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Pathology-induced NG2 proteoglycan expression in microglia

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Neural Regeneration Research 2023年第4期18卷 801-802页

作者： erika Meyer Anja Scheller Molecular Physiology Center for Integrative Physiology and Molecular MedicineUniversity of SaarlandHomburgGermany(Meyer EScheller A)Laboratory of Brain Ischemia and NeuroprotectionDepartment of Pharmacology and TherapeuticsState University of MaringáMaringáBrazil

Oligodendrocyte precursor cells(OPCs)and microglia are two very fascinating cell types with a multitude of important but different *** a first glance,they appear not to share many cellular properties,nor are directly related to one another or derived from a common *** all differences,emerging data show that both cell types express the protein nerve/glial antigen 2(NG2)after pathological insults(Figure 1).For years,it remained controversial whether microglia really could express NG2 upon injury,with contradictory results reported among different disease *** this question,we could recently show by using triple transgenic knock-in mice and either an acute injury model(stab wound injury)or the middle cerebral artery occlusion combined with immunohistochemistry that a subset of microglia activates the cspg4 gene in a disease dependent manner leading to a bonafide microglia-specific NG2 protein expression besides OPCs and *** data show that the cspg4 gene not only gets transcribed in microglia based on reporter expression after recombination,but also the protein itself is expressed(Huang et al.,2020).

关键词： NG2 wound Figure

A Procedure for the Design of Novel Assisting Devices for the Sit-to-Stand

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Journal of Bionic Engineering 2013年第4期10卷 488-496页

作者： Pierluigi Rea erika Ottaviano Gianni Castelli Department of Civil and Mechanical Engineering University of Cassino and Southern Lazio via G. Di Biasio 43 03043 Cassino (FR) Italy

The Sit-to-Stand （STS） is an activity most people perform numerous times daily. Standing up deals with the transition from two stabilized postures, namely seated to standing, with movement of all body segments except the feet. During the STS the body＇s Center of Gravity （COG） is moved upward from a sitting position to a standing position without losing balance and requiring a good coordination of many muscles. Three main phases of the STS movement can be recognized. One begins to stand up by inclining the upper body forward, which moves body mass toward the feet in order to maintain balance after lift-off. Prior to leaving the chair, hip and knee extensor muscles are activated to provide antigravity support for these joints, this action is commonly referred to as ＂weight shift＂. Finally; after leaving the chair, the leg and trunk joints are straightened to achieve upright stance. The STS task can be considered of major importance for impaired and elderly people to achieve minimal mo- bility and independence. In this paper we detail a procedure for the design of assisting devices to be used for the STS. In par- ticular, an experimental procedure is described firstly to track and record point trajectories and the orientation of the trunk during the STS. This analysis is then used to get information for the design of assisting devices. A proposal and simulation results are presented for a novel mechatronic system. In particular, for the case under study experimental tests are used to drive the actua- tion system for the reported simulation. A functional mechatronic scheme is then proposed to control the device during its operation.

关键词： Sit-to-Stand assisting devices mechatronic design experimental evaluation simulation

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库夫施泰因在童话世界和无垠山野共振

环球人文地理 2024年第11期 144-152页

作者：十一 ARochau erika Karl Allen Lugmayer Nikolai Sorokin Olivier pictureserver Roman Babakin Stephan Sühling Thomas Gross 摄图网

欧洲最适合隐居的地方在哪里？近日Lonely Planet公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边...

