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MicroRNA-630:A promising avenue for alleviating inflammation in diabetic kidney disease

World Journal of Diabetes 2024年第7期15卷 1398-1403页

作者： Javier Donate-correa Ainhoa González-Luis Jésica Díaz-Vera Juan Ramón Hernandez-Fernaud Research Unit University Hospital Nuestra Señora de Candelaria(UHNSC)Santa Cruz de Tenerife 38010Spain Department of Biochemistry MicrobiologyCell Biology and GeneticsInstituto de Tecnologías BiomédicasUniversidad de La LagunaSanta Cruz de Tenerife 38000Spain

Diabetic kidney disease(DKD)is one of the complications of diabetes,affecting millions of people *** relentless progression of this condition can lead to kidney failure,requiring life-altering interventions such as dialysis or *** evidence suggests that immunologic and inflammatory elements play an important role in initiating and perpetuating the damage inflicted on renal tissues,exacerbating the decline in organ ***-like receptors(TLRs)are a family of receptors that play a role in the activation of the innate immune system by the recognition of pathogen-associated molecular *** data from in vitro and in vivo studies have highlighted the critical role of TLRs,mainly TLR2 and TLR4,in the pathogenesis of *** the diabetic milieu,these TLRs recognize diabetic-associated molecular signals,triggering a proinflammatory cascade that initiates and perpetuates inflammation and fibrogenesis in the diabetic *** non-traditional strategies targeting TLR signaling with potential therapeutic implications in DKD have been *** of these approaches is the use of microRNAs,small non-coding RNAs that can regulate gene *** editorial comments on the results of this approach carried out in a rat model of diabetes by Wu et al,published in this issue of the World Journal of *** results of the experimental study by Wu et al shows that microRNA-630 decreased levels compared to non-diabetic ***,microRNA-630 exerted anti-inflammatory effects in the kidneys of diabetic rats through the modulation of *** findings indicate that the microRNA-630/TLR4 axis might represent a pathological mechanism of DKD and a potential therapeutic target capable of curbing the destructive inflammation characteristic of DKD.

关键词： Diabetes Diabetic kidney disease Inflammation Toll-like receptor 4 microRNA-630

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A prototype for on-site generation of chlorinated disinfectant for use in rural aqueducts

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Water Science and Engineering 2024年第1期17卷 33-40页

作者： Diana Marcela Cuesta Parra Felipe correa Mahecha Andrés Felipe Rubio Pinzon Davidcamilo Ramirez Bustos Leonel Alveyro Teran Llorente Miguel Fernando Jimenez Jimenez Chemical and Environmental Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Chemical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia Mecanical Engineering Department Fundacion Universidad de AmericaBogota 117111Colombia

Sodium hypochlorite has significant potential as a sanitation solution in hard-to-reach *** studies have investigated the optimal electrolysis parameters for its production with volumes greater than 1o *** study evaluated sodium hypochlorite production through electrolysis in a 22-L prototype and identified the optimal operating *** were performed using graphite electrodes with areas of 68.4 cm^(2) at the laboratory scale and 1865.0 cm^(2) at the prototype scale.A design for experiments with different operating times,chloride concentrations,and electric current intensities was *** optimal operating time,sodium chloride concentration,and current intensity at the laboratory scale were 120 min,150 g of chloride per liter,and 3 A,respectively,leading to the production of 5.02 g/L of the disinfectant with an energy efficiency of 12.21 mg of Cl_(2) per *** the prototype scale,the maximum sodium hypochlorite concentration of 3.99 g of chloride per liter was achieved with an operating time of 120 min,a sodium chloride concentration of 100 g of chloride per liter,and a current intensity of 70 A,reaching an energy efficiency of 42.56 mg of Cl_(2) per *** addition,this study evaluated the influences of the chloride concentration,current intensity,and operating time on the production of sodium hypochlorite at the two scales,and formulated the equations showing the trends of sodium hypochlorite production and energy efficiency in the electrochemical *** 22-L prototype model for production of this oxidizing substance is promising for disinfection of large volumes of water in areas that are difficult to access.

