other theoretical and experimental results in detail. We present an improved potential for triplet ground states of the Rb2 molecule, and calculate the scattering lengths at and the effective range r3 using WKB and Numerov methods for two rubidium-85 collisions in the triplet state. Also, we investigate the convergence of these scattering properties, i. e. the dependence on core radius and K0 parameter using quantum defect theory and the analytic calculations of scattering length obtained by szmytkowski. In addition, we present evaporative cooling and other results that include phase shift and cross section at zero energy limit.

关键词： Atomic and molecular physics Computational physics

Cyathus striatus:a new record from Arunachal Pradesh and a checklist of Bird’s nest fungi in India

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studies in Fungi 2021年第1期6卷 168-174页

作者： Niranjan M singh rk Department of Botany Rajiv Gandhi UniversityRono HillsDoimukhArunachal Pradesh 791112India

Twenty four species of Bird’s nest fungi belonging to four genera, namely Crucibulum, Cyathus, Nidula and sphaerobolus have been reported from India with most of the reports were from Northeastern states in the Eastern Himalaya region that is well recognized for its rich biodiversity. Among these genera, Cyathus is the largest genus with 61 species documented so far in the world including 17 species from India. so far, only Cyathus poeppigii has been reported from the Eastern Himalayan state of Arunachal Pradesh. In the present paper, another newly recorded species Cyathus striatus, is reported with its detail taxonomic characteristics. It produces comparatively smaller basidiocarps than the earlier reported collection from Darjeeling (West Bengal). Further, the basidiospores are thin walled but comparatively larger in size. The paper also lists all Bird’s nest fungi from India with detailed information.

关键词： Agaricomycetes Checklist Cyathus Eastern Himalaya

Condenser Optimization in steam Power Plant

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Journal of Thermal science 2003年第2期12卷 176-178,192页

作者： sükrüBekdemir Recepztürk ZehraYumurtac Yildiz Technical University Mechanical Engineering DepartmentIstanbulTurkeyYildiz Technical UniversityMechanical Engineering DepartmentIstanbulTurkeyYildiz Technical UniversityMechanical Engineering DepartmentIstanbulTurkey

In this paper the effects of the condenser design parameters(such as turbine inlet *** power and condenser pressure) on heat transfer area,cooling water *** cost and specific energy generation cost are studied for sur... 详细信息

关键词： condensers steam power plants energy cost.