欧洲最适合隐居的地方在哪里？近日Lonely Planet公布的名单中，阿尔卑斯山脚下的库夫施泰因榜上有名。古典音乐环绕小镇，而走进大自然的方式有无数种：夏季徒步，冬季滑雪……库夫施泰因，奥地利西部的一个美丽小镇。得益于德、奥边界的地理之势，无论从慕尼黑还是萨尔茨堡出发，都只需乘车约1小时就能到达。小镇夹在阿尔卑斯山的一个河谷，碧绿草坪、原始森林和清澈湖水环绕四周，八个村庄点缀其间，从高空俯瞰，犹如散落的珍珠。

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Role of non-steroidal anti-inflammatory drugs on intestinal permeability and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2017年第22期23卷 3954-3963页

作者： erika utzeri paolo usai department of medical sciences university of cagliari

The use of non-steroidal anti-inflammatory drugs(NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites. Thus leading to so-called topical effects, which, in turn, lead to an impairment of the intestinal barrier. This process determines bacterial translocation and toxic substances of intestinal origin in the portal circulation, leading to an endotoxaemia. This condition could determine a liver inflammatory response and might promote the development of nonalcoholic steatohepatitis, mostly in patients with risk factors such as obesity, metabolic syndrome and a high fat diet, which may induce a small intestinal bacterial overgrowth and dysbiosis. This alteration of gut microbiota may contribute to nonalcoholic fatty liver disease and its related disorders in two ways: firstly causing a malfunction of the tight junctions that play a critical role in the increase of intestinal permeability, and then secondly leading to the development of insulin resistance, body weight gain, lipogenesis, fibrogenesis and hepatic oxidative stress.

关键词： Non-steroidal anti-inflammatory drugs Intestinal barrier Intestinal permeability Non-steroidal anti-inflammatory drugs - enteropathy Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Microbiota Metabolic syndrome Proton pump inhibitors Endotoxaemia

The impact of different corona models on FD algorithms for the solution of multiconductor transmission lines equations

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High Voltage 2021年第5期6卷 822-835页

作者： erika Stracqualursi Rodolfo Araneo Amedeo Andreotti DIAEE-Electrical Engineering Division University of Rome“La Sapienza”RomeItaly Electrical Engineering Department University Federico II of NapoliNapoliItaly

In this study,the implementation of different corona discharge models in a transient program for overhead multiconductor lines based on the implicit Crank‐Nicolson Finite Difference Time Domain method is *** different corona models available in the literature,two empirical models(Gary's and Suliciu's models)and a physics‐based model(Malik's model)are discussed,which are broadly used in EMT programs,and their predictions under fast‐front lightning surges and slow‐front switching impulses are *** authors critically review the dynamic capacitance approach in terms of numerical accuracy,when dealing with slowly varying voltages,and applicability,regarding dispersive models assuming a non‐instantaneous charge‐voltage *** alternative voltage‐controlled generator approach is proposed,which is successfully included in the implicit Crank‐Nicolson *** of the objectives of this study is to show how different corona models may predict overvoltages with huge discrepancies,depending on the transient waveform and the propagation distance,despite the similarity of the q‐v hysteresis *** evident discrepancies between models under fast‐front voltage waves are reported,rather than for switching *** consistency of these results in terms of the models'features and q‐v curves is analysed,highlighting the necessity for new engineering tools for corona simulation of general predictive capability.

关键词： conductor transient dealing

COVID-19:Insights into long-term manifestations and lockdown impacts

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Journal of Sport and Health Science 2023年第4期12卷 438-463页

作者： erika Hilbold Christian Bär Thomas Thum Institute of Molecular and Translational Therapeutic Strategies(IMTTS) Hannover Medical SchoolHannover 30625Germany Fraunhofer Cluster of Excellence Immune-Mediated Diseases(CIMD) Hannover 30625Germany Fraunhofer Institute for Toxicology and Experimental Medicine(ITEM) Hannover 30625Germany

Coronaviruses are pathogens thought to primarily affect the respiratory tracts of *** outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in 2019 was also marked mainly by its symptoms of respiratory illness,which were named coronavirus disease 2019(COVID-19).Since its initial discovery,many other symptoms have been linked to acute SARS-CoV-2 infections as well as to the long-term outcomes of COVID-19 *** these symptoms are different categories of cardiovascular diseases(CVDs),which continue to be the main cause of death *** World Health Organization estimates that 17.9 million people die from CVDs each year,accounting for~32%of all deaths *** inactivity is one of the most important behavioral risk factors for *** COVID-19 pandemic has affected CVDs as well as the physical activity in different ***,we provide an overview of the current status as well as future challenges and possible solutions.