关键词： Disinfection Electrolysis Energy efficiency Optimization Sodium hypochlorite

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Benzyl Amino Purine and Gibberellic Acid Coupled to Nitrogen-Limited Stress Induce Fatty Acids,Biomass Accumulation,and Gene Expression in Scenedesmus Obliquus

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 515-531页

作者： Hans Christian correa-Aguado Gloria Viviana Cerrillo-Rojas Alejandro Rocha-Uribe Ruth Elena Soria-Guerra JoséFrancisco Morales-Domínguez Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Facultad de Ciencias Químicas Universidad Autónoma de San Luis PotosíSan Luis Potosí78210México Instituto Politécnico Nacional Unidad Profesional Interdisciplinaria de Ingeniería Campus ZacatecasBlvd.del Bote 202Cerro del Gato Ejido La EscondidaCol.Ciudad AdministrativaZacatecasZAC 98160Mexico

The need for renewable energy sources makes microalgae an essential feedstock for biofuels *** molecular aspects and the response to nitrogen(N)-limited conditions with a phytohormone stimulus in microalgae have been slightly *** this work,Scenedesmus obliquus was used as a study model to analyze the effect of benzyl amino purine(BAP)and gibberellic acid(GA)coupled to nitrogen limitation on cell growth,biomass and fatty *** selected 10^(-5)M BAP increased the biomass by 1.44-fold,and 10^(-6)M GA by *** total lipids also increased by 2.8 and 1.11-fold,*** 10^(-5)M BAP and 10^(-6)M GA addition to *** cultures at different initial nitrogen percentages(N-0,N-25,and N-50)showed a significant increase in cell growth and biomass productivity compared to the unstimulated *** N-0 and GA N-0 produced the highest lipid yields with 55%and 50%,*** lipid profile analysis revealed an increase,particularly in C18:1 and C16:0 fatty *** expression analysis showed an over-expression of acyl carrying protein(ACP),stearoyl-ACP desaturase(SAD),fatty acid acyl-ACP thioesterase(FATA),and diacylglycerol acyltransferase(DGAT)genes,which were mainly induced by nitrogen ***,BAP and GA produced a significant over-expression on these genes in the N-replete *** study shows that BAP and GA,coupled to N limitation stress,can be used to increase the biomass and lipid production in *** for sustainable biofuels.

关键词： Biodiesel gene expression lipids microalgae nitrogen deficiency phytohormones

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Diversity of Saxicolous Lichens along an Aridity Gradient in Central México

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Phyton-International Journal of Experimental Botany 2022年第4期91卷 827-840页

作者： JoséCarmen Soto-correa Abraham Saldaña-Vega Víctor Hugo Cambrón-Sandoval Laura Concostrina-Zubiri Mariela Gómez-Romero Facultad de Ciencias Naturales Universidad Autónoma de QuerétaroQuerétaro73230México Departamento de Biología y Geología Física y Química Inorgánica Tulipán s/nUniversidad Rey Juan CarlosMóstolesMadrid28933España Cátedra CONACYT–Facultad de Biología Universidad Michoacana de San Nicolás de HidalgoMoreliaMichoacán58030México

Lichens are symbiotic organisms that comprise a fungus and a photosynthetic partner wich are recognized as a good indicator of climate ***,our understanding of how aridity affects the diversity of saxicolous lichens in drylands is still *** evaluate the relationship between saxicolous lichen diversity and aridity in a central México dryland,a geographical transect was established of 100 km to build an aridity gradient in the semiarid zone of the State of Querétaro,Mexico,comprising ten sampling sites with a 10 km *** richness,abundance and diversity of soil lichen species were recorded using two sampling methods:the quadrat-intercept and the line-intercept method,to compare their performance in assessing soil lichen diversity in *** number of species and Shannon diversity of saxicolous lichens were higher at intermediate values of the aridity index(AI=0.10-0.34).Quadrat intercept and point intercept methods gave quite similar results,which means that the selected method does not influence the results in a significant *** study confirms the role of saxicolous lichens as climate change indicators and reveals the importance of the sampling method selection in the evaluation of different parameters of soil lichen diversity in drylands.

关键词： Climate change drylands ecological indicators environmental stress precipitation temperature

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Pancreatic cancer: treatment approaches and trends

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 351-364页

作者： Nabyla Paixao Pereira Jose Raimundo correa Laboratory of Microscopy and Microanalyses Group of Applied Chemotherapy and Fluorescent ProbesDepartment of Cellular BiologyInstitute of Biological ScienceUniversity of BrasiliaBrasiliaDF 70910-900Brazil

Pancreatic cancer is one of the most challenging diseases due to its often late diagnose which results in limited therapeutic options and poor *** date,the only curative treatment is complete tumor removal surgery but only a few patients are eligible to do *** median survival period after surgery followed by chemotherapy adjuvant treatment is about 2 *** its approval by the FDA,Gemcitabine has become the first-line chemotherapy agent for treatment of advanced pancreatic *** FOLFIRINOX regimen is also used as a treatment scheme for pancreatic cancer;however,this regimen has resulted in small improvements in overall patient’s *** is appropriated to clarify that the FOLFIRINOX regimen can only be administered in patients with good performance *** to the absence of outstanding result after patient’s treatment with diverse chemotherapeutic agents combinations or unsuccessful administration of single-agent drugs to treat pancreatic cancer,the immunotherapy has become a new hope.A more comprehensive understanding of cancer microenvironment and the chemical communication between cancer cells and immune cells can result in new therapeutic approaches that will improve the elimination of pancreatic cancer cells,enhancing life quality for these patients and increasing the overall survival.

关键词： Pancreatic cancer chemotherapy gemcitabine immunotherapy

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The Contribution of Waves in Mixing Processes of the Patos Lagoon Plume

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International Journal of Geosciences 2012年第5期3卷 1019-1026页

作者： Eduardo de Paula Kirinus Wiliam correa Marques Julliet correa da Costa Elisa Helena Leao Fernandes Instituto de Matematica Estatistica e Fisica Universidade Federal do Rio GrandeRio Grande do SulBrazil Instituto de Oceanografia Universidade Federal do Rio GrandeRio Grande do SulBrazil

The analysis of wave effects above salinity is important in order to define mixing processes and their potential to change density gradients, since action in the region of the Patos Lagoon plume is highly dynamic. This paper aims to evaluate the influence of waves on the mixing pattern of the adjacent continental shelf. Constantly marked by tides and circulation variations, changing from flood to ebb tide, salinity stands as a major parameter for analysis. The study is based on hydrodynamic numerical modeling experiments using the TELEMAC3D model and waves generated by the wind using the TOMAWAC coupled model. The comparison between the situations considering the waves generated by the wind and without waves was made through time series analysis, stratification series, transversal cross sections, longitudinal cross sections, salinity mean fields and diagrams by Richardson and Brünt-V?is?l?s frequency parameters. With the cross sections analysis, the mixing effect generated by the waves was observed, demonstrating clearly that the waves were capable of raising the superficial salinity in regions far from the Patos Lagoon entrance, while at the entrance, the wave effects enhanced the mixing on the deepest layers, decreasing the saline intrusion and expanding the plume more radially on the surface. The space-temporal diagrams were effective to demonstrate the modulation effect of the waves over the salt mixing of saline waters, revealing that wave effects decrease the stratification as well as the Brünt-V?is?l?s frequency and increase the period of buoyancy, due to the mixing increase.

关键词： Vertical Mixing Tridimensional Numerical Modeling Stratification

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Watt-scale super-octave mid-infrared intrapulse difference frequency generation

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Light(Science & Applications) 2018年第1期7卷 124-131页

作者： Christian Gaida Martin Gebhardt Tobias Heuermann Fabian Stutzki Cesar Jauregui Jose Antonio-Lopez Axel Schulzgen Rodrigo Amezcua-correa Andreas Tunnermann Ioachim Pupeza Jens Limpert Institute of Applied Physics Abbe Center of PhotonicsFriedrich-Schiller-Universitat JenaAlbert-Einstein-Str.1507745 JenaGermany Helmholtz-Institute Jena Frobelstieg 307743 JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering Albert-Einstein-Str.707745 JenaGermany CREOL College of Optics and PhotonicsUniversity of Central FloridaOrlandoFL 32816USA Max-Planck-Institute of Quantum Optics Hans-Kopfermann-Str.185748 GarchingGermany

The development of high-power,broadband sources of coherent mid-infrared radiation is currently the subject of intense research that is driven by a substantial number of existing and continuously emerging applications in medical diagnostics,spectroscopy,microscopy,and fundamental *** of the major,long-standing challenges in improving the performance of these applications has been the construction of compact,broadband mid-infrared radiation sources,which unify the properties of high brightness and spatial and temporal *** to the lack of such radiation sources,several emerging applications can be addressed only with infrared(IR)-beamlines in largescale synchrotron facilities,which are limited regarding user access and only partially fulfill these ***,we present a table-top,broadband,coherent mid-infrared light source that provides brightness at an unprecedented level that supersedes that of synchrotrons in the wavelength range between 3.7 and 18μm by several orders of *** result is enabled by a high-power,few-cycle Tm-doped fiber laser system,which is employed as a pump at 1.9μm wavelength for intrapulse difference frequency generation(IPDFG).IPDFG intrinsically ensures the formation of carrierenvelope-phase stable pulses,which provide ideal prerequisites for state-of-the-art spectroscopy and microscopy.