关键词： Cardiovascular disease COVID-19 Long COVID Physical activity Return to play

Hexagonal connectivity maps for Digital Earth

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International Journal of Digital Earth 2015年第9期8卷 750-769页

作者： Ali Mahdavi-Amiri erika Harrison Faramarz Samavati Department of Computer Science University of CalgaryCalgaryABCanada

Geospatial data are gathered through a variety of different *** integration and handling of such datasets within a Digital Earth framework are very important in many aspects of science and *** means of addressing these tasks is to use a Discrete Global Grid System and map points of the Earth’s surface to *** indexing mechanism is needed to access the data and handle data queries within these *** this paper,we present a general hierarchical indexing mechanism for hexagonal cells resulting from the refinement of triangular spherical polyhedra representing the *** this work,we establish a 2D hexagonal coordinate system and diamond-based hierarchies for hexagonal cells that enables efficient determination of hierarchical relationships for various hexagonal refinements and demonstrate its usefulness in Digital Earth frameworks.

关键词： Digital Earth framework hexagonal subdivision indexing triangulation hierarchy multiresolution

Carotid stenosis in women:time for a reappraisal

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Stroke & Vascular Neurology 2016年第4期1卷 192-196页

作者： erika Marulanda-Londono Seemant Chaturvedi Department of Neurology and Stroke Program University of Miami Miller School of MedicineMiamiFloridaUSA

The treatment approach for patients with internal carotid artery stenosis is receiving increased *** advances in optimal medical therapy have been associated with a declining stroke rate for symptomatic and asymptomatic patients with carotid *** treatment according to gender is worthy of consideration,since earlier clinical trials showed reduced benefit with carotid endarterectomy in women compared to *** this review,clinical trial results in women are summarised,studies pertaining to carotid plaque imaging in men and women are discussed and new clinical trials are ***,the rationale for a women’s carotid trial is provided.

关键词： stenosis clinical treatment

Beneficial effects of naringenin in liver diseases: Molecular mechanisms

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World Journal of Gastroenterology 2018年第16期24卷 1679-1707页

作者： erika Hernández-Aquino Pablo Muriel Laboratory of Experimental Hepatology Department of Pharmacology

Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress and inflammation that lead to the excessive production of extracellular matrix(ECM), followed by a progression to fibrosis, cirrhosis and hepatocellular carcinoma(HCC). It has been reported that some natural products display hepatoprotective properties. Naringenin is a flavonoid with antioxidant, antifibrogenic, anti-inflammatory and anticancer properties that is capable of preventing liver damage caused by different agents. The main protective effects of naringenin in liver diseases are the inhibition of oxidative stress, transforming growth factor(TGF-β) pathway and the prevention of the transdifferentiation of hepatic stellate cells(HSC), leading to decreased collagen synthesis. Other effects include the inhibition of the mitogen activated protein kinase(MAPK), toll-like receptor(TLR) and TGF-β non-canonical pathways, the inhibition of which further results in a strong reduction in ECM synthesis and deposition. In addition, naringenin has shown beneficial effects on nonalcoholic fatty liver disease(NAFLD) through the regulation of lipid metabolism, modulating the synthesis and oxidation of lipids and cholesterol. Moreover, naringenin protects from HCC, since it inhibits growth factors such as TGF-β and vascular endothelial growth factor(VEGF), inducing apoptosis and regulating MAPK pathways. Naringenin is safe and acts by targeting multiple proteins. However, it possesses low bioavailability and high intestinal metabolism. In this regard, formulations, such as nanoparticles or liposomes, have been developed to improve naringenin bioavailability. We conclude that naringenin should be considered in the future as an important candidate in the treatment of different liver diseases.

关键词： Naringenin transforming growth factor liver fibrosis MAPKs CCl4 flavonoids JNK hepatic stellate cells cirrhosis Smads α-SMA