关键词： pump coherent difference

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ADAM10 sheddase activation is controlled by cell membrane asymmetry

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Journal of Molecular Cell Biology 2019年第11期11卷 979-993页

作者： Florian Bleibaum Anselm Sommer Martin Veit Bjorn Rabe Jorg Andra Karl Kunzelmann Christian Nehls Wilmar correa Thomas Gutsmann Joachim Grotzinger Sucharit Bhakdi Karina Reiss Department of Dermatology University of Kiel24105 KielGermany Institute of Biochemistry University of KielOlshausenstraBe 4024098 KielGermany Hamburg University of Applied Science Ulmenliet 2021033 HamburgGermany Physiological Institute University of RegensburgUniversitatsstraBe 3193053 RegensburgGermany Forschungszentrum Borstel Leibniz-Zentrum fur Medizin und BiowissenschaftenParkallee 1023845 BorstelGermany

Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's *** mechanisms underlying ADAM10 sheddase activation are incompletely ***,we show that transient exposure of the negatively charged phospholipid phosphatidylserine(PS)is necessarily *** soluble PS headgroup was found to act as competitive inhibitor of substrate *** of the Ca2+-dependent phospholipid scramblase Anoctamin-6(AN06)led to increased PS externalization and substrate *** with a constitutively active form of AN06 resulted in maximum sheddase activity in the absence of any ***-dependent ADAM10 activation could not be induced in lymphocytes of patients with Scott syndrome harbouring a missense mutation in AN06.A putative PS-binding motif was identified in the conserved stalk *** of this motif resulted in strong reduction of sheddase *** conjunction with the recently described 3D structure of the ADAM10 extracellular domain,a model is advanced to explain how surface-exposed PS triggers ADAM 10 sheddase function.

关键词： ADAM10 activation shedding Anoctamin-6 phosphatidylserine cell membrane asymmetry

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维德汉·巴瓦尼州议会,博帕尔,印度

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世界建筑 2003年第1期 22-25页

作者： ARCHITECT: CHARLES correa ASSOCIATES 查尔斯.柯里亚建筑事务所建筑设计

场地面积:85 000 m2总建筑面积:32 000 m2项目造价:1153万美元(人民币 9544万元)业主:印度中央邦州政府土建和结构工程师:米哈第尔·哈吉机电工程师:SK莫西主承包商:M/s Sood &

关键词：德汉博帕尔州议会中央邦印度南亚

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Unveiling multimodal hot carrier excitation in plasmonic bimetallic Au@Ag nanostars for photochemistry and SERS sensing

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NANO RESEARCH 2024年第12期17卷 10355-10362页

作者： Negrin-Montecelo, Yoel Elsaidy, Amir Giraldez-Martinez, Jesus Carbo-Argibay, Enrique Wang, Zhiming Govorov, Alexander O. Alvarez-Puebla, Ramon A. correa-Duarte, Miguel A. Besteiro, Lucas V. Univ Rovira & Virgili Dept Phys & Inorgan Chem Carrer Marcelli Domingo S-N Tarragona 43007 Spain Mil Tech Coll Dept Chem Engn Cairo 4393010 Egypt Univ Vigo CINBIO Campus Univ Vigo Vigo 36310 Spain Int Iberian Nanotechnol Lab Ave Mestre Jose Veiga S-N P-4715330 Braga Portugal Univ Elect Sci & Technol China Inst Fundamental & Frontier Sci Chengdu 610054 Peoples R China Ohio Univ Dept Phys & Astron Athens OH 45701 USA ICREA Passeig Lluis Co 23 Barcelona 08010 Spain Univ Vigo Southern Galicia Inst Hlth Res IISGS Vigo 36310 Spain Univ Vigo Biomed Res Networking Ctr Mental Hlth CIBERSAM Vigo 36310 Spain

Plasmonic nanostructures stand at the forefront of nanophotonics research, particularly in sensing and energy conversion applications. Their unique ability to confine light energy at the nanoscale makes them indispensable for a wide array of technological advancements. The study of these structures often makes use of different materials and, even more extensively, explores new shapes and configurations to extend our common repertoire of useful nanophotonics tools. Exploring the creation of bimetallic plasmonic nanostructures combines these two dimensions determining the space of possible plasmonic resonators and opens the possibility of tailoring systems with behavior unavailable to single-metal plasmonic structures. In this paper, we delve into the exploration of bimetallic systems employing plasmonic nanostars. These structures have demonstrated remarkable capabilities for surface-enhanced Raman scattering (SERS) spectroscopy and photochemistry, due to the strong plasmonic response of their peaks, whose disposition following a spherical symmetry makes them largely polarization- and orientation-insensitive. Herein, we report the colloidal synthesis of two different water-stable Au@Ag nanostars, explore their performance as photocatalysts and SERS substrates, and provide an in-depth account of their non-trivial physical response.

关键词： hot-electrons field enhancement nanohybrids photocatalysis surface-enhanced Raman scattering (SERS) plasmonics

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